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evolution of complex organisms has been associated with the generation of gene families by the continual duplication of an initial relatively small set of ancestral genes. Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function."}

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{"project":"craft-ca-core-dev","denotations":[{"id":"T563","span":{"begin":25,"end":34},"obj":"NCBITaxon:1"},{"id":"T564","span":{"begin":78,"end":82},"obj":"SO:0000704"},{"id":"T565","span":{"begin":169,"end":174},"obj":"SO:0000704"},{"id":"T566","span":{"begin":249,"end":253},"obj":"SO:0000147"},{"id":"T567","span":{"begin":272,"end":276},"obj":"SO:0000704"},{"id":"T568","span":{"begin":287,"end":292},"obj":"SO:0000704"},{"id":"T569","span":{"begin":417,"end":423},"obj":"SO:0001026"},{"id":"T570","span":{"begin":447,"end":452},"obj":"NCBITaxon:9606"},{"id":"T571","span":{"begin":454,"end":459},"obj":"NCBITaxon:10088"},{"id":"T572","span":{"begin":461,"end":464},"obj":"NCBITaxon:10114"},{"id":"T573","span":{"begin":466,"end":475},"obj":"NCBITaxon:7215"},{"id":"T574","span":{"begin":480,"end":489},"obj":"NCBITaxon:6231"},{"id":"T575","span":{"begin":562,"end":567},"obj":"SO:0000704"},{"id":"T576","span":{"begin":605,"end":613},"obj":"NCBITaxon:1"},{"id":"T577","span":{"begin":727,"end":732},"obj":"SO:0000704"},{"id":"T578","span":{"begin":737,"end":741},"obj":"SO:0000704"},{"id":"T579","span":{"begin":765,"end":769},"obj":"SO:0000704"},{"id":"T580","span":{"begin":788,"end":797},"obj":"NCBITaxon:1"},{"id":"T581","span":{"begin":865,"end":872},"obj":"SO:0001026"},{"id":"T582","span":{"begin":994,"end":998},"obj":"SO:0000704"}],"text":"The evolution of complex organisms has been associated with the generation of gene families by the continual duplication of an initial relatively small set of ancestral genes. Through this process, followed by subsequent mutation, reduplication and exon shuffling between gene families, genes have evolved both discrete, and partially redundant functions with their related family members. With the completion of the genome sequencing projects of human, mouse, rat, fruit fly and nematodes, we are now in a position to ask fundamental questions in regard to how genes interact in the context of the whole organism. Thus, with the appropriate application of bioinformatics, it is now possible to trace the lineage of particular genes and gene families, with related gene families in other organisms. Furthermore, with the growing amount of large-scale proteomic and genomic data becoming publicly available, this analysis can now be extended to reveal the complex interplay between evolution of gene structure and protein function."}