PMC:3320587 / 36244-36988
Annnotations
pmc-enju-pas
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the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T13084","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T13083","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T13082","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T13081","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13080","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T13079","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13078","span":{"begin":45,"end":48},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T13225","span":{"begin":311,"end":314},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T13224","span":{"begin":191,"end":194},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T13223","span":{"begin":45,"end":48},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T13219","span":{"begin":311,"end":314},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T13218","span":{"begin":191,"end":194},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T13217","span":{"begin":45,"end":48},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T13213","span":{"begin":311,"end":314},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T13212","span":{"begin":191,"end":194},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T13211","span":{"begin":45,"end":48},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T13207","span":{"begin":311,"end":314},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T13206","span":{"begin":191,"end":194},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T13205","span":{"begin":45,"end":48},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T13202","span":{"begin":663,"end":666},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T13201","span":{"begin":427,"end":430},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T13200","span":{"begin":396,"end":399},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T13199","span":{"begin":267,"end":270},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T13177","span":{"begin":629,"end":634},"obj":"http://www.uniprot.org/uniprot/O94916"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T13101","span":{"begin":587,"end":600},"obj":"http://purl.obolibrary.org/obo/GO_0051059"},{"id":"T13098","span":{"begin":593,"end":600},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T13108","span":{"begin":471,"end":476},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T13107","span":{"begin":234,"end":239},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T13106","span":{"begin":75,"end":80},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
sentences
{"project":"sentences","denotations":[{"id":"T12311","span":{"begin":511,"end":744},"obj":"Sentence"},{"id":"T12310","span":{"begin":301,"end":510},"obj":"Sentence"},{"id":"T12309","span":{"begin":182,"end":300},"obj":"Sentence"},{"id":"T12308","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T210","span":{"begin":0,"end":181},"obj":"Sentence"},{"id":"T211","span":{"begin":182,"end":300},"obj":"Sentence"},{"id":"T212","span":{"begin":301,"end":510},"obj":"Sentence"},{"id":"T213","span":{"begin":511,"end":744},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
simple1
{"project":"simple1","denotations":[{"id":"T13147","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T13146","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T13145","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T13144","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13143","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T13142","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13141","span":{"begin":45,"end":48},"obj":"Protein"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T13569","span":{"begin":221,"end":230},"obj":"Negative_regulation"},{"id":"T13568","span":{"begin":56,"end":65},"obj":"Positive_regulation"},{"id":"T13562","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T13561","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T13560","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T13559","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13558","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T13557","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13556","span":{"begin":45,"end":48},"obj":"Protein"}],"relations":[{"id":"R10126","pred":"themeOf","subj":"T13556","obj":"T13568"},{"id":"R10127","pred":"themeOf","subj":"T13557","obj":"T13569"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T13307","span":{"begin":341,"end":346},"obj":"Positive_regulation"},{"id":"T13306","span":{"begin":221,"end":230},"obj":"Negative_regulation"},{"id":"T13305","span":{"begin":56,"end":65},"obj":"Positive_regulation"},{"id":"T13298","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T13297","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T13296","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T13295","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13294","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T13293","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13292","span":{"begin":45,"end":48},"obj":"Protein"}],"relations":[{"id":"R10086","pred":"themeOf","subj":"T13292","obj":"T13305"},{"id":"R10087","pred":"themeOf","subj":"T13293","obj":"T13306"},{"id":"R10088","pred":"themeOf","subj":"T13295","obj":"T13307"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T13265","span":{"begin":341,"end":346},"obj":"Positive_regulation"},{"id":"T13264","span":{"begin":221,"end":230},"obj":"Negative_regulation"},{"id":"T13263","span":{"begin":56,"end":65},"obj":"Positive_regulation"},{"id":"T13256","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T13255","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T13254","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T13253","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13252","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T13251","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13250","span":{"begin":45,"end":48},"obj":"Protein"}],"relations":[{"id":"R10075","pred":"themeOf","subj":"T13250","obj":"T13263"},{"id":"R10076","pred":"themeOf","subj":"T13251","obj":"T13264"},{"id":"R10077","pred":"themeOf","subj":"T13253","obj":"T13265"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T13642","span":{"begin":672,"end":675},"obj":"Protein"},{"id":"T13641","span":{"begin":40,"end":44},"obj":"Protein"},{"id":"T13639","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13630","span":{"begin":280,"end":281},"obj":"Entity"},{"id":"T13629","span":{"begin":468,"end":509},"obj":"Entity"},{"id":"T13628","span":{"begin":629,"end":640},"obj":"Protein"},{"id":"T13627","span":{"begin":629,"end":640},"obj":"Protein"},{"id":"T13620","span":{"begin":234,"end":248},"obj":"Entity"},{"id":"T13611","span":{"begin":152,"end":155},"obj":"Protein"},{"id":"T13608","span":{"begin":45,"end":48},"obj":"Protein"},{"id":"T13603","span":{"begin":271,"end":278},"obj":"Protein"},{"id":"T13602","span":{"begin":275,"end":278},"obj":"Protein"},{"id":"T13599","span":{"begin":635,"end":640},"obj":"Protein"},{"id":"T13590","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13586","span":{"begin":271,"end":278},"obj":"Protein"},{"id":"T13580","span":{"begin":601,"end":605},"obj":"Entity"},{"id":"T13574","span":{"begin":71,"end":80},"obj":"Entity"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
bionlp-st-ge-2016-test-tees
{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T13425","span":{"begin":672,"end":675},"obj":"Protein"},{"id":"T13424","span":{"begin":667,"end":671},"obj":"Protein"},{"id":"T13423","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T13422","span":{"begin":638,"end":640},"obj":"Protein"},{"id":"T13421","span":{"begin":629,"end":637},"obj":"Protein"},{"id":"T13420","span":{"begin":587,"end":592},"obj":"Protein"},{"id":"T13419","span":{"begin":431,"end":433},"obj":"Protein"},{"id":"T13418","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T13417","span":{"begin":406,"end":409},"obj":"Protein"},{"id":"T13416","span":{"begin":400,"end":405},"obj":"Protein"},{"id":"T13415","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T13414","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T13413","span":{"begin":221,"end":230},"obj":"Negative_regulation"},{"id":"T13412","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T13411","span":{"begin":56,"end":65},"obj":"Positive_regulation"},{"id":"T13410","span":{"begin":45,"end":48},"obj":"Protein"}],"relations":[{"id":"R10104","pred":"themeOf","subj":"T13410","obj":"T13411"},{"id":"R10105","pred":"themeOf","subj":"T13412","obj":"T13413"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
testone
{"project":"testone","denotations":[{"id":"T12226","span":{"begin":681,"end":691},"obj":"Negative_regulation"},{"id":"T12225","span":{"begin":221,"end":230},"obj":"Negative_regulation"},{"id":"T12220","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T12219","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T12218","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T12217","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T12216","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T12215","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T12214","span":{"begin":45,"end":48},"obj":"Protein"}],"relations":[{"id":"R9361","pred":"themeOf","subj":"T12215","obj":"T12225"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}
test3
{"project":"test3","denotations":[{"id":"T12294","span":{"begin":681,"end":691},"obj":"Negative_regulation"},{"id":"T12293","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T12292","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T12291","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T12290","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T12289","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T12288","span":{"begin":221,"end":230},"obj":"Negative_regulation"},{"id":"T12287","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T12286","span":{"begin":56,"end":65},"obj":"Positive_regulation"},{"id":"T12285","span":{"begin":45,"end":48},"obj":"Protein"},{"id":"T12258","span":{"begin":663,"end":666},"obj":"Protein"},{"id":"T12257","span":{"begin":427,"end":430},"obj":"Protein"},{"id":"T12256","span":{"begin":396,"end":399},"obj":"Protein"},{"id":"T12255","span":{"begin":311,"end":314},"obj":"Protein"},{"id":"T12254","span":{"begin":267,"end":270},"obj":"Protein"},{"id":"T12253","span":{"begin":191,"end":194},"obj":"Protein"},{"id":"T12252","span":{"begin":45,"end":48},"obj":"Protein"}],"relations":[{"id":"R9364","pred":"themeOf","subj":"T12285","obj":"T12286"},{"id":"R9365","pred":"themeOf","subj":"T12287","obj":"T12288"}],"text":"When the cultures were co-infected with MTb, p24 levels increased when the cells were infected with either the wild-type or, to lower levels, with the κB-I mutant virus (Figure 5B). However, p24 levels were significantly inhibited in cells infected with HIV-1Lai/Bal-env -N5-Mut (p\u003c0.01) (Figure 5D). Moreover, p24 levels were significantly lower at day 12 in cultures infected with HIV-1Lai/Bal-env-κB II-Mut and HIV-1Lai/Bal-env-κB I+II-Mut as compared to infection of cells with wild-type virus (Figure 5D). Notably, although replication of the mutant virus with the single, proximal NF-κB binding site mutation in the shared NFAT5/NF-κB element (HIV-1Lai/Bal-env-κB I-Mut) was diminished, this was not significant at day 12 (Figures 5B–5D)."}