PMC:2700745 / 33053-34563 JSONTXT

{"project":"2_test","denotations":[{"id":"19176218-17662125-3579248","span":{"begin":250,"end":254},"obj":"17662125"},{"id":"19176218-17662125-3579248","span":{"begin":250,"end":254},"obj":"17662125"},{"id":"19176218-17922570-3579249","span":{"begin":302,"end":306},"obj":"17922570"},{"id":"19176218-17922570-3579249","span":{"begin":302,"end":306},"obj":"17922570"},{"id":"19176218-16308530-3579250","span":{"begin":520,"end":524},"obj":"16308530"},{"id":"19176218-16308530-3579250","span":{"begin":520,"end":524},"obj":"16308530"},{"id":"19176218-16502281-3579251","span":{"begin":767,"end":771},"obj":"16502281"},{"id":"19176218-16502281-3579251","span":{"begin":767,"end":771},"obj":"16502281"},{"id":"19176218-10627555-3579253","span":{"begin":965,"end":969},"obj":"10627555"},{"id":"19176218-10627555-3579253","span":{"begin":965,"end":969},"obj":"10627555"},{"id":"19176218-11932409-3579255","span":{"begin":1150,"end":1154},"obj":"11932409"},{"id":"19176218-11932409-3579255","span":{"begin":1150,"end":1154},"obj":"11932409"},{"id":"19176218-16400021-3579257","span":{"begin":1363,"end":1367},"obj":"16400021"},{"id":"19176218-16400021-3579257","span":{"begin":1363,"end":1367},"obj":"16400021"},{"id":"19176218-12724572-3579258","span":{"begin":1461,"end":1465},"obj":"12724572"},{"id":"19176218-12724572-3579258","span":{"begin":1461,"end":1465},"obj":"12724572"},{"id":"19176218-14575089-3579259","span":{"begin":1505,"end":1509},"obj":"14575089"},{"id":"19176218-14575089-3579259","span":{"begin":1505,"end":1509},"obj":"14575089"}],"text":"Table 5 Summary of current animal models available for studying human disease caused by highly pathogenic H5N1 avian viruses.\nVirus Disease Model Animal Model References\nA/duck/Tuva/01/06 (H5N1) Interstitial pneumonia Mouse (BALB/c) Evseenko et al. (2007)\n\u2028\u2028\nA/Vietnam/1203/2004 (BALB/c) Hatta et al. (2007)\nVN1204PB2-627Lys (mutant)\nA/Vietnam/1204/2004\nVN1203PB2-627Glu (mutant)\nA/chicken/Vietnam/NCVD5/2003\nA/muscovy/duck/Vietnam/NCVD18/2003\n\u2028\u2028\nA/Vietnam/1194/04 (BALB/c)\nA/Vietnam/1203/04 (VN1203) Hatta and Kawaoka (2005)\nA/Vietnam/1204/04 (VN1204)\nA/duck/Vietnam/NCVD-5/03\nA/duck/Vietnam/NCVD-18/03\nA/duck/Vietnam/NCVD-25/03\nA/chicken/Vietnam/NCVD-8/03\nA/chicken/Vietnam/NCVD-15/03\nA/chicken/Vietnam/NCVD-30/03\n\u2028\u2028\nA/chicken/Yamaguchi/7/04 (BALB/c) Isoda et al. (2006)\n\u2028\u2028\nH5N1 viruses\nA/Hong Kong/481/97\nA/HongKong/483/97 (BALB/c) Katz et al. (2000b)\nA/Hong Kong/485197\nA/Hong Kong1486197\nA/Hong Kong/507/97\n\u2028\u2028\nH5N1 viruses\nA/ck/HK/220/97 BALB/c Dybing et al. (2000)\nA/ck/HK/728/97\nA/HK/156/97\nA/ck/Scotland/59\nA/tk/England/91\n\u2028\u2028\nA/HongKong/156/97 (BALB/c) Gubareva et al. (1998a)\n\u2028\u2028\nInfluenza A H5N1 Pathogenesis/Pneumonia Ferret Zitzow et al. (2002)\nA/Hong Kong/486/97\nA/Hong Kong/483/97\n\u2028\u2028\nInfluenza B clinical isolate related to B/Beijing/184/93 and B/Guangdong/8/93 Gubareva et al. (1998b)\nInfluenza A H5N1 Pathogenesis/Pneumonia Cat Rimmelzwaan et al. (2006)\nA/Vietnam/1194/04\nInfluenza A H5N1 Pathogenesis/Pneumonia Cynomolgus macaque Kuiken et al. (2003)\nA/HongKong/156/97 Rimmelzwaan et al. (2003)"}