PMC:3279418 / 15343-15593
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5200 | 0-16 | JJ | denotes | Stimulus-induced |
T5201 | 17-32 | NN | denotes | phosphorylation |
T5202 | 33-35 | IN | denotes | of |
T5203 | 36-39 | DT | denotes | the |
T5204 | 40-43 | NN | denotes | IκB |
T5205 | 44-50 | NN | denotes | kinase |
T5206 | 51-52 | -LRB- | denotes | ( |
T5207 | 52-58 | NN | denotes | IKK1/2 |
T5208 | 58-59 | -RRB- | denotes | ) |
T5209 | 60-62 | VB | denotes | is |
T5210 | 63-65 | DT | denotes | an |
T5211 | 66-75 | JJ | denotes | essential |
T5212 | 76-80 | NN | denotes | step |
T5213 | 81-83 | IN | denotes | in |
T5214 | 84-89 | NN | denotes | NF-κB |
T5215 | 90-99 | NN | denotes | signaling |
T5216 | 99-100 | -COMMA- | denotes | , |
T5217 | 101-109 | VB | denotes | allowing |
T5218 | 110-125 | NN | denotes | phosphorylation |
T5219 | 126-129 | CC | denotes | and |
T5220 | 130-149 | JJ | denotes | proteasome-mediated |
T5221 | 150-161 | NN | denotes | degradation |
T5222 | 162-164 | IN | denotes | of |
T5223 | 165-168 | DT | denotes | the |
T5224 | 169-174 | NN | denotes | NF-κB |
T5225 | 175-184 | NN | denotes | inhibitor |
T5226 | 185-189 | NN | denotes | IκBα |
T5227 | 190-192 | TO | denotes | to |
T5228 | 193-200 | VB | denotes | release |
T5229 | 201-204 | DT | denotes | the |
T5230 | 205-210 | NN | denotes | NF-κB |
T5231 | 211-224 | NN | denotes | transcription |
T5232 | 225-232 | NN | denotes | factors |
T5233 | 233-237 | IN | denotes | into |
T5234 | 238-241 | DT | denotes | the |
T5235 | 242-249 | NN | denotes | nucleus |
R4334 | T5201 | T5200 | arg1Of | phosphorylation,Stimulus-induced |
R4335 | T5201 | T5202 | arg1Of | phosphorylation,of |
R4336 | T5201 | T5209 | arg1Of | phosphorylation,is |
R4337 | T5205 | T5202 | arg2Of | kinase,of |
R4338 | T5205 | T5203 | arg1Of | kinase,the |
R4339 | T5205 | T5204 | arg1Of | kinase,IκB |
R4340 | T5205 | T5206 | arg1Of | kinase,( |
R4341 | T5207 | T5206 | arg2Of | IKK1/2,( |
R4342 | T5208 | T5206 | arg3Of | ),( |
R4343 | T5209 | T5216 | arg1Of | is,"," |
R4344 | T5209 | T5217 | modOf | is,allowing |
R4345 | T5212 | T5209 | arg2Of | step,is |
R4346 | T5212 | T5210 | arg1Of | step,an |
R4347 | T5212 | T5211 | arg1Of | step,essential |
R4348 | T5212 | T5213 | arg1Of | step,in |
R4349 | T5215 | T5213 | arg2Of | signaling,in |
R4350 | T5215 | T5214 | arg1Of | signaling,NF-κB |
R4351 | T5218 | T5219 | arg1Of | phosphorylation,and |
R4352 | T5219 | T5217 | arg2Of | and,allowing |
R4353 | T5219 | T5222 | arg1Of | and,of |
R4354 | T5219 | T5228 | arg1Of | and,release |
R4355 | T5221 | T5219 | arg2Of | degradation,and |
R4356 | T5221 | T5220 | arg1Of | degradation,proteasome-mediated |
R4357 | T5226 | T5222 | arg2Of | IκBα,of |
R4358 | T5226 | T5223 | arg1Of | IκBα,the |
R4359 | T5226 | T5224 | arg1Of | IκBα,NF-κB |
R4360 | T5226 | T5225 | arg1Of | IκBα,inhibitor |
R4361 | T5228 | T5217 | arg3Of | release,allowing |
R4362 | T5228 | T5227 | arg1Of | release,to |
R4363 | T5228 | T5233 | arg1Of | release,into |
R4364 | T5232 | T5228 | arg2Of | factors,release |
R4365 | T5232 | T5229 | arg1Of | factors,the |
R4366 | T5232 | T5230 | arg1Of | factors,NF-κB |
R4367 | T5232 | T5231 | arg1Of | factors,transcription |
R4368 | T5235 | T5233 | arg2Of | nucleus,into |
R4369 | T5235 | T5234 | arg1Of | nucleus,the |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4785 | 0-16 | JJ | denotes | Stimulus-induced |
T4786 | 17-32 | NN | denotes | phosphorylation |
T4787 | 33-35 | IN | denotes | of |
T4788 | 36-39 | DT | denotes | the |
T4789 | 40-43 | NNP | denotes | IκB |
T4790 | 44-50 | NN | denotes | kinase |
T4791 | 51-52 | -LRB- | denotes | ( |
T4792 | 52-58 | NNP | denotes | IKK1/2 |
T4793 | 58-59 | -RRB- | denotes | ) |
T4794 | 60-62 | VBZ | denotes | is |
T4795 | 63-65 | DT | denotes | an |
T4796 | 66-75 | JJ | denotes | essential |
T4797 | 76-80 | NN | denotes | step |
T4798 | 81-83 | IN | denotes | in |
T4799 | 84-89 | JJ | denotes | NF-κB |
T4800 | 90-99 | VBG | denotes | signaling |
T4801 | 99-100 | , | denotes | , |
T4802 | 101-109 | VBG | denotes | allowing |
T4803 | 110-125 | NN | denotes | phosphorylation |
T4804 | 126-129 | CC | denotes | and |
T4805 | 130-149 | JJ | denotes | proteasome-mediated |
T4806 | 150-161 | NN | denotes | degradation |
T4807 | 162-164 | IN | denotes | of |
T4808 | 165-168 | DT | denotes | the |
T4809 | 169-174 | NNP | denotes | NF-κB |
T4810 | 175-184 | NN | denotes | inhibitor |
T4811 | 185-189 | NNP | denotes | IκBα |
T4812 | 190-192 | TO | denotes | to |
T4813 | 193-200 | VB | denotes | release |
T4814 | 201-204 | DT | denotes | the |
T4815 | 205-210 | JJ | denotes | NF-κB |
T4816 | 211-224 | NN | denotes | transcription |
T4817 | 225-232 | NNS | denotes | factors |
T4818 | 233-237 | IN | denotes | into |
T4819 | 238-241 | DT | denotes | the |
T4820 | 242-249 | NN | denotes | nucleus |
T4821 | 249-250 | . | denotes | . |
R3920 | T4785 | T4786 | amod | Stimulus-induced,phosphorylation |
R3921 | T4786 | T4794 | nsubj | phosphorylation,is |
R3922 | T4787 | T4786 | prep | of,phosphorylation |
R3923 | T4788 | T4790 | det | the,kinase |
R3924 | T4789 | T4790 | compound | IκB,kinase |
R3925 | T4790 | T4787 | pobj | kinase,of |
R3926 | T4791 | T4792 | punct | (,IKK1/2 |
R3927 | T4792 | T4790 | appos | IKK1/2,kinase |
R3928 | T4793 | T4790 | punct | ),kinase |
R3929 | T4794 | T4794 | ROOT | is,is |
R3930 | T4795 | T4797 | det | an,step |
R3931 | T4796 | T4797 | amod | essential,step |
R3932 | T4797 | T4794 | attr | step,is |
R3933 | T4798 | T4797 | prep | in,step |
R3934 | T4799 | T4800 | amod | NF-κB,signaling |
R3935 | T4800 | T4798 | pcomp | signaling,in |
R3936 | T4801 | T4800 | punct | ",",signaling |
R3937 | T4802 | T4800 | conj | allowing,signaling |
R3938 | T4803 | T4806 | amod | phosphorylation,degradation |
R3939 | T4804 | T4803 | cc | and,phosphorylation |
R3940 | T4805 | T4803 | conj | proteasome-mediated,phosphorylation |
R3941 | T4806 | T4802 | dobj | degradation,allowing |
R3942 | T4807 | T4806 | prep | of,degradation |
R3943 | T4808 | T4810 | det | the,inhibitor |
R3944 | T4809 | T4810 | compound | NF-κB,inhibitor |
R3945 | T4810 | T4807 | pobj | inhibitor,of |
R3946 | T4811 | T4806 | appos | IκBα,degradation |
R3947 | T4812 | T4813 | aux | to,release |
R3948 | T4813 | T4802 | ccomp | release,allowing |
R3949 | T4814 | T4817 | det | the,factors |
R3950 | T4815 | T4817 | amod | NF-κB,factors |
R3951 | T4816 | T4817 | compound | transcription,factors |
R3952 | T4817 | T4813 | dobj | factors,release |
R3953 | T4818 | T4813 | prep | into,release |
R3954 | T4819 | T4820 | det | the,nucleus |
R3955 | T4820 | T4818 | pobj | nucleus,into |
R3956 | T4821 | T4794 | punct | .,is |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5384 | 90-99 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
T5397 | 211-224 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
T5411 | 17-32 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T5412 | 110-125 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T5414 | 17-43 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | phosphorylation of the IκB |
T5415 | 169-184 | http://purl.obolibrary.org/obo/GO_0007252 | denotes | NF-κB inhibitor |
T5416 | 150-161 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
T5417 | 169-184 | http://purl.obolibrary.org/obo/GO_0032088 | denotes | NF-κB inhibitor |
T5418 | 211-249 | http://purl.obolibrary.org/obo/GO_0042991 | denotes | transcription factors into the nucleus |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5435 | 130-140 | http://purl.obolibrary.org/obo/GO_0000502 | denotes | proteasome |
T5436 | 242-249 | http://purl.obolibrary.org/obo/GO_0005634 | denotes | nucleus |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4485 | 0-250 | Sentence | denotes | Stimulus-induced phosphorylation of the IκB kinase (IKK1/2) is an essential step in NF-κB signaling, allowing phosphorylation and proteasome-mediated degradation of the NF-κB inhibitor IκBα to release the NF-κB transcription factors into the nucleus. |
T104 | 0-250 | Sentence | denotes | Stimulus-induced phosphorylation of the IκB kinase (IKK1/2) is an essential step in NF-κB signaling, allowing phosphorylation and proteasome-mediated degradation of the NF-κB inhibitor IκBα to release the NF-κB transcription factors into the nucleus. |
events-check-again
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5601 | 52-56 | Protein | denotes | IKK1 |
T5602 | 57-58 | Protein | denotes | 2 |
T5603 | 101-109 | Positive_regulation | denotes | allowing |
T5604 | 101-109 | Positive_regulation | denotes | allowing |
T5605 | 110-125 | Phosphorylation | denotes | phosphorylation |
T5606 | 141-149 | Positive_regulation | denotes | mediated |
T5607 | 150-161 | Protein_catabolism | denotes | degradation |
T5608 | 185-189 | Protein | denotes | IκBα |
R4527 | T5605 | T5604 | themeOf | phosphorylation,allowing |
R4528 | T5607 | T5603 | themeOf | degradation,allowing |
R4529 | T5607 | T5606 | themeOf | degradation,mediated |
R4530 | T5608 | T5605 | themeOf | IκBα,phosphorylation |
R4531 | T5608 | T5607 | themeOf | IκBα,degradation |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5685 | 40-50 | Protein | denotes | IκB kinase |
T5686 | 52-58 | Protein | denotes | IKK1/2 |
T5687 | 84-89 | Protein | denotes | NF-κB |
T5688 | 169-174 | Protein | denotes | NF-κB |
T5689 | 185-189 | Protein | denotes | IκBα |
T5690 | 205-232 | Protein | denotes | NF-κB transcription factors |
T5691 | 17-32 | Phosphorylation | denotes | phosphorylation |
T5692 | 17-32 | Phosphorylation | denotes | phosphorylation |
T5693 | 110-125 | Phosphorylation | denotes | phosphorylation |
T5694 | 110-125 | Phosphorylation | denotes | phosphorylation |
T5695 | 150-161 | Protein_catabolism | denotes | degradation |
T5696 | 150-161 | Protein_catabolism | denotes | degradation |
T5697 | 150-161 | Protein_catabolism | denotes | degradation |
T5698 | 242-249 | Entity | denotes | nucleus |
T5699 | 0-16 | Positive_regulation | denotes | Stimulus-induced |
T5700 | 0-16 | Positive_regulation | denotes | Stimulus-induced |
T5701 | 101-109 | Positive_regulation | denotes | allowing |
T5702 | 101-109 | Positive_regulation | denotes | allowing |
T5703 | 101-109 | Positive_regulation | denotes | allowing |
T5704 | 130-149 | Positive_regulation | denotes | proteasome-mediated |
T5705 | 130-149 | Positive_regulation | denotes | proteasome-mediated |
T5706 | 130-149 | Positive_regulation | denotes | proteasome-mediated |
T5707 | 193-200 | Localization | denotes | release |
R4568 | T5685 | T5691 | themeOf | IκB kinase,phosphorylation |
R4569 | T5686 | T5692 | themeOf | IKK1/2,phosphorylation |
R4570 | T5686 | T5695 | themeOf | IKK1/2,degradation |
R4571 | T5688 | T5693 | themeOf | NF-κB,phosphorylation |
R4572 | T5688 | T5696 | themeOf | NF-κB,degradation |
R4573 | T5689 | T5694 | themeOf | IκBα,phosphorylation |
R4574 | T5689 | T5697 | themeOf | IκBα,degradation |
R4575 | T5690 | T5707 | themeOf | NF-κB transcription factors,release |
R4576 | T5691 | T5699 | themeOf | phosphorylation,Stimulus-induced |
R4577 | T5692 | T5700 | themeOf | phosphorylation,Stimulus-induced |
R4578 | T5695 | T5701 | themeOf | degradation,allowing |
R4579 | T5695 | T5704 | themeOf | degradation,proteasome-mediated |
R4580 | T5696 | T5702 | themeOf | degradation,allowing |
R4581 | T5696 | T5705 | themeOf | degradation,proteasome-mediated |
R4582 | T5697 | T5703 | themeOf | degradation,allowing |
R4583 | T5697 | T5706 | themeOf | degradation,proteasome-mediated |
R4584 | T5698 | T5707 | locationOf | nucleus,release |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4443 | 52-56 | Protein | denotes | IKK1 |
T4444 | 57-58 | Protein | denotes | 2 |
T4445 | 101-109 | Positive_regulation | denotes | allowing |
T4446 | 101-109 | Positive_regulation | denotes | allowing |
T4447 | 110-125 | Phosphorylation | denotes | phosphorylation |
T4448 | 141-149 | Positive_regulation | denotes | mediated |
T4449 | 150-161 | Protein_catabolism | denotes | degradation |
T4450 | 185-189 | Protein | denotes | IκBα |
R3609 | T4447 | T4446 | themeOf | phosphorylation,allowing |
R3610 | T4449 | T4445 | themeOf | degradation,allowing |
R3611 | T4449 | T4448 | themeOf | degradation,mediated |
R3612 | T4450 | T4447 | themeOf | IκBα,phosphorylation |
R3613 | T4450 | T4449 | themeOf | IκBα,degradation |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T5337 | 40-50 | Q60680-2 | denotes | IκB kinase |
T5338 | 40-50 | O15111 | denotes | IκB kinase |
T5339 | 52-56 | O15111 | denotes | IKK1 |
T5340 | 52-56 | Q60680-2 | denotes | IKK1 |
T5341 | 185-189 | P25963 | denotes | IκBα |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4384 | 52-56 | Protein | denotes | IKK1 |
T4385 | 57-58 | Protein | denotes | 2 |
T4386 | 110-125 | Phosphorylation | denotes | phosphorylation |
T4387 | 150-161 | Protein_catabolism | denotes | degradation |
T4388 | 185-189 | Protein | denotes | IκBα |
T4389 | 193-200 | Localization | denotes | release |
R3584 | T4388 | T4386 | themeOf | IκBα,phosphorylation |
R3585 | T4388 | T4389 | themeOf | IκBα,release |
R3586 | T4388 | T4387 | themeOf | IκBα,degradation |