PMC:1189073 / 7127-7467 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/1189073","sourcedb":"PMC","sourceid":"1189073","source_url":"http://www.ncbi.nlm.nih.gov/pmc/1189073","text":"The disorder in these mice segregated in a monogenic, autosomal recessive manner, making Aqp2 a candidate gene. Sequencing of Aqp2 coding region of affected mice identified a thymine to guanine (T to G) transversion (Figure 1A), which is predicted to lead to a valine for phenylalanine substitution at amino acid 204 of the protein (F204V).","tracks":[{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T8418","span":{"begin":131,"end":144},"obj":"SO_EXT:coding_sequence"},{"id":"T8435","span":{"begin":22,"end":26},"obj":"NCBITaxon:10088"},{"id":"T8436","span":{"begin":47,"end":52},"obj":"SO_EXT:0000704"},{"id":"T8437","span":{"begin":54,"end":63},"obj":"GO:0030849"},{"id":"T8438","span":{"begin":89,"end":93},"obj":"PR_EXT:000004182"},{"id":"T8439","span":{"begin":106,"end":110},"obj":"SO_EXT:0000704"},{"id":"T8440","span":{"begin":126,"end":130},"obj":"PR_EXT:000004182"},{"id":"T8441","span":{"begin":157,"end":161},"obj":"NCBITaxon:10088"},{"id":"T8442","span":{"begin":175,"end":182},"obj":"CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group"},{"id":"T8443","span":{"begin":175,"end":193},"obj":"_FRAGMENT"},{"id":"T8444","span":{"begin":203,"end":215},"obj":"SO_EXT:1000022"},{"id":"T8445","span":{"begin":186,"end":193},"obj":"CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group"},{"id":"T8446","span":{"begin":195,"end":196},"obj":"CHEBI_EXT:thymine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group"},{"id":"T8447","span":{"begin":195,"end":201},"obj":"_FRAGMENT"},{"id":"T8448","span":{"begin":200,"end":201},"obj":"CHEBI_EXT:guanine_nucleobase_or_nucleoside_or_nucleotide_molecular_entity_or_group"},{"id":"T8449","span":{"begin":261,"end":267},"obj":"CHEBI_SO_EXT:valine"},{"id":"T8450","span":{"begin":272,"end":285},"obj":"CHEBI_SO_EXT:phenylalanine"},{"id":"T8451","span":{"begin":286,"end":298},"obj":"SO_EXT:sequence_substitution_entity_or_process"},{"id":"T8452","span":{"begin":302,"end":312},"obj":"CHEBI_SO_EXT:amino_acid"},{"id":"T8453","span":{"begin":324,"end":331},"obj":"CHEBI_PR_EXT:protein"}],"relations":[{"id":"R912","pred":"_lexicallyChainedTo","subj":"T8444","obj":"T8443"},{"id":"R913","pred":"_lexicallyChainedTo","subj":"T8444","obj":"T8447"}],"attributes":[{"subj":"T8418","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8435","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8436","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8437","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8438","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8439","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8440","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8441","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8442","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8443","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8444","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8445","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8446","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8447","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8448","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8449","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8450","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8451","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8452","pred":"source","obj":"craft-ca-core-ex-dev"},{"subj":"T8453","pred":"source","obj":"craft-ca-core-ex-dev"}]},{"project":"craft-ca-core-dev","denotations":[{"id":"T8106","span":{"begin":22,"end":26},"obj":"NCBITaxon:10088"},{"id":"T8107","span":{"begin":47,"end":52},"obj":"SO:0000704"},{"id":"T8108","span":{"begin":54,"end":63},"obj":"GO:0030849"},{"id":"T8109","span":{"begin":89,"end":93},"obj":"PR:000004182"},{"id":"T8110","span":{"begin":106,"end":110},"obj":"SO:0000704"},{"id":"T8111","span":{"begin":126,"end":130},"obj":"PR:000004182"},{"id":"T8112","span":{"begin":157,"end":161},"obj":"NCBITaxon:10088"},{"id":"T8113","span":{"begin":175,"end":193},"obj":"_FRAGMENT"},{"id":"T8114","span":{"begin":203,"end":215},"obj":"SO:1000022"},{"id":"T8115","span":{"begin":195,"end":201},"obj":"_FRAGMENT"}],"relations":[{"id":"R907","pred":"_lexicallyChainedTo","subj":"T8114","obj":"T8113"},{"id":"R908","pred":"_lexicallyChainedTo","subj":"T8114","obj":"T8115"}],"attributes":[{"subj":"T8106","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8107","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8108","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8109","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8110","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8111","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8112","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8113","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8114","pred":"source","obj":"craft-ca-core-dev"},{"subj":"T8115","pred":"source","obj":"craft-ca-core-dev"}]},{"project":"craft-sa-dev","denotations":[{"id":"T9034","span":{"begin":0,"end":3},"obj":"DT"},{"id":"T9035","span":{"begin":4,"end":12},"obj":"NN"},{"id":"T9036","span":{"begin":27,"end":37},"obj":"VBD"},{"id":"T9037","span":{"begin":13,"end":15},"obj":"IN"},{"id":"T9038","span":{"begin":16,"end":21},"obj":"DT"},{"id":"T9039","span":{"begin":22,"end":26},"obj":"NNS"},{"id":"T9040","span":{"begin":38,"end":40},"obj":"IN"},{"id":"T9041","span":{"begin":41,"end":42},"obj":"DT"},{"id":"T9042","span":{"begin":74,"end":80},"obj":"NN"},{"id":"T9043","span":{"begin":43,"end":52},"obj":"JJ"},{"id":"T9044","span":{"begin":52,"end":54},"obj":","},{"id":"T9045","span":{"begin":54,"end":63},"obj":"JJ"},{"id":"T9046","span":{"begin":64,"end":73},"obj":"JJ"},{"id":"T9047","span":{"begin":80,"end":82},"obj":","},{"id":"T9048","span":{"begin":82,"end":88},"obj":"VBG"},{"id":"T9049","span":{"begin":89,"end":93},"obj":"NN"},{"id":"T9050","span":{"begin":106,"end":110},"obj":"NN"},{"id":"T9051","span":{"begin":94,"end":95},"obj":"DT"},{"id":"T9052","span":{"begin":96,"end":105},"obj":"NN"},{"id":"T9053","span":{"begin":110,"end":111},"obj":"."},{"id":"T9054","span":{"begin":111,"end":340},"obj":"sentence"},{"id":"T9055","span":{"begin":112,"end":122},"obj":"NN"},{"id":"T9056","span":{"begin":162,"end":172},"obj":"VBD"},{"id":"T9057","span":{"begin":123,"end":125},"obj":"IN"},{"id":"T9058","span":{"begin":126,"end":130},"obj":"NN"},{"id":"T9059","span":{"begin":138,"end":144},"obj":"NN"},{"id":"T9060","span":{"begin":131,"end":137},"obj":"NN"},{"id":"T9061","span":{"begin":145,"end":147},"obj":"IN"},{"id":"T9062","span":{"begin":148,"end":156},"obj":"VBN"},{"id":"T9063","span":{"begin":157,"end":161},"obj":"NNS"},{"id":"T9064","span":{"begin":173,"end":174},"obj":"DT"},{"id":"T9065","span":{"begin":203,"end":215},"obj":"NN"},{"id":"T9066","span":{"begin":175,"end":182},"obj":"NN"},{"id":"T9067","span":{"begin":183,"end":185},"obj":"IN"},{"id":"T9068","span":{"begin":186,"end":193},"obj":"NN"},{"id":"T9069","span":{"begin":194,"end":195},"obj":"-LRB-"},{"id":"T9070","span":{"begin":195,"end":196},"obj":"NN"},{"id":"T9071","span":{"begin":197,"end":199},"obj":"IN"},{"id":"T9072","span":{"begin":200,"end":201},"obj":"NN"},{"id":"T9073","span":{"begin":201,"end":202},"obj":"-RRB-"},{"id":"T9074","span":{"begin":216,"end":217},"obj":"-LRB-"},{"id":"T9075","span":{"begin":217,"end":223},"obj":"NN"},{"id":"T9076","span":{"begin":224,"end":226},"obj":"CD"},{"id":"T9077","span":{"begin":226,"end":227},"obj":"-RRB-"},{"id":"T9078","span":{"begin":227,"end":229},"obj":","},{"id":"T9079","span":{"begin":229,"end":234},"obj":"WDT"},{"id":"T9080","span":{"begin":238,"end":247},"obj":"VBN"},{"id":"T9081","span":{"begin":235,"end":237},"obj":"VBZ"},{"id":"T9082","span":{"begin":248,"end":250},"obj":"TO"},{"id":"T9083","span":{"begin":251,"end":255},"obj":"VB"},{"id":"T9084","span":{"begin":256,"end":258},"obj":"IN"},{"id":"T9085","span":{"begin":259,"end":260},"obj":"DT"},{"id":"T9086","span":{"begin":286,"end":298},"obj":"NN"},{"id":"T9087","span":{"begin":261,"end":267},"obj":"NN"},{"id":"T9088","span":{"begin":268,"end":271},"obj":"IN"},{"id":"T9089","span":{"begin":272,"end":285},"obj":"NN"},{"id":"T9090","span":{"begin":299,"end":301},"obj":"IN"},{"id":"T9091","span":{"begin":302,"end":307},"obj":"NN"},{"id":"T9092","span":{"begin":308,"end":312},"obj":"NN"},{"id":"T9093","span":{"begin":313,"end":316},"obj":"CD"},{"id":"T9094","span":{"begin":317,"end":319},"obj":"IN"},{"id":"T9095","span":{"begin":320,"end":323},"obj":"DT"},{"id":"T9096","span":{"begin":324,"end":331},"obj":"NN"},{"id":"T9097","span":{"begin":332,"end":333},"obj":"-LRB-"},{"id":"T9098","span":{"begin":333,"end":338},"obj":"NN"},{"id":"T9099","span":{"begin":338,"end":339},"obj":"-RRB-"},{"id":"T9100","span":{"begin":339,"end":340},"obj":"."}],"relations":[{"id":"R956","pred":"pobj","subj":"T9086","obj":"T9084"},{"id":"R957","pred":"nmod","subj":"T9087","obj":"T9086"},{"id":"R958","pred":"prep","subj":"T9088","obj":"T9087"},{"id":"R959","pred":"pobj","subj":"T9089","obj":"T9088"},{"id":"R960","pred":"prep","subj":"T9090","obj":"T9086"},{"id":"R962","pred":"compound","subj":"T9091","obj":"T9092"},{"id":"R963","pred":"pobj","subj":"T9092","obj":"T9090"},{"id":"R964","pred":"nummod","subj":"T9093","obj":"T9092"},{"id":"R965","pred":"prep","subj":"T9094","obj":"T9092"},{"id":"R967","pred":"det","subj":"T9095","obj":"T9096"},{"id":"R968","pred":"pobj","subj":"T9096","obj":"T9094"},{"id":"R969","pred":"punct","subj":"T9097","obj":"T9092"},{"id":"R971","pred":"appos","subj":"T9098","obj":"T9092"},{"id":"R972","pred":"punct","subj":"T9099","obj":"T9092"},{"id":"R973","pred":"punct","subj":"T9100","obj":"T9056"},{"id":"R1091","pred":"det","subj":"T9034","obj":"T9035"},{"id":"R1095","pred":"nsubj","subj":"T9035","obj":"T9036"},{"id":"R1099","pred":"prep","subj":"T9037","obj":"T9035"},{"id":"R1104","pred":"det","subj":"T9038","obj":"T9039"},{"id":"R1108","pred":"pobj","subj":"T9039","obj":"T9037"},{"id":"R1111","pred":"prep","subj":"T9040","obj":"T9036"},{"id":"R1118","pred":"det","subj":"T9041","obj":"T9042"},{"id":"R1122","pred":"pobj","subj":"T9042","obj":"T9040"},{"id":"R1124","pred":"amod","subj":"T9043","obj":"T9042"},{"id":"R1127","pred":"punct","subj":"T9044","obj":"T9042"},{"id":"R1132","pred":"amod","subj":"T9045","obj":"T9046"},{"id":"R1136","pred":"amod","subj":"T9046","obj":"T9042"},{"id":"R1139","pred":"punct","subj":"T9047","obj":"T9036"},{"id":"R1143","pred":"advcl","subj":"T9048","obj":"T9036"},{"id":"R1147","pred":"nsubj","subj":"T9049","obj":"T9050"},{"id":"R1149","pred":"ccomp","subj":"T9050","obj":"T9048"},{"id":"R1151","pred":"det","subj":"T9051","obj":"T9050"},{"id":"R1153","pred":"compound","subj":"T9052","obj":"T9050"},{"id":"R1156","pred":"punct","subj":"T9053","obj":"T9036"},{"id":"R1160","pred":"nsubj","subj":"T9055","obj":"T9056"},{"id":"R1165","pred":"prep","subj":"T9057","obj":"T9055"},{"id":"R1171","pred":"compound","subj":"T9058","obj":"T9059"},{"id":"R1175","pred":"pobj","subj":"T9059","obj":"T9057"},{"id":"R1179","pred":"compound","subj":"T9060","obj":"T9059"},{"id":"R1181","pred":"prep","subj":"T9061","obj":"T9059"},{"id":"R1184","pred":"amod","subj":"T9062","obj":"T9063"},{"id":"R1188","pred":"pobj","subj":"T9063","obj":"T9061"},{"id":"R1192","pred":"det","subj":"T9064","obj":"T9065"},{"id":"R1196","pred":"dobj","subj":"T9065","obj":"T9056"},{"id":"R1200","pred":"nmod","subj":"T9066","obj":"T9065"},{"id":"R1204","pred":"prep","subj":"T9067","obj":"T9066"},{"id":"R1208","pred":"pobj","subj":"T9068","obj":"T9067"},{"id":"R1212","pred":"punct","subj":"T9069","obj":"T9066"},{"id":"R1215","pred":"appos","subj":"T9070","obj":"T9066"},{"id":"R1221","pred":"prep","subj":"T9071","obj":"T9070"},{"id":"R1224","pred":"pobj","subj":"T9072","obj":"T9071"},{"id":"R1225","pred":"punct","subj":"T9073","obj":"T9065"},{"id":"R1226","pred":"punct","subj":"T9074","obj":"T9075"},{"id":"R1229","pred":"parataxis","subj":"T9075","obj":"T9065"},{"id":"R1232","pred":"nummod","subj":"T9076","obj":"T9075"},{"id":"R1235","pred":"punct","subj":"T9077","obj":"T9075"},{"id":"R1239","pred":"punct","subj":"T9078","obj":"T9065"},{"id":"R1243","pred":"dep","subj":"T9079","obj":"T9080"},{"id":"R1247","pred":"relcl","subj":"T9080","obj":"T9065"},{"id":"R1252","pred":"auxpass","subj":"T9081","obj":"T9080"},{"id":"R1256","pred":"aux","subj":"T9082","obj":"T9083"},{"id":"R1259","pred":"xcomp","subj":"T9083","obj":"T9080"},{"id":"R1262","pred":"prep","subj":"T9084","obj":"T9083"},{"id":"R1263","pred":"det","subj":"T9085","obj":"T9086"}],"attributes":[{"subj":"T9034","pred":"source","obj":"craft-sa-dev"},{"subj":"T9035","pred":"source","obj":"craft-sa-dev"},{"subj":"T9036","pred":"source","obj":"craft-sa-dev"},{"subj":"T9037","pred":"source","obj":"craft-sa-dev"},{"subj":"T9038","pred":"source","obj":"craft-sa-dev"},{"subj":"T9039","pred":"source","obj":"craft-sa-dev"},{"subj":"T9040","pred":"source","obj":"craft-sa-dev"},{"subj":"T9041","pred":"source","obj":"craft-sa-dev"},{"subj":"T9042","pred":"source","obj":"craft-sa-dev"},{"subj":"T9043","pred":"source","obj":"craft-sa-dev"},{"subj":"T9044","pred":"source","obj":"craft-sa-dev"},{"subj":"T9045","pred":"source","obj":"craft-sa-dev"},{"subj":"T9046","pred":"source","obj":"craft-sa-dev"},{"subj":"T9047","pred":"source","obj":"craft-sa-dev"},{"subj":"T9048","pred":"source","obj":"craft-sa-dev"},{"subj":"T9049","pred":"source","obj":"craft-sa-dev"},{"subj":"T9050","pred":"source","obj":"craft-sa-dev"},{"subj":"T9051","pred":"source","obj":"craft-sa-dev"},{"subj":"T9052","pred":"source","obj":"craft-sa-dev"},{"subj":"T9053","pred":"source","obj":"craft-sa-dev"},{"subj":"T9054","pred":"source","obj":"craft-sa-dev"},{"subj":"T9055","pred":"source","obj":"craft-sa-dev"},{"subj":"T9056","pred":"source","obj":"craft-sa-dev"},{"subj":"T9057","pred":"source","obj":"craft-sa-dev"},{"subj":"T9058","pred":"source","obj":"craft-sa-dev"},{"subj":"T9059","pred":"source","obj":"craft-sa-dev"},{"subj":"T9060","pred":"source","obj":"craft-sa-dev"},{"subj":"T9061","pred":"source","obj":"craft-sa-dev"},{"subj":"T9062","pred":"source","obj":"craft-sa-dev"},{"subj":"T9063","pred":"source","obj":"craft-sa-dev"},{"subj":"T9064","pred":"source","obj":"craft-sa-dev"},{"subj":"T9065","pred":"source","obj":"craft-sa-dev"},{"subj":"T9066","pred":"source","obj":"craft-sa-dev"},{"subj":"T9067","pred":"source","obj":"craft-sa-dev"},{"subj":"T9068","pred":"source","obj":"craft-sa-dev"},{"subj":"T9069","pred":"source","obj":"craft-sa-dev"},{"subj":"T9070","pred":"source","obj":"craft-sa-dev"},{"subj":"T9071","pred":"source","obj":"craft-sa-dev"},{"subj":"T9072","pred":"source","obj":"craft-sa-dev"},{"subj":"T9073","pred":"source","obj":"craft-sa-dev"},{"subj":"T9074","pred":"source","obj":"craft-sa-dev"},{"subj":"T9075","pred":"source","obj":"craft-sa-dev"},{"subj":"T9076","pred":"source","obj":"craft-sa-dev"},{"subj":"T9077","pred":"source","obj":"craft-sa-dev"},{"subj":"T9078","pred":"source","obj":"craft-sa-dev"},{"subj":"T9079","pred":"source","obj":"craft-sa-dev"},{"subj":"T9080","pred":"source","obj":"craft-sa-dev"},{"subj":"T9081","pred":"source","obj":"craft-sa-dev"},{"subj":"T9082","pred":"source","obj":"craft-sa-dev"},{"subj":"T9083","pred":"source","obj":"craft-sa-dev"},{"subj":"T9084","pred":"source","obj":"craft-sa-dev"},{"subj":"T9085","pred":"source","obj":"craft-sa-dev"},{"subj":"T9086","pred":"source","obj":"craft-sa-dev"},{"subj":"T9087","pred":"source","obj":"craft-sa-dev"},{"subj":"T9088","pred":"source","obj":"craft-sa-dev"},{"subj":"T9089","pred":"source","obj":"craft-sa-dev"},{"subj":"T9090","pred":"source","obj":"craft-sa-dev"},{"subj":"T9091","pred":"source","obj":"craft-sa-dev"},{"subj":"T9092","pred":"source","obj":"craft-sa-dev"},{"subj":"T9093","pred":"source","obj":"craft-sa-dev"},{"subj":"T9094","pred":"source","obj":"craft-sa-dev"},{"subj":"T9095","pred":"source","obj":"craft-sa-dev"},{"subj":"T9096","pred":"source","obj":"craft-sa-dev"},{"subj":"T9097","pred":"source","obj":"craft-sa-dev"},{"subj":"T9098","pred":"source","obj":"craft-sa-dev"},{"subj":"T9099","pred":"source","obj":"craft-sa-dev"},{"subj":"T9100","pred":"source","obj":"craft-sa-dev"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"craft-ca-core-ex-dev","color":"#93daec","default":true},{"id":"craft-ca-core-dev","color":"#ece393"},{"id":"craft-sa-dev","color":"#c993ec"}]}]}}