PMC:6650341 / 1070-2050
Annnotations
2_test
{"project":"2_test","denotations":[{"id":"30723314-29565029-83958225","span":{"begin":85,"end":86},"obj":"29565029"},{"id":"30723314-29565029-83958225","span":{"begin":85,"end":86},"obj":"29565029"},{"id":"30723314-29146532-83958226","span":{"begin":158,"end":159},"obj":"29146532"},{"id":"30723314-29146532-83958226","span":{"begin":158,"end":159},"obj":"29146532"},{"id":"30723314-29159417-83958226","span":{"begin":158,"end":159},"obj":"29159417"},{"id":"30723314-29159417-83958226","span":{"begin":158,"end":159},"obj":"29159417"},{"id":"30723314-26592190-83958226","span":{"begin":158,"end":159},"obj":"26592190"},{"id":"30723314-26592190-83958226","span":{"begin":158,"end":159},"obj":"26592190"},{"id":"30723314-29146532-83958227","span":{"begin":437,"end":438},"obj":"29146532"},{"id":"30723314-29146532-83958227","span":{"begin":437,"end":438},"obj":"29146532"},{"id":"30723314-29159417-83958228","span":{"begin":439,"end":440},"obj":"29159417"},{"id":"30723314-29159417-83958228","span":{"begin":439,"end":440},"obj":"29159417"},{"id":"30723314-29146532-83958229","span":{"begin":737,"end":738},"obj":"29146532"},{"id":"30723314-29146532-83958229","span":{"begin":737,"end":738},"obj":"29146532"},{"id":"30723314-26592190-83958230","span":{"begin":739,"end":740},"obj":"26592190"},{"id":"30723314-26592190-83958230","span":{"begin":739,"end":740},"obj":"26592190"},{"id":"30723314-26592190-83958231","span":{"begin":976,"end":977},"obj":"26592190"},{"id":"30723314-26592190-83958231","span":{"begin":976,"end":977},"obj":"26592190"},{"id":"T78543","span":{"begin":85,"end":86},"obj":"29565029"},{"id":"T62308","span":{"begin":85,"end":86},"obj":"29565029"},{"id":"T39766","span":{"begin":158,"end":159},"obj":"29146532"},{"id":"T96126","span":{"begin":158,"end":159},"obj":"29146532"},{"id":"T42005","span":{"begin":158,"end":159},"obj":"29159417"},{"id":"T55928","span":{"begin":158,"end":159},"obj":"29159417"},{"id":"T66634","span":{"begin":158,"end":159},"obj":"26592190"},{"id":"T39539","span":{"begin":158,"end":159},"obj":"26592190"},{"id":"T2830","span":{"begin":437,"end":438},"obj":"29146532"},{"id":"T87591","span":{"begin":437,"end":438},"obj":"29146532"},{"id":"T58508","span":{"begin":439,"end":440},"obj":"29159417"},{"id":"T86767","span":{"begin":439,"end":440},"obj":"29159417"},{"id":"T82208","span":{"begin":737,"end":738},"obj":"29146532"},{"id":"T66069","span":{"begin":737,"end":738},"obj":"29146532"},{"id":"T73751","span":{"begin":739,"end":740},"obj":"26592190"},{"id":"T87131","span":{"begin":739,"end":740},"obj":"26592190"},{"id":"T80748","span":{"begin":976,"end":977},"obj":"26592190"},{"id":"T6150","span":{"begin":976,"end":977},"obj":"26592190"},{"id":"T71462","span":{"begin":85,"end":86},"obj":"29565029"},{"id":"T22635","span":{"begin":85,"end":86},"obj":"29565029"},{"id":"T84005","span":{"begin":158,"end":159},"obj":"29146532"},{"id":"T98131","span":{"begin":158,"end":159},"obj":"29146532"},{"id":"T68388","span":{"begin":158,"end":159},"obj":"29159417"},{"id":"T4550","span":{"begin":158,"end":159},"obj":"29159417"},{"id":"T73609","span":{"begin":158,"end":159},"obj":"26592190"},{"id":"T91619","span":{"begin":158,"end":159},"obj":"26592190"},{"id":"T1245","span":{"begin":437,"end":438},"obj":"29146532"},{"id":"T12891","span":{"begin":437,"end":438},"obj":"29146532"},{"id":"T1248","span":{"begin":439,"end":440},"obj":"29159417"},{"id":"T56036","span":{"begin":439,"end":440},"obj":"29159417"},{"id":"T82203","span":{"begin":737,"end":738},"obj":"29146532"},{"id":"T34954","span":{"begin":737,"end":738},"obj":"29146532"},{"id":"T36155","span":{"begin":739,"end":740},"obj":"26592190"},{"id":"T11910","span":{"begin":739,"end":740},"obj":"26592190"},{"id":"T10142","span":{"begin":976,"end":977},"obj":"26592190"},{"id":"T82458","span":{"begin":976,"end":977},"obj":"26592190"}],"text":"Hypertension is the most prevalent cause of cardiovascular disease and kidney failure1, but the prevention and treatment of hypertension are still a challenge2–4. According to the 2017 High Blood Pressure Clinical Practice Guidelines, in adults (≥20 years of age), a “doctor’s office” reading of 120-129 mm Hg for systolic blood pressure (SBP) even with less than 80 mm Hg for diastolic blood pressure (DBP), is considered as elevated BP2,3. An SBP of 130-139 mm Hg or a DBP of 80-89 is now considered as Stage 1 hypertension, while the previous definition of hypertension ≥140 SBP or ≥90 DBP is now considered as Stage 2 hypertension. In the general population, only about 50% of treated patients achieve adequate blood pressure control2,4. The poor efficacy of hypertension treatment and the inter-individual variations in the response to antihypertensive medications have many causes, including non-compliance, but genetic variations could be important contributory factors4,5."}