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1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T18352","span":{"begin":22,"end":37},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T18353","span":{"begin":52,"end":72},"obj":"http://purl.obolibrary.org/obo/GO_0030154"},{"id":"T18354","span":{"begin":1182,"end":1192},"obj":"http://purl.obolibrary.org/obo/GO_0006887"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T18899","span":{"begin":52,"end":56},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18900","span":{"begin":173,"end":178},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18901","span":{"begin":229,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18902","span":{"begin":436,"end":441},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18903","span":{"begin":832,"end":837},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18904","span":{"begin":979,"end":984},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T18905","span":{"begin":576,"end":589},"obj":"http://purl.obolibrary.org/obo/GO_0005622"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    sentences

    {"project":"sentences","denotations":[{"id":"T18355","span":{"begin":10,"end":209},"obj":"Sentence"},{"id":"T18356","span":{"begin":210,"end":257},"obj":"Sentence"},{"id":"T18357","span":{"begin":258,"end":469},"obj":"Sentence"},{"id":"T18358","span":{"begin":470,"end":630},"obj":"Sentence"},{"id":"T18359","span":{"begin":631,"end":710},"obj":"Sentence"},{"id":"T18360","span":{"begin":711,"end":934},"obj":"Sentence"},{"id":"T18361","span":{"begin":935,"end":1067},"obj":"Sentence"},{"id":"T18362","span":{"begin":1068,"end":1223},"obj":"Sentence"},{"id":"T18363","span":{"begin":1224,"end":1308},"obj":"Sentence"},{"id":"T40","span":{"begin":0,"end":9},"obj":"Sentence"},{"id":"T41","span":{"begin":10,"end":209},"obj":"Sentence"},{"id":"T42","span":{"begin":210,"end":257},"obj":"Sentence"},{"id":"T43","span":{"begin":258,"end":469},"obj":"Sentence"},{"id":"T44","span":{"begin":470,"end":630},"obj":"Sentence"},{"id":"T45","span":{"begin":631,"end":710},"obj":"Sentence"},{"id":"T46","span":{"begin":711,"end":934},"obj":"Sentence"},{"id":"T47","span":{"begin":935,"end":1067},"obj":"Sentence"},{"id":"T48","span":{"begin":1068,"end":1223},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    events-check-again

    {"project":"events-check-again","denotations":[{"id":"T19018","span":{"begin":45,"end":48},"obj":"Protein"},{"id":"T19019","span":{"begin":90,"end":94},"obj":"Protein"},{"id":"T19020","span":{"begin":96,"end":100},"obj":"Protein"},{"id":"T19021","span":{"begin":102,"end":107},"obj":"Protein"},{"id":"T19022","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T19023","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T19024","span":{"begin":127,"end":142},"obj":"Transcription"},{"id":"T19025","span":{"begin":127,"end":142},"obj":"Transcription"},{"id":"T19026","span":{"begin":127,"end":142},"obj":"Transcription"},{"id":"T19027","span":{"begin":127,"end":142},"obj":"Transcription"},{"id":"T19028","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T19029","span":{"begin":429,"end":432},"obj":"Protein"},{"id":"T19030","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T19031","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T19032","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T19033","span":{"begin":603,"end":613},"obj":"Protein"},{"id":"T19034","span":{"begin":615,"end":620},"obj":"Protein"},{"id":"T19035","span":{"begin":626,"end":629},"obj":"Protein"},{"id":"T19036","span":{"begin":631,"end":641},"obj":"Protein"},{"id":"T19037","span":{"begin":642,"end":650},"obj":"Gene_expression"},{"id":"T19038","span":{"begin":825,"end":828},"obj":"Protein"},{"id":"T19039","span":{"begin":949,"end":958},"obj":"Protein"},{"id":"T19040","span":{"begin":992,"end":995},"obj":"Protein"},{"id":"T19041","span":{"begin":1194,"end":1202},"obj":"Protein"},{"id":"T19042","span":{"begin":1203,"end":1213},"obj":"Protein"}],"relations":[{"id":"R14774","pred":"themeOf","subj":"T19019","obj":"T19025"},{"id":"R14775","pred":"themeOf","subj":"T19020","obj":"T19027"},{"id":"R14776","pred":"themeOf","subj":"T19021","obj":"T19026"},{"id":"R14777","pred":"equivalentTo","subj":"T19022","obj":"T19021"},{"id":"R14778","pred":"themeOf","subj":"T19023","obj":"T19024"},{"id":"R14779","pred":"themeOf","subj":"T19033","obj":"T19031"},{"id":"R14780","pred":"themeOf","subj":"T19034","obj":"T19032"},{"id":"R14781","pred":"themeOf","subj":"T19035","obj":"T19030"},{"id":"R14782","pred":"themeOf","subj":"T19036","obj":"T19037"}],"attributes":[{"id":"M468","pred":"Speculation","subj":"T19025","obj":"true"},{"id":"M469","pred":"Speculation","subj":"T19026","obj":"true"},{"id":"M471","pred":"Speculation","subj":"T19030","obj":"true"},{"id":"M472","pred":"Speculation","subj":"T19031","obj":"true"},{"id":"M473","pred":"Speculation","subj":"T19032","obj":"true"},{"id":"M474","pred":"Speculation","subj":"T19037","obj":"true"},{"id":"M467","pred":"Speculation","subj":"T19024","obj":"true"},{"id":"M470","pred":"Speculation","subj":"T19027","obj":"true"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    bionlp-st-ge-2016-reference-tees

    {"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T19043","span":{"begin":45,"end":49},"obj":"Protein"},{"id":"T19044","span":{"begin":90,"end":94},"obj":"Protein"},{"id":"T19045","span":{"begin":96,"end":100},"obj":"Protein"},{"id":"T19046","span":{"begin":102,"end":107},"obj":"Protein"},{"id":"T19047","span":{"begin":121,"end":131},"obj":"Protein"},{"id":"T19048","span":{"begin":162,"end":165},"obj":"Protein"},{"id":"T19049","span":{"begin":132,"end":142},"obj":"Gene_expression"},{"id":"T19050","span":{"begin":132,"end":142},"obj":"Gene_expression"},{"id":"T19051","span":{"begin":132,"end":142},"obj":"Gene_expression"},{"id":"T19052","span":{"begin":132,"end":142},"obj":"Gene_expression"},{"id":"T19053","span":{"begin":425,"end":428},"obj":"Protein"},{"id":"T19054","span":{"begin":603,"end":613},"obj":"Protein"},{"id":"T19055","span":{"begin":615,"end":620},"obj":"Protein"},{"id":"T19056","span":{"begin":626,"end":629},"obj":"Protein"},{"id":"T19057","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T19058","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T19059","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T19060","span":{"begin":821,"end":824},"obj":"Protein"},{"id":"T19061","span":{"begin":885,"end":900},"obj":"Protein"},{"id":"T19062","span":{"begin":992,"end":995},"obj":"Protein"}],"relations":[{"id":"R14783","pred":"themeOf","subj":"T19044","obj":"T19049"},{"id":"R14784","pred":"themeOf","subj":"T19045","obj":"T19050"},{"id":"R14785","pred":"themeOf","subj":"T19046","obj":"T19051"},{"id":"R14786","pred":"themeOf","subj":"T19047","obj":"T19052"},{"id":"R14787","pred":"themeOf","subj":"T19054","obj":"T19057"},{"id":"R14788","pred":"themeOf","subj":"T19055","obj":"T19058"},{"id":"R14789","pred":"themeOf","subj":"T19056","obj":"T19059"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    bionlp-st-ge-2016-reference

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    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T18865","span":{"begin":45,"end":48},"obj":"P01732"},{"id":"T18866","span":{"begin":45,"end":48},"obj":"P10966"},{"id":"T18867","span":{"begin":90,"end":94},"obj":"P14222"},{"id":"T18868","span":{"begin":96,"end":100},"obj":"P10144"},{"id":"T18869","span":{"begin":102,"end":107},"obj":"Q9UL17"},{"id":"T18870","span":{"begin":109,"end":114},"obj":"Q9UL17"},{"id":"T18871","span":{"begin":121,"end":126},"obj":"O95936"},{"id":"T18872","span":{"begin":166,"end":169},"obj":"P10966"},{"id":"T18873","span":{"begin":166,"end":169},"obj":"P01732"},{"id":"T18874","span":{"begin":321,"end":329},"obj":"Q04864"},{"id":"T18875","span":{"begin":429,"end":432},"obj":"P10966"},{"id":"T18876","span":{"begin":429,"end":432},"obj":"P01732"},{"id":"T18877","span":{"begin":512,"end":520},"obj":"Q04864"},{"id":"T18878","span":{"begin":603,"end":613},"obj":"P10144"},{"id":"T18879","span":{"begin":615,"end":620},"obj":"P01579"},{"id":"T18880","span":{"begin":626,"end":629},"obj":"P01375"},{"id":"T18881","span":{"begin":631,"end":641},"obj":"P10144"},{"id":"T18882","span":{"begin":664,"end":672},"obj":"Q04864"},{"id":"T18883","span":{"begin":825,"end":828},"obj":"P01732"},{"id":"T18884","span":{"begin":825,"end":828},"obj":"P10966"},{"id":"T18885","span":{"begin":949,"end":958},"obj":"P08758"},{"id":"T18886","span":{"begin":992,"end":995},"obj":"P01732"},{"id":"T18887","span":{"begin":992,"end":995},"obj":"P10966"},{"id":"T18888","span":{"begin":1194,"end":1202},"obj":"P14222"},{"id":"T18889","span":{"begin":1203,"end":1213},"obj":"P10144"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}

    test2

    {"project":"test2","denotations":[{"id":"T18308","span":{"begin":45,"end":48},"obj":"Protein"},{"id":"T18309","span":{"begin":90,"end":94},"obj":"Protein"},{"id":"T18310","span":{"begin":96,"end":100},"obj":"Protein"},{"id":"T18311","span":{"begin":102,"end":107},"obj":"Protein"},{"id":"T18312","span":{"begin":109,"end":114},"obj":"Protein"},{"id":"T18313","span":{"begin":121,"end":126},"obj":"Protein"},{"id":"T18314","span":{"begin":127,"end":142},"obj":"Transcription"},{"id":"T18315","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T18316","span":{"begin":429,"end":432},"obj":"Protein"},{"id":"T18317","span":{"begin":590,"end":598},"obj":"Gene_expression"},{"id":"T18318","span":{"begin":603,"end":613},"obj":"Protein"},{"id":"T18319","span":{"begin":615,"end":620},"obj":"Protein"},{"id":"T18320","span":{"begin":626,"end":629},"obj":"Protein"},{"id":"T18321","span":{"begin":631,"end":641},"obj":"Protein"},{"id":"T18322","span":{"begin":825,"end":828},"obj":"Protein"},{"id":"T18323","span":{"begin":949,"end":958},"obj":"Protein"},{"id":"T18324","span":{"begin":992,"end":995},"obj":"Protein"},{"id":"T18325","span":{"begin":1194,"end":1202},"obj":"Protein"},{"id":"T18326","span":{"begin":1203,"end":1213},"obj":"Protein"}],"relations":[{"id":"R14219","pred":"themeOf","subj":"T18309","obj":"T18314"},{"id":"R14220","pred":"themeOf","subj":"T18310","obj":"T18314"},{"id":"R14221","pred":"themeOf","subj":"T18311","obj":"T18314"},{"id":"R14222","pred":"equivalentTo","subj":"T18312","obj":"T18311"},{"id":"R14223","pred":"themeOf","subj":"T18313","obj":"T18314"},{"id":"R14224","pred":"themeOf","subj":"T18318","obj":"T18317"},{"id":"R14225","pred":"themeOf","subj":"T18319","obj":"T18317"},{"id":"R14226","pred":"themeOf","subj":"T18320","obj":"T18317"}],"attributes":[{"id":"M428","pred":"Speculation","subj":"T18310","obj":"true"},{"id":"M427","pred":"Speculation","subj":"T18309","obj":"true"},{"id":"M429","pred":"Speculation","subj":"T18311","obj":"true"},{"id":"M426","pred":"Speculation","subj":"T18308","obj":"true"},{"id":"M431","pred":"Speculation","subj":"T18313","obj":"true"},{"id":"M430","pred":"Speculation","subj":"T18312","obj":"true"},{"id":"M432","pred":"Speculation","subj":"T18314","obj":"true"},{"id":"M433","pred":"Speculation","subj":"T18315","obj":"true"}],"text":"Figure 1. Kinetics of gene expression during CD8+ T cell differentiation. (A) Kinetics of Prf1, Gzmb, Tbx21 (T-bet), and Eomes mRNA expression in differentiating P14 CD8+ T cells analyzed by Northern blotting. RNA from day 7 Th1 cells was used as a control. Sizes of mRNA transcripts are indicated. (B) Quantification of relative mRNA amounts by phosphorimager analysis. (C) Kinetics of protein expression in differentiating P14 CD8+ T cells analyzed by immunoblotting. Sizes of protein bands are indicated. (D) Relative protein amounts quantified from the Western blots. (E) Intracellular staining for granzyme B, IFN-γ, and TNF. Granzyme B staining was specific relative to an isotype control (not depicted). Cells were restimulated with PMA and ionomycin for 4 h. (F) FACS-based assay to measure cytolytic activity of P14 CD8+ T cells against EL4 targets loaded with 0 (−) or 1 (+) μM Gp33 peptide (effector-to-target ratio = 5:1). Percentage of Annexin V+ (apoptotic) target cells in the CD8-negative EL4 target population (dot plots) was determined (histograms). Cytolytic activity was blocked by incubation with 2 mM EGTA (not depicted), confirming involvement of the granule exocytosis (perforin–granzyme B) pathway. Data are representative of at least five (A–E) or three (F) independent experiments."}