PMC:2222968 / 1103-1799
Annnotations
pmc-enju-pas
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process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
bionlp-st-ge-2016-spacy-parsed
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process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T71","span":{"begin":0,"end":15},"obj":"http://purl.obolibrary.org/obo/GO_2000144"},{"id":"T72","span":{"begin":89,"end":100},"obj":"http://purl.obolibrary.org/obo/GO_0032502"},{"id":"T73","span":{"begin":125,"end":140},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T74","span":{"begin":132,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0071353"},{"id":"T75","span":{"begin":132,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0070670"},{"id":"T76","span":{"begin":315,"end":334},"obj":"http://purl.obolibrary.org/obo/GO_0002507"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
GO-MF
{"project":"GO-MF","denotations":[{"id":"T632","span":{"begin":142,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0005136"},{"id":"T633","span":{"begin":248,"end":252},"obj":"http://purl.obolibrary.org/obo/GO_0005136"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T639","span":{"begin":179,"end":183},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
sentences
{"project":"sentences","denotations":[{"id":"T65","span":{"begin":25,"end":141},"obj":"Sentence"},{"id":"T66","span":{"begin":142,"end":390},"obj":"Sentence"},{"id":"T9","span":{"begin":25,"end":141},"obj":"Sentence"},{"id":"T10","span":{"begin":142,"end":390},"obj":"Sentence"},{"id":"T11","span":{"begin":392,"end":406},"obj":"Sentence"},{"id":"T12","span":{"begin":408,"end":621},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
ICD10
{"project":"ICD10","denotations":[{"id":"T630","span":{"begin":382,"end":389},"obj":"http://purl.bioontology.org/ontology/ICD10/T78.4"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
events-check-again
{"project":"events-check-again","denotations":[{"id":"T777","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T778","span":{"begin":241,"end":247},"obj":"Regulation"},{"id":"T779","span":{"begin":241,"end":247},"obj":"Regulation"},{"id":"T780","span":{"begin":248,"end":252},"obj":"Protein"},{"id":"T781","span":{"begin":256,"end":261},"obj":"Protein"}],"relations":[{"id":"R607","pred":"themeOf","subj":"T780","obj":"T778"},{"id":"R608","pred":"themeOf","subj":"T781","obj":"T779"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
bionlp-st-ge-2016-reference-tees
{"project":"bionlp-st-ge-2016-reference-tees","denotations":[{"id":"T666","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T667","span":{"begin":241,"end":252},"obj":"Protein"},{"id":"T668","span":{"begin":256,"end":261},"obj":"Protein"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
bionlp-st-ge-2016-reference
{"project":"bionlp-st-ge-2016-reference","denotations":[{"id":"T81","span":{"begin":241,"end":247},"obj":"Regulation"},{"id":"T82","span":{"begin":241,"end":247},"obj":"Regulation"},{"id":"T95","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T96","span":{"begin":248,"end":252},"obj":"Protein"},{"id":"T97","span":{"begin":256,"end":261},"obj":"Protein"}],"relations":[{"id":"R627","pred":"themeOf","subj":"T96","obj":"T81"},{"id":"R628","pred":"themeOf","subj":"T97","obj":"T82"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T349","span":{"begin":142,"end":146},"obj":"P05112"},{"id":"T350","span":{"begin":248,"end":252},"obj":"P05112"},{"id":"T351","span":{"begin":256,"end":261},"obj":"P23771"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}
test2
{"project":"test2","denotations":[{"id":"T53","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T54","span":{"begin":241,"end":247},"obj":"Binding"},{"id":"T55","span":{"begin":248,"end":252},"obj":"Protein"},{"id":"T56","span":{"begin":256,"end":261},"obj":"Protein"}],"relations":[{"id":"R36","pred":"themeOf","subj":"T53","obj":"T54"},{"id":"R37","pred":"themeOf","subj":"T55","obj":"T54"},{"id":"R38","pred":"themeOf","subj":"T56","obj":"T54"}],"text":"transactivation process. Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy.\n\nAuthor Summary\n\nSpecific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. The subsequent maturation process involves the differentiation of certain "}