PMC:6988269 / 12673-13620 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T53","span":{"begin":81,"end":84},"obj":"Body_part"},{"id":"T54","span":{"begin":142,"end":145},"obj":"Body_part"},{"id":"T55","span":{"begin":224,"end":227},"obj":"Body_part"},{"id":"T56","span":{"begin":234,"end":238},"obj":"Body_part"},{"id":"T57","span":{"begin":278,"end":281},"obj":"Body_part"},{"id":"T58","span":{"begin":291,"end":295},"obj":"Body_part"},{"id":"T59","span":{"begin":334,"end":337},"obj":"Body_part"},{"id":"T60","span":{"begin":344,"end":348},"obj":"Body_part"},{"id":"T61","span":{"begin":411,"end":414},"obj":"Body_part"},{"id":"T62","span":{"begin":433,"end":437},"obj":"Body_part"},{"id":"T63","span":{"begin":499,"end":502},"obj":"Body_part"},{"id":"T64","span":{"begin":519,"end":523},"obj":"Body_part"},{"id":"T65","span":{"begin":536,"end":539},"obj":"Body_part"},{"id":"T66","span":{"begin":567,"end":571},"obj":"Body_part"},{"id":"T67","span":{"begin":729,"end":733},"obj":"Body_part"}],"attributes":[{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A61","pred":"fma_id","subj":"T61","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A62","pred":"fma_id","subj":"T62","obj":"http://purl.org/sig/ont/fma/fma74402"},{"id":"A63","pred":"fma_id","subj":"T63","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A64","pred":"fma_id","subj":"T64","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A65","pred":"fma_id","subj":"T65","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A66","pred":"fma_id","subj":"T66","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A67","pred":"fma_id","subj":"T67","obj":"http://purl.org/sig/ont/fma/fma12520"}],"text":"Figure 3 Determination of limits of detection based on SARS coronavirus genomic RNA and 2019 novel coronavirus-specific in vitro transcribed RNA\nCI: confidence intervals; c/r: copies per reaction; IVT: in vitro-transcribed RNA.\nA: E gene assay, evaluated with SARS-CoV genomic RNA. B: RdRp gene assay evaluated with SARS-CoV genomic RNA. C: E-gene assay, evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard. D: RdRp gene assay evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard.\nThe x-axis shows input RNA copies per reaction. The y-axis shows positive results in all parallel reactions performed, squares are experimental data points resulting from replicate testing of given concentrations (x-axis) in parallels assays (eight replicate reactions per point).\nTechnical limits of detection are given in the panels headings. The inner line is a probit curve (dose-response rule). The outer dotted lines are 95% CI."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T39","span":{"begin":56,"end":60},"obj":"Disease"},{"id":"T40","span":{"begin":261,"end":269},"obj":"Disease"},{"id":"T41","span":{"begin":261,"end":265},"obj":"Disease"},{"id":"T42","span":{"begin":317,"end":325},"obj":"Disease"},{"id":"T43","span":{"begin":317,"end":321},"obj":"Disease"}],"attributes":[{"id":"A39","pred":"mondo_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A40","pred":"mondo_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A41","pred":"mondo_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A42","pred":"mondo_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Figure 3 Determination of limits of detection based on SARS coronavirus genomic RNA and 2019 novel coronavirus-specific in vitro transcribed RNA\nCI: confidence intervals; c/r: copies per reaction; IVT: in vitro-transcribed RNA.\nA: E gene assay, evaluated with SARS-CoV genomic RNA. B: RdRp gene assay evaluated with SARS-CoV genomic RNA. C: E-gene assay, evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard. D: RdRp gene assay evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard.\nThe x-axis shows input RNA copies per reaction. The y-axis shows positive results in all parallel reactions performed, squares are experimental data points resulting from replicate testing of given concentrations (x-axis) in parallels assays (eight replicate reactions per point).\nTechnical limits of detection are given in the panels headings. The inner line is a probit curve (dose-response rule). The outer dotted lines are 95% CI."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T114","span":{"begin":229,"end":233},"obj":"http://purl.obolibrary.org/obo/CLO_0051456"},{"id":"T115","span":{"begin":234,"end":238},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T116","span":{"begin":283,"end":284},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T117","span":{"begin":291,"end":295},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T118","span":{"begin":344,"end":348},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T119","span":{"begin":433,"end":437},"obj":"http://purl.obolibrary.org/obo/OGG_0000000002"},{"id":"T120","span":{"begin":694,"end":701},"obj":"http://purl.obolibrary.org/obo/UBERON_0000473"},{"id":"T121","span":{"begin":848,"end":856},"obj":"http://purl.obolibrary.org/obo/UBERON_0000033"},{"id":"T122","span":{"begin":848,"end":856},"obj":"http://www.ebi.ac.uk/efo/EFO_0000964"},{"id":"T123","span":{"begin":876,"end":877},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Figure 3 Determination of limits of detection based on SARS coronavirus genomic RNA and 2019 novel coronavirus-specific in vitro transcribed RNA\nCI: confidence intervals; c/r: copies per reaction; IVT: in vitro-transcribed RNA.\nA: E gene assay, evaluated with SARS-CoV genomic RNA. B: RdRp gene assay evaluated with SARS-CoV genomic RNA. C: E-gene assay, evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard. D: RdRp gene assay evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard.\nThe x-axis shows input RNA copies per reaction. The y-axis shows positive results in all parallel reactions performed, squares are experimental data points resulting from replicate testing of given concentrations (x-axis) in parallels assays (eight replicate reactions per point).\nTechnical limits of detection are given in the panels headings. The inner line is a probit curve (dose-response rule). The outer dotted lines are 95% CI."}

{"project":"LitCovid-sentences","denotations":[{"id":"T105","span":{"begin":0,"end":145},"obj":"Sentence"},{"id":"T106","span":{"begin":146,"end":228},"obj":"Sentence"},{"id":"T107","span":{"begin":229,"end":231},"obj":"Sentence"},{"id":"T108","span":{"begin":232,"end":282},"obj":"Sentence"},{"id":"T109","span":{"begin":283,"end":285},"obj":"Sentence"},{"id":"T110","span":{"begin":286,"end":338},"obj":"Sentence"},{"id":"T111","span":{"begin":339,"end":424},"obj":"Sentence"},{"id":"T112","span":{"begin":425,"end":427},"obj":"Sentence"},{"id":"T113","span":{"begin":428,"end":512},"obj":"Sentence"},{"id":"T114","span":{"begin":513,"end":560},"obj":"Sentence"},{"id":"T115","span":{"begin":561,"end":793},"obj":"Sentence"},{"id":"T116","span":{"begin":794,"end":857},"obj":"Sentence"},{"id":"T117","span":{"begin":858,"end":912},"obj":"Sentence"},{"id":"T118","span":{"begin":913,"end":947},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 3 Determination of limits of detection based on SARS coronavirus genomic RNA and 2019 novel coronavirus-specific in vitro transcribed RNA\nCI: confidence intervals; c/r: copies per reaction; IVT: in vitro-transcribed RNA.\nA: E gene assay, evaluated with SARS-CoV genomic RNA. B: RdRp gene assay evaluated with SARS-CoV genomic RNA. C: E-gene assay, evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard. D: RdRp gene assay evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard.\nThe x-axis shows input RNA copies per reaction. The y-axis shows positive results in all parallel reactions performed, squares are experimental data points resulting from replicate testing of given concentrations (x-axis) in parallels assays (eight replicate reactions per point).\nTechnical limits of detection are given in the panels headings. The inner line is a probit curve (dose-response rule). The outer dotted lines are 95% CI."}

{"project":"LitCovid-PubTator","denotations":[{"id":"216","span":{"begin":56,"end":72},"obj":"Species"},{"id":"217","span":{"begin":89,"end":111},"obj":"Species"},{"id":"219","span":{"begin":172,"end":175},"obj":"Gene"},{"id":"226","span":{"begin":286,"end":290},"obj":"Gene"},{"id":"227","span":{"begin":428,"end":432},"obj":"Gene"},{"id":"228","span":{"begin":261,"end":269},"obj":"Species"},{"id":"229","span":{"begin":317,"end":325},"obj":"Species"},{"id":"230","span":{"begin":371,"end":380},"obj":"Species"},{"id":"231","span":{"begin":459,"end":468},"obj":"Species"}],"attributes":[{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"Tax:694009"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Tax:2697049"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"Gene:43740578"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"Gene:43740578"},{"id":"A228","pred":"tao:has_database_id","subj":"228","obj":"Tax:694009"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Tax:694009"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Tax:2697049"},{"id":"A231","pred":"tao:has_database_id","subj":"231","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Figure 3 Determination of limits of detection based on SARS coronavirus genomic RNA and 2019 novel coronavirus-specific in vitro transcribed RNA\nCI: confidence intervals; c/r: copies per reaction; IVT: in vitro-transcribed RNA.\nA: E gene assay, evaluated with SARS-CoV genomic RNA. B: RdRp gene assay evaluated with SARS-CoV genomic RNA. C: E-gene assay, evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard. D: RdRp gene assay evaluated with 2019-nCoV-specific in vitro-transcribed RNA standard.\nThe x-axis shows input RNA copies per reaction. The y-axis shows positive results in all parallel reactions performed, squares are experimental data points resulting from replicate testing of given concentrations (x-axis) in parallels assays (eight replicate reactions per point).\nTechnical limits of detection are given in the panels headings. The inner line is a probit curve (dose-response rule). The outer dotted lines are 95% CI."}