PMC:6194691 / 64001-65779
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/6194691","sourcedb":"PMC","sourceid":"6194691","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6194691","text":"keff/min−1 t1/2/min Vd/mL/g CL/µL g−1 min−1 Ref # Notes\nSlc substrates Rat unless stated otherwise\n p-Aminohippuric acid (PAH) 0.059 12 0.80 47 [558] Influx much slower than efflux\n p-Aminohippuric acid (PAH) 0.039 18 [559] Abl. Oat3 based on inhibitors, lum. Mrp4 possible based on kidney [560]\n p-Aminohippuric acid (PAH) 0.0175 40 [131]\n Penicillin G, benzylpenicillin 0.043 16 [559] Oat3 based on inhibitors\n Taurocholate 0.023 30 [561]\n BQ-123 0.0078 100 [561]\n Estrone sulfate 0.066 9.9 1.1 75 [562]\n Estrone 0.061 11 3.3 227 [562]\n Dehydroepiandrosterone sulfate (DHEAS) 0.027 26 118 [563] Influx much slower than efflux, Oatp2\n Estradiol-17beta-glucuronide (E217betaG) 0.037 19 [564] Oatp2, 40% and Oat3 20%\n Pravastatin 0.060 12 0.99 59 [565] Oat3 (Slc22a8) and Oatp2 (Slco1a4) + others\n Pitavastatin 0.026 27 14 364 [565] Oat3, Oatp2 (Slco1a4) +others +diffusion\n Homovanillic acid 0.017 40.8 [566] Oat3 from inhibitors\n Indoxyl sulfate 0.011 64 [567] Oat3 and others\n Pemetrexed 0.018 39 0.62 11 [568] Mouse. Oat3 and unknown (not Mrp2 not Bcrp)\n Methotrexate 0.024 29 0.85 20 [568] Oat3 and Bcrp suggested\n Buprenorphine 0.025 27.5 6.1 154 [569] Pgp and unknown, possibly diffusion\n AZT, (3′-azido-3′-deoxythymidine) 0.032 22 [570] Oat3 from benzylpenicillin inhibition\n DDI, (2′,3′-dideoxyinosine) 0.253 2.8 [570] Oat3 from benzylpenicillin inhibition + diffusion\nMarkers for perivascular elimination\n Inulin 0.006 awake0.016 asleep 11543 0.2* 1.23.2 [128] Mouse\n Inulin 0.003 230 0.2* 0.6 [62] Mouse\n Inulin 0.005 135 0.2* 1 [131] Rat\n Mannitol 0.004 170 0.2* 0.8 [25] Mouse\n Sucrose 0.0028 awake0.0043 anesth. 245160 0.2* 0.560.86 [131] Rat\n Albumin 0.006 115 0.2* 1.2 [131] Rat\n Dextran-10K 0.0035 197 0.2* 0.7 [131] Rat\n Dextran-70K 0.004 170 0.2* 0.8 [131] Rat","divisions":[{"label":"tr","span":{"begin":0,"end":55}},{"label":"th","span":{"begin":0,"end":10}},{"label":"th","span":{"begin":11,"end":19}},{"label":"th","span":{"begin":20,"end":27}},{"label":"th","span":{"begin":28,"end":43}},{"label":"th","span":{"begin":44,"end":49}},{"label":"th","span":{"begin":50,"end":55}},{"label":"tr","span":{"begin":56,"end":98}},{"label":"td","span":{"begin":56,"end":70}},{"label":"td","span":{"begin":71,"end":98}},{"label":"tr","span":{"begin":99,"end":180}},{"label":"td","span":{"begin":99,"end":126}},{"label":"td","span":{"begin":127,"end":132}},{"label":"td","span":{"begin":133,"end":135}},{"label":"td","span":{"begin":136,"end":140}},{"label":"td","span":{"begin":141,"end":143}},{"label":"td","span":{"begin":144,"end":149}},{"label":"td","span":{"begin":150,"end":180}},{"label":"tr","span":{"begin":181,"end":295}},{"label":"td","span":{"begin":181,"end":208}},{"label":"td","span":{"begin":209,"end":214}},{"label":"td","span":{"begin":215,"end":217}},{"label":"td","span":{"begin":218,"end":223}},{"label":"td","span":{"begin":224,"end":295}},{"label":"tr","span":{"begin":296,"end":339}},{"label":"td","span":{"begin":296,"end":323}},{"label":"td","span":{"begin":324,"end":330}},{"label":"td","span":{"begin":331,"end":333}},{"label":"td","span":{"begin":334,"end":339}},{"label":"tr","span":{"begin":340,"end":411}},{"label":"td","span":{"begin":340,"end":371}},{"label":"td","span":{"begin":372,"end":377}},{"label":"td","span":{"begin":378,"end":380}},{"label":"td","span":{"begin":381,"end":386}},{"label":"td","span":{"begin":387,"end":411}},{"label":"tr","span":{"begin":412,"end":440}},{"label":"td","span":{"begin":412,"end":425}},{"label":"td","span":{"begin":426,"end":431}},{"label":"td","span":{"begin":432,"end":434}},{"label":"td","span":{"begin":435,"end":440}},{"label":"tr","span":{"begin":441,"end":465}},{"label":"td","span":{"begin":441,"end":448}},{"label":"td","span":{"begin":449,"end":455}},{"label":"td","span":{"begin":456,"end":459}},{"label":"td","span":{"begin":460,"end":465}},{"label":"tr","span":{"begin":466,"end":505}},{"label":"td","span":{"begin":466,"end":482}},{"label":"td","span":{"begin":483,"end":488}},{"label":"td","span":{"begin":489,"end":492}},{"label":"td","span":{"begin":493,"end":496}},{"label":"td","span":{"begin":497,"end":499}},{"label":"td","span":{"begin":500,"end":505}},{"label":"tr","span":{"begin":506,"end":537}},{"label":"td","span":{"begin":506,"end":514}},{"label":"td","span":{"begin":515,"end":520}},{"label":"td","span":{"begin":521,"end":523}},{"label":"td","span":{"begin":524,"end":527}},{"label":"td","span":{"begin":528,"end":531}},{"label":"td","span":{"begin":532,"end":537}},{"label":"tr","span":{"begin":538,"end":634}},{"label":"td","span":{"begin":538,"end":577}},{"label":"td","span":{"begin":578,"end":583}},{"label":"td","span":{"begin":584,"end":586}},{"label":"td","span":{"begin":587,"end":590}},{"label":"td","span":{"begin":591,"end":596}},{"label":"td","span":{"begin":597,"end":634}},{"label":"tr","span":{"begin":635,"end":715}},{"label":"td","span":{"begin":635,"end":676}},{"label":"td","span":{"begin":677,"end":682}},{"label":"td","span":{"begin":683,"end":685}},{"label":"td","span":{"begin":686,"end":691}},{"label":"td","span":{"begin":692,"end":715}},{"label":"tr","span":{"begin":716,"end":795}},{"label":"td","span":{"begin":716,"end":728}},{"label":"td","span":{"begin":729,"end":734}},{"label":"td","span":{"begin":735,"end":737}},{"label":"td","span":{"begin":738,"end":742}},{"label":"td","span":{"begin":743,"end":745}},{"label":"td","span":{"begin":746,"end":751}},{"label":"td","span":{"begin":752,"end":795}},{"label":"tr","span":{"begin":796,"end":872}},{"label":"td","span":{"begin":796,"end":809}},{"label":"td","span":{"begin":810,"end":815}},{"label":"td","span":{"begin":816,"end":818}},{"label":"td","span":{"begin":819,"end":821}},{"label":"td","span":{"begin":822,"end":825}},{"label":"td","span":{"begin":826,"end":831}},{"label":"td","span":{"begin":832,"end":872}},{"label":"tr","span":{"begin":873,"end":929}},{"label":"td","span":{"begin":873,"end":891}},{"label":"td","span":{"begin":892,"end":897}},{"label":"td","span":{"begin":898,"end":902}},{"label":"td","span":{"begin":903,"end":908}},{"label":"td","span":{"begin":909,"end":929}},{"label":"tr","span":{"begin":930,"end":977}},{"label":"td","span":{"begin":930,"end":946}},{"label":"td","span":{"begin":947,"end":952}},{"label":"td","span":{"begin":953,"end":955}},{"label":"td","span":{"begin":956,"end":961}},{"label":"td","span":{"begin":962,"end":977}},{"label":"tr","span":{"begin":978,"end":1056}},{"label":"td","span":{"begin":978,"end":989}},{"label":"td","span":{"begin":990,"end":995}},{"label":"td","span":{"begin":996,"end":998}},{"label":"td","span":{"begin":999,"end":1003}},{"label":"td","span":{"begin":1004,"end":1006}},{"label":"td","span":{"begin":1007,"end":1012}},{"label":"td","span":{"begin":1013,"end":1056}},{"label":"tr","span":{"begin":1057,"end":1117}},{"label":"td","span":{"begin":1057,"end":1070}},{"label":"td","span":{"begin":1071,"end":1076}},{"label":"td","span":{"begin":1077,"end":1079}},{"label":"td","span":{"begin":1080,"end":1084}},{"label":"td","span":{"begin":1085,"end":1087}},{"label":"td","span":{"begin":1088,"end":1093}},{"label":"td","span":{"begin":1094,"end":1117}},{"label":"tr","span":{"begin":1118,"end":1193}},{"label":"td","span":{"begin":1118,"end":1132}},{"label":"td","span":{"begin":1133,"end":1138}},{"label":"td","span":{"begin":1139,"end":1143}},{"label":"td","span":{"begin":1144,"end":1147}},{"label":"td","span":{"begin":1148,"end":1151}},{"label":"td","span":{"begin":1152,"end":1157}},{"label":"td","span":{"begin":1158,"end":1193}},{"label":"tr","span":{"begin":1194,"end":1281}},{"label":"td","span":{"begin":1194,"end":1228}},{"label":"td","span":{"begin":1229,"end":1234}},{"label":"td","span":{"begin":1235,"end":1237}},{"label":"td","span":{"begin":1238,"end":1243}},{"label":"td","span":{"begin":1244,"end":1281}},{"label":"tr","span":{"begin":1282,"end":1376}},{"label":"td","span":{"begin":1282,"end":1310}},{"label":"td","span":{"begin":1311,"end":1316}},{"label":"td","span":{"begin":1317,"end":1320}},{"label":"td","span":{"begin":1321,"end":1326}},{"label":"td","span":{"begin":1327,"end":1376}},{"label":"tr","span":{"begin":1377,"end":1413}},{"label":"td","span":{"begin":1377,"end":1413}},{"label":"tr","span":{"begin":1414,"end":1475}},{"label":"td","span":{"begin":1414,"end":1421}},{"label":"td","span":{"begin":1422,"end":1445}},{"label":"td","span":{"begin":1446,"end":1451}},{"label":"td","span":{"begin":1452,"end":1456}},{"label":"td","span":{"begin":1457,"end":1463}},{"label":"td","span":{"begin":1464,"end":1469}},{"label":"td","span":{"begin":1470,"end":1475}},{"label":"tr","span":{"begin":1476,"end":1513}},{"label":"td","span":{"begin":1476,"end":1483}},{"label":"td","span":{"begin":1484,"end":1489}},{"label":"td","span":{"begin":1490,"end":1493}},{"label":"td","span":{"begin":1494,"end":1498}},{"label":"td","span":{"begin":1499,"end":1502}},{"label":"td","span":{"begin":1503,"end":1507}},{"label":"td","span":{"begin":1508,"end":1513}},{"label":"tr","span":{"begin":1514,"end":1548}},{"label":"td","span":{"begin":1514,"end":1521}},{"label":"td","span":{"begin":1522,"end":1527}},{"label":"td","span":{"begin":1528,"end":1531}},{"label":"td","span":{"begin":1532,"end":1536}},{"label":"td","span":{"begin":1537,"end":1538}},{"label":"td","span":{"begin":1539,"end":1544}},{"label":"td","span":{"begin":1545,"end":1548}},{"label":"tr","span":{"begin":1549,"end":1588}},{"label":"td","span":{"begin":1549,"end":1558}},{"label":"td","span":{"begin":1559,"end":1564}},{"label":"td","span":{"begin":1565,"end":1568}},{"label":"td","span":{"begin":1569,"end":1573}},{"label":"td","span":{"begin":1574,"end":1577}},{"label":"td","span":{"begin":1578,"end":1582}},{"label":"td","span":{"begin":1583,"end":1588}},{"label":"tr","span":{"begin":1589,"end":1655}},{"label":"td","span":{"begin":1589,"end":1597}},{"label":"td","span":{"begin":1598,"end":1624}},{"label":"td","span":{"begin":1625,"end":1631}},{"label":"td","span":{"begin":1632,"end":1636}},{"label":"td","span":{"begin":1637,"end":1645}},{"label":"td","span":{"begin":1646,"end":1651}},{"label":"td","span":{"begin":1652,"end":1655}},{"label":"tr","span":{"begin":1656,"end":1693}},{"label":"td","span":{"begin":1656,"end":1664}},{"label":"td","span":{"begin":1665,"end":1670}},{"label":"td","span":{"begin":1671,"end":1674}},{"label":"td","span":{"begin":1675,"end":1679}},{"label":"td","span":{"begin":1680,"end":1683}},{"label":"td","span":{"begin":1684,"end":1689}},{"label":"td","span":{"begin":1690,"end":1693}},{"label":"tr","span":{"begin":1694,"end":1736}},{"label":"td","span":{"begin":1694,"end":1706}},{"label":"td","span":{"begin":1707,"end":1713}},{"label":"td","span":{"begin":1714,"end":1717}},{"label":"td","span":{"begin":1718,"end":1722}},{"label":"td","span":{"begin":1723,"end":1726}},{"label":"td","span":{"begin":1727,"end":1732}},{"label":"td","span":{"begin":1733,"end":1736}},{"label":"td","span":{"begin":1737,"end":1749}},{"label":"td","span":{"begin":1750,"end":1755}},{"label":"td","span":{"begin":1756,"end":1759}},{"label":"td","span":{"begin":1760,"end":1764}},{"label":"td","span":{"begin":1765,"end":1768}},{"label":"td","span":{"begin":1769,"end":1774}}],"tracks":[{"project":"MyTest","denotations":[{"id":"30340614-9399971-30706145","span":{"begin":145,"end":148},"obj":"9399971"},{"id":"30340614-12684544-30706146","span":{"begin":219,"end":222},"obj":"12684544"},{"id":"30340614-15504935-30706147","span":{"begin":291,"end":294},"obj":"15504935"},{"id":"30340614-16639426-30706148","span":{"begin":335,"end":338},"obj":"16639426"},{"id":"30340614-12684544-30706149","span":{"begin":382,"end":385},"obj":"12684544"},{"id":"30340614-9694947-30706150","span":{"begin":436,"end":439},"obj":"9694947"},{"id":"30340614-9694947-30706151","span":{"begin":461,"end":464},"obj":"9694947"},{"id":"30340614-11105986-30706152","span":{"begin":501,"end":504},"obj":"11105986"},{"id":"30340614-11105986-30706153","span":{"begin":533,"end":536},"obj":"11105986"},{"id":"30340614-11032880-30706154","span":{"begin":592,"end":595},"obj":"11032880"},{"id":"30340614-11408557-30706155","span":{"begin":687,"end":690},"obj":"11408557"},{"id":"30340614-15292460-30706156","span":{"begin":747,"end":750},"obj":"15292460"},{"id":"30340614-15292460-30706157","span":{"begin":827,"end":830},"obj":"15292460"},{"id":"30340614-12679720-30706158","span":{"begin":904,"end":907},"obj":"12679720"},{"id":"30340614-12358729-30706159","span":{"begin":957,"end":960},"obj":"12358729"},{"id":"30340614-23297298-30706160","span":{"begin":1008,"end":1011},"obj":"23297298"},{"id":"30340614-23297298-30706161","span":{"begin":1089,"end":1092},"obj":"23297298"},{"id":"30340614-17365275-30706162","span":{"begin":1153,"end":1156},"obj":"17365275"},{"id":"30340614-9103519-30706163","span":{"begin":1239,"end":1242},"obj":"9103519"},{"id":"30340614-9103519-30706164","span":{"begin":1322,"end":1325},"obj":"9103519"},{"id":"30340614-24136970-30706165","span":{"begin":1465,"end":1468},"obj":"24136970"},{"id":"30340614-11120756-30706166","span":{"begin":1504,"end":1506},"obj":"11120756"},{"id":"30340614-16639426-30706167","span":{"begin":1540,"end":1543},"obj":"16639426"},{"id":"30340614-16639426-30706168","span":{"begin":1647,"end":1650},"obj":"16639426"},{"id":"30340614-16639426-30706169","span":{"begin":1685,"end":1688},"obj":"16639426"},{"id":"30340614-16639426-30706170","span":{"begin":1728,"end":1731},"obj":"16639426"},{"id":"30340614-16639426-30706171","span":{"begin":1770,"end":1773},"obj":"16639426"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"attributes":[{"subj":"30340614-9399971-30706145","pred":"source","obj":"MyTest"},{"subj":"30340614-12684544-30706146","pred":"source","obj":"MyTest"},{"subj":"30340614-15504935-30706147","pred":"source","obj":"MyTest"},{"subj":"30340614-16639426-30706148","pred":"source","obj":"MyTest"},{"subj":"30340614-12684544-30706149","pred":"source","obj":"MyTest"},{"subj":"30340614-9694947-30706150","pred":"source","obj":"MyTest"},{"subj":"30340614-9694947-30706151","pred":"source","obj":"MyTest"},{"subj":"30340614-11105986-30706152","pred":"source","obj":"MyTest"},{"subj":"30340614-11105986-30706153","pred":"source","obj":"MyTest"},{"subj":"30340614-11032880-30706154","pred":"source","obj":"MyTest"},{"subj":"30340614-11408557-30706155","pred":"source","obj":"MyTest"},{"subj":"30340614-15292460-30706156","pred":"source","obj":"MyTest"},{"subj":"30340614-15292460-30706157","pred":"source","obj":"MyTest"},{"subj":"30340614-12679720-30706158","pred":"source","obj":"MyTest"},{"subj":"30340614-12358729-30706159","pred":"source","obj":"MyTest"},{"subj":"30340614-23297298-30706160","pred":"source","obj":"MyTest"},{"subj":"30340614-23297298-30706161","pred":"source","obj":"MyTest"},{"subj":"30340614-17365275-30706162","pred":"source","obj":"MyTest"},{"subj":"30340614-9103519-30706163","pred":"source","obj":"MyTest"},{"subj":"30340614-9103519-30706164","pred":"source","obj":"MyTest"},{"subj":"30340614-24136970-30706165","pred":"source","obj":"MyTest"},{"subj":"30340614-11120756-30706166","pred":"source","obj":"MyTest"},{"subj":"30340614-16639426-30706167","pred":"source","obj":"MyTest"},{"subj":"30340614-16639426-30706168","pred":"source","obj":"MyTest"},{"subj":"30340614-16639426-30706169","pred":"source","obj":"MyTest"},{"subj":"30340614-16639426-30706170","pred":"source","obj":"MyTest"},{"subj":"30340614-16639426-30706171","pred":"source","obj":"MyTest"}]},{"project":"2_test","denotations":[{"id":"30340614-9399971-30706145","span":{"begin":145,"end":148},"obj":"9399971"},{"id":"30340614-12684544-30706146","span":{"begin":219,"end":222},"obj":"12684544"},{"id":"30340614-15504935-30706147","span":{"begin":291,"end":294},"obj":"15504935"},{"id":"30340614-16639426-30706148","span":{"begin":335,"end":338},"obj":"16639426"},{"id":"30340614-12684544-30706149","span":{"begin":382,"end":385},"obj":"12684544"},{"id":"30340614-9694947-30706150","span":{"begin":436,"end":439},"obj":"9694947"},{"id":"30340614-9694947-30706151","span":{"begin":461,"end":464},"obj":"9694947"},{"id":"30340614-11105986-30706152","span":{"begin":501,"end":504},"obj":"11105986"},{"id":"30340614-11105986-30706153","span":{"begin":533,"end":536},"obj":"11105986"},{"id":"30340614-11032880-30706154","span":{"begin":592,"end":595},"obj":"11032880"},{"id":"30340614-11408557-30706155","span":{"begin":687,"end":690},"obj":"11408557"},{"id":"30340614-15292460-30706156","span":{"begin":747,"end":750},"obj":"15292460"},{"id":"30340614-15292460-30706157","span":{"begin":827,"end":830},"obj":"15292460"},{"id":"30340614-12679720-30706158","span":{"begin":904,"end":907},"obj":"12679720"},{"id":"30340614-12358729-30706159","span":{"begin":957,"end":960},"obj":"12358729"},{"id":"30340614-23297298-30706160","span":{"begin":1008,"end":1011},"obj":"23297298"},{"id":"30340614-23297298-30706161","span":{"begin":1089,"end":1092},"obj":"23297298"},{"id":"30340614-17365275-30706162","span":{"begin":1153,"end":1156},"obj":"17365275"},{"id":"30340614-9103519-30706163","span":{"begin":1239,"end":1242},"obj":"9103519"},{"id":"30340614-9103519-30706164","span":{"begin":1322,"end":1325},"obj":"9103519"},{"id":"30340614-24136970-30706165","span":{"begin":1465,"end":1468},"obj":"24136970"},{"id":"30340614-11120756-30706166","span":{"begin":1504,"end":1506},"obj":"11120756"},{"id":"30340614-16639426-30706167","span":{"begin":1540,"end":1543},"obj":"16639426"},{"id":"30340614-16639426-30706168","span":{"begin":1647,"end":1650},"obj":"16639426"},{"id":"30340614-16639426-30706169","span":{"begin":1685,"end":1688},"obj":"16639426"},{"id":"30340614-16639426-30706170","span":{"begin":1728,"end":1731},"obj":"16639426"},{"id":"30340614-16639426-30706171","span":{"begin":1770,"end":1773},"obj":"16639426"}],"attributes":[{"subj":"30340614-9399971-30706145","pred":"source","obj":"2_test"},{"subj":"30340614-12684544-30706146","pred":"source","obj":"2_test"},{"subj":"30340614-15504935-30706147","pred":"source","obj":"2_test"},{"subj":"30340614-16639426-30706148","pred":"source","obj":"2_test"},{"subj":"30340614-12684544-30706149","pred":"source","obj":"2_test"},{"subj":"30340614-9694947-30706150","pred":"source","obj":"2_test"},{"subj":"30340614-9694947-30706151","pred":"source","obj":"2_test"},{"subj":"30340614-11105986-30706152","pred":"source","obj":"2_test"},{"subj":"30340614-11105986-30706153","pred":"source","obj":"2_test"},{"subj":"30340614-11032880-30706154","pred":"source","obj":"2_test"},{"subj":"30340614-11408557-30706155","pred":"source","obj":"2_test"},{"subj":"30340614-15292460-30706156","pred":"source","obj":"2_test"},{"subj":"30340614-15292460-30706157","pred":"source","obj":"2_test"},{"subj":"30340614-12679720-30706158","pred":"source","obj":"2_test"},{"subj":"30340614-12358729-30706159","pred":"source","obj":"2_test"},{"subj":"30340614-23297298-30706160","pred":"source","obj":"2_test"},{"subj":"30340614-23297298-30706161","pred":"source","obj":"2_test"},{"subj":"30340614-17365275-30706162","pred":"source","obj":"2_test"},{"subj":"30340614-9103519-30706163","pred":"source","obj":"2_test"},{"subj":"30340614-9103519-30706164","pred":"source","obj":"2_test"},{"subj":"30340614-24136970-30706165","pred":"source","obj":"2_test"},{"subj":"30340614-11120756-30706166","pred":"source","obj":"2_test"},{"subj":"30340614-16639426-30706167","pred":"source","obj":"2_test"},{"subj":"30340614-16639426-30706168","pred":"source","obj":"2_test"},{"subj":"30340614-16639426-30706169","pred":"source","obj":"2_test"},{"subj":"30340614-16639426-30706170","pred":"source","obj":"2_test"},{"subj":"30340614-16639426-30706171","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"MyTest","color":"#ec93e0","default":true},{"id":"2_test","color":"#93ecde"}]}]}}