PMC:6194691 / 64001-65779
Annnotations
MyTest
{"project":"MyTest","denotations":[{"id":"30340614-9399971-30706145","span":{"begin":145,"end":148},"obj":"9399971"},{"id":"30340614-12684544-30706146","span":{"begin":219,"end":222},"obj":"12684544"},{"id":"30340614-15504935-30706147","span":{"begin":291,"end":294},"obj":"15504935"},{"id":"30340614-16639426-30706148","span":{"begin":335,"end":338},"obj":"16639426"},{"id":"30340614-12684544-30706149","span":{"begin":382,"end":385},"obj":"12684544"},{"id":"30340614-9694947-30706150","span":{"begin":436,"end":439},"obj":"9694947"},{"id":"30340614-9694947-30706151","span":{"begin":461,"end":464},"obj":"9694947"},{"id":"30340614-11105986-30706152","span":{"begin":501,"end":504},"obj":"11105986"},{"id":"30340614-11105986-30706153","span":{"begin":533,"end":536},"obj":"11105986"},{"id":"30340614-11032880-30706154","span":{"begin":592,"end":595},"obj":"11032880"},{"id":"30340614-11408557-30706155","span":{"begin":687,"end":690},"obj":"11408557"},{"id":"30340614-15292460-30706156","span":{"begin":747,"end":750},"obj":"15292460"},{"id":"30340614-15292460-30706157","span":{"begin":827,"end":830},"obj":"15292460"},{"id":"30340614-12679720-30706158","span":{"begin":904,"end":907},"obj":"12679720"},{"id":"30340614-12358729-30706159","span":{"begin":957,"end":960},"obj":"12358729"},{"id":"30340614-23297298-30706160","span":{"begin":1008,"end":1011},"obj":"23297298"},{"id":"30340614-23297298-30706161","span":{"begin":1089,"end":1092},"obj":"23297298"},{"id":"30340614-17365275-30706162","span":{"begin":1153,"end":1156},"obj":"17365275"},{"id":"30340614-9103519-30706163","span":{"begin":1239,"end":1242},"obj":"9103519"},{"id":"30340614-9103519-30706164","span":{"begin":1322,"end":1325},"obj":"9103519"},{"id":"30340614-24136970-30706165","span":{"begin":1465,"end":1468},"obj":"24136970"},{"id":"30340614-11120756-30706166","span":{"begin":1504,"end":1506},"obj":"11120756"},{"id":"30340614-16639426-30706167","span":{"begin":1540,"end":1543},"obj":"16639426"},{"id":"30340614-16639426-30706168","span":{"begin":1647,"end":1650},"obj":"16639426"},{"id":"30340614-16639426-30706169","span":{"begin":1685,"end":1688},"obj":"16639426"},{"id":"30340614-16639426-30706170","span":{"begin":1728,"end":1731},"obj":"16639426"},{"id":"30340614-16639426-30706171","span":{"begin":1770,"end":1773},"obj":"16639426"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"keff/min−1 t1/2/min Vd/mL/g CL/µL g−1 min−1 Ref # Notes\nSlc substrates Rat unless stated otherwise\n p-Aminohippuric acid (PAH) 0.059 12 0.80 47 [558] Influx much slower than efflux\n p-Aminohippuric acid (PAH) 0.039 18 [559] Abl. Oat3 based on inhibitors, lum. Mrp4 possible based on kidney [560]\n p-Aminohippuric acid (PAH) 0.0175 40 [131]\n Penicillin G, benzylpenicillin 0.043 16 [559] Oat3 based on inhibitors\n Taurocholate 0.023 30 [561]\n BQ-123 0.0078 100 [561]\n Estrone sulfate 0.066 9.9 1.1 75 [562]\n Estrone 0.061 11 3.3 227 [562]\n Dehydroepiandrosterone sulfate (DHEAS) 0.027 26 118 [563] Influx much slower than efflux, Oatp2\n Estradiol-17beta-glucuronide (E217betaG) 0.037 19 [564] Oatp2, 40% and Oat3 20%\n Pravastatin 0.060 12 0.99 59 [565] Oat3 (Slc22a8) and Oatp2 (Slco1a4) + others\n Pitavastatin 0.026 27 14 364 [565] Oat3, Oatp2 (Slco1a4) +others +diffusion\n Homovanillic acid 0.017 40.8 [566] Oat3 from inhibitors\n Indoxyl sulfate 0.011 64 [567] Oat3 and others\n Pemetrexed 0.018 39 0.62 11 [568] Mouse. Oat3 and unknown (not Mrp2 not Bcrp)\n Methotrexate 0.024 29 0.85 20 [568] Oat3 and Bcrp suggested\n Buprenorphine 0.025 27.5 6.1 154 [569] Pgp and unknown, possibly diffusion\n AZT, (3′-azido-3′-deoxythymidine) 0.032 22 [570] Oat3 from benzylpenicillin inhibition\n DDI, (2′,3′-dideoxyinosine) 0.253 2.8 [570] Oat3 from benzylpenicillin inhibition + diffusion\nMarkers for perivascular elimination\n Inulin 0.006 awake0.016 asleep 11543 0.2* 1.23.2 [128] Mouse\n Inulin 0.003 230 0.2* 0.6 [62] Mouse\n Inulin 0.005 135 0.2* 1 [131] Rat\n Mannitol 0.004 170 0.2* 0.8 [25] Mouse\n Sucrose 0.0028 awake0.0043 anesth. 245160 0.2* 0.560.86 [131] Rat\n Albumin 0.006 115 0.2* 1.2 [131] Rat\n Dextran-10K 0.0035 197 0.2* 0.7 [131] Rat\n Dextran-70K 0.004 170 0.2* 0.8 [131] Rat"}
2_test
{"project":"2_test","denotations":[{"id":"30340614-9399971-30706145","span":{"begin":145,"end":148},"obj":"9399971"},{"id":"30340614-12684544-30706146","span":{"begin":219,"end":222},"obj":"12684544"},{"id":"30340614-15504935-30706147","span":{"begin":291,"end":294},"obj":"15504935"},{"id":"30340614-16639426-30706148","span":{"begin":335,"end":338},"obj":"16639426"},{"id":"30340614-12684544-30706149","span":{"begin":382,"end":385},"obj":"12684544"},{"id":"30340614-9694947-30706150","span":{"begin":436,"end":439},"obj":"9694947"},{"id":"30340614-9694947-30706151","span":{"begin":461,"end":464},"obj":"9694947"},{"id":"30340614-11105986-30706152","span":{"begin":501,"end":504},"obj":"11105986"},{"id":"30340614-11105986-30706153","span":{"begin":533,"end":536},"obj":"11105986"},{"id":"30340614-11032880-30706154","span":{"begin":592,"end":595},"obj":"11032880"},{"id":"30340614-11408557-30706155","span":{"begin":687,"end":690},"obj":"11408557"},{"id":"30340614-15292460-30706156","span":{"begin":747,"end":750},"obj":"15292460"},{"id":"30340614-15292460-30706157","span":{"begin":827,"end":830},"obj":"15292460"},{"id":"30340614-12679720-30706158","span":{"begin":904,"end":907},"obj":"12679720"},{"id":"30340614-12358729-30706159","span":{"begin":957,"end":960},"obj":"12358729"},{"id":"30340614-23297298-30706160","span":{"begin":1008,"end":1011},"obj":"23297298"},{"id":"30340614-23297298-30706161","span":{"begin":1089,"end":1092},"obj":"23297298"},{"id":"30340614-17365275-30706162","span":{"begin":1153,"end":1156},"obj":"17365275"},{"id":"30340614-9103519-30706163","span":{"begin":1239,"end":1242},"obj":"9103519"},{"id":"30340614-9103519-30706164","span":{"begin":1322,"end":1325},"obj":"9103519"},{"id":"30340614-24136970-30706165","span":{"begin":1465,"end":1468},"obj":"24136970"},{"id":"30340614-11120756-30706166","span":{"begin":1504,"end":1506},"obj":"11120756"},{"id":"30340614-16639426-30706167","span":{"begin":1540,"end":1543},"obj":"16639426"},{"id":"30340614-16639426-30706168","span":{"begin":1647,"end":1650},"obj":"16639426"},{"id":"30340614-16639426-30706169","span":{"begin":1685,"end":1688},"obj":"16639426"},{"id":"30340614-16639426-30706170","span":{"begin":1728,"end":1731},"obj":"16639426"},{"id":"30340614-16639426-30706171","span":{"begin":1770,"end":1773},"obj":"16639426"}],"text":"keff/min−1 t1/2/min Vd/mL/g CL/µL g−1 min−1 Ref # Notes\nSlc substrates Rat unless stated otherwise\n p-Aminohippuric acid (PAH) 0.059 12 0.80 47 [558] Influx much slower than efflux\n p-Aminohippuric acid (PAH) 0.039 18 [559] Abl. Oat3 based on inhibitors, lum. Mrp4 possible based on kidney [560]\n p-Aminohippuric acid (PAH) 0.0175 40 [131]\n Penicillin G, benzylpenicillin 0.043 16 [559] Oat3 based on inhibitors\n Taurocholate 0.023 30 [561]\n BQ-123 0.0078 100 [561]\n Estrone sulfate 0.066 9.9 1.1 75 [562]\n Estrone 0.061 11 3.3 227 [562]\n Dehydroepiandrosterone sulfate (DHEAS) 0.027 26 118 [563] Influx much slower than efflux, Oatp2\n Estradiol-17beta-glucuronide (E217betaG) 0.037 19 [564] Oatp2, 40% and Oat3 20%\n Pravastatin 0.060 12 0.99 59 [565] Oat3 (Slc22a8) and Oatp2 (Slco1a4) + others\n Pitavastatin 0.026 27 14 364 [565] Oat3, Oatp2 (Slco1a4) +others +diffusion\n Homovanillic acid 0.017 40.8 [566] Oat3 from inhibitors\n Indoxyl sulfate 0.011 64 [567] Oat3 and others\n Pemetrexed 0.018 39 0.62 11 [568] Mouse. Oat3 and unknown (not Mrp2 not Bcrp)\n Methotrexate 0.024 29 0.85 20 [568] Oat3 and Bcrp suggested\n Buprenorphine 0.025 27.5 6.1 154 [569] Pgp and unknown, possibly diffusion\n AZT, (3′-azido-3′-deoxythymidine) 0.032 22 [570] Oat3 from benzylpenicillin inhibition\n DDI, (2′,3′-dideoxyinosine) 0.253 2.8 [570] Oat3 from benzylpenicillin inhibition + diffusion\nMarkers for perivascular elimination\n Inulin 0.006 awake0.016 asleep 11543 0.2* 1.23.2 [128] Mouse\n Inulin 0.003 230 0.2* 0.6 [62] Mouse\n Inulin 0.005 135 0.2* 1 [131] Rat\n Mannitol 0.004 170 0.2* 0.8 [25] Mouse\n Sucrose 0.0028 awake0.0043 anesth. 245160 0.2* 0.560.86 [131] Rat\n Albumin 0.006 115 0.2* 1.2 [131] Rat\n Dextran-10K 0.0035 197 0.2* 0.7 [131] Rat\n Dextran-70K 0.004 170 0.2* 0.8 [131] Rat"}