PMC:1472690 / 10898-11679
Annnotations
pmc-enju-pas
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bionlp-st-ge-2016-test-proteins
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bionlp-st-ge-2016-uniprot
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UBERON-AE
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GO-BP
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GO-MF
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GO-CC
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sentences
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simple1
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BioNLP16_DUT
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BioNLP16_Messiy
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DLUT931
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bionlp-st-ge-2016-test-ihmc
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testone
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test3
{"project":"test3","denotations":[{"id":"T4615","span":{"begin":773,"end":779},"obj":"Protein"},{"id":"T4614","span":{"begin":197,"end":201},"obj":"Protein"},{"id":"T4613","span":{"begin":191,"end":195},"obj":"Protein"},{"id":"T4612","span":{"begin":185,"end":189},"obj":"Protein"},{"id":"T4611","span":{"begin":179,"end":183},"obj":"Protein"},{"id":"T4610","span":{"begin":165,"end":175},"obj":"Gene_expression"},{"id":"T4609","span":{"begin":157,"end":161},"obj":"Positive_regulation"},{"id":"T4608","span":{"begin":83,"end":87},"obj":"Protein"},{"id":"T4607","span":{"begin":74,"end":78},"obj":"Protein"},{"id":"T4606","span":{"begin":68,"end":72},"obj":"Protein"},{"id":"T4605","span":{"begin":62,"end":66},"obj":"Protein"},{"id":"T4539","span":{"begin":773,"end":779},"obj":"Protein"},{"id":"T4538","span":{"begin":197,"end":201},"obj":"Protein"},{"id":"T4537","span":{"begin":191,"end":195},"obj":"Protein"},{"id":"T4536","span":{"begin":185,"end":189},"obj":"Protein"},{"id":"T4535","span":{"begin":179,"end":183},"obj":"Protein"},{"id":"T4534","span":{"begin":83,"end":87},"obj":"Protein"},{"id":"T4533","span":{"begin":74,"end":78},"obj":"Protein"},{"id":"T4532","span":{"begin":68,"end":72},"obj":"Protein"},{"id":"T4531","span":{"begin":62,"end":66},"obj":"Protein"}],"relations":[{"id":"R2792","pred":"themeOf","subj":"T4610","obj":"T4609"},{"id":"R2793","pred":"themeOf","subj":"T4611","obj":"T4610"},{"id":"R2794","pred":"themeOf","subj":"T4612","obj":"T4610"},{"id":"R2795","pred":"themeOf","subj":"T4613","obj":"T4610"},{"id":"R2796","pred":"themeOf","subj":"T4614","obj":"T4610"}],"text":"Because of the GP-induced band shifts to seven sites from the TNFα, IL-8, IL-6 and IFNγ promoters, it could be assumed that GP treatment of human PBMC would lead to production of TNFα, IL-8, IL-6, IFNγ and other pro-inflammatory mediators. Previous studies reported that β-1→3-D-glucans induced only a limited cytokine secretion of human blood cells [15-18]. Corroborating and extending these singular findings in terms of examining pro- (eight) as well as anti- (three) inflammatory cytokines over time (48 h) and six additional transcription factor binding sites, our comprehensive analysis revealed the following cytokine profile of human leukocytes in response to a highly purified water soluble β-1→3-D-glucan and in comparison to two pro-inflammatory mediators (LPS, TSST-1):"}