PMC:400732 / 102-1110 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/400732","sourcedb":"PMC","sourceid":"400732","source_url":"http://www.ncbi.nlm.nih.gov/pmc/400732","text":"Background\nDopamine modulation of neuronal signaling in the frontal cortex, midbrain, and striatum is essential for processing and integrating diverse external sensory stimuli and attaching salience to environmental cues that signal causal relationships, thereby guiding goal-directed, adaptable behaviors. At the cellular level, dopamine signaling is mediated through D1-like or D2-like receptors. Although a role for D1-like receptors in a variety of goal-directed behaviors has been identified, an explicit involvement of D2 receptors has not been clearly established. To determine whether dopamine D2 receptor-mediated signaling contributes to associative and reversal learning, we compared C57Bl/6J mice that completely lack functional dopamine D2 receptors to wild-type mice with respect to their ability to attach appropriate salience to external stimuli (stimulus discrimination) and disengage from inappropriate behavioral strategies when reinforcement contingencies change (e.g. reversal learning).","divisions":[{"label":"title","span":{"begin":0,"end":10}}],"tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T247","span":{"begin":0,"end":10},"obj":"sentence"},{"id":"T248","span":{"begin":0,"end":10},"obj":"NN"},{"id":"T249","span":{"begin":10,"end":306},"obj":"sentence"},{"id":"T250","span":{"begin":11,"end":19},"obj":"NN"},{"id":"T251","span":{"begin":20,"end":30},"obj":"NN"},{"id":"T252","span":{"begin":99,"end":101},"obj":"VBZ"},{"id":"T253","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T254","span":{"begin":34,"end":42},"obj":"JJ"},{"id":"T255","span":{"begin":43,"end":52},"obj":"NN"},{"id":"T256","span":{"begin":53,"end":55},"obj":"IN"},{"id":"T257","span":{"begin":56,"end":59},"obj":"DT"},{"id":"T258","span":{"begin":68,"end":74},"obj":"NN"},{"id":"T259","span":{"begin":60,"end":67},"obj":"JJ"},{"id":"T260","span":{"begin":74,"end":76},"obj":","},{"id":"T261","span":{"begin":76,"end":84},"obj":"NN"},{"id":"T262","span":{"begin":84,"end":86},"obj":","},{"id":"T263","span":{"begin":86,"end":89},"obj":"CC"},{"id":"T264","span":{"begin":90,"end":98},"obj":"NN"},{"id":"T265","span":{"begin":102,"end":111},"obj":"JJ"},{"id":"T266","span":{"begin":112,"end":115},"obj":"IN"},{"id":"T267","span":{"begin":116,"end":126},"obj":"VBG"},{"id":"T268","span":{"begin":127,"end":130},"obj":"CC"},{"id":"T269","span":{"begin":131,"end":142},"obj":"VBG"},{"id":"T270","span":{"begin":143,"end":150},"obj":"JJ"},{"id":"T271","span":{"begin":168,"end":175},"obj":"NNS"},{"id":"T272","span":{"begin":151,"end":159},"obj":"JJ"},{"id":"T273","span":{"begin":160,"end":167},"obj":"JJ"},{"id":"T274","span":{"begin":176,"end":179},"obj":"CC"},{"id":"T275","span":{"begin":180,"end":189},"obj":"VBG"},{"id":"T276","span":{"begin":190,"end":198},"obj":"NN"},{"id":"T277","span":{"begin":199,"end":201},"obj":"IN"},{"id":"T278","span":{"begin":202,"end":215},"obj":"JJ"},{"id":"T279","span":{"begin":216,"end":220},"obj":"NNS"},{"id":"T280","span":{"begin":221,"end":225},"obj":"WDT"},{"id":"T281","span":{"begin":226,"end":232},"obj":"VBP"},{"id":"T282","span":{"begin":233,"end":239},"obj":"JJ"},{"id":"T283","span":{"begin":240,"end":253},"obj":"NNS"},{"id":"T284","span":{"begin":253,"end":255},"obj":","},{"id":"T285","span":{"begin":255,"end":262},"obj":"RB"},{"id":"T286","span":{"begin":263,"end":270},"obj":"VBG"},{"id":"T287","span":{"begin":271,"end":275},"obj":"NN"},{"id":"T288","span":{"begin":276,"end":284},"obj":"VBN"},{"id":"T289","span":{"begin":275,"end":276},"obj":"HYPH"},{"id":"T290","span":{"begin":296,"end":305},"obj":"NNS"},{"id":"T291","span":{"begin":284,"end":286},"obj":","},{"id":"T292","span":{"begin":286,"end":295},"obj":"JJ"},{"id":"T293","span":{"begin":305,"end":306},"obj":"."},{"id":"T294","span":{"begin":306,"end":398},"obj":"sentence"},{"id":"T295","span":{"begin":307,"end":309},"obj":"IN"},{"id":"T296","span":{"begin":352,"end":360},"obj":"VBN"},{"id":"T297","span":{"begin":310,"end":313},"obj":"DT"},{"id":"T298","span":{"begin":323,"end":328},"obj":"NN"},{"id":"T299","span":{"begin":314,"end":322},"obj":"JJ"},{"id":"T300","span":{"begin":328,"end":330},"obj":","},{"id":"T301","span":{"begin":330,"end":338},"obj":"NN"},{"id":"T302","span":{"begin":339,"end":348},"obj":"NN"},{"id":"T303","span":{"begin":349,"end":351},"obj":"VBZ"},{"id":"T304","span":{"begin":361,"end":368},"obj":"IN"},{"id":"T305","span":{"begin":369,"end":371},"obj":"NN"},{"id":"T306","span":{"begin":372,"end":376},"obj":"JJ"},{"id":"T307","span":{"begin":371,"end":372},"obj":"HYPH"},{"id":"T308","span":{"begin":388,"end":397},"obj":"NNS"},{"id":"T309","span":{"begin":377,"end":379},"obj":"CC"},{"id":"T310","span":{"begin":380,"end":382},"obj":"NN"},{"id":"T311","span":{"begin":383,"end":387},"obj":"JJ"},{"id":"T312","span":{"begin":382,"end":383},"obj":"HYPH"},{"id":"T313","span":{"begin":397,"end":398},"obj":"."},{"id":"T314","span":{"begin":398,"end":571},"obj":"sentence"},{"id":"T315","span":{"begin":399,"end":407},"obj":"IN"},{"id":"T316","span":{"begin":486,"end":496},"obj":"VBN"},{"id":"T317","span":{"begin":408,"end":409},"obj":"DT"},{"id":"T318","span":{"begin":410,"end":414},"obj":"NN"},{"id":"T319","span":{"begin":415,"end":418},"obj":"IN"},{"id":"T320","span":{"begin":419,"end":421},"obj":"NN"},{"id":"T321","span":{"begin":422,"end":426},"obj":"JJ"},{"id":"T322","span":{"begin":421,"end":422},"obj":"HYPH"},{"id":"T323","span":{"begin":427,"end":436},"obj":"NNS"},{"id":"T324","span":{"begin":437,"end":439},"obj":"IN"},{"id":"T325","span":{"begin":440,"end":441},"obj":"DT"},{"id":"T326","span":{"begin":442,"end":449},"obj":"NN"},{"id":"T327","span":{"begin":450,"end":452},"obj":"IN"},{"id":"T328","span":{"begin":453,"end":457},"obj":"NN"},{"id":"T329","span":{"begin":458,"end":466},"obj":"VBN"},{"id":"T330","span":{"begin":457,"end":458},"obj":"HYPH"},{"id":"T331","span":{"begin":467,"end":476},"obj":"NNS"},{"id":"T332","span":{"begin":477,"end":480},"obj":"VBZ"},{"id":"T333","span":{"begin":481,"end":485},"obj":"VBN"},{"id":"T334","span":{"begin":559,"end":570},"obj":"VBN"},{"id":"T335","span":{"begin":496,"end":498},"obj":","},{"id":"T336","span":{"begin":498,"end":500},"obj":"DT"},{"id":"T337","span":{"begin":510,"end":521},"obj":"NN"},{"id":"T338","span":{"begin":501,"end":509},"obj":"JJ"},{"id":"T339","span":{"begin":522,"end":524},"obj":"IN"},{"id":"T340","span":{"begin":525,"end":527},"obj":"NN"},{"id":"T341","span":{"begin":528,"end":537},"obj":"NNS"},{"id":"T342","span":{"begin":538,"end":541},"obj":"VBZ"},{"id":"T343","span":{"begin":542,"end":545},"obj":"RB"},{"id":"T344","span":{"begin":546,"end":550},"obj":"VBN"},{"id":"T345","span":{"begin":551,"end":558},"obj":"RB"},{"id":"T346","span":{"begin":570,"end":571},"obj":"."},{"id":"T347","span":{"begin":571,"end":1008},"obj":"sentence"},{"id":"T348","span":{"begin":572,"end":574},"obj":"TO"},{"id":"T349","span":{"begin":575,"end":584},"obj":"VB"},{"id":"T350","span":{"begin":686,"end":694},"obj":"VBD"},{"id":"T351","span":{"begin":585,"end":592},"obj":"IN"},{"id":"T352","span":{"begin":633,"end":644},"obj":"VBZ"},{"id":"T353","span":{"begin":593,"end":601},"obj":"NN"},{"id":"T354","span":{"begin":602,"end":604},"obj":"NN"},{"id":"T355","span":{"begin":605,"end":613},"obj":"NN"},{"id":"T356","span":{"begin":614,"end":622},"obj":"VBN"},{"id":"T357","span":{"begin":613,"end":614},"obj":"HYPH"},{"id":"T358","span":{"begin":623,"end":632},"obj":"NN"},{"id":"T359","span":{"begin":645,"end":647},"obj":"IN"},{"id":"T360","span":{"begin":648,"end":659},"obj":"JJ"},{"id":"T361","span":{"begin":673,"end":681},"obj":"NN"},{"id":"T362","span":{"begin":660,"end":663},"obj":"CC"},{"id":"T363","span":{"begin":664,"end":672},"obj":"JJ"},{"id":"T364","span":{"begin":681,"end":683},"obj":","},{"id":"T365","span":{"begin":683,"end":685},"obj":"PRP"},{"id":"T366","span":{"begin":695,"end":700},"obj":"NN"},{"id":"T367","span":{"begin":701,"end":703},"obj":"NN"},{"id":"T368","span":{"begin":700,"end":701},"obj":"HYPH"},{"id":"T369","span":{"begin":704,"end":708},"obj":"NNS"},{"id":"T370","span":{"begin":709,"end":713},"obj":"WDT"},{"id":"T371","span":{"begin":725,"end":729},"obj":"VBP"},{"id":"T372","span":{"begin":714,"end":724},"obj":"RB"},{"id":"T373","span":{"begin":730,"end":740},"obj":"JJ"},{"id":"T374","span":{"begin":753,"end":762},"obj":"NNS"},{"id":"T375","span":{"begin":741,"end":749},"obj":"NN"},{"id":"T376","span":{"begin":750,"end":752},"obj":"NN"},{"id":"T377","span":{"begin":763,"end":765},"obj":"IN"},{"id":"T378","span":{"begin":766,"end":770},"obj":"JJ"},{"id":"T379","span":{"begin":771,"end":775},"obj":"NN"},{"id":"T380","span":{"begin":770,"end":771},"obj":"HYPH"},{"id":"T381","span":{"begin":776,"end":780},"obj":"NNS"},{"id":"T382","span":{"begin":781,"end":785},"obj":"IN"},{"id":"T383","span":{"begin":786,"end":793},"obj":"NN"},{"id":"T384","span":{"begin":794,"end":796},"obj":"IN"},{"id":"T385","span":{"begin":797,"end":802},"obj":"PRP$"},{"id":"T386","span":{"begin":803,"end":810},"obj":"NN"},{"id":"T387","span":{"begin":811,"end":813},"obj":"TO"},{"id":"T388","span":{"begin":814,"end":820},"obj":"VB"},{"id":"T389","span":{"begin":821,"end":832},"obj":"JJ"},{"id":"T390","span":{"begin":833,"end":841},"obj":"NN"},{"id":"T391","span":{"begin":842,"end":844},"obj":"IN"},{"id":"T392","span":{"begin":845,"end":853},"obj":"JJ"},{"id":"T393","span":{"begin":854,"end":861},"obj":"NNS"},{"id":"T394","span":{"begin":862,"end":863},"obj":"-LRB-"},{"id":"T395","span":{"begin":872,"end":886},"obj":"NN"},{"id":"T396","span":{"begin":863,"end":871},"obj":"NN"},{"id":"T397","span":{"begin":886,"end":887},"obj":"-RRB-"},{"id":"T398","span":{"begin":888,"end":891},"obj":"CC"},{"id":"T399","span":{"begin":892,"end":901},"obj":"VB"},{"id":"T400","span":{"begin":902,"end":906},"obj":"IN"},{"id":"T401","span":{"begin":907,"end":920},"obj":"JJ"},{"id":"T402","span":{"begin":932,"end":942},"obj":"NNS"},{"id":"T403","span":{"begin":921,"end":931},"obj":"JJ"},{"id":"T404","span":{"begin":943,"end":947},"obj":"WRB"},{"id":"T405","span":{"begin":976,"end":982},"obj":"VBP"},{"id":"T406","span":{"begin":948,"end":961},"obj":"NN"},{"id":"T407","span":{"begin":962,"end":975},"obj":"NNS"},{"id":"T408","span":{"begin":983,"end":984},"obj":"-LRB-"},{"id":"T409","span":{"begin":998,"end":1006},"obj":"NN"},{"id":"T410","span":{"begin":984,"end":988},"obj":"FW"},{"id":"T411","span":{"begin":989,"end":997},"obj":"NN"},{"id":"T412","span":{"begin":1006,"end":1007},"obj":"-RRB-"},{"id":"T413","span":{"begin":1007,"end":1008},"obj":"."}],"relations":[{"id":"R21","pred":"compound","subj":"T250","obj":"T251"},{"id":"R22","pred":"nsubj","subj":"T251","obj":"T252"},{"id":"R23","pred":"prep","subj":"T253","obj":"T251"},{"id":"R24","pred":"amod","subj":"T254","obj":"T255"},{"id":"R25","pred":"pobj","subj":"T255","obj":"T253"},{"id":"R26","pred":"prep","subj":"T256","obj":"T251"},{"id":"R27","pred":"det","subj":"T257","obj":"T258"},{"id":"R28","pred":"pobj","subj":"T258","obj":"T256"},{"id":"R29","pred":"amod","subj":"T259","obj":"T258"},{"id":"R30","pred":"punct","subj":"T260","obj":"T258"},{"id":"R31","pred":"conj","subj":"T261","obj":"T258"},{"id":"R32","pred":"punct","subj":"T262","obj":"T261"},{"id":"R33","pred":"cc","subj":"T263","obj":"T261"},{"id":"R34","pred":"conj","subj":"T264","obj":"T261"},{"id":"R35","pred":"acomp","subj":"T265","obj":"T252"},{"id":"R36","pred":"prep","subj":"T266","obj":"T252"},{"id":"R37","pred":"pcomp","subj":"T267","obj":"T266"},{"id":"R38","pred":"cc","subj":"T268","obj":"T267"},{"id":"R39","pred":"conj","subj":"T269","obj":"T267"},{"id":"R40","pred":"amod","subj":"T270","obj":"T271"},{"id":"R41","pred":"dobj","subj":"T271","obj":"T269"},{"id":"R42","pred":"amod","subj":"T272","obj":"T271"},{"id":"R43","pred":"amod","subj":"T273","obj":"T271"},{"id":"R44","pred":"cc","subj":"T274","obj":"T267"},{"id":"R45","pred":"conj","subj":"T275","obj":"T267"},{"id":"R46","pred":"dobj","subj":"T276","obj":"T275"},{"id":"R47","pred":"prep","subj":"T277","obj":"T275"},{"id":"R48","pred":"amod","subj":"T278","obj":"T279"},{"id":"R49","pred":"pobj","subj":"T279","obj":"T277"},{"id":"R50","pred":"dep","subj":"T280","obj":"T281"},{"id":"R51","pred":"relcl","subj":"T281","obj":"T279"},{"id":"R52","pred":"amod","subj":"T282","obj":"T283"},{"id":"R53","pred":"dobj","subj":"T283","obj":"T281"},{"id":"R54","pred":"punct","subj":"T284","obj":"T275"},{"id":"R55","pred":"advmod","subj":"T285","obj":"T286"},{"id":"R56","pred":"advcl","subj":"T286","obj":"T275"},{"id":"R57","pred":"npadvmod","subj":"T287","obj":"T288"},{"id":"R58","pred":"amod","subj":"T288","obj":"T290"},{"id":"R59","pred":"punct","subj":"T289","obj":"T288"},{"id":"R60","pred":"dobj","subj":"T290","obj":"T286"},{"id":"R61","pred":"punct","subj":"T291","obj":"T290"},{"id":"R62","pred":"amod","subj":"T292","obj":"T290"},{"id":"R63","pred":"punct","subj":"T293","obj":"T252"},{"id":"R64","pred":"prep","subj":"T295","obj":"T296"},{"id":"R65","pred":"det","subj":"T297","obj":"T298"},{"id":"R66","pred":"pobj","subj":"T298","obj":"T295"},{"id":"R67","pred":"amod","subj":"T299","obj":"T298"},{"id":"R68","pred":"punct","subj":"T300","obj":"T296"},{"id":"R69","pred":"compound","subj":"T301","obj":"T302"},{"id":"R70","pred":"nsubjpass","subj":"T302","obj":"T296"},{"id":"R71","pred":"auxpass","subj":"T303","obj":"T296"},{"id":"R72","pred":"prep","subj":"T304","obj":"T296"},{"id":"R73","pred":"npadvmod","subj":"T305","obj":"T306"},{"id":"R74","pred":"amod","subj":"T306","obj":"T308"},{"id":"R75","pred":"punct","subj":"T307","obj":"T306"},{"id":"R76","pred":"pobj","subj":"T308","obj":"T304"},{"id":"R77","pred":"cc","subj":"T309","obj":"T306"},{"id":"R78","pred":"npadvmod","subj":"T310","obj":"T311"},{"id":"R79","pred":"conj","subj":"T311","obj":"T306"},{"id":"R80","pred":"punct","subj":"T312","obj":"T311"},{"id":"R81","pred":"punct","subj":"T313","obj":"T296"},{"id":"R82","pred":"mark","subj":"T315","obj":"T316"},{"id":"R83","pred":"advcl","subj":"T316","obj":"T334"},{"id":"R84","pred":"det","subj":"T317","obj":"T318"},{"id":"R85","pred":"nsubjpass","subj":"T318","obj":"T316"},{"id":"R86","pred":"prep","subj":"T319","obj":"T318"},{"id":"R87","pred":"npadvmod","subj":"T320","obj":"T321"},{"id":"R88","pred":"amod","subj":"T321","obj":"T323"},{"id":"R89","pred":"punct","subj":"T322","obj":"T321"},{"id":"R90","pred":"pobj","subj":"T323","obj":"T319"},{"id":"R91","pred":"prep","subj":"T324","obj":"T318"},{"id":"R92","pred":"det","subj":"T325","obj":"T326"},{"id":"R93","pred":"pobj","subj":"T326","obj":"T324"},{"id":"R94","pred":"prep","subj":"T327","obj":"T326"},{"id":"R95","pred":"npadvmod","subj":"T328","obj":"T329"},{"id":"R96","pred":"amod","subj":"T329","obj":"T331"},{"id":"R97","pred":"punct","subj":"T330","obj":"T329"},{"id":"R98","pred":"pobj","subj":"T331","obj":"T327"},{"id":"R99","pred":"aux","subj":"T332","obj":"T316"},{"id":"R100","pred":"auxpass","subj":"T333","obj":"T316"},{"id":"R101","pred":"punct","subj":"T335","obj":"T334"},{"id":"R102","pred":"det","subj":"T336","obj":"T337"},{"id":"R103","pred":"nsubjpass","subj":"T337","obj":"T334"},{"id":"R104","pred":"amod","subj":"T338","obj":"T337"},{"id":"R105","pred":"prep","subj":"T339","obj":"T337"},{"id":"R106","pred":"compound","subj":"T340","obj":"T341"},{"id":"R107","pred":"pobj","subj":"T341","obj":"T339"},{"id":"R108","pred":"aux","subj":"T342","obj":"T334"},{"id":"R109","pred":"neg","subj":"T343","obj":"T334"},{"id":"R110","pred":"auxpass","subj":"T344","obj":"T334"},{"id":"R111","pred":"advmod","subj":"T345","obj":"T334"},{"id":"R112","pred":"punct","subj":"T346","obj":"T334"},{"id":"R113","pred":"aux","subj":"T348","obj":"T349"},{"id":"R114","pred":"advcl","subj":"T349","obj":"T350"},{"id":"R115","pred":"mark","subj":"T351","obj":"T352"},{"id":"R116","pred":"ccomp","subj":"T352","obj":"T349"},{"id":"R117","pred":"compound","subj":"T353","obj":"T354"},{"id":"R118","pred":"compound","subj":"T354","obj":"T355"},{"id":"R119","pred":"npadvmod","subj":"T355","obj":"T356"},{"id":"R120","pred":"amod","subj":"T356","obj":"T358"},{"id":"R121","pred":"punct","subj":"T357","obj":"T356"},{"id":"R122","pred":"nsubj","subj":"T358","obj":"T352"},{"id":"R123","pred":"prep","subj":"T359","obj":"T352"},{"id":"R124","pred":"amod","subj":"T360","obj":"T361"},{"id":"R125","pred":"pobj","subj":"T361","obj":"T359"},{"id":"R126","pred":"cc","subj":"T362","obj":"T360"},{"id":"R127","pred":"conj","subj":"T363","obj":"T360"},{"id":"R128","pred":"punct","subj":"T364","obj":"T350"},{"id":"R129","pred":"nsubj","subj":"T365","obj":"T350"},{"id":"R130","pred":"compound","subj":"T366","obj":"T367"},{"id":"R131","pred":"compound","subj":"T367","obj":"T369"},{"id":"R132","pred":"punct","subj":"T368","obj":"T367"},{"id":"R133","pred":"dobj","subj":"T369","obj":"T350"},{"id":"R134","pred":"dep","subj":"T370","obj":"T371"},{"id":"R135","pred":"relcl","subj":"T371","obj":"T369"},{"id":"R136","pred":"advmod","subj":"T372","obj":"T371"},{"id":"R137","pred":"amod","subj":"T373","obj":"T374"},{"id":"R138","pred":"dobj","subj":"T374","obj":"T371"},{"id":"R139","pred":"compound","subj":"T375","obj":"T376"},{"id":"R140","pred":"compound","subj":"T376","obj":"T374"},{"id":"R141","pred":"prep","subj":"T377","obj":"T350"},{"id":"R142","pred":"amod","subj":"T378","obj":"T379"},{"id":"R143","pred":"compound","subj":"T379","obj":"T381"},{"id":"R144","pred":"punct","subj":"T380","obj":"T379"},{"id":"R145","pred":"pobj","subj":"T381","obj":"T377"},{"id":"R146","pred":"prep","subj":"T382","obj":"T350"},{"id":"R147","pred":"pobj","subj":"T383","obj":"T382"},{"id":"R148","pred":"prep","subj":"T384","obj":"T383"},{"id":"R149","pred":"poss","subj":"T385","obj":"T386"},{"id":"R150","pred":"pobj","subj":"T386","obj":"T384"},{"id":"R151","pred":"aux","subj":"T387","obj":"T388"},{"id":"R152","pred":"acl","subj":"T388","obj":"T386"},{"id":"R153","pred":"amod","subj":"T389","obj":"T390"},{"id":"R154","pred":"dobj","subj":"T390","obj":"T388"},{"id":"R155","pred":"prep","subj":"T391","obj":"T388"},{"id":"R156","pred":"amod","subj":"T392","obj":"T393"},{"id":"R157","pred":"pobj","subj":"T393","obj":"T391"},{"id":"R158","pred":"punct","subj":"T394","obj":"T395"},{"id":"R159","pred":"parataxis","subj":"T395","obj":"T388"},{"id":"R160","pred":"compound","subj":"T396","obj":"T395"},{"id":"R161","pred":"punct","subj":"T397","obj":"T395"},{"id":"R162","pred":"cc","subj":"T398","obj":"T388"},{"id":"R163","pred":"conj","subj":"T399","obj":"T388"},{"id":"R164","pred":"prep","subj":"T400","obj":"T399"},{"id":"R165","pred":"amod","subj":"T401","obj":"T402"},{"id":"R166","pred":"pobj","subj":"T402","obj":"T400"},{"id":"R167","pred":"amod","subj":"T403","obj":"T402"},{"id":"R168","pred":"advmod","subj":"T404","obj":"T405"},{"id":"R169","pred":"advcl","subj":"T405","obj":"T399"},{"id":"R170","pred":"compound","subj":"T406","obj":"T407"},{"id":"R171","pred":"nsubj","subj":"T407","obj":"T405"},{"id":"R172","pred":"punct","subj":"T408","obj":"T409"},{"id":"R173","pred":"parataxis","subj":"T409","obj":"T399"},{"id":"R174","pred":"advmod","subj":"T410","obj":"T409"},{"id":"R175","pred":"compound","subj":"T411","obj":"T409"},{"id":"R176","pred":"punct","subj":"T412","obj":"T409"},{"id":"R177","pred":"punct","subj":"T413","obj":"T350"}],"attributes":[{"subj":"T247","pred":"source","obj":"craft-sa-dev"},{"subj":"T248","pred":"source","obj":"craft-sa-dev"},{"subj":"T249","pred":"source","obj":"craft-sa-dev"},{"subj":"T250","pred":"source","obj":"craft-sa-dev"},{"subj":"T251","pred":"source","obj":"craft-sa-dev"},{"subj":"T252","pred":"source","obj":"craft-sa-dev"},{"subj":"T253","pred":"source","obj":"craft-sa-dev"},{"subj":"T254","pred":"source","obj":"craft-sa-dev"},{"subj":"T255","pred":"source","obj":"craft-sa-dev"},{"subj":"T256","pred":"source","obj":"craft-sa-dev"},{"subj":"T257","pred":"source","obj":"craft-sa-dev"},{"subj":"T258","pred":"source","obj":"craft-sa-dev"},{"subj":"T259","pred":"source","obj":"craft-sa-dev"},{"subj":"T260","pred":"source","obj":"craft-sa-dev"},{"subj":"T261","pred":"source","obj":"craft-sa-dev"},{"subj":"T262","pred":"source","obj":"craft-sa-dev"},{"subj":"T263","pred":"source","obj":"craft-sa-dev"},{"subj":"T264","pred":"source","obj":"craft-sa-dev"},{"subj":"T265","pred":"source","obj":"craft-sa-dev"},{"subj":"T266","pred":"source","obj":"craft-sa-dev"},{"subj":"T267","pred":"source","obj":"craft-sa-dev"},{"subj":"T268","pred":"source","obj":"craft-sa-dev"},{"subj":"T269","pred":"source","obj":"craft-sa-dev"},{"subj":"T270","pred":"source","obj":"craft-sa-dev"},{"subj":"T271","pred":"source","obj":"craft-sa-dev"},{"subj":"T272","pred":"source","obj":"craft-sa-dev"},{"subj":"T273","pred":"source","obj":"craft-sa-dev"},{"subj":"T274","pred":"source","obj":"craft-sa-dev"},{"subj":"T275","pred":"source","obj":"craft-sa-dev"},{"subj":"T276","pred":"source","obj":"craft-sa-dev"},{"subj":"T277","pred":"source","obj":"craft-sa-dev"},{"subj":"T278","pred":"source","obj":"craft-sa-dev"},{"subj":"T279","pred":"source","obj":"craft-sa-dev"},{"subj":"T280","pred":"source","obj":"craft-sa-dev"},{"subj":"T281","pred":"source","obj":"craft-sa-dev"},{"subj":"T282","pred":"source","obj":"craft-sa-dev"},{"subj":"T283","pred":"source","obj":"craft-sa-dev"},{"subj":"T284","pred":"source","obj":"craft-sa-dev"},{"subj":"T285","pred":"source","obj":"craft-sa-dev"},{"subj":"T286","pred":"source","obj":"craft-sa-dev"},{"subj":"T287","pred":"source","obj":"craft-sa-dev"},{"subj":"T288","pred":"source","obj":"craft-sa-dev"},{"subj":"T289","pred":"source","obj":"craft-sa-dev"},{"subj":"T290","pred":"source","obj":"craft-sa-dev"},{"subj":"T291","pred":"source","obj":"craft-sa-dev"},{"subj":"T292","pred":"source","obj":"craft-sa-dev"},{"subj":"T293","pred":"source","obj":"craft-sa-dev"},{"subj":"T294","pred":"source","obj":"craft-sa-dev"},{"subj":"T295","pred":"source","obj":"craft-sa-dev"},{"subj":"T296","pred":"source","obj":"craft-sa-dev"},{"subj":"T297","pred":"source","obj":"craft-sa-dev"},{"subj":"T298","pred":"source","obj":"craft-sa-dev"},{"subj":"T299","pred":"source","obj":"craft-sa-dev"},{"subj":"T300","pred":"source","obj":"craft-sa-dev"},{"subj":"T301","pred":"source","obj":"craft-sa-dev"},{"subj":"T302","pred":"source","obj":"craft-sa-dev"},{"subj":"T303","pred":"source","obj":"craft-sa-dev"},{"subj":"T304","pred":"source","obj":"craft-sa-dev"},{"subj":"T305","pred":"source","obj":"craft-sa-dev"},{"subj":"T306","pred":"source","obj":"craft-sa-dev"},{"subj":"T307","pred":"source","obj":"craft-sa-dev"},{"subj":"T308","pred":"source","obj":"craft-sa-dev"},{"subj":"T309","pred":"source","obj":"craft-sa-dev"},{"subj":"T310","pred":"source","obj":"craft-sa-dev"},{"subj":"T311","pred":"source","obj":"craft-sa-dev"},{"subj":"T312","pred":"source","obj":"craft-sa-dev"},{"subj":"T313","pred":"source","obj":"craft-sa-dev"},{"subj":"T314","pred":"source","obj":"craft-sa-dev"},{"subj":"T315","pred":"source","obj":"craft-sa-dev"},{"subj":"T316","pred":"source","obj":"craft-sa-dev"},{"subj":"T317","pred":"source","obj":"craft-sa-dev"},{"subj":"T318","pred":"source","obj":"craft-sa-dev"},{"subj":"T319","pred":"source","obj":"craft-sa-dev"},{"subj":"T320","pred":"source","obj":"craft-sa-dev"},{"subj":"T321","pred":"source","obj":"craft-sa-dev"},{"subj":"T322","pred":"source","obj":"craft-sa-dev"},{"subj":"T323","pred":"source","obj":"craft-sa-dev"},{"subj":"T324","pred":"source","obj":"craft-sa-dev"},{"subj":"T325","pred":"source","obj":"craft-sa-dev"},{"subj":"T326","pred":"source","obj":"craft-sa-dev"},{"subj":"T327","pred":"source","obj":"craft-sa-dev"},{"subj":"T328","pred":"source","obj":"craft-sa-dev"},{"subj":"T329","pred":"source","obj":"craft-sa-dev"},{"subj":"T330","pred":"source","obj":"craft-sa-dev"},{"subj":"T331","pred":"source","obj":"craft-sa-dev"},{"subj":"T332","pred":"source","obj":"craft-sa-dev"},{"subj":"T333","pred":"source","obj":"craft-sa-dev"},{"subj":"T334","pred":"source","obj":"craft-sa-dev"},{"subj":"T335","pred":"source","obj":"craft-sa-dev"},{"subj":"T336","pred":"source","obj":"craft-sa-dev"},{"subj":"T337","pred":"source","obj":"craft-sa-dev"},{"subj":"T338","pred":"source","obj":"craft-sa-dev"},{"subj":"T339","pred":"source","obj":"craft-sa-dev"},{"subj":"T340","pred":"source","obj":"craft-sa-dev"},{"subj":"T341","pred":"source","obj":"craft-sa-dev"},{"subj":"T342","pred":"source","obj":"craft-sa-dev"},{"subj":"T343","pred":"source","obj":"craft-sa-dev"},{"subj":"T344","pred":"source","obj":"craft-sa-dev"},{"subj":"T345","pred":"source","obj":"craft-sa-dev"},{"subj":"T346","pred":"source","obj":"craft-sa-dev"},{"subj":"T347","pred":"source","obj":"craft-sa-dev"},{"subj":"T348","pred":"source","obj":"craft-sa-dev"},{"subj":"T349","pred":"source","obj":"craft-sa-dev"},{"subj":"T350","pred":"source","obj":"craft-sa-dev"},{"subj":"T351","pred":"source","obj":"craft-sa-dev"},{"subj":"T352","pred":"source","obj":"craft-sa-dev"},{"subj":"T353","pred":"source","obj":"craft-sa-dev"},{"subj":"T354","pred":"source","obj":"craft-sa-dev"},{"subj":"T355","pred":"source","obj":"craft-sa-dev"},{"subj":"T356","pred":"source","obj":"craft-sa-dev"},{"subj":"T357","pred":"source","obj":"craft-sa-dev"},{"subj":"T358","pred":"source","obj":"craft-sa-dev"},{"subj":"T359","pred":"source","obj":"craft-sa-dev"},{"subj":"T360","pred":"source","obj":"craft-sa-dev"},{"subj":"T361","pred":"source","obj":"craft-sa-dev"},{"subj":"T362","pred":"source","obj":"craft-sa-dev"},{"subj":"T363","pred":"source","obj":"craft-sa-dev"},{"subj":"T364","pred":"source","obj":"craft-sa-dev"},{"subj":"T365","pred":"source","obj":"craft-sa-dev"},{"subj":"T366","pred":"source","obj":"craft-sa-dev"},{"subj":"T367","pred":"source","obj":"craft-sa-dev"},{"subj":"T368","pred":"source","obj":"craft-sa-dev"},{"subj":"T369","pred":"source","obj":"craft-sa-dev"},{"subj":"T370","pred":"source","obj":"craft-sa-dev"},{"subj":"T371","pred":"source","obj":"craft-sa-dev"},{"subj":"T372","pred":"source","obj":"craft-sa-dev"},{"subj":"T373","pred":"source","obj":"craft-sa-dev"},{"subj":"T374","pred":"source","obj":"craft-sa-dev"},{"subj":"T375","pred":"source","obj":"craft-sa-dev"},{"subj":"T376","pred":"source","obj":"craft-sa-dev"},{"subj":"T377","pred":"source","obj":"craft-sa-dev"},{"subj":"T378","pred":"source","obj":"craft-sa-dev"},{"subj":"T379","pred":"source","obj":"craft-sa-dev"},{"subj":"T380","pred":"source","obj":"craft-sa-dev"},{"subj":"T381","pred":"source","obj":"craft-sa-dev"},{"subj":"T382","pred":"source","obj":"craft-sa-dev"},{"subj":"T383","pred":"source","obj":"craft-sa-dev"},{"subj":"T384","pred":"source","obj":"craft-sa-dev"},{"subj":"T385","pred":"source","obj":"craft-sa-dev"},{"subj":"T386","pred":"source","obj":"craft-sa-dev"},{"subj":"T387","pred":"source","obj":"craft-sa-dev"},{"subj":"T388","pred":"source","obj":"craft-sa-dev"},{"subj":"T389","pred":"source","obj":"craft-sa-dev"},{"subj":"T390","pred":"source","obj":"craft-sa-dev"},{"subj":"T391","pred":"source","obj":"craft-sa-dev"},{"subj":"T392","pred":"source","obj":"craft-sa-dev"},{"subj":"T393","pred":"source","obj":"craft-sa-dev"},{"subj":"T394","pred":"source","obj":"craft-sa-dev"},{"subj":"T395","pred":"source","obj":"craft-sa-dev"},{"subj":"T396","pred":"source","obj":"craft-sa-dev"},{"subj":"T397","pred":"source","obj":"craft-sa-dev"},{"subj":"T398","pred":"source","obj":"craft-sa-dev"},{"subj":"T399","pred":"source","obj":"craft-sa-dev"},{"subj":"T400","pred":"source","obj":"craft-sa-dev"},{"subj":"T401","pred":"source","obj":"craft-sa-dev"},{"subj":"T402","pred":"source","obj":"craft-sa-dev"},{"subj":"T403","pred":"source","obj":"craft-sa-dev"},{"subj":"T404","pred":"source","obj":"craft-sa-dev"},{"subj":"T405","pred":"source","obj":"craft-sa-dev"},{"subj":"T406","pred":"source","obj":"craft-sa-dev"},{"subj":"T407","pred":"source","obj":"craft-sa-dev"},{"subj":"T408","pred":"source","obj":"craft-sa-dev"},{"subj":"T409","pred":"source","obj":"craft-sa-dev"},{"subj":"T410","pred":"source","obj":"craft-sa-dev"},{"subj":"T411","pred":"source","obj":"craft-sa-dev"},{"subj":"T412","pred":"source","obj":"craft-sa-dev"},{"subj":"T413","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T149","span":{"begin":11,"end":19},"obj":"CHEBI:18243"},{"id":"T150","span":{"begin":20,"end":30},"obj":"GO:0065007"},{"id":"T151","span":{"begin":34,"end":42},"obj":"CL:0000540"},{"id":"T152","span":{"begin":43,"end":52},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T153","span":{"begin":60,"end":74},"obj":"UBERON:0001870"},{"id":"T154","span":{"begin":76,"end":84},"obj":"UBERON:0001891"},{"id":"T155","span":{"begin":90,"end":98},"obj":"UBERON:0002435"},{"id":"T156","span":{"begin":160,"end":167},"obj":"GO_EXT:detection_or_sensing_of_stimulus"},{"id":"T157","span":{"begin":263,"end":270},"obj":"GO_EXT:biological_direction_or_guidance"},{"id":"T158","span":{"begin":276,"end":284},"obj":"GO_EXT:biological_direction_or_guidance"},{"id":"T159","span":{"begin":286,"end":305},"obj":"GO:0051867"},{"id":"T160","span":{"begin":314,"end":322},"obj":"CL_GO_EXT:cell"},{"id":"T161","span":{"begin":330,"end":338},"obj":"CHEBI:18243"},{"id":"T162","span":{"begin":330,"end":348},"obj":"GO:0007212"},{"id":"T163","span":{"begin":369,"end":376},"obj":"_FRAGMENT"},{"id":"T164","span":{"begin":388,"end":397},"obj":"PR_EXT:000001107"},{"id":"T165","span":{"begin":380,"end":397},"obj":"PR_EXT:000001108"},{"id":"T166","span":{"begin":388,"end":397},"obj":"GO_EXT:0004872"},{"id":"T167","span":{"begin":419,"end":436},"obj":"PR_EXT:000001107"},{"id":"T168","span":{"begin":427,"end":436},"obj":"GO_EXT:0004872"},{"id":"T169","span":{"begin":458,"end":466},"obj":"GO_EXT:biological_direction_or_guidance"},{"id":"T170","span":{"begin":467,"end":476},"obj":"GO_PATO_EXT:biological_behavior"},{"id":"T171","span":{"begin":525,"end":537},"obj":"PR_EXT:000001177"},{"id":"T172","span":{"begin":528,"end":537},"obj":"GO_EXT:0004872"},{"id":"T173","span":{"begin":593,"end":601},"obj":"CHEBI:18243"},{"id":"T174","span":{"begin":593,"end":613},"obj":"PR_EXT:000001177"},{"id":"T175","span":{"begin":605,"end":613},"obj":"GO_EXT:0004872"},{"id":"T176","span":{"begin":623,"end":632},"obj":"GO_EXT:cell_communication_or_signaling_or_signal_transduction"},{"id":"T177","span":{"begin":648,"end":659},"obj":"_FRAGMENT"},{"id":"T178","span":{"begin":673,"end":681},"obj":"GO:0008306"},{"id":"T179","span":{"begin":704,"end":708},"obj":"NCBITaxon:10088"},{"id":"T180","span":{"begin":741,"end":749},"obj":"CHEBI:18243"},{"id":"T181","span":{"begin":741,"end":762},"obj":"PR_EXT:000001177"},{"id":"T182","span":{"begin":753,"end":762},"obj":"GO_EXT:0004872"},{"id":"T183","span":{"begin":766,"end":775},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T184","span":{"begin":776,"end":780},"obj":"NCBITaxon:10088"},{"id":"T185","span":{"begin":921,"end":931},"obj":"GO_PATO_EXT:biological_behavior"},{"id":"T186","span":{"begin":998,"end":1006},"obj":"GO:0007612"}],"relations":[{"id":"R4","pred":"_lexicallyChainedTo","subj":"T164","obj":"T163"},{"id":"R5","pred":"_lexicallyChainedTo","subj":"T178","obj":"T177"}],"attributes":[{"subj":"T149","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T150","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T151","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T152","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T153","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T154","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T155","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T156","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T157","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T158","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T159","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T160","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T161","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T162","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T163","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T164","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T165","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T166","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T167","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T168","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T169","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T170","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T171","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T172","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T173","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T174","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T175","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T176","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T177","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T178","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T179","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T180","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T181","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T182","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T183","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T184","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T185","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T186","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T91","span":{"begin":11,"end":19},"obj":"CHEBI:18243"},{"id":"T92","span":{"begin":20,"end":30},"obj":"GO:0065007"},{"id":"T93","span":{"begin":34,"end":42},"obj":"CL:0000540"},{"id":"T94","span":{"begin":60,"end":74},"obj":"UBERON:0001870"},{"id":"T95","span":{"begin":76,"end":84},"obj":"UBERON:0001891"},{"id":"T96","span":{"begin":90,"end":98},"obj":"UBERON:0002435"},{"id":"T97","span":{"begin":286,"end":305},"obj":"GO:0051867"},{"id":"T98","span":{"begin":330,"end":338},"obj":"CHEBI:18243"},{"id":"T99","span":{"begin":330,"end":348},"obj":"GO:0007212"},{"id":"T100","span":{"begin":369,"end":376},"obj":"_FRAGMENT"},{"id":"T101","span":{"begin":388,"end":397},"obj":"PR:000001107"},{"id":"T102","span":{"begin":380,"end":397},"obj":"PR:000001108"},{"id":"T103","span":{"begin":419,"end":436},"obj":"PR:000001107"},{"id":"T104","span":{"begin":525,"end":537},"obj":"PR:000001177"},{"id":"T105","span":{"begin":593,"end":601},"obj":"CHEBI:18243"},{"id":"T106","span":{"begin":593,"end":613},"obj":"PR:000001177"},{"id":"T107","span":{"begin":648,"end":659},"obj":"_FRAGMENT"},{"id":"T108","span":{"begin":673,"end":681},"obj":"GO:0008306"},{"id":"T109","span":{"begin":704,"end":708},"obj":"NCBITaxon:10088"},{"id":"T110","span":{"begin":741,"end":749},"obj":"CHEBI:18243"},{"id":"T111","span":{"begin":741,"end":762},"obj":"PR:000001177"},{"id":"T112","span":{"begin":776,"end":780},"obj":"NCBITaxon:10088"},{"id":"T113","span":{"begin":998,"end":1006},"obj":"GO:0007612"}],"relations":[{"id":"R1","pred":"_lexicallyChainedTo","subj":"T101","obj":"T100"},{"id":"R2","pred":"_lexicallyChainedTo","subj":"T108","obj":"T107"}],"attributes":[{"subj":"T91","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T92","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T93","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T94","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T95","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T96","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T97","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T98","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T99","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T100","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T101","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T102","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T103","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T104","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T105","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T106","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T107","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T108","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T109","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T110","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T111","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T112","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T113","pred":"source","obj":"craft-ca-core-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#ec93d3","default":true},{"id":"craft-ca-core-ex-dev","color":"#93ecea"},{"id":"craft-ca-core-dev","color":"#ecd093"}]}]}}