
PMC:2222968 / 1103-1799
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T280 | 0-15 | NN | denotes | transactivation |
T281 | 16-23 | NN | denotes | process |
T282 | 25-34 | RB | denotes | Therefore |
T283 | 34-35 | -COMMA- | denotes | , |
T284 | 36-40 | DT | denotes | this |
T285 | 41-46 | NN | denotes | study |
T286 | 47-55 | VB | denotes | provides |
T287 | 56-57 | DT | denotes | a |
T288 | 58-61 | JJ | denotes | new |
T289 | 62-75 | NN | denotes | understanding |
T290 | 76-78 | IN | denotes | of |
T291 | 79-88 | NN | denotes | tolerance |
T292 | 89-100 | NN | denotes | development |
T293 | 100-101 | -COMMA- | denotes | , |
T294 | 102-112 | VB | denotes | controlled |
T295 | 113-115 | IN | denotes | by |
T296 | 116-117 | DT | denotes | a |
T297 | 118-122 | NN | denotes | type |
T298 | 123-124 | CD | denotes | 2 |
T299 | 125-131 | JJ | denotes | immune |
T300 | 132-140 | NN | denotes | response |
T301 | 142-146 | NN | denotes | IL-4 |
T302 | 147-156 | NN | denotes | treatment |
T303 | 157-159 | IN | denotes | in |
T304 | 160-164 | NN | denotes | mice |
T305 | 165-172 | VB | denotes | reduces |
T306 | 173-178 | NN | denotes | iTreg |
T307 | 179-183 | NN | denotes | cell |
T308 | 184-193 | NN | denotes | frequency |
T309 | 193-194 | -COMMA- | denotes | , |
T310 | 195-207 | VB | denotes | highlighting |
T311 | 208-212 | IN | denotes | that |
T312 | 213-224 | JJ | denotes | therapeutic |
T313 | 225-235 | NN | denotes | approaches |
T314 | 236-240 | WDT | denotes | that |
T315 | 241-247 | VB | denotes | target |
T316 | 248-252 | NN | denotes | IL-4 |
T317 | 253-255 | CC | denotes | or |
T318 | 256-261 | NN | denotes | GATA3 |
T319 | 262-267 | MD | denotes | might |
T320 | 268-275 | VB | denotes | provide |
T321 | 276-279 | JJ | denotes | new |
T322 | 280-290 | JJ | denotes | preventive |
T323 | 291-301 | NN | denotes | strategies |
T324 | 302-314 | VB | denotes | facilitating |
T325 | 315-324 | NN | denotes | tolerance |
T326 | 325-334 | NN | denotes | induction |
T327 | 335-347 | RB | denotes | particularly |
T328 | 348-350 | IN | denotes | in |
T329 | 351-363 | JJ | denotes | Th2-mediated |
T330 | 364-372 | NN | denotes | diseases |
T331 | 372-373 | -COMMA- | denotes | , |
T332 | 374-378 | JJ | denotes | such |
T333 | 379-381 | IN | denotes | as |
T334 | 382-389 | NN | denotes | allergy |
R227 | T281 | T280 | arg1Of | process,transactivation |
R228 | T285 | T284 | arg1Of | study,this |
R229 | T285 | T286 | arg1Of | study,provides |
R230 | T286 | T282 | arg1Of | provides,Therefore |
R231 | T286 | T283 | arg1Of | provides,"," |
R232 | T289 | T286 | arg2Of | understanding,provides |
R233 | T289 | T287 | arg1Of | understanding,a |
R234 | T289 | T288 | arg1Of | understanding,new |
R235 | T289 | T290 | arg1Of | understanding,of |
R236 | T289 | T293 | arg1Of | understanding,"," |
R237 | T289 | T294 | arg2Of | understanding,controlled |
R238 | T292 | T290 | arg2Of | development,of |
R239 | T292 | T291 | arg1Of | development,tolerance |
R240 | T300 | T294 | arg1Of | response,controlled |
R241 | T300 | T295 | arg2Of | response,by |
R242 | T300 | T296 | arg1Of | response,a |
R243 | T300 | T297 | arg1Of | response,type |
R244 | T300 | T298 | arg1Of | response,2 |
R245 | T300 | T299 | arg1Of | response,immune |
R246 | T302 | T301 | arg1Of | treatment,IL-4 |
R247 | T302 | T303 | arg1Of | treatment,in |
R248 | T302 | T305 | arg1Of | treatment,reduces |
R249 | T302 | T310 | arg1Of | treatment,highlighting |
R250 | T304 | T303 | arg2Of | mice,in |
R251 | T305 | T309 | arg1Of | reduces,"," |
R252 | T305 | T310 | modOf | reduces,highlighting |
R253 | T308 | T305 | arg2Of | frequency,reduces |
R254 | T308 | T306 | arg1Of | frequency,iTreg |
R255 | T308 | T307 | arg1Of | frequency,cell |
R256 | T313 | T312 | arg1Of | approaches,therapeutic |
R257 | T313 | T314 | arg1Of | approaches,that |
R258 | T313 | T315 | arg1Of | approaches,target |
R259 | T313 | T319 | arg1Of | approaches,might |
R260 | T313 | T320 | arg1Of | approaches,provide |
R261 | T316 | T317 | arg1Of | IL-4,or |
R262 | T317 | T315 | arg2Of | or,target |
R263 | T318 | T317 | arg2Of | GATA3,or |
R264 | T320 | T310 | arg2Of | provide,highlighting |
R265 | T320 | T311 | arg1Of | provide,that |
R266 | T320 | T319 | arg2Of | provide,might |
R267 | T320 | T328 | arg1Of | provide,in |
R268 | T323 | T320 | arg2Of | strategies,provide |
R269 | T323 | T321 | arg1Of | strategies,new |
R270 | T323 | T322 | arg1Of | strategies,preventive |
R271 | T323 | T324 | arg1Of | strategies,facilitating |
R272 | T326 | T324 | arg2Of | induction,facilitating |
R273 | T326 | T325 | arg1Of | induction,tolerance |
R274 | T328 | T327 | arg1Of | in,particularly |
R275 | T330 | T328 | arg2Of | diseases,in |
R276 | T330 | T329 | arg1Of | diseases,Th2-mediated |
R277 | T330 | T331 | arg1Of | diseases,"," |
R278 | T330 | T333 | arg1Of | diseases,as |
R279 | T333 | T332 | arg1Of | as,such |
R280 | T334 | T333 | arg2Of | allergy,as |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T542 | 0-15 | NN | denotes | transactivation |
T543 | 16-23 | NN | denotes | process |
T544 | 23-24 | . | denotes | . |
T545 | 25-34 | RB | denotes | Therefore |
T546 | 34-35 | , | denotes | , |
T547 | 36-40 | DT | denotes | this |
T548 | 41-46 | NN | denotes | study |
T549 | 47-55 | VBZ | denotes | provides |
T550 | 56-57 | DT | denotes | a |
T551 | 58-61 | JJ | denotes | new |
T552 | 62-75 | NN | denotes | understanding |
T553 | 76-78 | IN | denotes | of |
T554 | 79-88 | NN | denotes | tolerance |
T555 | 89-100 | NN | denotes | development |
T556 | 100-101 | , | denotes | , |
T557 | 102-112 | VBN | denotes | controlled |
T558 | 113-115 | IN | denotes | by |
T559 | 116-117 | DT | denotes | a |
T560 | 118-122 | NN | denotes | type |
T561 | 123-124 | CD | denotes | 2 |
T562 | 125-131 | JJ | denotes | immune |
T563 | 132-140 | NN | denotes | response |
T564 | 140-141 | . | denotes | . |
T565 | 142-146 | NN | denotes | IL-4 |
T566 | 147-156 | NN | denotes | treatment |
T567 | 157-159 | IN | denotes | in |
T568 | 160-164 | NNS | denotes | mice |
T569 | 165-172 | VBZ | denotes | reduces |
T570 | 173-178 | NNP | denotes | iTreg |
T571 | 179-183 | NN | denotes | cell |
T572 | 184-193 | NN | denotes | frequency |
T573 | 193-194 | , | denotes | , |
T574 | 195-207 | VBG | denotes | highlighting |
T575 | 208-212 | IN | denotes | that |
T576 | 213-224 | JJ | denotes | therapeutic |
T577 | 225-235 | NNS | denotes | approaches |
T578 | 236-240 | WDT | denotes | that |
T579 | 241-247 | VBP | denotes | target |
T580 | 248-252 | NN | denotes | IL-4 |
T581 | 253-255 | CC | denotes | or |
T582 | 256-261 | NN | denotes | GATA3 |
T583 | 262-267 | MD | denotes | might |
T584 | 268-275 | VB | denotes | provide |
T585 | 276-279 | JJ | denotes | new |
T586 | 280-290 | JJ | denotes | preventive |
T587 | 291-301 | NNS | denotes | strategies |
T588 | 302-314 | VBG | denotes | facilitating |
T589 | 315-324 | NN | denotes | tolerance |
T590 | 325-334 | NN | denotes | induction |
T591 | 335-347 | RB | denotes | particularly |
T592 | 348-350 | IN | denotes | in |
T593 | 351-363 | JJ | denotes | Th2-mediated |
T594 | 364-372 | NNS | denotes | diseases |
T595 | 372-373 | , | denotes | , |
T596 | 374-378 | JJ | denotes | such |
T597 | 379-381 | IN | denotes | as |
T598 | 382-389 | NN | denotes | allergy |
T599 | 389-390 | . | denotes | . |
R462 | T542 | T543 | compound | transactivation,process |
R465 | T545 | T549 | advmod | Therefore,provides |
R466 | T546 | T549 | punct | ",",provides |
R467 | T547 | T548 | det | this,study |
R468 | T548 | T549 | nsubj | study,provides |
R469 | T549 | T549 | ROOT | provides,provides |
R470 | T550 | T552 | det | a,understanding |
R471 | T551 | T552 | amod | new,understanding |
R472 | T552 | T549 | dobj | understanding,provides |
R473 | T553 | T552 | prep | of,understanding |
R474 | T554 | T555 | compound | tolerance,development |
R475 | T555 | T553 | pobj | development,of |
R476 | T556 | T552 | punct | ",",understanding |
R477 | T557 | T552 | acl | controlled,understanding |
R478 | T558 | T557 | agent | by,controlled |
R479 | T559 | T563 | det | a,response |
R480 | T560 | T563 | nmod | type,response |
R481 | T561 | T560 | nummod | 2,type |
R482 | T562 | T563 | amod | immune,response |
R483 | T563 | T558 | pobj | response,by |
R484 | T564 | T549 | punct | .,provides |
R485 | T565 | T566 | compound | IL-4,treatment |
R486 | T566 | T569 | nsubj | treatment,reduces |
R487 | T567 | T566 | prep | in,treatment |
R488 | T568 | T567 | pobj | mice,in |
R489 | T569 | T569 | ROOT | reduces,reduces |
R490 | T570 | T572 | compound | iTreg,frequency |
R491 | T571 | T572 | compound | cell,frequency |
R492 | T572 | T569 | dobj | frequency,reduces |
R493 | T573 | T569 | punct | ",",reduces |
R494 | T574 | T569 | advcl | highlighting,reduces |
R495 | T575 | T584 | mark | that,provide |
R496 | T576 | T577 | amod | therapeutic,approaches |
R497 | T577 | T584 | nsubj | approaches,provide |
R498 | T578 | T579 | nsubj | that,target |
R499 | T579 | T577 | relcl | target,approaches |
R500 | T580 | T579 | dobj | IL-4,target |
R501 | T581 | T580 | cc | or,IL-4 |
R502 | T582 | T580 | conj | GATA3,IL-4 |
R503 | T583 | T584 | aux | might,provide |
R504 | T584 | T574 | ccomp | provide,highlighting |
R505 | T585 | T587 | amod | new,strategies |
R506 | T586 | T587 | amod | preventive,strategies |
R507 | T587 | T584 | dobj | strategies,provide |
R508 | T588 | T584 | advcl | facilitating,provide |
R509 | T589 | T590 | compound | tolerance,induction |
R510 | T590 | T588 | dobj | induction,facilitating |
R511 | T591 | T592 | advmod | particularly,in |
R512 | T592 | T590 | prep | in,induction |
R513 | T593 | T594 | amod | Th2-mediated,diseases |
R514 | T594 | T592 | pobj | diseases,in |
R515 | T595 | T594 | punct | ",",diseases |
R516 | T596 | T597 | amod | such,as |
R517 | T597 | T594 | prep | as,diseases |
R518 | T598 | T597 | pobj | allergy,as |
R519 | T599 | T569 | punct | .,reduces |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T71 | 0-15 | http://purl.obolibrary.org/obo/GO_2000144 | denotes | transactivation |
T72 | 89-100 | http://purl.obolibrary.org/obo/GO_0032502 | denotes | development |
T73 | 125-140 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
T74 | 132-146 | http://purl.obolibrary.org/obo/GO_0071353 | denotes | response. IL-4 |
T75 | 132-146 | http://purl.obolibrary.org/obo/GO_0070670 | denotes | response. IL-4 |
T76 | 315-334 | http://purl.obolibrary.org/obo/GO_0002507 | denotes | tolerance induction |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T632 | 142-146 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
T633 | 248-252 | http://purl.obolibrary.org/obo/GO_0005136 | denotes | IL-4 |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T639 | 179-183 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T65 | 25-141 | Sentence | denotes | Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. |
T66 | 142-390 | Sentence | denotes | IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy. |
T9 | 25-141 | Sentence | denotes | Therefore, this study provides a new understanding of tolerance development, controlled by a type 2 immune response. |
T10 | 142-390 | Sentence | denotes | IL-4 treatment in mice reduces iTreg cell frequency, highlighting that therapeutic approaches that target IL-4 or GATA3 might provide new preventive strategies facilitating tolerance induction particularly in Th2-mediated diseases, such as allergy. |
T11 | 392-406 | Sentence | denotes | Author Summary |
T12 | 408-621 | Sentence | denotes | Specific immune responses against foreign or autologous antigens are driven by specialized epitope-specific T cells, whose numbers expand upon recognition of antigen found on professional antigen-presenting cells. |
ICD10
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T630 | 382-389 | http://purl.bioontology.org/ontology/ICD10/T78.4 | denotes | allergy |
events-check-again
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T777 | 142-146 | Protein | denotes | IL-4 |
T778 | 241-247 | Regulation | denotes | target |
T779 | 241-247 | Regulation | denotes | target |
T780 | 248-252 | Protein | denotes | IL-4 |
T781 | 256-261 | Protein | denotes | GATA3 |
R607 | T780 | T778 | themeOf | IL-4,target |
R608 | T781 | T779 | themeOf | GATA3,target |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T666 | 142-146 | Protein | denotes | IL-4 |
T667 | 241-252 | Protein | denotes | target IL-4 |
T668 | 256-261 | Protein | denotes | GATA3 |
bionlp-st-ge-2016-reference
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T81 | 241-247 | Regulation | denotes | target |
T82 | 241-247 | Regulation | denotes | target |
T95 | 142-146 | Protein | denotes | IL-4 |
T96 | 248-252 | Protein | denotes | IL-4 |
T97 | 256-261 | Protein | denotes | GATA3 |
R627 | T96 | T81 | themeOf | IL-4,target |
R628 | T97 | T82 | themeOf | GATA3,target |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T349 | 142-146 | P05112 | denotes | IL-4 |
T350 | 248-252 | P05112 | denotes | IL-4 |
T351 | 256-261 | P23771 | denotes | GATA3 |
test2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T53 | 142-146 | Protein | denotes | IL-4 |
T54 | 241-247 | Binding | denotes | target |
T55 | 248-252 | Protein | denotes | IL-4 |
T56 | 256-261 | Protein | denotes | GATA3 |
R36 | T53 | T54 | themeOf | IL-4,target |
R37 | T55 | T54 | themeOf | IL-4,target |
R38 | T56 | T54 | themeOf | GATA3,target |