PMC:2626671 / 4291-5467 JSONTXT

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There were only minor differences in gene expression during differentiation induced by antigen/APC versus anti-CD3/anti-CD28, and the major conclusions presented in this report are the same for both activating conditions.\nUnder our culture conditions, activated CD8+ T cells expanded exponentially and accumulated for \u003e8 d. We limited our analysis to the first 6–8 d after activation, a period that coincides with clonal expansion of CD8+ T cells after activation in 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