PMC:6650341 / 1070-2050
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6650341","sourcedb":"PMC","sourceid":"6650341","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6650341","text":"Hypertension is the most prevalent cause of cardiovascular disease and kidney failure1, but the prevention and treatment of hypertension are still a challenge2–4. According to the 2017 High Blood Pressure Clinical Practice Guidelines, in adults (≥20 years of age), a “doctor’s office” reading of 120-129 mm Hg for systolic blood pressure (SBP) even with less than 80 mm Hg for diastolic blood pressure (DBP), is considered as elevated BP2,3. An SBP of 130-139 mm Hg or a DBP of 80-89 is now considered as Stage 1 hypertension, while the previous definition of hypertension ≥140 SBP or ≥90 DBP is now considered as Stage 2 hypertension. In the general population, only about 50% of treated patients achieve adequate blood pressure control2,4. The poor efficacy of hypertension treatment and the inter-individual variations in the response to antihypertensive medications have many causes, including non-compliance, but genetic variations could be important contributory 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