PMC:2222968 / 19625-20016
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8599 | 0-3 | DT | denotes | The |
T8600 | 4-14 | NN | denotes | expression |
T8601 | 15-22 | JJ | denotes | kinetic |
T8602 | 23-25 | IN | denotes | of |
T8603 | 26-31 | JJ | denotes | naive |
T8604 | 32-33 | NN | denotes | T |
T8605 | 34-39 | NN | denotes | cells |
T8606 | 40-47 | VB | denotes | exposed |
T8607 | 48-50 | TO | denotes | to |
T8608 | 51-55 | NN | denotes | IL-4 |
T8609 | 56-59 | CC | denotes | and |
T8610 | 60-65 | NN | denotes | TGF-β |
T8611 | 66-78 | VB | denotes | demonstrated |
T8612 | 79-83 | IN | denotes | that |
T8613 | 84-89 | NN | denotes | GATA3 |
T8614 | 90-93 | CC | denotes | and |
T8615 | 94-99 | NN | denotes | FOXP3 |
T8616 | 100-103 | VB | denotes | are |
T8617 | 104-113 | RB | denotes | initially |
T8618 | 114-119 | VB | denotes | found |
T8619 | 120-122 | IN | denotes | in |
T8620 | 123-131 | JJ | denotes | separate |
T8621 | 132-143 | NN | denotes | populations |
T8622 | 144-145 | -LRB- | denotes | ( |
T8623 | 145-148 | NN | denotes | day |
T8624 | 149-150 | CD | denotes | 2 |
T8625 | 150-151 | -RRB- | denotes | ) |
T8626 | 151-152 | -COMMA- | denotes | , |
T8627 | 153-156 | CC | denotes | but |
T8628 | 157-168 | RB | denotes | transiently |
T8629 | 169-179 | VB | denotes | co-express |
T8630 | 180-184 | DT | denotes | both |
T8631 | 185-192 | NN | denotes | factors |
T8632 | 193-194 | -LRB- | denotes | ( |
T8633 | 194-198 | NN | denotes | days |
T8634 | 199-202 | CD | denotes | 4–8 |
T8635 | 202-203 | -RRB- | denotes | ) |
T8636 | 203-204 | -COMMA- | denotes | , |
T8637 | 205-211 | IN | denotes | before |
T8638 | 212-224 | VB | denotes | establishing |
T8639 | 225-233 | JJ | denotes | separate |
T8640 | 234-245 | NN | denotes | populations |
T8641 | 246-248 | IN | denotes | at |
T8642 | 249-252 | DT | denotes | the |
T8643 | 253-256 | NN | denotes | end |
T8644 | 257-259 | IN | denotes | of |
T8645 | 260-263 | DT | denotes | the |
T8646 | 264-279 | NN | denotes | differentiation |
T8647 | 280-287 | NN | denotes | process |
T8648 | 288-289 | -LRB- | denotes | ( |
T8649 | 289-292 | NN | denotes | day |
T8650 | 293-295 | CD | denotes | 10 |
T8651 | 295-296 | -COLON- | denotes | ; |
T8652 | 297-303 | NN | denotes | Figure |
T8653 | 304-306 | NN | denotes | 6C |
T8654 | 306-307 | -RRB- | denotes | ) |
T8655 | 307-308 | -COMMA- | denotes | , |
T8656 | 309-319 | VB | denotes | suggesting |
T8657 | 320-324 | IN | denotes | that |
T8658 | 325-330 | NN | denotes | GATA3 |
T8659 | 331-339 | VB | denotes | inhibits |
T8660 | 340-343 | DT | denotes | the |
T8661 | 344-355 | NN | denotes | development |
T8662 | 356-358 | IN | denotes | of |
T8663 | 359-364 | NN | denotes | iTreg |
T8664 | 365-370 | NN | denotes | cells |
T8665 | 371-373 | IN | denotes | by |
T8666 | 374-384 | VB | denotes | repressing |
T8667 | 385-390 | NN | denotes | FOXP3 |
R6573 | T8600 | T8599 | arg1Of | expression,The |
R6574 | T8600 | T8601 | arg1Of | expression,kinetic |
R6575 | T8600 | T8611 | arg1Of | expression,demonstrated |
R6576 | T8601 | T8602 | arg1Of | kinetic,of |
R6577 | T8605 | T8602 | arg2Of | cells,of |
R6578 | T8605 | T8603 | arg1Of | cells,naive |
R6579 | T8605 | T8604 | arg1Of | cells,T |
R6580 | T8605 | T8606 | arg2Of | cells,exposed |
R6581 | T8606 | T8607 | arg1Of | exposed,to |
R6582 | T8608 | T8609 | arg1Of | IL-4,and |
R6583 | T8609 | T8607 | arg2Of | and,to |
R6584 | T8610 | T8609 | arg2Of | TGF-β,and |
R6585 | T8613 | T8614 | arg1Of | GATA3,and |
R6586 | T8614 | T8616 | arg1Of | and,are |
R6587 | T8614 | T8618 | arg2Of | and,found |
R6588 | T8614 | T8629 | arg1Of | and,co-express |
R6589 | T8614 | T8638 | arg1Of | and,establishing |
R6590 | T8615 | T8614 | arg2Of | FOXP3,and |
R6591 | T8618 | T8616 | arg2Of | found,are |
R6592 | T8618 | T8617 | arg1Of | found,initially |
R6593 | T8618 | T8619 | arg1Of | found,in |
R6594 | T8618 | T8627 | arg1Of | found,but |
R6595 | T8621 | T8619 | arg2Of | populations,in |
R6596 | T8621 | T8620 | arg1Of | populations,separate |
R6597 | T8621 | T8622 | arg1Of | populations,( |
R6598 | T8623 | T8622 | arg2Of | day,( |
R6599 | T8623 | T8624 | arg1Of | day,2 |
R6600 | T8625 | T8622 | arg3Of | ),( |
R6601 | T8627 | T8611 | arg2Of | but,demonstrated |
R6602 | T8627 | T8612 | arg1Of | but,that |
R6603 | T8627 | T8626 | arg1Of | but,"," |
R6604 | T8627 | T8655 | arg1Of | but,"," |
R6605 | T8627 | T8656 | modOf | but,suggesting |
R6606 | T8629 | T8627 | arg2Of | co-express,but |
R6607 | T8629 | T8628 | arg1Of | co-express,transiently |
R6608 | T8629 | T8636 | arg1Of | co-express,"," |
R6609 | T8629 | T8637 | arg1Of | co-express,before |
R6610 | T8631 | T8629 | arg2Of | factors,co-express |
R6611 | T8631 | T8630 | arg1Of | factors,both |
R6612 | T8631 | T8632 | arg1Of | factors,( |
R6613 | T8634 | T8632 | arg2Of | 4–8,( |
R6614 | T8634 | T8633 | arg1Of | 4–8,days |
R6615 | T8635 | T8632 | arg3Of | ),( |
R6616 | T8638 | T8637 | arg2Of | establishing,before |
R6617 | T8638 | T8641 | arg1Of | establishing,at |
R6618 | T8640 | T8638 | arg2Of | populations,establishing |
R6619 | T8640 | T8639 | arg1Of | populations,separate |
R6620 | T8643 | T8641 | arg2Of | end,at |
R6621 | T8643 | T8642 | arg1Of | end,the |
R6622 | T8643 | T8644 | arg1Of | end,of |
R6623 | T8647 | T8644 | arg2Of | process,of |
R6624 | T8647 | T8645 | arg1Of | process,the |
R6625 | T8647 | T8646 | arg1Of | process,differentiation |
R6626 | T8647 | T8648 | arg1Of | process,( |
R6627 | T8649 | T8650 | arg1Of | day,10 |
R6628 | T8649 | T8651 | arg1Of | day,; |
R6629 | T8651 | T8648 | arg2Of | ;,( |
R6630 | T8653 | T8651 | arg2Of | 6C,; |
R6631 | T8653 | T8652 | arg1Of | 6C,Figure |
R6632 | T8654 | T8648 | arg3Of | ),( |
R6633 | T8658 | T8659 | arg1Of | GATA3,inhibits |
R6634 | T8658 | T8666 | arg1Of | GATA3,repressing |
R6635 | T8659 | T8656 | arg2Of | inhibits,suggesting |
R6636 | T8659 | T8657 | arg1Of | inhibits,that |
R6637 | T8659 | T8665 | arg1Of | inhibits,by |
R6638 | T8661 | T8659 | arg2Of | development,inhibits |
R6639 | T8661 | T8660 | arg1Of | development,the |
R6640 | T8661 | T8662 | arg1Of | development,of |
R6641 | T8664 | T8662 | arg2Of | cells,of |
R6642 | T8664 | T8663 | arg1Of | cells,iTreg |
R6643 | T8666 | T8665 | arg2Of | repressing,by |
R6644 | T8667 | T8666 | arg2Of | FOXP3,repressing |
bionlp-st-ge-2016-coref
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8704 | 180-192 | Anaphor | denotes | both factors |
T8705 | 84-89 | Antecedent | denotes | GATA3 |
T8706 | 94-99 | Antecedent | denotes | FOXP3 |
R6681 | T8704 | T8705 | boundBy | both factors,GATA3 |
R6682 | T8704 | T8706 | boundBy | both factors,FOXP3 |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9036 | 0-3 | DT | denotes | The |
T9037 | 4-14 | NN | denotes | expression |
T9038 | 15-22 | NN | denotes | kinetic |
T9039 | 23-25 | IN | denotes | of |
T9040 | 26-31 | JJ | denotes | naive |
T9041 | 32-33 | NNP | denotes | T |
T9042 | 34-39 | NNS | denotes | cells |
T9043 | 40-47 | VBN | denotes | exposed |
T9044 | 48-50 | TO | denotes | to |
T9045 | 51-55 | NN | denotes | IL-4 |
T9046 | 56-59 | CC | denotes | and |
T9047 | 60-65 | JJ | denotes | TGF-β |
T9048 | 66-78 | VBD | denotes | demonstrated |
T9049 | 79-83 | IN | denotes | that |
T9050 | 84-89 | NNP | denotes | GATA3 |
T9051 | 90-93 | CC | denotes | and |
T9052 | 94-99 | NNP | denotes | FOXP3 |
T9053 | 100-103 | VBP | denotes | are |
T9054 | 104-113 | RB | denotes | initially |
T9055 | 114-119 | VBN | denotes | found |
T9056 | 120-122 | IN | denotes | in |
T9057 | 123-131 | JJ | denotes | separate |
T9058 | 132-143 | NNS | denotes | populations |
T9059 | 144-145 | -LRB- | denotes | ( |
T9060 | 145-148 | NN | denotes | day |
T9061 | 149-150 | CD | denotes | 2 |
T9062 | 150-151 | -RRB- | denotes | ) |
T9063 | 151-152 | , | denotes | , |
T9064 | 153-156 | CC | denotes | but |
T9065 | 157-168 | RB | denotes | transiently |
T9066 | 169-179 | JJ | denotes | co-express |
T9067 | 180-184 | DT | denotes | both |
T9068 | 185-192 | NNS | denotes | factors |
T9069 | 193-194 | -LRB- | denotes | ( |
T9070 | 194-198 | NNS | denotes | days |
T9071 | 199-200 | CD | denotes | 4 |
T9072 | 201-202 | CD | denotes | 8 |
T9073 | 202-203 | -RRB- | denotes | ) |
T9074 | 203-204 | , | denotes | , |
T9075 | 205-211 | IN | denotes | before |
T9076 | 212-224 | VBG | denotes | establishing |
T9077 | 225-233 | JJ | denotes | separate |
T9078 | 234-245 | NNS | denotes | populations |
T9079 | 246-248 | IN | denotes | at |
T9080 | 249-252 | DT | denotes | the |
T9081 | 253-256 | NN | denotes | end |
T9082 | 257-259 | IN | denotes | of |
T9083 | 260-263 | DT | denotes | the |
T9084 | 264-279 | NN | denotes | differentiation |
T9085 | 280-287 | NN | denotes | process |
T9086 | 288-289 | -LRB- | denotes | ( |
T9087 | 289-292 | NN | denotes | day |
T9088 | 293-295 | CD | denotes | 10 |
T9089 | 295-296 | : | denotes | ; |
T9090 | 297-303 | NN | denotes | Figure |
T9091 | 304-306 | NN | denotes | 6C |
T9092 | 306-307 | -RRB- | denotes | ) |
T9093 | 307-308 | , | denotes | , |
T9094 | 309-319 | VBG | denotes | suggesting |
T9095 | 320-324 | IN | denotes | that |
T9096 | 325-330 | NNP | denotes | GATA3 |
T9097 | 331-339 | VBZ | denotes | inhibits |
T9098 | 340-343 | DT | denotes | the |
T9099 | 344-355 | NN | denotes | development |
T9100 | 356-358 | IN | denotes | of |
T9101 | 359-364 | NNP | denotes | iTreg |
T9102 | 365-370 | NNS | denotes | cells |
T9103 | 371-373 | IN | denotes | by |
T9104 | 374-384 | VBG | denotes | repressing |
T9105 | 385-390 | NNP | denotes | FOXP3 |
T9106 | 390-391 | . | denotes | . |
R6955 | T9036 | T9038 | det | The,kinetic |
R6956 | T9037 | T9038 | compound | expression,kinetic |
R6957 | T9038 | T9043 | nsubj | kinetic,exposed |
R6958 | T9039 | T9038 | prep | of,kinetic |
R6959 | T9040 | T9042 | amod | naive,cells |
R6960 | T9041 | T9042 | compound | T,cells |
R6961 | T9042 | T9039 | pobj | cells,of |
R6962 | T9043 | T9048 | csubj | exposed,demonstrated |
R6963 | T9044 | T9043 | prep | to,exposed |
R6964 | T9045 | T9044 | pobj | IL-4,to |
R6965 | T9046 | T9045 | cc | and,IL-4 |
R6966 | T9047 | T9045 | conj | TGF-β,IL-4 |
R6967 | T9048 | T9048 | ROOT | demonstrated,demonstrated |
R6968 | T9049 | T9055 | mark | that,found |
R6969 | T9050 | T9055 | nsubjpass | GATA3,found |
R6970 | T9051 | T9050 | cc | and,GATA3 |
R6971 | T9052 | T9050 | conj | FOXP3,GATA3 |
R6972 | T9053 | T9055 | auxpass | are,found |
R6973 | T9054 | T9055 | advmod | initially,found |
R6974 | T9055 | T9048 | ccomp | found,demonstrated |
R6975 | T9056 | T9055 | prep | in,found |
R6976 | T9057 | T9058 | amod | separate,populations |
R6977 | T9058 | T9056 | pobj | populations,in |
R6978 | T9059 | T9060 | punct | (,day |
R6979 | T9060 | T9055 | npadvmod | day,found |
R6980 | T9061 | T9060 | nummod | 2,day |
R6981 | T9062 | T9060 | punct | ),day |
R6982 | T9063 | T9055 | punct | ",",found |
R6983 | T9064 | T9055 | cc | but,found |
R6984 | T9065 | T9066 | advmod | transiently,co-express |
R6985 | T9066 | T9068 | nummod | co-express,factors |
R6986 | T9067 | T9068 | det | both,factors |
R6987 | T9068 | T9048 | dobj | factors,demonstrated |
R6988 | T9069 | T9068 | punct | (,factors |
R6989 | T9070 | T9068 | appos | days,factors |
R6990 | T9071 | T9070 | nummod | 4,days |
R6991 | T9072 | T9070 | appos | 8,days |
R6992 | T9073 | T9070 | punct | ),days |
R6993 | T9074 | T9068 | punct | ",",factors |
R6994 | T9075 | T9087 | prep | before,day |
R6995 | T9076 | T9075 | pcomp | establishing,before |
R6996 | T9077 | T9078 | amod | separate,populations |
R6997 | T9078 | T9076 | dobj | populations,establishing |
R6998 | T9079 | T9076 | prep | at,establishing |
R6999 | T9080 | T9081 | det | the,end |
R7000 | T9081 | T9079 | pobj | end,at |
R7001 | T9082 | T9081 | prep | of,end |
R7002 | T9083 | T9085 | det | the,process |
R7003 | T9084 | T9085 | compound | differentiation,process |
R7004 | T9085 | T9082 | pobj | process,of |
R7005 | T9086 | T9087 | punct | (,day |
R7006 | T9087 | T9068 | appos | day,factors |
R7007 | T9088 | T9087 | nummod | 10,day |
R7008 | T9089 | T9068 | punct | ;,factors |
R7009 | T9090 | T9091 | compound | Figure,6C |
R7010 | T9091 | T9068 | appos | 6C,factors |
R7011 | T9092 | T9068 | punct | ),factors |
R7012 | T9093 | T9048 | punct | ",",demonstrated |
R7013 | T9094 | T9048 | advcl | suggesting,demonstrated |
R7014 | T9095 | T9097 | mark | that,inhibits |
R7015 | T9096 | T9097 | nsubj | GATA3,inhibits |
R7016 | T9097 | T9094 | ccomp | inhibits,suggesting |
R7017 | T9098 | T9099 | det | the,development |
R7018 | T9099 | T9097 | dobj | development,inhibits |
R7019 | T9100 | T9099 | prep | of,development |
R7020 | T9101 | T9102 | compound | iTreg,cells |
R7021 | T9102 | T9100 | pobj | cells,of |
R7022 | T9103 | T9097 | prep | by,inhibits |
R7023 | T9104 | T9103 | pcomp | repressing,by |
R7024 | T9105 | T9104 | dobj | FOXP3,repressing |
R7025 | T9106 | T9048 | punct | .,demonstrated |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8277 | 344-355 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9223 | 51-55 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T9239 | 34-39 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T9240 | 365-370 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8271 | 0-391 | Sentence | denotes | The expression kinetic of naive T cells exposed to IL-4 and TGF-β demonstrated that GATA3 and FOXP3 are initially found in separate populations (day 2), but transiently co-express both factors (days 4–8), before establishing separate populations at the end of the differentiation process (day 10; Figure 6C), suggesting that GATA3 inhibits the development of iTreg cells by repressing FOXP3. |
T149 | 0-391 | Sentence | denotes | The expression kinetic of naive T cells exposed to IL-4 and TGF-β demonstrated that GATA3 and FOXP3 are initially found in separate populations (day 2), but transiently co-express both factors (days 4–8), before establishing separate populations at the end of the differentiation process (day 10; Figure 6C), suggesting that GATA3 inhibits the development of iTreg cells by repressing FOXP3. |
events-check-again
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T9486 | 51-55 | Protein | denotes | IL-4 | |
T9487 | 60-65 | Protein | denotes | TGF-β | |
T9488 | 66-78 | Positive_regulation | denotes | demonstrated | |
T9489 | 66-78 | Positive_regulation | denotes | demonstrated | |
T9490 | 66-78 | Positive_regulation | denotes | demonstrated | |
T9491 | 66-78 | Positive_regulation | denotes | demonstrated | |
T9492 | 84-89 | Protein | denotes | GATA3 | |
T9493 | 94-99 | Protein | denotes | FOXP3 | |
T9494 | 169-179 | Gene_expression | denotes | co-express | |
T9495 | 169-179 | Gene_expression | denotes | co-express | |
T9496 | 325-330 | Protein | denotes | GATA3 | |
T9497 | 374-384 | Negative_regulation | denotes | repressing | true |
T9498 | 385-390 | Protein | denotes | FOXP3 | |
R7232 | T9486 | T9488 | causeOf | IL-4,demonstrated | |
R7233 | T9486 | T9490 | causeOf | IL-4,demonstrated | |
R7234 | T9487 | T9489 | causeOf | TGF-β,demonstrated | |
R7235 | T9487 | T9491 | causeOf | TGF-β,demonstrated | |
R7236 | T9492 | T9494 | themeOf | GATA3,co-express | |
R7237 | T9493 | T9495 | themeOf | FOXP3,co-express | |
R7238 | T9494 | T9488 | themeOf | co-express,demonstrated | |
R7239 | T9494 | T9489 | themeOf | co-express,demonstrated | |
R7240 | T9495 | T9490 | themeOf | co-express,demonstrated | |
R7241 | T9495 | T9491 | themeOf | co-express,demonstrated | |
R7242 | T9496 | T9497 | causeOf | GATA3,repressing | |
R7243 | T9498 | T9497 | themeOf | FOXP3,repressing |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue | Speculation |
---|---|---|---|---|---|
T8289 | 66-78 | Positive_regulation | denotes | demonstrated | |
T8290 | 169-179 | Gene_expression | denotes | co-express | |
T8292 | 66-78 | Positive_regulation | denotes | demonstrated | |
T8293 | 66-78 | Positive_regulation | denotes | demonstrated | |
T8294 | 169-179 | Gene_expression | denotes | co-express | |
T8295 | 66-78 | Positive_regulation | denotes | demonstrated | |
T8296 | 374-384 | Negative_regulation | denotes | repressing | true |
T8339 | 325-330 | Protein | denotes | GATA3 | |
T8341 | 385-390 | Protein | denotes | FOXP3 | |
T8335 | 51-55 | Protein | denotes | IL-4 | |
T8336 | 60-65 | Protein | denotes | TGF-β | |
T8337 | 84-89 | Protein | denotes | GATA3 | |
T8338 | 94-99 | Protein | denotes | FOXP3 | |
R6280 | T8290 | T8289 | themeOf | co-express,demonstrated | |
R6281 | T8290 | T8292 | themeOf | co-express,demonstrated | |
R6283 | T8294 | T8293 | themeOf | co-express,demonstrated | |
R6284 | T8294 | T8295 | themeOf | co-express,demonstrated | |
R6302 | T8335 | T8289 | causeOf | IL-4,demonstrated | |
R6303 | T8335 | T8293 | causeOf | IL-4,demonstrated | |
R6304 | T8336 | T8292 | causeOf | TGF-β,demonstrated | |
R6305 | T8336 | T8295 | causeOf | TGF-β,demonstrated | |
R6306 | T8337 | T8290 | themeOf | GATA3,co-express | |
R6307 | T8338 | T8294 | themeOf | FOXP3,co-express | |
R6308 | T8339 | T8296 | causeOf | GATA3,repressing | |
R6310 | T8341 | T8296 | themeOf | FOXP3,repressing |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8742 | 51-55 | P05112 | denotes | IL-4 |
T8743 | 60-65 | P01137 | denotes | TGF-β |
T8744 | 84-89 | P23771 | denotes | GATA3 |
T8745 | 94-99 | Q9BZS1 | denotes | FOXP3 |
T8746 | 325-330 | P23771 | denotes | GATA3 |
T8747 | 385-390 | Q9BZS1 | denotes | FOXP3 |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T8245 | 51-55 | Protein | denotes | IL-4 |
T8246 | 60-65 | Protein | denotes | TGF-β |
T8247 | 84-89 | Protein | denotes | GATA3 |
T8248 | 94-99 | Protein | denotes | FOXP3 |
T8249 | 169-179 | Gene_expression | denotes | co-express |
T8250 | 325-330 | Protein | denotes | GATA3 |
T8251 | 374-384 | Negative_regulation | denotes | repressing |
T8252 | 385-390 | Protein | denotes | FOXP3 |
R6270 | T8247 | T8249 | themeOf | GATA3,co-express |
R6271 | T8248 | T8249 | themeOf | FOXP3,co-express |
R6272 | T8250 | T8251 | causeOf | GATA3,repressing |
R6273 | T8250 | T8249 | themeOf | GATA3,co-express |
R6274 | T8252 | T8251 | themeOf | FOXP3,repressing |