PMC:2791889 / 5303-5529 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/2791889","sourcedb":"PMC","sourceid":"2791889","source_url":"http://www.ncbi.nlm.nih.gov/pmc/2791889","text":"Here, we showed that in vitro differentiation of IL-10-producing Th1 cells from naive CD4+ T cells required IL-12-induced STAT4 signaling, strong TCR activation (high antigen dose), and sustained ERK1 and ERK2 phosphorylation.","tracks":[{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T1181","span":{"begin":49,"end":54},"obj":"P22301"},{"id":"T1182","span":{"begin":86,"end":89},"obj":"P01730"},{"id":"T1183","span":{"begin":108,"end":113},"obj":"P29459"},{"id":"T1184","span":{"begin":108,"end":113},"obj":"P29460"},{"id":"T1185","span":{"begin":122,"end":127},"obj":"Q14765"},{"id":"T1186","span":{"begin":196,"end":200},"obj":"P27361"},{"id":"T1187","span":{"begin":205,"end":209},"obj":"P28482"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"attributes":[{"subj":"T1181","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1182","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1183","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1184","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1185","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1186","pred":"source","obj":"bionlp-st-ge-2016-uniprot"},{"subj":"T1187","pred":"source","obj":"bionlp-st-ge-2016-uniprot"}]},{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T1097","span":{"begin":49,"end":54},"obj":"Protein"},{"id":"T1098","span":{"begin":55,"end":64},"obj":"Gene_expression"},{"id":"T1099","span":{"begin":86,"end":89},"obj":"Protein"},{"id":"T1100","span":{"begin":108,"end":113},"obj":"Protein"},{"id":"T1101","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T1102","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T1103","span":{"begin":205,"end":209},"obj":"Protein"},{"id":"T1104","span":{"begin":210,"end":225},"obj":"Phosphorylation"},{"id":"T1105","span":{"begin":210,"end":225},"obj":"Phosphorylation"}],"relations":[{"id":"R801","pred":"themeOf","subj":"T1097","obj":"T1098"},{"id":"R802","pred":"themeOf","subj":"T1102","obj":"T1105"},{"id":"R803","pred":"themeOf","subj":"T1103","obj":"T1104"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"attributes":[{"subj":"T1097","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1098","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1099","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1100","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1101","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1102","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1103","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1104","pred":"source","obj":"bionlp-st-ge-2016-reference"},{"subj":"T1105","pred":"source","obj":"bionlp-st-ge-2016-reference"}]},{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T2012","span":{"begin":0,"end":4},"obj":"RB"},{"id":"T2013","span":{"begin":4,"end":5},"obj":","},{"id":"T2014","span":{"begin":6,"end":8},"obj":"PRP"},{"id":"T2015","span":{"begin":9,"end":15},"obj":"VBD"},{"id":"T2016","span":{"begin":16,"end":20},"obj":"IN"},{"id":"T2017","span":{"begin":21,"end":23},"obj":"IN"},{"id":"T2018","span":{"begin":24,"end":29},"obj":"NN"},{"id":"T2019","span":{"begin":30,"end":45},"obj":"NN"},{"id":"T2020","span":{"begin":46,"end":48},"obj":"IN"},{"id":"T2021","span":{"begin":49,"end":64},"obj":"JJ"},{"id":"T2022","span":{"begin":65,"end":68},"obj":"JJ"},{"id":"T2023","span":{"begin":69,"end":74},"obj":"NNS"},{"id":"T2024","span":{"begin":75,"end":79},"obj":"IN"},{"id":"T2025","span":{"begin":80,"end":85},"obj":"JJ"},{"id":"T2026","span":{"begin":86,"end":89},"obj":"NNP"},{"id":"T2027","span":{"begin":89,"end":90},"obj":"CD"},{"id":"T2028","span":{"begin":91,"end":92},"obj":"NNP"},{"id":"T2029","span":{"begin":93,"end":98},"obj":"NNS"},{"id":"T2030","span":{"begin":99,"end":107},"obj":"VBN"},{"id":"T2031","span":{"begin":108,"end":121},"obj":"JJ"},{"id":"T2032","span":{"begin":122,"end":127},"obj":"CD"},{"id":"T2033","span":{"begin":128,"end":137},"obj":"VBG"},{"id":"T2034","span":{"begin":137,"end":138},"obj":","},{"id":"T2035","span":{"begin":139,"end":145},"obj":"JJ"},{"id":"T2036","span":{"begin":146,"end":149},"obj":"NNP"},{"id":"T2037","span":{"begin":150,"end":160},"obj":"NN"},{"id":"T2038","span":{"begin":161,"end":162},"obj":"-LRB-"},{"id":"T2039","span":{"begin":162,"end":166},"obj":"JJ"},{"id":"T2040","span":{"begin":167,"end":174},"obj":"NN"},{"id":"T2041","span":{"begin":175,"end":179},"obj":"NN"},{"id":"T2042","span":{"begin":179,"end":180},"obj":"-RRB-"},{"id":"T2043","span":{"begin":180,"end":181},"obj":","},{"id":"T2044","span":{"begin":182,"end":185},"obj":"CC"},{"id":"T2045","span":{"begin":186,"end":195},"obj":"VBD"},{"id":"T2046","span":{"begin":196,"end":200},"obj":"CD"},{"id":"T2047","span":{"begin":201,"end":204},"obj":"CC"},{"id":"T2048","span":{"begin":205,"end":209},"obj":"CD"},{"id":"T2049","span":{"begin":210,"end":225},"obj":"NN"},{"id":"T2050","span":{"begin":225,"end":226},"obj":"."}],"relations":[{"id":"R1603","pred":"punct","subj":"T2050","obj":"T2015"},{"id":"R1642","pred":"advmod","subj":"T2012","obj":"T2015"},{"id":"R1643","pred":"punct","subj":"T2013","obj":"T2015"},{"id":"R1644","pred":"nsubj","subj":"T2014","obj":"T2015"},{"id":"R1645","pred":"ROOT","subj":"T2015","obj":"T2015"},{"id":"R1647","pred":"mark","subj":"T2016","obj":"T2030"},{"id":"R1648","pred":"prep","subj":"T2017","obj":"T2030"},{"id":"R1649","pred":"amod","subj":"T2018","obj":"T2019"},{"id":"R1650","pred":"pobj","subj":"T2019","obj":"T2017"},{"id":"R1652","pred":"prep","subj":"T2020","obj":"T2019"},{"id":"R1653","pred":"amod","subj":"T2021","obj":"T2023"},{"id":"R1654","pred":"amod","subj":"T2022","obj":"T2023"},{"id":"R1656","pred":"pobj","subj":"T2023","obj":"T2020"},{"id":"R1657","pred":"prep","subj":"T2024","obj":"T2023"},{"id":"R1659","pred":"amod","subj":"T2025","obj":"T2029"},{"id":"R1660","pred":"compound","subj":"T2026","obj":"T2029"},{"id":"R1661","pred":"nummod","subj":"T2027","obj":"T2029"},{"id":"R1663","pred":"compound","subj":"T2028","obj":"T2029"},{"id":"R1664","pred":"pobj","subj":"T2029","obj":"T2024"},{"id":"R1665","pred":"ccomp","subj":"T2030","obj":"T2015"},{"id":"R1667","pred":"npadvmod","subj":"T2031","obj":"T2033"},{"id":"R1668","pred":"nummod","subj":"T2032","obj":"T2033"},{"id":"R1669","pred":"dobj","subj":"T2033","obj":"T2030"},{"id":"R1670","pred":"punct","subj":"T2034","obj":"T2033"},{"id":"R1672","pred":"amod","subj":"T2035","obj":"T2037"},{"id":"R1673","pred":"compound","subj":"T2036","obj":"T2037"},{"id":"R1675","pred":"appos","subj":"T2037","obj":"T2033"},{"id":"R1676","pred":"punct","subj":"T2038","obj":"T2037"},{"id":"R1677","pred":"amod","subj":"T2039","obj":"T2040"},{"id":"R1679","pred":"compound","subj":"T2040","obj":"T2041"},{"id":"R1680","pred":"appos","subj":"T2041","obj":"T2037"},{"id":"R1681","pred":"punct","subj":"T2042","obj":"T2037"},{"id":"R1682","pred":"punct","subj":"T2043","obj":"T2030"},{"id":"R1683","pred":"cc","subj":"T2044","obj":"T2030"},{"id":"R1684","pred":"conj","subj":"T2045","obj":"T2030"},{"id":"R1685","pred":"dobj","subj":"T2046","obj":"T2045"},{"id":"R1687","pred":"cc","subj":"T2047","obj":"T2046"},{"id":"R1688","pred":"nummod","subj":"T2048","obj":"T2049"},{"id":"R1689","pred":"conj","subj":"T2049","obj":"T2046"}],"attributes":[{"subj":"T2012","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2013","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2014","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2015","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2016","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2017","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2018","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2019","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2020","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2021","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2022","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2023","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2024","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2025","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2026","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2027","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2028","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2029","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2030","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2031","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2032","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2033","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2034","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2035","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2036","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2037","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2038","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2039","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2040","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2041","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2042","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2043","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2044","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2045","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2046","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2047","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2048","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2049","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"},{"subj":"T2050","pred":"source","obj":"bionlp-st-ge-2016-spacy-parsed"}]},{"project":"GO-BP","denotations":[{"id":"T2138","span":{"begin":146,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0006283"},{"id":"T2176","span":{"begin":196,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T2178","span":{"begin":205,"end":209},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T2185","span":{"begin":210,"end":225},"obj":"http://purl.obolibrary.org/obo/GO_0016310"},{"id":"T2159","span":{"begin":128,"end":137},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"attributes":[{"subj":"T2138","pred":"source","obj":"GO-BP"},{"subj":"T2176","pred":"source","obj":"GO-BP"},{"subj":"T2178","pred":"source","obj":"GO-BP"},{"subj":"T2185","pred":"source","obj":"GO-BP"},{"subj":"T2159","pred":"source","obj":"GO-BP"}]},{"project":"GO-MF","denotations":[{"id":"T2200","span":{"begin":49,"end":54},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T2207","span":{"begin":108,"end":113},"obj":"http://purl.obolibrary.org/obo/GO_0005143"},{"id":"T2220","span":{"begin":196,"end":200},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T2222","span":{"begin":205,"end":209},"obj":"http://purl.obolibrary.org/obo/GO_0004707"}],"attributes":[{"subj":"T2200","pred":"source","obj":"GO-MF"},{"subj":"T2207","pred":"source","obj":"GO-MF"},{"subj":"T2220","pred":"source","obj":"GO-MF"},{"subj":"T2222","pred":"source","obj":"GO-MF"}]},{"project":"GO-CC","denotations":[{"id":"T2243","span":{"begin":146,"end":149},"obj":"http://purl.obolibrary.org/obo/GO_0042101"}],"attributes":[{"subj":"T2243","pred":"source","obj":"GO-CC"}]},{"project":"sentences","denotations":[{"id":"T1131","span":{"begin":0,"end":226},"obj":"Sentence"},{"id":"T27","span":{"begin":0,"end":226},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T1131","pred":"source","obj":"sentences"},{"subj":"T27","pred":"source","obj":"sentences"}]},{"project":"events-check-again","denotations":[{"id":"T2534","span":{"begin":49,"end":54},"obj":"Protein"},{"id":"T2535","span":{"begin":55,"end":64},"obj":"Gene_expression"},{"id":"T2536","span":{"begin":86,"end":89},"obj":"Protein"},{"id":"T2537","span":{"begin":108,"end":113},"obj":"Protein"},{"id":"T2538","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T2539","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T2540","span":{"begin":205,"end":209},"obj":"Protein"},{"id":"T2541","span":{"begin":210,"end":225},"obj":"Phosphorylation"},{"id":"T2542","span":{"begin":210,"end":225},"obj":"Phosphorylation"}],"relations":[{"id":"R1952","pred":"themeOf","subj":"T2534","obj":"T2535"},{"id":"R1953","pred":"themeOf","subj":"T2539","obj":"T2542"},{"id":"R1954","pred":"themeOf","subj":"T2540","obj":"T2541"}],"attributes":[{"subj":"T2534","pred":"source","obj":"events-check-again"},{"subj":"T2535","pred":"source","obj":"events-check-again"},{"subj":"T2536","pred":"source","obj":"events-check-again"},{"subj":"T2537","pred":"source","obj":"events-check-again"},{"subj":"T2538","pred":"source","obj":"events-check-again"},{"subj":"T2539","pred":"source","obj":"events-check-again"},{"subj":"T2540","pred":"source","obj":"events-check-again"},{"subj":"T2541","pred":"source","obj":"events-check-again"},{"subj":"T2542","pred":"source","obj":"events-check-again"}]},{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T2635","span":{"begin":86,"end":90},"obj":"Protein"},{"id":"T2636","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T2637","span":{"begin":146,"end":149},"obj":"Protein"},{"id":"T2638","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T2639","span":{"begin":205,"end":209},"obj":"Protein"},{"id":"T2640","span":{"begin":210,"end":225},"obj":"Phosphorylation"},{"id":"T2641","span":{"begin":210,"end":225},"obj":"Phosphorylation"},{"id":"T2642","span":{"begin":150,"end":160},"obj":"Positive_regulation"},{"id":"T2643","span":{"begin":150,"end":160},"obj":"Positive_regulation"}],"relations":[{"id":"R1996","pred":"themeOf","subj":"T2638","obj":"T2640"},{"id":"R1997","pred":"themeOf","subj":"T2639","obj":"T2641"},{"id":"R1998","pred":"themeOf","subj":"T2640","obj":"T2642"},{"id":"R1999","pred":"themeOf","subj":"T2641","obj":"T2643"}],"attributes":[{"subj":"T2635","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2636","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2637","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2638","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2639","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2640","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2641","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2642","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"},{"subj":"T2643","pred":"source","obj":"bionlp-st-ge-2016-reference-tees"}]},{"project":"test2","denotations":[{"id":"T993","span":{"begin":49,"end":54},"obj":"Protein"},{"id":"T994","span":{"begin":55,"end":64},"obj":"Gene_expression"},{"id":"T995","span":{"begin":86,"end":89},"obj":"Protein"},{"id":"T996","span":{"begin":99,"end":107},"obj":"Positive_regulation"},{"id":"T997","span":{"begin":108,"end":113},"obj":"Protein"},{"id":"T998","span":{"begin":114,"end":121},"obj":"Positive_regulation"},{"id":"T999","span":{"begin":122,"end":127},"obj":"Protein"},{"id":"T1000","span":{"begin":186,"end":195},"obj":"Positive_regulation"},{"id":"T1001","span":{"begin":196,"end":200},"obj":"Protein"},{"id":"T1002","span":{"begin":205,"end":209},"obj":"Protein"},{"id":"T1003","span":{"begin":210,"end":225},"obj":"Phosphorylation"}],"relations":[{"id":"R728","pred":"themeOf","subj":"T993","obj":"T994"},{"id":"R729","pred":"causeOf","subj":"T997","obj":"T998"},{"id":"R730","pred":"themeOf","subj":"T998","obj":"T996"},{"id":"R731","pred":"themeOf","subj":"T1001","obj":"T1003"},{"id":"R732","pred":"themeOf","subj":"T1002","obj":"T1003"},{"id":"R733","pred":"themeOf","subj":"T1003","obj":"T1000"}],"attributes":[{"subj":"T993","pred":"source","obj":"test2"},{"subj":"T994","pred":"source","obj":"test2"},{"subj":"T995","pred":"source","obj":"test2"},{"subj":"T996","pred":"source","obj":"test2"},{"subj":"T997","pred":"source","obj":"test2"},{"subj":"T998","pred":"source","obj":"test2"},{"subj":"T999","pred":"source","obj":"test2"},{"subj":"T1000","pred":"source","obj":"test2"},{"subj":"T1001","pred":"source","obj":"test2"},{"subj":"T1002","pred":"source","obj":"test2"},{"subj":"T1003","pred":"source","obj":"test2"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"bionlp-st-ge-2016-uniprot","color":"#93eca3","default":true},{"id":"bionlp-st-ge-2016-reference","color":"#ec939d"},{"id":"bionlp-st-ge-2016-spacy-parsed","color":"#93b7ec"},{"id":"GO-BP","color":"#d1ec93"},{"id":"GO-MF","color":"#ec93eb"},{"id":"GO-CC","color":"#93ecd3"},{"id":"sentences","color":"#ecb993"},{"id":"events-check-again","color":"#9f93ec"},{"id":"bionlp-st-ge-2016-reference-tees","color":"#a0ec93"},{"id":"test2","color":"#ec93ba"}]}]}}