PMC:6019327 / 631144-658856 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6019327","sourcedb":"PMC","sourceid":"6019327","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6019327","text":"The authors acknowledge the support of Jun Dong, MD, PhD; Kan Fang, MD; and Mark Fellman at the Division of Cardiovascular Devices, Center for Devices and Radiological Health, U.S. Food and Drug Administration (FDA) during the preparation of this document. This document does not necessarily represent the opinions, policies, or recommendations of the FDA. Document Reviewers: Carina Blomström-Lundqvist, MD, PhD; Angelo A.V. De Paola, MD, PhD; Peter M. Kistler, MBBS, PhD; Gregory Y.H. Lip, MD; Nicholas S. Peters, MD; Cristiano F. Pisani, MD; Antonio Raviele, MD; Eduardo B. Saad, MD, PhD; Kazuhiro Satomi, MD, PhD; Martin K. Stiles, MB ChB, PhD; Stephan Willems, MD, PhD\n\nDeveloped in partnership with and endorsed by the European Heart Rhythm Association (EHRA), the European Cardiac Arrhythmia Society (ECAS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin American Society of Cardiac Stimulation and Electrophysiology (Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología [SOLAECE]). Developed in collaboration with and endorsed by the Society of Thoracic Surgeons (STS), the American College of Cardiology (ACC), the American Heart Association (AHA), the Canadian Heart Rhythm Society (CHRS), the Japanese Heart Rhythm Society (JHRS), and the Brazilian Society of Cardiac Arrhythmias (Sociedade Brasileira de Arritmias Cardíacas [SOBRAC]). Chair: Hugh Calkins, MD, Johns Hopkins Medical Institutions, Baltimore, MD, USA. Section Chairs: Definitions, Mechanisms, and Rationale for AF Ablation: Shih-Ann Chen, MD, National Yang-Ming University, Taipei, Taiwan. Modifiable Risk Factors for AF and Impact on Ablation: Jonathan M. Kalman, MBBS, PhD, Royal Melbourne Hospital and University of Melbourne, Melbourne, Australia. Indications: Claudio Tondo, MD, PhD, Cardiac Arrhythmia Research Center, Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, University of Milan, Milan, Italy. Strategies, Techniques, and Endpoints: Karl Heinz Kuck, MD, PhD, Asklepios Klinik St. Georg, Hamburg, Germany. Technology and Tools: Andrea Natale, MD, Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, Austin, TX, USA. Technical Aspects of Ablation to Maximize Safety and Anticoagulation: David E. Haines, MD, Beaumont Health System, Royal Oak, MI, USA. Follow-up Considerations: Francis E. Marchlinski, MD, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA, USA. Outcomes and Efficacy: Matthew R. Reynolds, MD, MSc, Lahey Hospital and Medical Center, Burlington, MA, USA. Complications: D. Wyn Davies, MD, Imperial College Healthcare NHS Trust, London, United Kingdom. Training Requirements: Bruce D. Lindsay, MD, Cleveland Clinic, Cleveland, OH, USA. Surgical and Hybrid AF Ablation: James R. Edgerton, MD, The Heart Hospital, Baylor Plano, Plano, TX, USA. Clinical Trial Design: Atul Verma, MD, Southlake Regional Health Centre, University of Toronto, Toronto, Canada.\n\nAppendix A\nAuthor disclosure table\nWriting group member Institution Consultant/Advisory board/Honoraria Speakers’ bureau Research grant Fellowship support Stock options/Partner Board Mbs/Other\nHugh Calkins, MD (Chair) Johns Hopkins Medical Institutions, Baltimore, MD 1: Abbott Laboratories, 1: AtriCure, Inc., 1: Boston Scientific Corp., 1: Pfizer Inc., 1: St. Jude Medical, 1: Toray Industries Inc., 2: iRhythm, 3: Boehringer Ingelheim, 3: Medtronic, Inc. None 2: Medtronic, Inc., 2: Boston Scientific Corp. None None None\nGerhard Hindricks, MD (Vice-Chair) Heart Center Leipzig, Leipzig, Germany None None 1: SIEMENS, 3: Biosense Webster, Inc., 3: Stereotaxis, Inc., 4: BIOTRONIK, 5: Boston Scientific Corp., 5: St. Jude Medical None None None\nRiccardo Cappato, MD (Vice-Chair) Humanitas Research Hospital, Arrhythmias and Electrophysiology Research Center, Milan, Italy* None None None None None None\nYoung-Hoon Kim, MD, PhD (Vice-Chair) Korea University, Seoul, South Korea None 1: St. Jude Medical 2: St. Jude Medical None None None\nEduardo B. Saad, MD, PhD (Vice-Chair) Hospital Pro-Cardiaco and Hospital Samaritano, Botafogo, Rio de Janeiro, Brazil None None None None None None\nLuis Aguinaga, MD, PhD Centro Privado de Cardiología, Tucuman, Argentina None None None None None None\nJoseph G. Akar, MD, PhD Yale University School of Medicine, New Haven, CT 1: Biosense Webster None None None None None\nVinay Badhwar, MD West Virginia University School of Medicine, Morgantown, WV None None None None None None\nJosep Brugada, MD, PhD Cardiovascular Institute, Hospital Clínic, University of Barcelona, Catalonia, Spain None None None None None None\nJohn Camm, MD St. George’s University of London, London, United Kingdom 1: Actelion Pharmaceuticals, 1: Daiichi-Sankyo, 1: Eli Lilly, 1: Gilead Sciences, Inc., 1: Heart Metabolics, 1: InCarda Therapeutics, 1: InfoBionic, 1: Johnson and Johnson, 1: Medtronic, Inc., 1: Milestone, 1: Pfizer, Inc., 2: Boehringer Ingelheim, 2: Boston Scientific Corp., 2: Novartis 3: Bayer HealthCare, LLC 1: Daiichi- Sankyo, 1: Servier, 2: Bayer/Schering Pharma, 2: Boehringer Ingelheim 3: Boehringer Ingelheim, 3: Daiichi-Sankyo, 3: Pfizer, Inc. None None 0: European Heart Rhythm Association, 1: Oxford\nPeng-Sheng Chen, MD Indiana University School of Medicine, Indianapolis, IN None None 5: National Institutes of Health None 5: Arrhythmotech None\nShih-Ann Chen, MD National Yang-Ming University, Taipei, Taiwan 1: Bayer/Schering Pharma, 1: Biosense Webster, 1: Boehringer Ingelheim, 1: Boston Scientific Corp., 1: Daiichi- Sankyo, 1: Medtronic Inc., 1: Pfizer Inc., 1: St. Jude Medical 1: St. Jude Medical 2: Biosense Webster, 2: St. Jude Medical None None None\nMina K. Chung, MD Cleveland Clinic, Cleveland, OH 0: Amarin, 0: BIOTRONIK, 0: Boston Scientific Corp., 0: Medtronic, Inc., 0: St. Jude Medical, 0: Zoll Medical Corporation 1: American College of Cardiology None None None 1: Up to Date\nJens Cosedis Nielsen, DMSc, PhD Aarhus University Hospital, Skejby, Denmark None None 5. Novo Nordisk Foundation None None None\nAnne B. Curtis, MD University at Buffalo, Buffalo, NY 1: Daiichi-Sankyo, 1: Medtronic, Inc., 1: Projects in Knowledge, 2: St. Jude Medical None None None None None\nD. Wyn Davies, MD Imperial College Healthcare NHS Trust, London, United Kingdom 1: Boston Scientific Corp., 1: Janssen Pharmaceuticals, 1: Medtronic, Inc., 1: Rhythmia Medical None None None 3: Rhythmia Medical None\nJohn D. Day, MD Intermountain Medical Center Heart Institute, Salt Lake City, UT 1: BIOTRONIK, 1: Boston Scientific Corp., 3: St. Jude Medical None None None None None\nAndré d’Avila, MD, PhD Hospital SOS Cardio, Florianopolis, SC, Brazil None 0: BIOTRONIK, 0: St. Jude Medical 0: BIOTRONIK, 0: St. Jude Medical None None None\nN.M.S. (Natasja) de Groot, MD, PhD Erasmus Medical Center, Rotterdam, the Netherlands None None None None None None\nLuigi Di Biase, MD, PhD Albert Einstein College of Medicine, Montefiore-Einstein Center for Heart \u0026 Vascular Care, Bronx, NY 1: Atricure, 1: Biosense Webster, Inc., 1: BIOTRONIK, 1: Boston Scientific Corp., 1: EpiEP, 1: Medtronic, Inc., 1: St. Jude Medical, 1: Stereotaxis, Inc. None None None None None\nMattias Duytschaever, MD, PhD Universitair Ziekenhuis Gent (Ghent University Hospital), Ghent, Belgium None None None None None None\nJames R. Edgerton, MD The Heart Hospital, Baylor Plano, Plano, TX 2: AtriCure, Inc. 1: AtriCure, Inc. 2: AtriCure, Inc. None None None\nKenneth A. Ellenbogen, MD Virginia Commonwealth University School of Medicine, Richmond, VA 1: American Heart Association, 1: Heart Rhythm Society, 2: Boston Scientific Corp. 1: AtriCure, Inc., 1: Biosense Webster, Inc., 1: BIOTRONIK, 1: St. Jude Medical, 2: Boston Scientific Corp., 2: Medtronic, Inc. 2: Biosense Webster, Inc., 2: Daiichi-Sankyo, 2: National Institutes of Health, 4: Boston Scientific Corp., 4: Medtronic, Inc. None None 1: Elsevier, 1: Wiley-Blackwell\nPatrick T. Ellinor, MD, PhD Massachusetts General Hospital, Boston, MA 1: Bayer HealthCare, LLC, 1: Quest Diagnostics None 1: Leducq Foundation, 3: American Heart Association, 3: National Institutes of Health, 5: Bayer HealthCare, LLC None None None\nSabine Ernst, MD, PhD Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute, Imperial College London, London, United Kingdom 2: Biosense Webster, Inc. None 4: Spectrum Dynamics None None None\nGuilherme Fenelon, MD, PhD Albert Einstein Jewish Hospital, Federal University of S~ ao Paulo, S~ ao Paulo, Brazil 1: Biosense Webster, Inc., 1: BIOTRONIK, 1: St. Jude Medical None None None None None\nEdward P. Gerstenfeld, MS, MD University of California, San Francisco, San Francisco, CA 1: Boehringer Ingelheim, 1: Boston Scientific Corp., 1: Medtronic, Inc., 1: St. Jude Medical None 4: Biosense Webster, Inc., 4: St. Jude Medical 2: Biosense Webster, Inc., 2: BIOTRONIK, 2: Boston Scientific Corp., 2: Medtronic, Inc. 1: Rhythm Diagnostic Systems Inc. None\nDavid E. Haines, MD Beaumont Health System, Royal Oak, MI 1: Lake Region Medical, 1: Terumo Medical Corp None None None None 1: Biosense Webster, Inc., 1: Boston Scientific Corp., 1: Medtronic, Inc., 1: St. Jude Medical\nMichel Haissaguerre, MD Hopital Cardiologique ^ du Haut-Lév^ eque, Pessac, France None None None None None None\nRobert H. Helm, MD Boston University Medical Center, Boston, MA None None None None None 1: Boston Scientific Corp.\nElaine Hylek, MD, MPH Boston University School of Medicine, Boston, MA 1: Bayer, 1: Boehringer Ingelheim, 1: Bristol- Myers Squibb, 1: Daiichi-Sankyo, 1: Medtronic, 1: Portola, 1: Pfizer None 2: Janssen Pharmaceuticals None None None\nWarren M. Jackman, MD Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 1: ACT, 1: VytronUS, Inc., 2: Biosense Webster, Inc., 2: Boston Scientific Corp., 2: Spectrum Dynamics 1: BIOTRONIK, 1: St. Jude Medical, 2: Biosense Webster, Inc., 2: Boston Scientific Corp. None None None None\nJose Jalife, MD University of Michigan, Ann Arbor, MI, the National Center for Cardiovascular Research Carlos III (CNIC) and CIBERCV, Madrid, Spain 1: Topera Medical None 1: Medtronic, Inc. None None None\nJonathan M. Kalman, MBBS, PhD Royal Melbourne Hospital and University of Melbourne, Melbourne, Australia None 1: Boston Scientific Corp., 1: Medtronic, Inc. 4: Medtronic, Inc. 3: St. Jude Medical, 4: Biosense Webster, Inc., 4: Medtronic, Inc. None 2: Biosense Webster, Inc., 4: Boston Scientific Corp.\nJosef Kautzner, MD, PhD Institute for Clinical and Experimental Medicine, Prague, Czech Republic 1: Bayer/Schering Pharma, 1: Boehringer Ingelheim, 1: Boston Scientific Corp., 1: Daiichi-Sankyo, 1: Sorin Group, 1: St. Jude Medical, 1: Biosense Webster, Inc., 2: Medtronic, Inc. 1: BIOTRONIK 1: Medtronic, Inc. 1: St. Jude Medical None None None None\nHans Kottkamp, MD Hirslanden Hospital, Dept. of Electrophysiology, Zurich, Switzerland 1: Biosense Webster, Inc., 1: Kardium None None None 1: Kardium None\nKarl Heinz Kuck, MD, PhD Asklepios Klinik St. Georg, Hamburg, Germany 1: Biosense Webster, Inc., 1: BIOTRONIK, 1: St. Jude Medical, 1: Stereotaxis, Inc. None 1: Biosense Webster, Inc., 1: BIOTRONIK, 1: St. Jude Medical, 1: Stereotaxis, Inc. None 1: Endosense None\nKoichiro Kumagai, MD, PhD Heart Rhythm Center, Fukuoka Sanno Hospital, Fukuoka, Japan None None None None None None\nRichard Lee, MD, MBA Saint Louis University Medical School, St. Louis, MO None None None None None None\nThorsten Lewalter, MD, PhD Dept. of Cardiology and Intensive Care, Hospital Munich- Thalkirchen, Munich, Germany 1: BIOTRONIK, 1: Medtronic, Inc., 1: St. Jude Medical 1: Abbott Vascular, 1: BIOTRONIK, 1: Medtronic, Inc., 1: St. Jude Medical None None None None\nBruce D. Lindsay, MD Cleveland Clinic, Cleveland, OH 0: Medtronic, Inc., 1: Abbott Vascular, 1: Biosense Webster, Inc. None None 3: Boston Scientific Corp., 3: Medtronic, Inc., 3: St. Jude Medical None None\nLaurent Macle, MD Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, Canada 1: Bayer HealthCare, LLC, 1: Biosense Webster, Inc., 1: Boehringer Ingelheim, 1: Bristol- Myers Squibb, 1: Medtronic, Inc., 1: Pfizer, Inc., 1: Servier, 1: St. Jude Medical None 4: Biosense Webster, Inc., 5: St. Jude Medical None None None\nMoussa Mansour, MD Massachusetts General Hospital, Boston, MA 1: Biosense Webster, Inc., 1: St. Jude Medical None 4: Biosense Webster, Inc., 4: St. Jude Medical, 5: Pfizer, 5: Boehringer Ingelheim None 4: NewPace Ltd. None\nFrancis E. Marchlinski, MD Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia, PA 1: Abbot Medical; 1: Biosense Webster, Inc., 2: BIOTRONIK, 1: Medtronic, Inc., 1: Boston Scientific Corp., 1: St. Jude Medical None 3: Medtronic, Inc., 4: Biosense Webster, Inc. 1: BIOTRONIK, 3: Boston Scientific Corp., 3: Medtronic, Inc., 4: Biosense Webster, Inc., 5: St. Jude Medical None None\nGregory F. Michaud, MD Brigham and Women’s Hospital, Boston, MA 1: Biosense Webster, Inc., 1: Boston Scientific Corp., 1: Medtronic, Inc., 1: St. Jude Medical None 4: Biosense Webster, Inc., 4: Boston Scientific Corp. None None None\nHiroshi Nakagawa, MD, PhD Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK 2: Biosense Webster, Inc 1: Boston Scientific Corp., 2: Stereotaxis, Inc., 3: Japan Lifeline, 3: Fukuda Denshi 1: Medtronic, Inc, 2: Boston Scientific Corp., 1: Spectrum Dynamics 4: Biosense Webster, Inc., 2: Japan Lifeline, 2: Affera None None None\nAndrea Natale, MD Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, Austin, TX 1: Boston Scientific Corp., 1: Janssen Pharmaceuticals, 1: Medtronic, Inc., 1: St. Jude Medical, 2: Biosense Webster, Inc. None None None None None\nStanley Nattel, MD Montreal Heart Institute and Université de Montréal, Montreal, Canada, McGill University, Montreal, Canada, and University Duisburg- Essen, Essen, Germany 1: Merck Pharmaceuticals, 1: Xention Discovery None 3: OMEICOS Therapeutics None None 0: Montreal Heart Institute/Inventor Patents\nKen Okumura, MD, PhD Division of Cardiology, Saiseikai Kumamoto Hospital, Kumamoto, Japan 1: Biosense Webster, Inc., 1: Boehringer Ingelheim, 1: Bristol- Myers Squibb, 1: Medtronic, Inc., 2: Bayer/Schering Pharma, 3: Daiichi-Sankyo None 2: Biosense Webster, Inc., 2: Medtronic, Inc. None None None\nDouglas Packer, MD Mayo Clinic, Rochester, MN 0: Abbott Laboratories, 0: Abiomed, 0: Aperture Diagnostics, 0: Biosense Webster, Inc., 0: Boston Scientific Corp., 0: CardioFocus, Inc., 0: CardioInsight Technologies, 0: Johnson and Johnson, 0: Johnson and Johnson Healthcare Systems, 0: MediaSphere Medical, LLC, 0: Medtronic CryoCath, 0: SIEMENS, 0: St. Jude Medical None 0: American Heart Association, 0: Boston Scientific/EPT, 0: CardioInsight, 0: Endosense, 0: SIEMENS Acuson, 0: SIEMENS Acunav, 1: CardioFocus, 1: Hansen Medical, 1: Medtronic, Inc. 2: National Institutes of Health, 3: Thermedical (EP Limited), 5: Biosense Webster, 5: St. Jude Medical None None 1: Medtronic, 1: Oxford Press (Royalty), 1: SIEMENS, 1: WebMD, 1: Wiley- Blackwell (Royalty), 2: Biosense Webster, 4: St. Jude Medical (Royalty)\nEvgeny Pokushalov, MD, PhD State Research Institute of Circulation Pathology, Novosibirsk, Russia 1: Biosense Webster, Inc., 1: Boston Scientific Corp., 1: Medtronic, Inc. None None None None None\nMatthew R. Reynolds, MD, MSc Lahey Hospital and Medical Center, Burlington, MA 1: Biosense Webster, Inc., 1: Medtronic, Inc., 1: St. Jude Medical None None None None None\nPrashanthan Sanders, MBBS, PhD Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia 1: Biosense Webster, Inc., 1: Boston Scientific Corp., 1: CathRx, 1: Medtronic, Inc., 1: St. Jude Medical 1: Biosense Webster, Inc., 1: Boston Scientific Corp., 1: Medtronic, Inc., 1: St. Jude Medical 4: Sorin Group, 5: BIOTRONIK, 5: Boston Scientific Corp., 5: Medtronic, Inc., 5: St. Jude Medical None None None\nMauricio Scanavacca, MD, PhD Instituto do Corac ¸~ ao (InCor), S~ ao Paulo, Brazil 1: Biosense Webster, Inc., 1: St. Jude Medical 1: Bayer/Schering Pharma, 1: Bristol-Myers Squibb, 1: Johnson and Johnson, 1: Daiichi- Sankyo 2: Johnson and Johnson 2: Johnson and Johnson None None\nRichard Schilling, MD Barts Heart Centre, London, United Kingdom 1: Biosense Webster, Inc., 1: Boehringer Ingelheim, 1: Daiichi- Sankyo, 1: Hansen Medical, 1: Medtronic, Inc., 1: St. Jude Medical None 1: Boston Scientific Corp., 1: Hansen Medical, 1: Medtronic, Inc., 1: St. Jude Medical, 4: Boston Scientific Corp., 4: Medtronic, Inc., 4: St. Jude Medical None None None\nClaudio Tondo, MD, PhD Cardiac Arrhythmia Research Center, Centro Cardiologico Monzino, IRCCS, Department of Cardiovascular Sciences, University of Milan, Milan, Italy None None None None None None\nHsuan-Ming Tsao, MD National Yang-Ming University Hospital, Yilan City, Taiwan None None None None None None\nAtul Verma, MD Southlake Regional Health Centre, University of Toronto, Toronto, Canada 1: Bayer HealthCare, LLC, 1: Boehringer Ingelheim None 5: Bayer HealthCare, LLC, 5: Biosense Webster, Inc., 5: BIOTRONIK, 5: Medtronic, Inc. None None None\nDavid J. Wilber, MD Loyola University of Chicago, Chicago, IL 1: Biosense Webster, Inc., 1: Janssen Pharmaceuticals, 1: Medtronic, Inc., 1: St. Jude Medical, 1: Thermedical None 1: Abbott Vascular, 1: Medtronic, Inc., 1: St. Jude Medical, 1: Thermedical, 3: Biosense Webster, Inc. 3: Biosense Webster, Inc., 3: Medtronic, Inc., 3: St. Jude Medical None 1: Elsevier, 1: Wiley-Blackwell, 4: American College of Cardiology Foundation\nTeiichi Yamane, MD, PhD Jikei University School of Medicine, Tokyo, Japan 1: Bayer HealthCare, 1: Medtronic, 2: Abott Japan, 2: Daiichi- Sankyo, 2: Boehringer Ingelheim, 2: Bristol- Myers Squibb None 1: Boehringer Ingelheim, 1: Bayer HealthCare None None None\nNumber Value: 0 = $0; 1 = ≤ $10,000; 2 = \u003e $10,000 to ≤ $25,000; 3 = \u003e $25,000 to ≤ $50,000; 4 = \u003e $50,000 to ≤ $100,000; 5 = \u003e $100,000.\n* Dr. Cappato is now with the Department of Biomedical Sciences, Humanitas University, Milan, Italy, and IRCCS, Humanitas Clinical and Research Center, Milan, Italy.\n\nAppendix B\nReviewer disclosure table\nPeer reviewer Institution Consultant/Advisory board/Honoraria Speakers’ bureau Research grant Fellowship support Stock options/Partner Board Mbs/Other\nCarina Blomström-Lundqvist, MD, PhD Department of Cardiology and Medical Science, Uppsala University, Uppsala, Sweden 1: Bayer/Schering Pharma, 1: Boston Scientific Corp., 1: Medtronic, Inc., 1: Sano3, 1: Pfizer, MSD, Bristol-Myers Squibb, Biosense Webster, Inc. None 1: Cardiome Pharma/Astellas, 1: Medtronic, Inc. None None None\nAngelo A.V. De Paola, MD, PhD Hospital São Paulo – Federal University of São Paulo, São Paulo, Brazil None None None None None None\nPeter M. Kistler, MBBS, PhD The Alfred Hospital Heart Centre, Melbourne, Australia None 1: St. Jude Medical None None None None\nGregory Y.H. Lip, MD University of Birmingham, Birmingham, United Kingdom; Aalborg University, Aalborg, Denmark 1: Medtronic, 3: Bayer/Janssen, BMS/Pfizer, Boehringer Ingelheim, Daiichi- Sankyo 3: Bayer, BMS/Pfizer, Boehringer Ingelheim, Daiichi-Sankyo. No fees are received personally None None None None\nNicholas S. Peters, MD St Mary’s Hospital, Imperial College London, London, United Kingdom 1: Boston Scientific Corp., 1: Cardialen, Inc., 1: Cardiologs, 1: Magnetecs, 1: Medtronic, Inc., 1: St. Jude Medical None None None None None\nCristiano F. Pisani, MD InCor, Heart Insitute, HCFMUSP, Arrhythmia Unit None None None None None None\nAntonio Raviele, MD ALFA-Alliance to Fight Atrial Fibrillation, Rimini, Italy None None None None None None\nEduardo B. Saad, MD, PhD Hospital Pro-Cardiaco and Hospital Samaritano, Botafogo, Rio de Janeiro, Brazil None None None None None None\nKazuhiro Satomi, MD, PhD Tokyo Medical University, Tokyo, Japan 1: Bayer/Schering Pharma, 1: Boehringer Ingelheim, 1: Bristol- Myers Squibb, 1: Japan Lifeline, 1: Johnson and Johnson, 1: Medtronic, Inc., 1: Sankyo Pharmaceuticals, 1: St. Jude Medical None None None None None\nMartin K. Stiles, MB ChB, PhD Waikato Hospital, Hamilton, New Zealand 1: Boston Scientific Corp., 1: Biosense Webster, Inc., 1: BIOTRONIK, 1: Medtronic, Inc. None None 1: Medtronic, Inc. None None\nStephan Willems, MD, PhD University Medical Center Hamburg- Eppendorf, Hamburg, Germany 1: Bayer HealthCare, LLC, 1: Biosense Webster, Inc., 1: Boehringer Ingelheim, 1: Bristol- Myers Squibb, 1: Sano3, 1: St. Jude Medical, 1: Medtronic None None None None None\nNumber Value: 0 = $0; 1 = ≤ $10,000; 2 = \u003e $10,000 to ≤ $25,000; 3 = \u003e $25,000 to ≤ $50,000; 4 = \u003e$50,000 to ≤ $100,000; 5 = \u003e $100,000. ABBREVIATIONS\n3D three-dimensional\nAADs antiarrhythmic drugs\nAATAC Ablation vs Amiodarone for Treatment of Atrial Fibrillation in Patients With Congestive Heart Failure and an Implanted ICD/CRTD\nACE asymptomatic cerebral emboli\nACT activated clotting time\nADVICE Adenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination study\nAEF atrial esophageal flstula\nAF atrial fibrillation\nAFACART Non-Invasive Mapping of Atrial Fibrillation study\nAFACT Atrial Fibrillation Ablation and Autonomic Modulation via Thoracoscopic Surgery study\nAFCL atrial fibrillation cycle length\nAFEQT Atrial Fibrillation Effect on QualiTy-of-Life questionnaire\nAFL atrial flutter\nAH arterial hypertension\nANS autonomic nervous system\nAPD action potential duration\nARREST-AF Aggressive Risk Factor Reduction Study for Atrial Fibrillation and Implications for the Outcome of Ablation study\nASD atrial septal defect\nASTA Arrhythmia-Specific questionnaire in Tachycardia and Arrhythmia\nAT atrial tachycardia\nATA atrial tachyarrhythmia\nATP adenosine triphosphate\nAV atrioventricular\nAVR aortic valve replacement\nBIFA box isolation of fibrotic areas\nBMI body mass index\nBP blood pressure\nBpm beats per minute\nBSM body surface mapping\nCABANA Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial\nCABG coronary artery bypass grafting\nCaMKII Ca2+/calmodulin-dependent protein kinase II\nCB cryoballoon\nCBA cryoballoon ablation\nCF contact force\nCFAE complex fractionated atrial electrogram\nCFS contact force sensing\nCGCI Catheter Guidance, Control, and Imaging\nCHASE-AF Catheter Ablation of Persistent Atrial Fibrillation study\nCI confidence interval\nCMAP compound motor action potentials\nCPAP continuous positive airway pressure\nCPVA circumferential PV ablation\nCryo-FIRST Catheter Cryoa-blation vs Antiarrhythmic Drug as First-Line Therapy of Paroxysmal AF trial\nCS coronary sinus\nCSA central sleep apnea\nCT com-puted tomography\nCV conduction velocity\nDAD delayed after-depolarization\nDE delayed enhancement\nDECAAF Delayed Enhancement MRI and Atrial Fibrillation Catheter Ablation study\nDF dominant excitation frequency\nDM diabetes mellitus\nDW-MRI diffusion-weighted magnetic resonance imaging\nEAM electroanatomical mapping\nEAST Early Treatment of Atrial Fibrillation for Stroke Prevention Trial\nEAVM electroanatomical voltage mapping\nECG electrocardio-gram\nECGI noninvasive electrocardiographic imaging\nEF ejection fraction\nERAF early recurrence of AF\nERP effective refractory period\nFACM fibrotic atrial cardiomy-opathy\nFAP fractionated atrial potential\nFAST AF Catheter Ablation Versus Surgical Ablation Treatment trial\nFDA U.S. Food and Drug Administration\nFIRM focal impulse and rotor modulation\nFLAIR fluid-attenuated inversion recovery\nFTI force-time integral\nGP ganglionated plexi\nHCM hyper-trophic cardiomyopathy\nHDF highest dominant excitation frequency\nHF heart failure\nHFS high-frequency stimulation\nHR hazard ratio\nICE intracardiac echocardiography\nIRGP inferior right ganglionated plexi\nILR implantable loop recorder\nINR international normalized ratio\nLA left atrial\nLAA left atrial appendage\nLAD left atrial dimension\nLALA left atrial linear ablation\nLEGACY Long-Term Effect of Goal Directed Weight Management on an Atrial Fibrillation Cohort study\nLGE late gadolinium-enhanced\nLI left inferior\nLICU low-intensity collimated ultrasound\nLIPV left inferior pulmonary vein\nLOE Level of Evidence\nLook AHEAD Action for Health in Diabetes\nLS left superior\nLSPV left superior pulmonary vein\nLVEF left ventricular ejection fraction\nMANTRA-PAF Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation\nMAP mean arterial pressure\nMLWHF Minnesota Living with Heart Failure questionnaire\nMRI magnetic resonance imaging\nMVRR mitral valve repair or replacement\nNCDR National Cardiovascular Data Registry\nNCX Na+-Ca2+ exchanger\nNOAC novel oral anticoagulant\nNSAID nonsteroidal anti-inflammatory drug\nOAC oral anticoagulation\nOCEAN Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation\nODIn-AF Prevention of Silent Cerebral Thromboembolism by Oral Anticoagulation With Dabigatran After PVI for Atrial Fibrillation trial\nOPC objective performance criteria\nOR odds ratio\nOSA obstructive sleep apnea\nPA peripheral artery\nPABA-CHF Pulmonary Vein Antrum Isolation versus AV Node Ablation with Bi-Ventricular Pacing for Treatment of AF in Patients with Congestive Heart Failure\nPAF paroxysmal AF\nPCC pro-thrombin complex concentrates\nPCWP pulmonary capillary wedge pressure\nPKA protein kinase A\nPN phrenic nerve\nPPIs proton pump inhibitors\nPROTECT AF WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillation\nPS phase singularity\nPSD peak skin dose\nPV pulmonary vein\nPVAC pulmonary vein ablation catheter\nPVI pulmonary vein isolation\nQALY quality-adjusted life year\nQOL quality of life\nRA right atrium\nRAAFT First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment\nRAAFT-2 Radiofrequency Ablation versus Antiarrhythmic drugs as First-line Treatment of Paroxysmal AF\nRCA right coronary artery\nRCT randomized controlled trial\nRD risk difference\nRE-CIRCUIT Randomized Evaluation of Da-bigatran Etexilate Compared to Warfarin in Pulmonary Vein Ablation: Assessment of an Uninterrupted Periprocedural Anticoagulation Strategy\nRF radiofrequency\nRFA radiofre-quency energy ablation\nRFC radiofrequency catheter\nRFCA radiofrequency catheter ablation\nRI right inferior\nRIPV right inferior pulmonary vein\nRP refractory period\nRR relative risk\nRS right superior\nRSPV right superior pulmonary vein\nRVSP right ventricular systolic pressure\nSARA Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation\nSMART-AF ThermoCool SmartTouch Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation\nSNP single nucleotide polymorphism\nSPECULATE Effect of Amiodarone on the Procedure Outcome in Long-standing persistent AF Undergoing PV Antral Isolation\nSR sarcoplasmic reticulum\nSTAR AF II Substrate and Trigger Ablation for Reduction of AF Trial Part II\nSTOP-AF Sustained Treatment of Paroxysmal Atrial Fibrillation\nSVC superior vena cava\nTEE transesophageal echo-cardiogram\nTIA transient ischemic attack\nVATS video-assisted thoracoscopic surgery\nVKA vitamin K antagonist\nWACA wide-area circumferential ablation\nWL 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