PMC:1584416 / 570-946 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1584416","sourcedb":"PMC","sourceid":"1584416","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1584416","text":"gmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models. Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria. We report a variety of biallelic effects on organism","tracks":[{"project":"craft-sa-dev","denotations":[{"id":"T168","span":{"begin":7,"end":17},"obj":"NN"},{"id":"T170","span":{"begin":18,"end":28},"obj":"VBN"},{"id":"T171","span":{"begin":29,"end":33},"obj":"IN"},{"id":"T172","span":{"begin":34,"end":37},"obj":"NN"},{"id":"T173","span":{"begin":48,"end":57},"obj":"NNS"},{"id":"T174","span":{"begin":38,"end":47},"obj":"JJ"},{"id":"T175","span":{"begin":58,"end":60},"obj":"IN"},{"id":"T176","span":{"begin":61,"end":69},"obj":"NN"},{"id":"T177","span":{"begin":89,"end":95},"obj":"NNS"},{"id":"T178","span":{"begin":70,"end":82},"obj":"JJ"},{"id":"T179","span":{"begin":83,"end":88},"obj":"NN"},{"id":"T180","span":{"begin":95,"end":96},"obj":"."},{"id":"T181","span":{"begin":96,"end":323},"obj":"sentence"},{"id":"T182","span":{"begin":97,"end":108},"obj":"NNS"},{"id":"T183","span":{"begin":196,"end":202},"obj":"VBP"},{"id":"T184","span":{"begin":109,"end":111},"obj":"IN"},{"id":"T185","span":{"begin":112,"end":116},"obj":"DT"},{"id":"T186","span":{"begin":127,"end":135},"obj":"NN"},{"id":"T187","span":{"begin":117,"end":126},"obj":"JJ"},{"id":"T188","span":{"begin":135,"end":137},"obj":","},{"id":"T189","span":{"begin":137,"end":141},"obj":"IN"},{"id":"T190","span":{"begin":142,"end":151},"obj":"NNS"},{"id":"T191","span":{"begin":152,"end":154},"obj":"IN"},{"id":"T192","span":{"begin":155,"end":159},"obj":"CC"},{"id":"T193","span":{"begin":164,"end":170},"obj":"NN"},{"id":"T194","span":{"begin":160,"end":163},"obj":"NN"},{"id":"T195","span":{"begin":171,"end":174},"obj":"CC"},{"id":"T196","span":{"begin":175,"end":180},"obj":"JJ"},{"id":"T197","span":{"begin":181,"end":194},"obj":"NN"},{"id":"T198","span":{"begin":194,"end":196},"obj":","},{"id":"T199","span":{"begin":203,"end":205},"obj":"IN"},{"id":"T200","span":{"begin":206,"end":213},"obj":"JJ"},{"id":"T201","span":{"begin":214,"end":225},"obj":"NNS"},{"id":"T202","span":{"begin":226,"end":233},"obj":"VBG"},{"id":"T203","span":{"begin":234,"end":238},"obj":"IN"},{"id":"T204","span":{"begin":239,"end":247},"obj":"VBN"},{"id":"T205","span":{"begin":251,"end":262},"obj":"NN"},{"id":"T206","span":{"begin":248,"end":250},"obj":"NN"},{"id":"T207","span":{"begin":263,"end":266},"obj":"CC"},{"id":"T208","span":{"begin":267,"end":273},"obj":"NN"},{"id":"T209","span":{"begin":274,"end":288},"obj":"NN"},{"id":"T210","span":{"begin":289,"end":291},"obj":"IN"},{"id":"T211","span":{"begin":292,"end":303},"obj":"VBN"},{"id":"T212","span":{"begin":314,"end":322},"obj":"NN"},{"id":"T213","span":{"begin":304,"end":313},"obj":"JJ"},{"id":"T214","span":{"begin":322,"end":323},"obj":"."},{"id":"T216","span":{"begin":324,"end":326},"obj":"PRP"},{"id":"T217","span":{"begin":327,"end":333},"obj":"VBP"},{"id":"T218","span":{"begin":334,"end":335},"obj":"DT"},{"id":"T219","span":{"begin":336,"end":343},"obj":"NN"},{"id":"T220","span":{"begin":344,"end":346},"obj":"IN"},{"id":"T221","span":{"begin":347,"end":356},"obj":"JJ"},{"id":"T222","span":{"begin":357,"end":364},"obj":"NNS"},{"id":"T223","span":{"begin":365,"end":367},"obj":"IN"}],"relations":[{"id":"R82","pred":"pobj","subj":"T173","obj":"T171"},{"id":"R83","pred":"amod","subj":"T174","obj":"T173"},{"id":"R86","pred":"pobj","subj":"T177","obj":"T175"},{"id":"R87","pred":"amod","subj":"T178","obj":"T177"},{"id":"R88","pred":"compound","subj":"T179","obj":"T177"},{"id":"R93","pred":"pobj","subj":"T186","obj":"T184"},{"id":"R94","pred":"amod","subj":"T187","obj":"T186"},{"id":"R100","pred":"pobj","subj":"T193","obj":"T191"},{"id":"R101","pred":"compound","subj":"T194","obj":"T193"},{"id":"R112","pred":"pobj","subj":"T205","obj":"T203"},{"id":"R113","pred":"compound","subj":"T206","obj":"T205"},{"id":"R119","pred":"pobj","subj":"T212","obj":"T210"},{"id":"R120","pred":"amod","subj":"T213","obj":"T212"},{"id":"R79","pred":"acl","subj":"T170","obj":"T168"},{"id":"R80","pred":"prep","subj":"T171","obj":"T170"},{"id":"R81","pred":"nmod","subj":"T172","obj":"T173"},{"id":"R84","pred":"prep","subj":"T175","obj":"T170"},{"id":"R85","pred":"nmod","subj":"T176","obj":"T177"},{"id":"R90","pred":"nsubj","subj":"T182","obj":"T183"},{"id":"R91","pred":"prep","subj":"T184","obj":"T182"},{"id":"R92","pred":"det","subj":"T185","obj":"T186"},{"id":"R95","pred":"punct","subj":"T188","obj":"T186"},{"id":"R96","pred":"prep","subj":"T189","obj":"T186"},{"id":"R97","pred":"pobj","subj":"T190","obj":"T189"},{"id":"R98","pred":"prep","subj":"T191","obj":"T190"},{"id":"R99","pred":"preconj","subj":"T192","obj":"T193"},{"id":"R102","pred":"cc","subj":"T195","obj":"T193"},{"id":"R103","pred":"amod","subj":"T196","obj":"T197"},{"id":"R104","pred":"conj","subj":"T197","obj":"T193"},{"id":"R105","pred":"punct","subj":"T198","obj":"T183"},{"id":"R106","pred":"prep","subj":"T199","obj":"T183"},{"id":"R107","pred":"amod","subj":"T200","obj":"T201"},{"id":"R108","pred":"pobj","subj":"T201","obj":"T199"},{"id":"R109","pred":"acl","subj":"T202","obj":"T201"},{"id":"R110","pred":"prep","subj":"T203","obj":"T202"},{"id":"R111","pred":"amod","subj":"T204","obj":"T205"},{"id":"R114","pred":"cc","subj":"T207","obj":"T205"},{"id":"R115","pred":"compound","subj":"T208","obj":"T209"},{"id":"R116","pred":"conj","subj":"T209","obj":"T205"},{"id":"R117","pred":"prep","subj":"T210","obj":"T203"},{"id":"R118","pred":"amod","subj":"T211","obj":"T212"},{"id":"R121","pred":"punct","subj":"T214","obj":"T183"},{"id":"R122","pred":"nsubj","subj":"T216","obj":"T217"},{"id":"R123","pred":"det","subj":"T218","obj":"T219"},{"id":"R124","pred":"dobj","subj":"T219","obj":"T217"},{"id":"R125","pred":"prep","subj":"T220","obj":"T219"},{"id":"R126","pred":"amod","subj":"T221","obj":"T222"},{"id":"R127","pred":"pobj","subj":"T222","obj":"T220"},{"id":"R128","pred":"prep","subj":"T223","obj":"T222"}],"attributes":[{"subj":"T168","pred":"source","obj":"craft-sa-dev"},{"subj":"T170","pred":"source","obj":"craft-sa-dev"},{"subj":"T171","pred":"source","obj":"craft-sa-dev"},{"subj":"T172","pred":"source","obj":"craft-sa-dev"},{"subj":"T173","pred":"source","obj":"craft-sa-dev"},{"subj":"T174","pred":"source","obj":"craft-sa-dev"},{"subj":"T175","pred":"source","obj":"craft-sa-dev"},{"subj":"T176","pred":"source","obj":"craft-sa-dev"},{"subj":"T177","pred":"source","obj":"craft-sa-dev"},{"subj":"T178","pred":"source","obj":"craft-sa-dev"},{"subj":"T179","pred":"source","obj":"craft-sa-dev"},{"subj":"T180","pred":"source","obj":"craft-sa-dev"},{"subj":"T181","pred":"source","obj":"craft-sa-dev"},{"subj":"T182","pred":"source","obj":"craft-sa-dev"},{"subj":"T183","pred":"source","obj":"craft-sa-dev"},{"subj":"T184","pred":"source","obj":"craft-sa-dev"},{"subj":"T185","pred":"source","obj":"craft-sa-dev"},{"subj":"T186","pred":"source","obj":"craft-sa-dev"},{"subj":"T187","pred":"source","obj":"craft-sa-dev"},{"subj":"T188","pred":"source","obj":"craft-sa-dev"},{"subj":"T189","pred":"source","obj":"craft-sa-dev"},{"subj":"T190","pred":"source","obj":"craft-sa-dev"},{"subj":"T191","pred":"source","obj":"craft-sa-dev"},{"subj":"T192","pred":"source","obj":"craft-sa-dev"},{"subj":"T193","pred":"source","obj":"craft-sa-dev"},{"subj":"T194","pred":"source","obj":"craft-sa-dev"},{"subj":"T195","pred":"source","obj":"craft-sa-dev"},{"subj":"T196","pred":"source","obj":"craft-sa-dev"},{"subj":"T197","pred":"source","obj":"craft-sa-dev"},{"subj":"T198","pred":"source","obj":"craft-sa-dev"},{"subj":"T199","pred":"source","obj":"craft-sa-dev"},{"subj":"T200","pred":"source","obj":"craft-sa-dev"},{"subj":"T201","pred":"source","obj":"craft-sa-dev"},{"subj":"T202","pred":"source","obj":"craft-sa-dev"},{"subj":"T203","pred":"source","obj":"craft-sa-dev"},{"subj":"T204","pred":"source","obj":"craft-sa-dev"},{"subj":"T205","pred":"source","obj":"craft-sa-dev"},{"subj":"T206","pred":"source","obj":"craft-sa-dev"},{"subj":"T207","pred":"source","obj":"craft-sa-dev"},{"subj":"T208","pred":"source","obj":"craft-sa-dev"},{"subj":"T209","pred":"source","obj":"craft-sa-dev"},{"subj":"T210","pred":"source","obj":"craft-sa-dev"},{"subj":"T211","pred":"source","obj":"craft-sa-dev"},{"subj":"T212","pred":"source","obj":"craft-sa-dev"},{"subj":"T213","pred":"source","obj":"craft-sa-dev"},{"subj":"T214","pred":"source","obj":"craft-sa-dev"},{"subj":"T216","pred":"source","obj":"craft-sa-dev"},{"subj":"T217","pred":"source","obj":"craft-sa-dev"},{"subj":"T218","pred":"source","obj":"craft-sa-dev"},{"subj":"T219","pred":"source","obj":"craft-sa-dev"},{"subj":"T220","pred":"source","obj":"craft-sa-dev"},{"subj":"T221","pred":"source","obj":"craft-sa-dev"},{"subj":"T222","pred":"source","obj":"craft-sa-dev"},{"subj":"T223","pred":"source","obj":"craft-sa-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T28","span":{"begin":34,"end":37},"obj":"PR:000007164"},{"id":"T29","span":{"begin":83,"end":88},"obj":"NCBITaxon:10088"},{"id":"T30","span":{"begin":160,"end":170},"obj":"GO:0006281"},{"id":"T31","span":{"begin":349,"end":356},"obj":"SO:0001023"}],"attributes":[{"subj":"T28","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T29","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T30","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T31","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T58","span":{"begin":34,"end":37},"obj":"PR_EXT:000007164"},{"id":"T59","span":{"begin":83,"end":88},"obj":"NCBITaxon:10088"},{"id":"T60","span":{"begin":97,"end":108},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T61","span":{"begin":127,"end":135},"obj":"GO_EXT:0004386"},{"id":"T62","span":{"begin":160,"end":163},"obj":"CHEBI_SO_EXT:DNA"},{"id":"T63","span":{"begin":160,"end":170},"obj":"GO:0006281"},{"id":"T64","span":{"begin":181,"end":194},"obj":"GO_EXT:transcription"},{"id":"T65","span":{"begin":349,"end":356},"obj":"SO_EXT:0001023"}],"attributes":[{"subj":"T58","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T59","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T60","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T61","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T62","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T63","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T64","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T65","pred":"source","obj":"craft-ca-core-ex-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-sa-dev","color":"#cc93ec","default":true},{"id":"craft-ca-core-dev","color":"#93ecb2"},{"id":"craft-ca-core-ex-dev","color":"#ec9893"}]}]}}