PMC:3586680 / 12631-12920 JSONTXT

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Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T7373","span":{"begin":243,"end":256},"obj":"Positive_regulation"},{"id":"T7354","span":{"begin":243,"end":256},"obj":"Protein"},{"id":"T5769","span":{"begin":82,"end":203},"obj":"Gene_expression"},{"id":"T5757","span":{"begin":7,"end":54},"obj":"Binding"},{"id":"T5745","span":{"begin":160,"end":203},"obj":"Positive_regulation"},{"id":"T5719","span":{"begin":7,"end":36},"obj":"Protein"},{"id":"T5714","span":{"begin":144,"end":155},"obj":"Entity"},{"id":"T5695","span":{"begin":43,"end":49},"obj":"Protein"},{"id":"T5684","span":{"begin":103,"end":120},"obj":"Protein"},{"id":"T5644","span":{"begin":103,"end":120},"obj":"Protein"},{"id":"T5639","span":{"begin":55,"end":71},"obj":"Protein"},{"id":"T5659","span":{"begin":186,"end":194},"obj":"Entity"},{"id":"T5652","span":{"begin":103,"end":107},"obj":"Protein"},{"id":"T5648","span":{"begin":108,"end":114},"obj":"Protein"}],"relations":[{"id":"R3873","pred":"themeOf","subj":"T5684","obj":"T5769"},{"id":"R3881","pred":"themeOf","subj":"T5695","obj":"T5757"},{"id":"R3889","pred":"themeOf","subj":"T5719","obj":"T5757"},{"id":"R5190","pred":"themeOf","subj":"T7354","obj":"T7373"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"DLUT931","denotations":[{"id":"T7086","span":{"begin":243,"end":252},"obj":"Positive_regulation"},{"id":"T7070","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T5252","span":{"begin":37,"end":42},"obj":"Binding"},{"id":"T5222","span":{"begin":43,"end":49},"obj":"Protein"},{"id":"T5221","span":{"begin":7,"end":36},"obj":"Protein"}],"relations":[{"id":"R3687","pred":"themeOf","subj":"T5221","obj":"T5252"},{"id":"R3688","pred":"themeOf","subj":"T5222","obj":"T5252"},{"id":"R4967","pred":"themeOf","subj":"T7070","obj":"T7086"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T7123","span":{"begin":243,"end":252},"obj":"Positive_regulation"},{"id":"T7107","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T5410","span":{"begin":37,"end":42},"obj":"Binding"},{"id":"T5373","span":{"begin":43,"end":49},"obj":"Protein"},{"id":"T5372","span":{"begin":7,"end":36},"obj":"Protein"}],"relations":[{"id":"R3762","pred":"themeOf","subj":"T5372","obj":"T5410"},{"id":"R3763","pred":"themeOf","subj":"T5373","obj":"T5410"},{"id":"R4978","pred":"themeOf","subj":"T7107","obj":"T7123"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"BioNLP16_DUT","denotations":[{"id":"T7059","span":{"begin":243,"end":252},"obj":"Positive_regulation"},{"id":"T7043","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T5133","span":{"begin":37,"end":42},"obj":"Binding"},{"id":"T5100","span":{"begin":43,"end":49},"obj":"Protein"},{"id":"T5099","span":{"begin":7,"end":36},"obj":"Protein"}],"relations":[{"id":"R3626","pred":"themeOf","subj":"T5099","obj":"T5133"},{"id":"R3627","pred":"themeOf","subj":"T5100","obj":"T5133"},{"id":"R4955","pred":"themeOf","subj":"T7043","obj":"T7059"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T7064","span":{"begin":253,"end":256},"obj":"http://www.uniprot.org/uniprot/P04637"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T4023","span":{"begin":43,"end":49},"obj":"Protein"},{"id":"T6806","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T4022","span":{"begin":7,"end":36},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

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Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"2_test","denotations":[{"id":"23459853-16438931-38778569","span":{"begin":0,"end":4},"obj":"16438931"},{"id":"23459853-19366691-38778570","span":{"begin":217,"end":221},"obj":"19366691"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"UBERON-AE","denotations":[{"id":"T3822","span":{"begin":108,"end":112},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"T3821","span":{"begin":43,"end":47},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"GO-BP","denotations":[{"id":"T6826","span":{"begin":277,"end":287},"obj":"http://purl.obolibrary.org/obo/GO_0007049"},{"id":"T6824","span":{"begin":266,"end":275},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T6822","span":{"begin":266,"end":275},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T4039","span":{"begin":20,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T4065","span":{"begin":86,"end":95},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T4050","span":{"begin":75,"end":81},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"GO-CC","denotations":[{"id":"T6846","span":{"begin":277,"end":281},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4091","span":{"begin":148,"end":155},"obj":"http://purl.obolibrary.org/obo/GO_0005634"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"sentences","denotations":[{"id":"T3848","span":{"begin":7,"end":223},"obj":"Sentence"},{"id":"T89","span":{"begin":7,"end":223},"obj":"Sentence"},{"id":"T90","span":{"begin":225,"end":242},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}

{"project":"simple1","denotations":[{"id":"T6851","span":{"begin":253,"end":256},"obj":"Protein"},{"id":"T4146","span":{"begin":43,"end":49},"obj":"Protein"},{"id":"T4145","span":{"begin":7,"end":36},"obj":"Protein"}],"text":"2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).\n\np53 and Functions\nActivated p53 mediates apoptosis, cell cycle a"}