PMC:7060195 / 2815-3870 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"52","span":{"begin":869,"end":875},"obj":"Species"},{"id":"53","span":{"begin":902,"end":910},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"Tax:9606"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"MESH:D064420"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T5","span":{"begin":764,"end":767},"obj":"Body_part"},{"id":"T6","span":{"begin":914,"end":918},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma67122"}],"text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T21","span":{"begin":135,"end":140},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T22","span":{"begin":288,"end":293},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T23","span":{"begin":869,"end":875},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"}],"text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7","span":{"begin":625,"end":634},"obj":"Chemical"},{"id":"T8","span":{"begin":764,"end":767},"obj":"Chemical"}],"attributes":[{"id":"A7","pred":"chebi_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/CHEBI_60809"},{"id":"A8","pred":"chebi_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T2","span":{"begin":334,"end":350},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T3","span":{"begin":504,"end":528},"obj":"http://purl.obolibrary.org/obo/GO_0006959"},{"id":"T4","span":{"begin":697,"end":721},"obj":"http://purl.obolibrary.org/obo/GO_0006959"},{"id":"T5","span":{"begin":849,"end":865},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T6","span":{"begin":989,"end":1005},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23"}

{"project":"LitCovid-sentences","denotations":[{"id":"T21","span":{"begin":0,"end":69},"obj":"Sentence"},{"id":"T22","span":{"begin":70,"end":122},"obj":"Sentence"},{"id":"T23","span":{"begin":123,"end":276},"obj":"Sentence"},{"id":"T24","span":{"begin":277,"end":426},"obj":"Sentence"},{"id":"T25","span":{"begin":427,"end":640},"obj":"Sentence"},{"id":"T26","span":{"begin":641,"end":763},"obj":"Sentence"},{"id":"T27","span":{"begin":764,"end":913},"obj":"Sentence"},{"id":"T28","span":{"begin":914,"end":1055},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Table 1 Advantages and disadvantages of different vaccine strategies.\nVaccine strategy Advantages Disadvantages References\nInactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25\nAttenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25\nSubunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14\nViral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12\nDNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23\nmRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23"}