PMC:7040011 / 130-1595 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7040011","sourcedb":"PMC","sourceid":"7040011","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7040011","text":"The ACE2 gene encodes the angiotensin-converting enzyme-2, which has been proved to be the receptor for both the SARS-coronavirus (SARS-CoV) and the human respiratory coronavirus NL63. Recent studies and analyses indicate that ACE2 could be the host receptor for the novel coronavirus 2019-nCoV/SARS-CoV-21,2. Previous studies demonstrated the positive correlation of ACE2 expression and the infection of SARS-CoV in vitro3,4. A number of ACE2 variants could reduce the association between ACE2 and S-protein in SARS-CoV or NL635. Therefore, the expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection. A recent single-cell RNA-sequencing (RNA-seq) analysis indicated that Asian males may have higher expression of ACE26. Currently, the clinical reports of 2019-nCoV/SARS-CoV-2 infection from non-Asian populations for comparison are very limited. A study from Munich reported four German cases, all of which showed mild clinical symptoms without severe illness7. However, the genetic basis of ACE2 expression and function in different populations is still largely unknown. Therefore, genetic analysis of expression quantitative trait loci (eQTLs)8 and potential functional coding variants in ACE2 among populations are required for further epidemiological investigations of 2019-nCoV/SARS-CoV-2 spreading in East Asian (EAS) and other 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