PMC:7060195 / 2815-3870 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7060195","sourcedb":"PMC","sourceid":"7060195","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7060195","text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 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