PMC:1166548 / 10736-14406 JSONTXT

{"project":"craft-sa-dev","denotations":[{"id":"T2802","span":{"begin":0,"end":2},"obj":"NN"},{"id":"T2803","span":{"begin":3,"end":7},"obj":"NNS"},{"id":"T2804","span":{"begin":32,"end":36},"obj":"VBP"},{"id":"T2805","span":{"begin":8,"end":10},"obj":"IN"},{"id":"T2806","span":{"begin":11,"end":14},"obj":"DT"},{"id":"T2807","span":{"begin":21,"end":31},"obj":"NN"},{"id":"T2808","span":{"begin":15,"end":20},"obj":"JJ"},{"id":"T2809","span":{"begin":37,"end":41},"obj":"RBR"},{"id":"T2810","span":{"begin":59,"end":71},"obj":"NN"},{"id":"T2811","span":{"begin":42,"end":52},"obj":"JJ"},{"id":"T2812","span":{"begin":53,"end":58},"obj":"NN"},{"id":"T2813","span":{"begin":71,"end":315},"obj":"sentence"},{"id":"T2814","span":{"begin":72,"end":75},"obj":"DT"},{"id":"T2815","span":{"begin":103,"end":113},"obj":"NN"},{"id":"T2816","span":{"begin":76,"end":80},"obj":"RBS"},{"id":"T2817","span":{"begin":81,"end":89},"obj":"JJ"},{"id":"T2818","span":{"begin":90,"end":102},"obj":"JJ"},{"id":"T2819","span":{"begin":146,"end":148},"obj":"VBZ"},{"id":"T2820","span":{"begin":114,"end":116},"obj":"IN"},{"id":"T2821","span":{"begin":117,"end":120},"obj":"DT"},{"id":"T2822","span":{"begin":136,"end":145},"obj":"NN"},{"id":"T2823","span":{"begin":121,"end":123},"obj":"NN"},{"id":"T2824","span":{"begin":124,"end":129},"obj":"NN"},{"id":"T2825","span":{"begin":130,"end":135},"obj":"JJ"},{"id":"T2826","span":{"begin":149,"end":152},"obj":"DT"},{"id":"T2827","span":{"begin":153,"end":165},"obj":"NN"},{"id":"T2828","span":{"begin":166,"end":168},"obj":"IN"},{"id":"T2829","span":{"begin":169,"end":174},"obj":"NN"},{"id":"T2830","span":{"begin":175,"end":177},"obj":"IN"},{"id":"T2831","span":{"begin":178,"end":188},"obj":"JJ"},{"id":"T2832","span":{"begin":189,"end":195},"obj":"NNS"},{"id":"T2833","span":{"begin":196,"end":201},"obj":"WDT"},{"id":"T2834","span":{"begin":205,"end":215},"obj":"VBN"},{"id":"T2835","span":{"begin":202,"end":204},"obj":"VBZ"},{"id":"T2836","span":{"begin":216,"end":220},"obj":"IN"},{"id":"T2837","span":{"begin":221,"end":224},"obj":"DT"},{"id":"T2838","span":{"begin":232,"end":243},"obj":"NN"},{"id":"T2839","span":{"begin":225,"end":231},"obj":"JJ"},{"id":"T2840","span":{"begin":244,"end":248},"obj":"WDT"},{"id":"T2841","span":{"begin":249,"end":256},"obj":"VBZ"},{"id":"T2842","span":{"begin":257,"end":259},"obj":"IN"},{"id":"T2843","span":{"begin":260,"end":265},"obj":"NN"},{"id":"T2844","span":{"begin":266,"end":268},"obj":"IN"},{"id":"T2845","span":{"begin":269,"end":274},"obj":"DT"},{"id":"T2846","span":{"begin":275,"end":279},"obj":"NNS"},{"id":"T2847","span":{"begin":280,"end":282},"obj":"IN"},{"id":"T2848","span":{"begin":283,"end":284},"obj":"DT"},{"id":"T2849","span":{"begin":305,"end":309},"obj":"NN"},{"id":"T2850","span":{"begin":285,"end":293},"obj":"JJ"},{"id":"T2851","span":{"begin":294,"end":299},"obj":"JJ"},{"id":"T2852","span":{"begin":300,"end":304},"obj":"NN"},{"id":"T2853","span":{"begin":310,"end":311},"obj":"-LRB-"},{"id":"T2854","span":{"begin":311,"end":313},"obj":"CD"},{"id":"T2855","span":{"begin":313,"end":314},"obj":"-RRB-"},{"id":"T2856","span":{"begin":314,"end":315},"obj":"."},{"id":"T2857","span":{"begin":315,"end":437},"obj":"sentence"},{"id":"T2858","span":{"begin":316,"end":321},"obj":"VBG"},{"id":"T2859","span":{"begin":427,"end":436},"obj":"VBN"},{"id":"T2860","span":{"begin":322,"end":330},"obj":"JJ"},{"id":"T2861","span":{"begin":331,"end":335},"obj":"NN"},{"id":"T2862","span":{"begin":345,"end":353},"obj":"NN"},{"id":"T2863","span":{"begin":336,"end":342},"obj":"NNP"},{"id":"T2864","span":{"begin":342,"end":344},"obj":"POS"},{"id":"T2865","span":{"begin":354,"end":357},"obj":"IN"},{"id":"T2866","span":{"begin":358,"end":365},"obj":"JJ"},{"id":"T2867","span":{"begin":366,"end":372},"obj":"NNS"},{"id":"T2868","span":{"begin":372,"end":374},"obj":","},{"id":"T2869","span":{"begin":374,"end":386},"obj":"JJ"},{"id":"T2870","span":{"begin":387,"end":395},"obj":"NN"},{"id":"T2871","span":{"begin":396,"end":398},"obj":"IN"},{"id":"T2872","span":{"begin":399,"end":404},"obj":"JJ"},{"id":"T2873","span":{"begin":415,"end":422},"obj":"NNS"},{"id":"T2874","span":{"begin":405,"end":414},"obj":"NN"},{"id":"T2875","span":{"begin":423,"end":426},"obj":"VBD"},{"id":"T2876","span":{"begin":436,"end":437},"obj":"."},{"id":"T2877","span":{"begin":437,"end":530},"obj":"sentence"},{"id":"T2878","span":{"begin":438,"end":441},"obj":"DT"},{"id":"T2879","span":{"begin":458,"end":467},"obj":"NN"},{"id":"T2880","span":{"begin":442,"end":446},"obj":"JJ"},{"id":"T2881","span":{"begin":447,"end":451},"obj":"NN"},{"id":"T2882","span":{"begin":452,"end":457},"obj":"JJ"},{"id":"T2883","span":{"begin":517,"end":521},"obj":"VBD"},{"id":"T2884","span":{"begin":468,"end":470},"obj":"IN"},{"id":"T2885","span":{"begin":471,"end":475},"obj":"CC"},{"id":"T2886","span":{"begin":480,"end":482},"obj":"NN"},{"id":"T2887","span":{"begin":476,"end":479},"obj":"DT"},{"id":"T2888","span":{"begin":483,"end":486},"obj":"CC"},{"id":"T2889","span":{"begin":487,"end":490},"obj":"DT"},{"id":"T2890","span":{"begin":491,"end":496},"obj":"JJ"},{"id":"T2891","span":{"begin":505,"end":516},"obj":"NNS"},{"id":"T2892","span":{"begin":497,"end":504},"obj":"JJ"},{"id":"T2893","span":{"begin":522,"end":529},"obj":"JJ"},{"id":"T2894","span":{"begin":529,"end":530},"obj":"."},{"id":"T2895","span":{"begin":530,"end":648},"obj":"sentence"},{"id":"T2896","span":{"begin":531,"end":534},"obj":"DT"},{"id":"T2897","span":{"begin":546,"end":552},"obj":"NNS"},{"id":"T2898","span":{"begin":535,"end":545},"obj":"JJ"},{"id":"T2899","span":{"begin":553,"end":557},"obj":"VBD"},{"id":"T2900","span":{"begin":558,"end":562},"obj":"RB"},{"id":"T2901","span":{"begin":563,"end":568},"obj":"JJ"},{"id":"T2902","span":{"begin":569,"end":573},"obj":"IN"},{"id":"T2903","span":{"begin":574,"end":578},"obj":"JJ"},{"id":"T2904","span":{"begin":579,"end":585},"obj":"NNS"},{"id":"T2905","span":{"begin":586,"end":588},"obj":"IN"},{"id":"T2906","span":{"begin":589,"end":592},"obj":"NN"},{"id":"T2907","span":{"begin":593,"end":603},"obj":"NN"},{"id":"T2908","span":{"begin":592,"end":593},"obj":"HYPH"},{"id":"T2909","span":{"begin":604,"end":606},"obj":"IN"},{"id":"T2910","span":{"begin":607,"end":610},"obj":"DT"},{"id":"T2911","span":{"begin":611,"end":616},"obj":"NN"},{"id":"T2912","span":{"begin":617,"end":618},"obj":"-LRB-"},{"id":"T2913","span":{"begin":623,"end":625},"obj":"CD"},{"id":"T2914","span":{"begin":618,"end":622},"obj":"NN"},{"id":"T2915","span":{"begin":626,"end":629},"obj":"CC"},{"id":"T2916","span":{"begin":630,"end":632},"obj":"CD"},{"id":"T2917","span":{"begin":632,"end":634},"obj":","},{"id":"T2918","span":{"begin":634,"end":646},"obj":"RB"},{"id":"T2919","span":{"begin":646,"end":647},"obj":"-RRB-"},{"id":"T2920","span":{"begin":647,"end":648},"obj":"."},{"id":"T2921","span":{"begin":648,"end":775},"obj":"sentence"},{"id":"T2922","span":{"begin":649,"end":652},"obj":"DT"},{"id":"T2923","span":{"begin":653,"end":661},"obj":"NNS"},{"id":"T2924","span":{"begin":687,"end":691},"obj":"VBD"},{"id":"T2925","span":{"begin":662,"end":664},"obj":"IN"},{"id":"T2926","span":{"begin":665,"end":668},"obj":"DT"},{"id":"T2927","span":{"begin":676,"end":686},"obj":"NN"},{"id":"T2928","span":{"begin":669,"end":675},"obj":"NN"},{"id":"T2929","span":{"begin":692,"end":702},"obj":"RB"},{"id":"T2930","span":{"begin":703,"end":710},"obj":"JJ"},{"id":"T2931","span":{"begin":711,"end":714},"obj":"CC"},{"id":"T2932","span":{"begin":715,"end":721},"obj":"NN"},{"id":"T2933","span":{"begin":722,"end":727},"obj":"NNS"},{"id":"T2934","span":{"begin":742,"end":749},"obj":"VBN"},{"id":"T2935","span":{"begin":728,"end":732},"obj":"VBD"},{"id":"T2936","span":{"begin":733,"end":741},"obj":"RB"},{"id":"T2937","span":{"begin":750,"end":752},"obj":"IN"},{"id":"T2938","span":{"begin":753,"end":756},"obj":"DT"},{"id":"T2939","span":{"begin":767,"end":774},"obj":"NNS"},{"id":"T2940","span":{"begin":757,"end":761},"obj":"JJ"},{"id":"T2941","span":{"begin":762,"end":766},"obj":"NN"},{"id":"T2942","span":{"begin":774,"end":775},"obj":"."},{"id":"T2943","span":{"begin":775,"end":917},"obj":"sentence"},{"id":"T2944","span":{"begin":776,"end":778},"obj":"IN"},{"id":"T2945","span":{"begin":843,"end":852},"obj":"VBD"},{"id":"T2946","span":{"begin":779,"end":787},"obj":"NN"},{"id":"T2947","span":{"begin":787,"end":789},"obj":","},{"id":"T2948","span":{"begin":789,"end":792},"obj":"DT"},{"id":"T2949","span":{"begin":793,"end":802},"obj":"NN"},{"id":"T2950","span":{"begin":803,"end":805},"obj":"IN"},{"id":"T2951","span":{"begin":806,"end":808},"obj":"NN"},{"id":"T2952","span":{"begin":809,"end":813},"obj":"NNS"},{"id":"T2953","span":{"begin":814,"end":816},"obj":"IN"},{"id":"T2954","span":{"begin":817,"end":820},"obj":"DT"},{"id":"T2955","span":{"begin":832,"end":842},"obj":"NN"},{"id":"T2956","span":{"begin":821,"end":823},"obj":"NN"},{"id":"T2957","span":{"begin":824,"end":831},"obj":"JJ"},{"id":"T2958","span":{"begin":853,"end":860},"obj":"RB"},{"id":"T2959","span":{"begin":861,"end":868},"obj":"VBN"},{"id":"T2960","span":{"begin":869,"end":875},"obj":"NNS"},{"id":"T2961","span":{"begin":876,"end":882},"obj":"VBN"},{"id":"T2962","span":{"begin":883,"end":887},"obj":"IN"},{"id":"T2963","span":{"begin":888,"end":891},"obj":"NN"},{"id":"T2964","span":{"begin":892,"end":900},"obj":"JJ"},{"id":"T2965","span":{"begin":891,"end":892},"obj":"HYPH"},{"id":"T2966","span":{"begin":901,"end":906},"obj":"NN"},{"id":"T2967","span":{"begin":907,"end":908},"obj":"-LRB-"},{"id":"T2968","span":{"begin":908,"end":912},"obj":"NN"},{"id":"T2969","span":{"begin":913,"end":915},"obj":"CD"},{"id":"T2970","span":{"begin":915,"end":916},"obj":"-RRB-"},{"id":"T2971","span":{"begin":916,"end":917},"obj":"."},{"id":"T2972","span":{"begin":917,"end":1024},"obj":"sentence"},{"id":"T2973","span":{"begin":918,"end":920},"obj":"NN"},{"id":"T2974","span":{"begin":921,"end":925},"obj":"NNS"},{"id":"T2975","span":{"begin":950,"end":953},"obj":"VBD"},{"id":"T2976","span":{"begin":926,"end":928},"obj":"IN"},{"id":"T2977","span":{"begin":929,"end":932},"obj":"DT"},{"id":"T2978","span":{"begin":939,"end":949},"obj":"NN"},{"id":"T2979","span":{"begin":933,"end":938},"obj":"JJ"},{"id":"T2980","span":{"begin":954,"end":958},"obj":"JJ"},{"id":"T2981","span":{"begin":965,"end":977},"obj":"NN"},{"id":"T2982","span":{"begin":959,"end":964},"obj":"NN"},{"id":"T2983","span":{"begin":978,"end":982},"obj":"IN"},{"id":"T2984","span":{"begin":983,"end":985},"obj":"NN"},{"id":"T2985","span":{"begin":986,"end":990},"obj":"NNS"},{"id":"T2986","span":{"begin":991,"end":993},"obj":"IN"},{"id":"T2987","span":{"begin":994,"end":997},"obj":"DT"},{"id":"T2988","span":{"begin":1001,"end":1011},"obj":"NN"},{"id":"T2989","span":{"begin":998,"end":1000},"obj":"NN"},{"id":"T2990","span":{"begin":1012,"end":1013},"obj":"-LRB-"},{"id":"T2991","span":{"begin":1013,"end":1017},"obj":"NN"},{"id":"T2992","span":{"begin":1018,"end":1020},"obj":"CD"},{"id":"T2993","span":{"begin":1020,"end":1021},"obj":"SYM"},{"id":"T2994","span":{"begin":1021,"end":1022},"obj":"NN"},{"id":"T2995","span":{"begin":1022,"end":1023},"obj":"-RRB-"},{"id":"T2996","span":{"begin":1023,"end":1024},"obj":"."},{"id":"T2997","span":{"begin":1024,"end":1113},"obj":"sentence"},{"id":"T2998","span":{"begin":1025,"end":1028},"obj":"DT"},{"id":"T2999","span":{"begin":1029,"end":1035},"obj":"NN"},{"id":"T3000","span":{"begin":1080,"end":1083},"obj":"VBD"},{"id":"T3001","span":{"begin":1036,"end":1038},"obj":"IN"},{"id":"T3002","span":{"begin":1039,"end":1044},"obj":"NN"},{"id":"T3003","span":{"begin":1045,"end":1047},"obj":"IN"},{"id":"T3004","span":{"begin":1048,"end":1050},"obj":"NN"},{"id":"T3005","span":{"begin":1051,"end":1055},"obj":"NNS"},{"id":"T3006","span":{"begin":1056,"end":1058},"obj":"IN"},{"id":"T3007","span":{"begin":1059,"end":1062},"obj":"DT"},{"id":"T3008","span":{"begin":1069,"end":1079},"obj":"NN"},{"id":"T3009","span":{"begin":1063,"end":1068},"obj":"JJ"},{"id":"T3010","span":{"begin":1084,"end":1092},"obj":"JJ"},{"id":"T3011","span":{"begin":1093,"end":1097},"obj":"IN"},{"id":"T3012","span":{"begin":1098,"end":1103},"obj":"NN"},{"id":"T3013","span":{"begin":1104,"end":1106},"obj":"IN"},{"id":"T3014","span":{"begin":1107,"end":1112},"obj":"NN"},{"id":"T3015","span":{"begin":1112,"end":1113},"obj":"."},{"id":"T3016","span":{"begin":1113,"end":1226},"obj":"sentence"},{"id":"T3017","span":{"begin":1114,"end":1116},"obj":"IN"},{"id":"T3018","span":{"begin":1165,"end":1176},"obj":"VBN"},{"id":"T3019","span":{"begin":1117,"end":1121},"obj":"DT"},{"id":"T3020","span":{"begin":1122,"end":1126},"obj":"NNS"},{"id":"T3021","span":{"begin":1127,"end":1128},"obj":"-LRB-"},{"id":"T3022","span":{"begin":1128,"end":1132},"obj":"NN"},{"id":"T3023","span":{"begin":1133,"end":1135},"obj":"CD"},{"id":"T3024","span":{"begin":1135,"end":1136},"obj":"-RRB-"},{"id":"T3025","span":{"begin":1136,"end":1138},"obj":","},{"id":"T3026","span":{"begin":1138,"end":1142},"obj":"RB"},{"id":"T3027","span":{"begin":1154,"end":1160},"obj":"NNS"},{"id":"T3028","span":{"begin":1143,"end":1153},"obj":"JJ"},{"id":"T3029","span":{"begin":1161,"end":1164},"obj":"VBD"},{"id":"T3030","span":{"begin":1177,"end":1182},"obj":"NN"},{"id":"T3031","span":{"begin":1183,"end":1186},"obj":"CC"},{"id":"T3032","span":{"begin":1187,"end":1190},"obj":"DT"},{"id":"T3033","span":{"begin":1197,"end":1203},"obj":"NNS"},{"id":"T3034","span":{"begin":1191,"end":1196},"obj":"NN"},{"id":"T3035","span":{"begin":1204,"end":1208},"obj":"VBD"},{"id":"T3036","span":{"begin":1209,"end":1212},"obj":"RB"},{"id":"T3037","span":{"begin":1213,"end":1217},"obj":"RB"},{"id":"T3038","span":{"begin":1218,"end":1225},"obj":"JJ"},{"id":"T3039","span":{"begin":1225,"end":1226},"obj":"."},{"id":"T3040","span":{"begin":1226,"end":1341},"obj":"sentence"},{"id":"T3041","span":{"begin":1227,"end":1229},"obj":"IN"},{"id":"T3042","span":{"begin":1246,"end":1249},"obj":"VBD"},{"id":"T3043","span":{"begin":1230,"end":1234},"obj":"DT"},{"id":"T3044","span":{"begin":1235,"end":1239},"obj":"NNS"},{"id":"T3045","span":{"begin":1240,"end":1245},"obj":"EX"},{"id":"T3046","span":{"begin":1250,"end":1254},"obj":"JJR"},{"id":"T3047","span":{"begin":1255,"end":1260},"obj":"NN"},{"id":"T3048","span":{"begin":1261,"end":1263},"obj":"IN"},{"id":"T3072","span":{"begin":1353,"end":1356},"obj":"CD"},{"id":"T3073","span":{"begin":1360,"end":1364},"obj":"NNS"},{"id":"T3074","span":{"begin":1357,"end":1359},"obj":"NN"},{"id":"T3075","span":{"begin":1365,"end":1367},"obj":"IN"},{"id":"T3076","span":{"begin":1368,"end":1371},"obj":"DT"},{"id":"T3077","span":{"begin":1378,"end":1388},"obj":"NN"},{"id":"T3078","span":{"begin":1372,"end":1377},"obj":"JJ"},{"id":"T3079","span":{"begin":1389,"end":1393},"obj":"VBD"},{"id":"T3080","span":{"begin":1403,"end":1417},"obj":"RB"},{"id":"T3081","span":{"begin":1417,"end":1419},"obj":","},{"id":"T3082","span":{"begin":1419,"end":1422},"obj":"CC"},{"id":"T3083","span":{"begin":1423,"end":1428},"obj":"CD"},{"id":"T3084","span":{"begin":1429,"end":1432},"obj":"VBD"},{"id":"T3085","span":{"begin":1433,"end":1439},"obj":"JJ"},{"id":"T3086","span":{"begin":1440,"end":1445},"obj":"NN"},{"id":"T3087","span":{"begin":1445,"end":1447},"obj":","},{"id":"T3088","span":{"begin":1447,"end":1450},"obj":"CD"},{"id":"T3089","span":{"begin":1451,"end":1454},"obj":"VBD"},{"id":"T3090","span":{"begin":1455,"end":1459},"obj":"DT"},{"id":"T3091","span":{"begin":1460,"end":1465},"obj":"NN"},{"id":"T3092","span":{"begin":1465,"end":1467},"obj":","},{"id":"T3093","span":{"begin":1467,"end":1470},"obj":"CC"},{"id":"T3094","span":{"begin":1471,"end":1474},"obj":"CD"},{"id":"T3095","span":{"begin":1475,"end":1478},"obj":"VBD"},{"id":"T3096","span":{"begin":1479,"end":1487},"obj":"JJ"},{"id":"T3097","span":{"begin":1488,"end":1495},"obj":"NNS"},{"id":"T3098","span":{"begin":1496,"end":1498},"obj":"IN"},{"id":"T3099","span":{"begin":1499,"end":1504},"obj":"NN"},{"id":"T3100","span":{"begin":1504,"end":1505},"obj":"."},{"id":"T3101","span":{"begin":1505,"end":1664},"obj":"sentence"},{"id":"T3102","span":{"begin":1506,"end":1513},"obj":"IN"},{"id":"T3103","span":{"begin":1571,"end":1574},"obj":"VBD"},{"id":"T3104","span":{"begin":1514,"end":1517},"obj":"DT"},{"id":"T3105","span":{"begin":1518,"end":1529},"obj":"NN"},{"id":"T3106","span":{"begin":1529,"end":1531},"obj":","},{"id":"T3107","span":{"begin":1531,"end":1534},"obj":"PDT"},{"id":"T3108","span":{"begin":1542,"end":1546},"obj":"NNS"},{"id":"T3109","span":{"begin":1535,"end":1538},"obj":"DT"},{"id":"T3110","span":{"begin":1539,"end":1541},"obj":"NN"},{"id":"T3111","span":{"begin":1547,"end":1549},"obj":"IN"},{"id":"T3112","span":{"begin":1550,"end":1553},"obj":"DT"},{"id":"T3113","span":{"begin":1560,"end":1570},"obj":"NN"},{"id":"T3114","span":{"begin":1554,"end":1559},"obj":"JJ"},{"id":"T3115","span":{"begin":1575,"end":1579},"obj":"JJ"},{"id":"T3116","span":{"begin":1586,"end":1594},"obj":"NN"},{"id":"T3117","span":{"begin":1580,"end":1585},"obj":"NN"},{"id":"T3118","span":{"begin":1595,"end":1598},"obj":"CC"},{"id":"T3119","span":{"begin":1599,"end":1603},"obj":"JJ"},{"id":"T3120","span":{"begin":1610,"end":1622},"obj":"NN"},{"id":"T3121","span":{"begin":1604,"end":1609},"obj":"NN"},{"id":"T3122","span":{"begin":1623,"end":1631},"obj":"VBN"},{"id":"T3123","span":{"begin":1632,"end":1634},"obj":"IN"},{"id":"T3124","span":{"begin":1635,"end":1637},"obj":"NN"},{"id":"T3125","span":{"begin":1638,"end":1642},"obj":"NNS"},{"id":"T3126","span":{"begin":1643,"end":1645},"obj":"IN"},{"id":"T3127","span":{"begin":1646,"end":1649},"obj":"DT"},{"id":"T3128","span":{"begin":1653,"end":1663},"obj":"NN"},{"id":"T3129","span":{"begin":1650,"end":1652},"obj":"NN"},{"id":"T3130","span":{"begin":1663,"end":1664},"obj":"."},{"id":"T3133","span":{"begin":2696,"end":2703},"obj":"VBZ"},{"id":"T3134","span":{"begin":2691,"end":2693},"obj":","},{"id":"T3135","span":{"begin":2693,"end":2695},"obj":"PRP"},{"id":"T3136","span":{"begin":2704,"end":2708},"obj":"IN"},{"id":"T3137","span":{"begin":2797,"end":2803},"obj":"VBP"},{"id":"T3138","span":{"begin":2709,"end":2717},"obj":"WDT"},{"id":"T3139","span":{"begin":2722,"end":2728},"obj":"NN"},{"id":"T3140","span":{"begin":2718,"end":2721},"obj":"DT"},{"id":"T3141","span":{"begin":2729,"end":2731},"obj":"IN"},{"id":"T3142","span":{"begin":2732,"end":2735},"obj":"DT"},{"id":"T3143","span":{"begin":2744,"end":2755},"obj":"NNS"},{"id":"T3144","span":{"begin":2736,"end":2743},"obj":"JJ"},{"id":"T3145","span":{"begin":2756,"end":2763},"obj":"IN"},{"id":"T3146","span":{"begin":2764,"end":2767},"obj":"DT"},{"id":"T3147","span":{"begin":2783,"end":2790},"obj":"NNS"},{"id":"T3148","span":{"begin":2768,"end":2771},"obj":"CD"},{"id":"T3149","span":{"begin":2772,"end":2782},"obj":"NN"},{"id":"T3150","span":{"begin":2790,"end":2792},"obj":","},{"id":"T3151","span":{"begin":2792,"end":2796},"obj":"PRP"},{"id":"T3152","span":{"begin":2804,"end":2813},"obj":"NN"},{"id":"T3153","span":{"begin":2814,"end":2817},"obj":"CC"},{"id":"T3154","span":{"begin":2818,"end":2830},"obj":"NN"},{"id":"T3155","span":{"begin":2831,"end":2833},"obj":"IN"},{"id":"T3156","span":{"begin":2834,"end":2839},"obj":"NN"},{"id":"T3157","span":{"begin":2840,"end":2842},"obj":"IN"},{"id":"T3158","span":{"begin":2843,"end":2846},"obj":"DT"},{"id":"T3159","span":{"begin":2856,"end":2865},"obj":"NN"},{"id":"T3160","span":{"begin":2847,"end":2849},"obj":"NN"},{"id":"T3161","span":{"begin":2850,"end":2855},"obj":"JJ"},{"id":"T3162","span":{"begin":2865,"end":2866},"obj":"."},{"id":"T3163","span":{"begin":2866,"end":3058},"obj":"sentence"},{"id":"T3164","span":{"begin":2867,"end":2869},"obj":"TO"},{"id":"T3165","span":{"begin":2870,"end":2879},"obj":"VB"},{"id":"T3166","span":{"begin":2979,"end":2983},"obj":"VBN"},{"id":"T3167","span":{"begin":2880,"end":2882},"obj":"IN"},{"id":"T3168","span":{"begin":2907,"end":2916},"obj":"VBN"},{"id":"T3169","span":{"begin":2883,"end":2886},"obj":"DT"},{"id":"T3170","span":{"begin":2887,"end":2897},"obj":"NN"},{"id":"T3171","span":{"begin":2898,"end":2903},"obj":"MD"},{"id":"T3172","span":{"begin":2904,"end":2906},"obj":"VB"},{"id":"T3173","span":{"begin":2917,"end":2920},"obj":"IN"},{"id":"T3174","span":{"begin":2921,"end":2923},"obj":"IN"},{"id":"T3175","span":{"begin":2924,"end":2931},"obj":"JJ"},{"id":"T3176","span":{"begin":2938,"end":2942},"obj":"NN"},{"id":"T3177","span":{"begin":2932,"end":2937},"obj":"NN"},{"id":"T3178","span":{"begin":2943,"end":2953},"obj":"NN"},{"id":"T3179","span":{"begin":2953,"end":2955},"obj":","},{"id":"T3180","span":{"begin":2955,"end":2967},"obj":"JJ"},{"id":"T3181","span":{"begin":2971,"end":2974},"obj":"NN"},{"id":"T3182","span":{"begin":2968,"end":2970},"obj":"NN"},{"id":"T3183","span":{"begin":2970,"end":2971},"obj":"HYPH"},{"id":"T3184","span":{"begin":2975,"end":2978},"obj":"VBD"},{"id":"T3185","span":{"begin":2984,"end":2986},"obj":"TO"},{"id":"T3186","span":{"begin":2987,"end":2994},"obj":"VB"},{"id":"T3187","span":{"begin":2995,"end":2999},"obj":"NN"},{"id":"T3188","span":{"begin":3000,"end":3010},"obj":"NN"},{"id":"T3189","span":{"begin":3011,"end":3013},"obj":"IN"},{"id":"T3190","span":{"begin":3014,"end":3017},"obj":"DT"},{"id":"T3191","span":{"begin":3047,"end":3051},"obj":"NN"},{"id":"T3192","span":{"begin":3018,"end":3028},"obj":"JJ"},{"id":"T3193","span":{"begin":3036,"end":3040},"obj":"NN"},{"id":"T3194","span":{"begin":3029,"end":3035},"obj":"NN"},{"id":"T3195","span":{"begin":3041,"end":3046},"obj":"NN"},{"id":"T3196","span":{"begin":3051,"end":3053},"obj":","},{"id":"T3197","span":{"begin":3053,"end":3057},"obj":"NN"},{"id":"T3198","span":{"begin":3057,"end":3058},"obj":"."},{"id":"T3199","span":{"begin":3058,"end":3208},"obj":"sentence"},{"id":"T3200","span":{"begin":3059,"end":3061},"obj":"IN"},{"id":"T3201","span":{"begin":3091,"end":3094},"obj":"VBD"},{"id":"T3202","span":{"begin":3062,"end":3066},"obj":"JJ"},{"id":"T3203","span":{"begin":3067,"end":3071},"obj":"NN"},{"id":"T3204","span":{"begin":3072,"end":3081},"obj":"NN"},{"id":"T3205","span":{"begin":3081,"end":3083},"obj":","},{"id":"T3206","span":{"begin":3083,"end":3085},"obj":"NN"},{"id":"T3207","span":{"begin":3086,"end":3090},"obj":"NNS"},{"id":"T3208","span":{"begin":3095,"end":3100},"obj":"CD"},{"id":"T3209","span":{"begin":3105,"end":3110},"obj":"CD"},{"id":"T3210","span":{"begin":3101,"end":3102},"obj":"SYM"},{"id":"T3211","span":{"begin":3102,"end":3103},"obj":"HYPH"},{"id":"T3212","span":{"begin":3103,"end":3104},"obj":"SYM"},{"id":"T3213","span":{"begin":3111,"end":3117},"obj":"NNS"},{"id":"T3214","span":{"begin":3118,"end":3120},"obj":"IN"},{"id":"T3215","span":{"begin":3121,"end":3125},"obj":"NN"},{"id":"T3216","span":{"begin":3126,"end":3131},"obj":"NN"},{"id":"T3217","span":{"begin":3125,"end":3126},"obj":"HYPH"},{"id":"T3218","span":{"begin":3132,"end":3133},"obj":"-LRB-"},{"id":"T3219","span":{"begin":3137,"end":3138},"obj":"CD"},{"id":"T3220","span":{"begin":3133,"end":3134},"obj":"NN"},{"id":"T3221","span":{"begin":3135,"end":3136},"obj":"SYM"},{"id":"T3222","span":{"begin":3138,"end":3139},"obj":"-RRB-"},{"id":"T3223","span":{"begin":3139,"end":3141},"obj":","},{"id":"T3224","span":{"begin":3141,"end":3144},"obj":"CC"},{"id":"T3225","span":{"begin":3145,"end":3147},"obj":"IN"},{"id":"T3226","span":{"begin":3179,"end":3182},"obj":"VBD"},{"id":"T3227","span":{"begin":3148,"end":3151},"obj":"DT"},{"id":"T3228","span":{"begin":3158,"end":3168},"obj":"NN"},{"id":"T3229","span":{"begin":3152,"end":3157},"obj":"JJ"},{"id":"T3230","span":{"begin":3169,"end":3172},"obj":"DT"},{"id":"T3231","span":{"begin":3173,"end":3178},"obj":"NN"},{"id":"T3232","span":{"begin":3183,"end":3188},"obj":"CD"},{"id":"T3233","span":{"begin":3193,"end":3198},"obj":"CD"},{"id":"T3234","span":{"begin":3189,"end":3190},"obj":"SYM"},{"id":"T3235","span":{"begin":3190,"end":3191},"obj":"HYPH"},{"id":"T3236","span":{"begin":3191,"end":3192},"obj":"SYM"},{"id":"T3237","span":{"begin":3199,"end":3200},"obj":"-LRB-"},{"id":"T3238","span":{"begin":3204,"end":3206},"obj":"CD"},{"id":"T3239","span":{"begin":3200,"end":3201},"obj":"NN"},{"id":"T3240","span":{"begin":3202,"end":3203},"obj":"SYM"},{"id":"T3241","span":{"begin":3206,"end":3207},"obj":"-RRB-"},{"id":"T3242","span":{"begin":3207,"end":3208},"obj":"."},{"id":"T3243","span":{"begin":3208,"end":3365},"obj":"sentence"},{"id":"T3244","span":{"begin":3209,"end":3211},"obj":"NN"},{"id":"T3245","span":{"begin":3212,"end":3216},"obj":"NNS"},{"id":"T3246","span":{"begin":3238,"end":3241},"obj":"VBD"},{"id":"T3247","span":{"begin":3217,"end":3219},"obj":"IN"},{"id":"T3248","span":{"begin":3220,"end":3223},"obj":"DT"},{"id":"T3249","span":{"begin":3227,"end":3237},"obj":"NN"},{"id":"T3250","span":{"begin":3224,"end":3226},"obj":"NN"},{"id":"T3251","span":{"begin":3242,"end":3247},"obj":"CD"},{"id":"T3252","span":{"begin":3252,"end":3257},"obj":"CD"},{"id":"T3253","span":{"begin":3248,"end":3249},"obj":"SYM"},{"id":"T3254","span":{"begin":3249,"end":3250},"obj":"HYPH"},{"id":"T3255","span":{"begin":3250,"end":3251},"obj":"SYM"},{"id":"T3256","span":{"begin":3258,"end":3264},"obj":"NNS"},{"id":"T3257","span":{"begin":3265,"end":3267},"obj":"IN"},{"id":"T3258","span":{"begin":3268,"end":3272},"obj":"NN"},{"id":"T3259","span":{"begin":3273,"end":3277},"obj":"NN"},{"id":"T3260","span":{"begin":3278,"end":3281},"obj":"IN"},{"id":"T3261","span":{"begin":3282,"end":3287},"obj":"NN"},{"id":"T3262","span":{"begin":3288,"end":3289},"obj":"-LRB-"},{"id":"T3263","span":{"begin":3293,"end":3295},"obj":"CD"},{"id":"T3264","span":{"begin":3289,"end":3290},"obj":"NN"},{"id":"T3265","span":{"begin":3291,"end":3292},"obj":"SYM"},{"id":"T3266","span":{"begin":3295,"end":3296},"obj":"-RRB-"},{"id":"T3267","span":{"begin":3296,"end":3298},"obj":","},{"id":"T3268","span":{"begin":3298,"end":3301},"obj":"CC"},{"id":"T3269","span":{"begin":3302,"end":3304},"obj":"IN"},{"id":"T3270","span":{"begin":3336,"end":3339},"obj":"VBD"},{"id":"T3271","span":{"begin":3305,"end":3308},"obj":"DT"},{"id":"T3272","span":{"begin":3315,"end":3325},"obj":"NN"},{"id":"T3273","span":{"begin":3309,"end":3314},"obj":"JJ"},{"id":"T3274","span":{"begin":3326,"end":3329},"obj":"DT"},{"id":"T3275","span":{"begin":3330,"end":3335},"obj":"NN"},{"id":"T3276","span":{"begin":3340,"end":3345},"obj":"CD"},{"id":"T3277","span":{"begin":3350,"end":3355},"obj":"CD"},{"id":"T3278","span":{"begin":3346,"end":3347},"obj":"SYM"},{"id":"T3279","span":{"begin":3347,"end":3348},"obj":"HYPH"},{"id":"T3280","span":{"begin":3348,"end":3349},"obj":"SYM"},{"id":"T3281","span":{"begin":3356,"end":3357},"obj":"-LRB-"},{"id":"T3282","span":{"begin":3361,"end":3363},"obj":"CD"},{"id":"T3283","span":{"begin":3357,"end":3358},"obj":"NN"},{"id":"T3284","span":{"begin":3359,"end":3360},"obj":"SYM"},{"id":"T3285","span":{"begin":3363,"end":3364},"obj":"-RRB-"},{"id":"T3286","span":{"begin":3364,"end":3365},"obj":"."},{"id":"T3287","span":{"begin":3365,"end":3522},"obj":"sentence"},{"id":"T3288","span":{"begin":3366,"end":3373},"obj":"IN"},{"id":"T3289","span":{"begin":3420,"end":3422},"obj":"VBZ"},{"id":"T3290","span":{"begin":3374,"end":3377},"obj":"DT"},{"id":"T3291","span":{"begin":3394,"end":3406},"obj":"NN"},{"id":"T3292","span":{"begin":3378,"end":3387},"obj":"VBN"},{"id":"T3293","span":{"begin":3388,"end":3393},"obj":"NN"},{"id":"T3294","span":{"begin":3407,"end":3409},"obj":"IN"},{"id":"T3295","span":{"begin":3410,"end":3412},"obj":"NN"},{"id":"T3296","span":{"begin":3412,"end":3414},"obj":","},{"id":"T3297","span":{"begin":3414,"end":3419},"obj":"EX"},{"id":"T3298","span":{"begin":3423,"end":3424},"obj":"DT"},{"id":"T3299","span":{"begin":3432,"end":3440},"obj":"NN"},{"id":"T3300","span":{"begin":3425,"end":3431},"obj":"JJ"},{"id":"T3301","span":{"begin":3441,"end":3443},"obj":"IN"},{"id":"T3302","span":{"begin":3444,"end":3448},"obj":"NN"},{"id":"T3303","span":{"begin":3449,"end":3453},"obj":"NN"},{"id":"T3304","span":{"begin":3454,"end":3456},"obj":"IN"},{"id":"T3305","span":{"begin":3457,"end":3460},"obj":"DT"},{"id":"T3306","span":{"begin":3470,"end":3479},"obj":"NN"},{"id":"T3307","span":{"begin":3461,"end":3463},"obj":"NN"},{"id":"T3308","span":{"begin":3464,"end":3469},"obj":"JJ"},{"id":"T3309","span":{"begin":3480,"end":3481},"obj":"-LRB-"},{"id":"T3310","span":{"begin":3485,"end":3491},"obj":"CD"},{"id":"T3311","span":{"begin":3481,"end":3482},"obj":"NN"},{"id":"T3312","span":{"begin":3483,"end":3484},"obj":"SYM"},{"id":"T3313","span":{"begin":3491,"end":3492},"obj":"-RRB-"},{"id":"T3314","span":{"begin":3492,"end":3494},"obj":","},{"id":"T3315","span":{"begin":3494,"end":3496},"obj":"IN"},{"id":"T3316","span":{"begin":3508,"end":3516},"obj":"VBN"},{"id":"T3317","span":{"begin":3497,"end":3507},"obj":"RB"},{"id":"T3318","span":{"begin":3517,"end":3518},"obj":"-LRB-"},{"id":"T3319","span":{"begin":3518,"end":3520},"obj":"CD"},{"id":"T3320","span":{"begin":3520,"end":3521},"obj":"-RRB-"},{"id":"T3321","span":{"begin":3521,"end":3522},"obj":"."},{"id":"T3322","span":{"begin":3522,"end":3670},"obj":"sentence"},{"id":"T3323","span":{"begin":3523,"end":3530},"obj":"RB"},{"id":"T3324","span":{"begin":3630,"end":3637},"obj":"VB"},{"id":"T3325","span":{"begin":3530,"end":3532},"obj":","},{"id":"T3326","span":{"begin":3532,"end":3535},"obj":"DT"},{"id":"T3327","span":{"begin":3546,"end":3555},"obj":"NN"},{"id":"T3328","span":{"begin":3536,"end":3542},"obj":"JJR"},{"id":"T3329","span":{"begin":3543,"end":3545},"obj":"NN"},{"id":"T3330","span":{"begin":3556,"end":3558},"obj":"IN"},{"id":"T3331","span":{"begin":3559,"end":3562},"obj":"DT"},{"id":"T3332","span":{"begin":3569,"end":3579},"obj":"NN"},{"id":"T3333","span":{"begin":3563,"end":3568},"obj":"JJ"},{"id":"T3334","span":{"begin":3579,"end":3581},"obj":","},{"id":"T3335","span":{"begin":3581,"end":3586},"obj":"WDT"},{"id":"T3336","span":{"begin":3587,"end":3595},"obj":"VBZ"},{"id":"T3337","span":{"begin":3596,"end":3600},"obj":"JJ"},{"id":"T3338","span":{"begin":3607,"end":3619},"obj":"NN"},{"id":"T3339","span":{"begin":3601,"end":3606},"obj":"NN"},{"id":"T3340","span":{"begin":3619,"end":3621},"obj":","},{"id":"T3341","span":{"begin":3621,"end":3625},"obj":"VBZ"},{"id":"T3342","span":{"begin":3626,"end":3629},"obj":"RB"},{"id":"T3343","span":{"begin":3638,"end":3647},"obj":"VBN"},{"id":"T3344","span":{"begin":3659,"end":3669},"obj":"NN"},{"id":"T3345","span":{"begin":3648,"end":3653},"obj":"NN"},{"id":"T3346","span":{"begin":3654,"end":3658},"obj":"NN"},{"id":"T3347","span":{"begin":3669,"end":3670},"obj":"."},{"id":"T6955","span":{"begin":1675,"end":1687},"obj":"JJ"},{"id":"T6956","span":{"begin":1688,"end":1698},"obj":"NN"},{"id":"T6957","span":{"begin":1699,"end":1701},"obj":"IN"},{"id":"T6958","span":{"begin":1702,"end":1705},"obj":"DT"},{"id":"T6959","span":{"begin":1712,"end":1721},"obj":"NN"},{"id":"T6960","span":{"begin":1706,"end":1711},"obj":"JJ"},{"id":"T6961","span":{"begin":1722,"end":1724},"obj":"IN"},{"id":"T6962","span":{"begin":1725,"end":1729},"obj":"JJ"},{"id":"T6963","span":{"begin":1730,"end":1734},"obj":"NN"},{"id":"T6964","span":{"begin":1742,"end":1746},"obj":"NNS"},{"id":"T6965","span":{"begin":1735,"end":1738},"obj":"CC"},{"id":"T6966","span":{"begin":1739,"end":1741},"obj":"NN"},{"id":"T6967","span":{"begin":1747,"end":1749},"obj":"IN"},{"id":"T6968","span":{"begin":1750,"end":1753},"obj":"DT"},{"id":"T6969","span":{"begin":1772,"end":1783},"obj":"NNS"},{"id":"T6970","span":{"begin":1754,"end":1763},"obj":"JJ"},{"id":"T6971","span":{"begin":1764,"end":1771},"obj":"JJ"},{"id":"T6972","span":{"begin":1783,"end":1784},"obj":"."},{"id":"T6973","span":{"begin":1784,"end":1854},"obj":"sentence"},{"id":"T6974","span":{"begin":1785,"end":1791},"obj":"NN"},{"id":"T6975","span":{"begin":1805,"end":1813},"obj":"VBN"},{"id":"T6976","span":{"begin":1792,"end":1795},"obj":"VBD"},{"id":"T6977","span":{"begin":1796,"end":1804},"obj":"NN"},{"id":"T6978","span":{"begin":1814,"end":1817},"obj":"CC"},{"id":"T6979","span":{"begin":1818,"end":1825},"obj":"VBN"},{"id":"T6980","span":{"begin":1826,"end":1830},"obj":"IN"},{"id":"T6981","span":{"begin":1831,"end":1834},"obj":"NN"},{"id":"T6982","span":{"begin":1835,"end":1838},"obj":"IN"},{"id":"T6983","span":{"begin":1839,"end":1846},"obj":"JJ"},{"id":"T6984","span":{"begin":1847,"end":1853},"obj":"NNS"},{"id":"T6985","span":{"begin":1853,"end":1854},"obj":"."},{"id":"T6986","span":{"begin":1854,"end":1918},"obj":"sentence"},{"id":"T6987","span":{"begin":1855,"end":1858},"obj":"DT"},{"id":"T6988","span":{"begin":1859,"end":1867},"obj":"NNS"},{"id":"T6989","span":{"begin":1868,"end":1871},"obj":"VBP"},{"id":"T6990","span":{"begin":1872,"end":1876},"obj":"IN"},{"id":"T6991","span":{"begin":1877,"end":1880},"obj":"DT"},{"id":"T6992","span":{"begin":1888,"end":1895},"obj":"NN"},{"id":"T6993","span":{"begin":1881,"end":1887},"obj":"JJ"},{"id":"T6994","span":{"begin":1896,"end":1898},"obj":"IN"},{"id":"T6995","span":{"begin":1899,"end":1902},"obj":"DT"},{"id":"T6996","span":{"begin":1909,"end":1918},"obj":"NN"},{"id":"T6997","span":{"begin":1903,"end":1908},"obj":"JJ"},{"id":"T6998","span":{"begin":1918,"end":1954},"obj":"sentence"},{"id":"T6999","span":{"begin":1919,"end":1920},"obj":"-LRB-"},{"id":"T7000","span":{"begin":1920,"end":1921},"obj":"LS"},{"id":"T7001","span":{"begin":1928,"end":1932},"obj":"NN"},{"id":"T7002","span":{"begin":1921,"end":1922},"obj":"-RRB-"},{"id":"T7003","span":{"begin":1923,"end":1927},"obj":"JJ"},{"id":"T7004","span":{"begin":1933,"end":1935},"obj":"IN"},{"id":"T7005","span":{"begin":1936,"end":1939},"obj":"DT"},{"id":"T7006","span":{"begin":1943,"end":1953},"obj":"NN"},{"id":"T7007","span":{"begin":1940,"end":1942},"obj":"NN"},{"id":"T7008","span":{"begin":1953,"end":1954},"obj":"."},{"id":"T7009","span":{"begin":1954,"end":1983},"obj":"sentence"},{"id":"T7010","span":{"begin":1955,"end":1956},"obj":"-LRB-"},{"id":"T7011","span":{"begin":1956,"end":1957},"obj":"LS"},{"id":"T7012","span":{"begin":1959,"end":1961},"obj":"NN"},{"id":"T7013","span":{"begin":1957,"end":1958},"obj":"-RRB-"},{"id":"T7014","span":{"begin":1962,"end":1964},"obj":"IN"},{"id":"T7015","span":{"begin":1965,"end":1968},"obj":"DT"},{"id":"T7016","span":{"begin":1972,"end":1982},"obj":"NN"},{"id":"T7017","span":{"begin":1969,"end":1971},"obj":"NN"},{"id":"T7018","span":{"begin":1982,"end":1983},"obj":"."},{"id":"T7019","span":{"begin":1983,"end":2022},"obj":"sentence"},{"id":"T7020","span":{"begin":1984,"end":1985},"obj":"-LRB-"},{"id":"T7021","span":{"begin":1985,"end":1986},"obj":"LS"},{"id":"T7022","span":{"begin":1993,"end":1997},"obj":"NN"},{"id":"T7023","span":{"begin":1986,"end":1987},"obj":"-RRB-"},{"id":"T7024","span":{"begin":1988,"end":1992},"obj":"JJ"},{"id":"T7025","span":{"begin":1998,"end":2000},"obj":"IN"},{"id":"T7026","span":{"begin":2001,"end":2004},"obj":"DT"},{"id":"T7027","span":{"begin":2011,"end":2021},"obj":"NN"},{"id":"T7028","span":{"begin":2005,"end":2010},"obj":"JJ"},{"id":"T7029","span":{"begin":2021,"end":2022},"obj":"."},{"id":"T7030","span":{"begin":2022,"end":2056},"obj":"sentence"},{"id":"T7031","span":{"begin":2023,"end":2024},"obj":"-LRB-"},{"id":"T7032","span":{"begin":2024,"end":2025},"obj":"LS"},{"id":"T7033","span":{"begin":2029,"end":2031},"obj":"NN"},{"id":"T7034","span":{"begin":2025,"end":2026},"obj":"HYPH"},{"id":"T7035","span":{"begin":2026,"end":2027},"obj":"LS"},{"id":"T7036","span":{"begin":2027,"end":2028},"obj":"-RRB-"},{"id":"T7037","span":{"begin":2032,"end":2034},"obj":"IN"},{"id":"T7038","span":{"begin":2035,"end":2038},"obj":"DT"},{"id":"T7039","span":{"begin":2045,"end":2055},"obj":"NN"},{"id":"T7040","span":{"begin":2039,"end":2044},"obj":"JJ"},{"id":"T7041","span":{"begin":2055,"end":2056},"obj":"."},{"id":"T7042","span":{"begin":2056,"end":2164},"obj":"sentence"},{"id":"T7043","span":{"begin":2057,"end":2058},"obj":"-LRB-"},{"id":"T7044","span":{"begin":2058,"end":2059},"obj":"LS"},{"id":"T7045","span":{"begin":2122,"end":2125},"obj":"VBP"},{"id":"T7046","span":{"begin":2059,"end":2061},"obj":","},{"id":"T7047","span":{"begin":2061,"end":2062},"obj":"LS"},{"id":"T7048","span":{"begin":2062,"end":2063},"obj":"-RRB-"},{"id":"T7049","span":{"begin":2064,"end":2066},"obj":"IN"},{"id":"T7050","span":{"begin":2067,"end":2070},"obj":"DT"},{"id":"T7051","span":{"begin":2081,"end":2087},"obj":"NN"},{"id":"T7052","span":{"begin":2071,"end":2075},"obj":"JJ"},{"id":"T7053","span":{"begin":2076,"end":2080},"obj":"NN"},{"id":"T7054","span":{"begin":2088,"end":2092},"obj":"IN"},{"id":"T7055","span":{"begin":2093,"end":2097},"obj":"DT"},{"id":"T7056","span":{"begin":2098,"end":2109},"obj":"NNS"},{"id":"T7057","span":{"begin":2109,"end":2111},"obj":","},{"id":"T7058","span":{"begin":2111,"end":2114},"obj":"DT"},{"id":"T7059","span":{"begin":2115,"end":2121},"obj":"NNS"},{"id":"T7060","span":{"begin":2126,"end":2131},"obj":"JJ"},{"id":"T7061","span":{"begin":2132,"end":2135},"obj":"CC"},{"id":"T7062","span":{"begin":2136,"end":2140},"obj":"VBP"},{"id":"T7063","span":{"begin":2141,"end":2147},"obj":"JJ"},{"id":"T7064","span":{"begin":2148,"end":2154},"obj":"NNS"},{"id":"T7065","span":{"begin":2155,"end":2156},"obj":"-LRB-"},{"id":"T7066","span":{"begin":2156,"end":2162},"obj":"NNS"},{"id":"T7067","span":{"begin":2162,"end":2163},"obj":"-RRB-"},{"id":"T7068","span":{"begin":2163,"end":2164},"obj":"."},{"id":"T7069","span":{"begin":2164,"end":2289},"obj":"sentence"},{"id":"T7070","span":{"begin":2165,"end":2166},"obj":"-LRB-"},{"id":"T7071","span":{"begin":2166,"end":2167},"obj":"LS"},{"id":"T7072","span":{"begin":2225,"end":2228},"obj":"VBP"},{"id":"T7073","span":{"begin":2167,"end":2168},"obj":"-RRB-"},{"id":"T7074","span":{"begin":2169,"end":2171},"obj":"IN"},{"id":"T7075","span":{"begin":2172,"end":2175},"obj":"DT"},{"id":"T7076","span":{"begin":2179,"end":2185},"obj":"NN"},{"id":"T7077","span":{"begin":2176,"end":2178},"obj":"NN"},{"id":"T7078","span":{"begin":2186,"end":2188},"obj":"IN"},{"id":"T7079","span":{"begin":2189,"end":2192},"obj":"DT"},{"id":"T7080","span":{"begin":2196,"end":2206},"obj":"NN"},{"id":"T7081","span":{"begin":2193,"end":2195},"obj":"NN"},{"id":"T7082","span":{"begin":2206,"end":2208},"obj":","},{"id":"T7083","span":{"begin":2208,"end":2211},"obj":"DT"},{"id":"T7084","span":{"begin":2218,"end":2224},"obj":"NNS"},{"id":"T7085","span":{"begin":2212,"end":2217},"obj":"NN"},{"id":"T7086","span":{"begin":2229,"end":2236},"obj":"RB"},{"id":"T7087","span":{"begin":2237,"end":2244},"obj":"VBN"},{"id":"T7088","span":{"begin":2245,"end":2248},"obj":"CC"},{"id":"T7089","span":{"begin":2249,"end":2255},"obj":"VBN"},{"id":"T7090","span":{"begin":2256,"end":2260},"obj":"IN"},{"id":"T7091","span":{"begin":2261,"end":2264},"obj":"NN"},{"id":"T7092","span":{"begin":2265,"end":2273},"obj":"JJ"},{"id":"T7093","span":{"begin":2264,"end":2265},"obj":"HYPH"},{"id":"T7094","span":{"begin":2274,"end":2279},"obj":"NN"},{"id":"T7095","span":{"begin":2280,"end":2281},"obj":"-LRB-"},{"id":"T7096","span":{"begin":2281,"end":2287},"obj":"NNS"},{"id":"T7097","span":{"begin":2287,"end":2288},"obj":"-RRB-"},{"id":"T7098","span":{"begin":2288,"end":2289},"obj":"."},{"id":"T7099","span":{"begin":2289,"end":2436},"obj":"sentence"},{"id":"T7100","span":{"begin":2290,"end":2292},"obj":"IN"},{"id":"T7101","span":{"begin":2342,"end":2345},"obj":"VBP"},{"id":"T7102","span":{"begin":2293,"end":2297},"obj":"DT"},{"id":"T7103","span":{"begin":2301,"end":2305},"obj":"NNS"},{"id":"T7104","span":{"begin":2298,"end":2300},"obj":"NN"},{"id":"T7105","span":{"begin":2306,"end":2308},"obj":"IN"},{"id":"T7106","span":{"begin":2309,"end":2312},"obj":"DT"},{"id":"T7107","span":{"begin":2319,"end":2329},"obj":"NN"},{"id":"T7108","span":{"begin":2313,"end":2318},"obj":"JJ"},{"id":"T7109","span":{"begin":2329,"end":2331},"obj":","},{"id":"T7110","span":{"begin":2331,"end":2334},"obj":"DT"},{"id":"T7111","span":{"begin":2335,"end":2341},"obj":"NNS"},{"id":"T7112","span":{"begin":2346,"end":2349},"obj":"RB"},{"id":"T7113","span":{"begin":2350,"end":2360},"obj":"RB"},{"id":"T7114","span":{"begin":2361,"end":2370},"obj":"JJ"},{"id":"T7115","span":{"begin":2371,"end":2375},"obj":"IN"},{"id":"T7116","span":{"begin":2376,"end":2380},"obj":"JJ"},{"id":"T7117","span":{"begin":2381,"end":2385},"obj":"NN"},{"id":"T7118","span":{"begin":2386,"end":2387},"obj":"-LRB-"},{"id":"T7119","span":{"begin":2387,"end":2388},"obj":"NN"},{"id":"T7120","span":{"begin":2388,"end":2389},"obj":"-RRB-"},{"id":"T7121","span":{"begin":2389,"end":2391},"obj":","},{"id":"T7122","span":{"begin":2391,"end":2394},"obj":"CC"},{"id":"T7123","span":{"begin":2395,"end":2398},"obj":"DT"},{"id":"T7124","span":{"begin":2399,"end":2405},"obj":"NNS"},{"id":"T7125","span":{"begin":2406,"end":2409},"obj":"VBP"},{"id":"T7126","span":{"begin":2410,"end":2416},"obj":"JJ"},{"id":"T7127","span":{"begin":2417,"end":2426},"obj":"VBG"},{"id":"T7128","span":{"begin":2427,"end":2428},"obj":"-LRB-"},{"id":"T7129","span":{"begin":2428,"end":2434},"obj":"NNS"},{"id":"T7130","span":{"begin":2434,"end":2435},"obj":"-RRB-"},{"id":"T7131","span":{"begin":2435,"end":2436},"obj":"."},{"id":"T7132","span":{"begin":2436,"end":2573},"obj":"sentence"},{"id":"T7133","span":{"begin":2437,"end":2441},"obj":"DT"},{"id":"T7134","span":{"begin":2445,"end":2449},"obj":"NNS"},{"id":"T7135","span":{"begin":2442,"end":2444},"obj":"NN"},{"id":"T7136","span":{"begin":2474,"end":2477},"obj":"VBD"},{"id":"T7137","span":{"begin":2450,"end":2452},"obj":"IN"},{"id":"T7138","span":{"begin":2453,"end":2456},"obj":"DT"},{"id":"T7139","span":{"begin":2463,"end":2473},"obj":"NN"},{"id":"T7140","span":{"begin":2457,"end":2462},"obj":"JJ"},{"id":"T7141","span":{"begin":2478,"end":2484},"obj":"RB"},{"id":"T7142","span":{"begin":2494,"end":2500},"obj":"NNS"},{"id":"T7143","span":{"begin":2485,"end":2493},"obj":"VBN"},{"id":"T7144","span":{"begin":2501,"end":2502},"obj":"-LRB-"},{"id":"T7145","span":{"begin":2502,"end":2503},"obj":"NN"},{"id":"T7146","span":{"begin":2503,"end":2504},"obj":"-RRB-"},{"id":"T7147","span":{"begin":2504,"end":2506},"obj":","},{"id":"T7148","span":{"begin":2506,"end":2511},"obj":"IN"},{"id":"T7149","span":{"begin":2519,"end":2522},"obj":"VBD"},{"id":"T7150","span":{"begin":2512,"end":2518},"obj":"NNS"},{"id":"T7151","span":{"begin":2523,"end":2530},"obj":"JJR"},{"id":"T7152","span":{"begin":2537,"end":2545},"obj":"NN"},{"id":"T7153","span":{"begin":2531,"end":2536},"obj":"NN"},{"id":"T7154","span":{"begin":2546,"end":2549},"obj":"CC"},{"id":"T7155","span":{"begin":2550,"end":2555},"obj":"NN"},{"id":"T7156","span":{"begin":2556,"end":2568},"obj":"NN"},{"id":"T7157","span":{"begin":2569,"end":2570},"obj":"-LRB-"},{"id":"T7158","span":{"begin":2570,"end":2571},"obj":"NN"},{"id":"T7159","span":{"begin":2571,"end":2572},"obj":"-RRB-"},{"id":"T7160","span":{"begin":2572,"end":2573},"obj":"."},{"id":"T7161","span":{"begin":2573,"end":2686},"obj":"sentence"},{"id":"T7162","span":{"begin":2574,"end":2581},"obj":"RB"},{"id":"T7163","span":{"begin":2638,"end":2646},"obj":"VBN"},{"id":"T7164","span":{"begin":2581,"end":2583},"obj":","},{"id":"T7165","span":{"begin":2583,"end":2586},"obj":"DT"},{"id":"T7166","span":{"begin":2590,"end":2594},"obj":"NNS"},{"id":"T7167","span":{"begin":2587,"end":2589},"obj":"NN"},{"id":"T7168","span":{"begin":2595,"end":2597},"obj":"IN"},{"id":"T7169","span":{"begin":2598,"end":2601},"obj":"DT"},{"id":"T7170","span":{"begin":2608,"end":2618},"obj":"NN"},{"id":"T7171","span":{"begin":2602,"end":2607},"obj":"JJ"},{"id":"T7172","span":{"begin":2619,"end":2623},"obj":"VBD"},{"id":"T7173","span":{"begin":2624,"end":2628},"obj":"RBR"},{"id":"T7174","span":{"begin":2629,"end":2637},"obj":"RB"},{"id":"T7175","span":{"begin":2647,"end":2655},"obj":"VBN"},{"id":"T7176","span":{"begin":2656,"end":2658},"obj":"IN"},{"id":"T7177","span":{"begin":2659,"end":2664},"obj":"DT"},{"id":"T7178","span":{"begin":2665,"end":2667},"obj":"IN"},{"id":"T7179","span":{"begin":2668,"end":2671},"obj":"DT"},{"id":"T7180","span":{"begin":2675,"end":2685},"obj":"NN"},{"id":"T7181","span":{"begin":2672,"end":2674},"obj":"NN"},{"id":"T7182","span":{"begin":2685,"end":2686},"obj":"."},{"id":"T3049","span":{"begin":1264,"end":1267},"obj":"DT"},{"id":"T3050","span":{"begin":1268,"end":1274},"obj":"NNS"},{"id":"T3051","span":{"begin":1275,"end":1276},"obj":"-LRB-"},{"id":"T3052","span":{"begin":1276,"end":1280},"obj":"NN"},{"id":"T3053","span":{"begin":1281,"end":1283},"obj":"CD"},{"id":"T3054","span":{"begin":1283,"end":1284},"obj":"-RRB-"},{"id":"T3055","span":{"begin":1284,"end":1286},"obj":","},{"id":"T3056","span":{"begin":1286,"end":1291},"obj":"IN"},{"id":"T3057","span":{"begin":1299,"end":1302},"obj":"VBD"},{"id":"T3058","span":{"begin":1292,"end":1298},"obj":"NNS"},{"id":"T3059","span":{"begin":1303,"end":1311},"obj":"JJ"},{"id":"T3060","span":{"begin":1318,"end":1330},"obj":"NN"},{"id":"T3061","span":{"begin":1312,"end":1317},"obj":"NN"},{"id":"T3062","span":{"begin":1331,"end":1332},"obj":"-LRB-"},{"id":"T3063","span":{"begin":1332,"end":1336},"obj":"NN"},{"id":"T3064","span":{"begin":1337,"end":1339},"obj":"CD"},{"id":"T3065","span":{"begin":1339,"end":1340},"obj":"-RRB-"},{"id":"T3066","span":{"begin":1340,"end":1341},"obj":"."},{"id":"T3067","span":{"begin":1341,"end":1505},"obj":"sentence"},{"id":"T3068","span":{"begin":1342,"end":1343},"obj":"DT"},{"id":"T3069","span":{"begin":1344,"end":1349},"obj":"NN"},{"id":"T3070","span":{"begin":1394,"end":1402},"obj":"VBN"},{"id":"T3071","span":{"begin":1350,"end":1352},"obj":"IN"},{"id":"T3131","span":{"begin":1664,"end":2866},"obj":"sentence"},{"id":"T3132","span":{"begin":2687,"end":2691},"obj":"RB"}],"relations":[{"id":"R1738","pred":"compound","subj":"T2802","obj":"T2803"},{"id":"R1739","pred":"nsubj","subj":"T2803","obj":"T2804"},{"id":"R1740","pred":"prep","subj":"T2805","obj":"T2803"},{"id":"R1741","pred":"det","subj":"T2806","obj":"T2807"},{"id":"R1742","pred":"pobj","subj":"T2807","obj":"T2805"},{"id":"R1743","pred":"amod","subj":"T2808","obj":"T2807"},{"id":"R1744","pred":"advmod","subj":"T2809","obj":"T2810"},{"id":"R1745","pred":"dobj","subj":"T2810","obj":"T2804"},{"id":"R1746","pred":"amod","subj":"T2811","obj":"T2812"},{"id":"R1747","pred":"compound","subj":"T2812","obj":"T2810"},{"id":"R1748","pred":"det","subj":"T2814","obj":"T2815"},{"id":"R1749","pred":"nsubj","subj":"T2815","obj":"T2819"},{"id":"R1750","pred":"advmod","subj":"T2816","obj":"T2817"},{"id":"R1751","pred":"amod","subj":"T2817","obj":"T2815"},{"id":"R1752","pred":"amod","subj":"T2818","obj":"T2815"},{"id":"R1753","pred":"prep","subj":"T2820","obj":"T2815"},{"id":"R1754","pred":"det","subj":"T2821","obj":"T2822"},{"id":"R1755","pred":"pobj","subj":"T2822","obj":"T2820"},{"id":"R1756","pred":"nmod","subj":"T2823","obj":"T2824"},{"id":"R1757","pred":"nmod","subj":"T2824","obj":"T2822"},{"id":"R1758","pred":"amod","subj":"T2825","obj":"T2822"},{"id":"R1759","pred":"det","subj":"T2826","obj":"T2827"},{"id":"R1760","pred":"attr","subj":"T2827","obj":"T2819"},{"id":"R1761","pred":"prep","subj":"T2828","obj":"T2827"},{"id":"R1762","pred":"pobj","subj":"T2829","obj":"T2828"},{"id":"R1763","pred":"prep","subj":"T2830","obj":"T2827"},{"id":"R1764","pred":"amod","subj":"T2831","obj":"T2832"},{"id":"R1765","pred":"pobj","subj":"T2832","obj":"T2830"},{"id":"R1766","pred":"dep","subj":"T2833","obj":"T2834"},{"id":"R1767","pred":"relcl","subj":"T2834","obj":"T2827"},{"id":"R1768","pred":"auxpass","subj":"T2835","obj":"T2834"},{"id":"R1769","pred":"prep","subj":"T2836","obj":"T2834"},{"id":"R1770","pred":"det","subj":"T2837","obj":"T2838"},{"id":"R1771","pred":"pobj","subj":"T2838","obj":"T2836"},{"id":"R1772","pred":"amod","subj":"T2839","obj":"T2838"},{"id":"R1773","pred":"dep","subj":"T2840","obj":"T2841"},{"id":"R1774","pred":"relcl","subj":"T2841","obj":"T2838"},{"id":"R1775","pred":"prep","subj":"T2842","obj":"T2841"},{"id":"R1776","pred":"pobj","subj":"T2843","obj":"T2842"},{"id":"R1777","pred":"prep","subj":"T2844","obj":"T2843"},{"id":"R1778","pred":"det","subj":"T2845","obj":"T2846"},{"id":"R1779","pred":"pobj","subj":"T2846","obj":"T2844"},{"id":"R1780","pred":"prep","subj":"T2847","obj":"T2841"},{"id":"R1781","pred":"det","subj":"T2848","obj":"T2849"},{"id":"R1782","pred":"pobj","subj":"T2849","obj":"T2847"},{"id":"R1783","pred":"amod","subj":"T2850","obj":"T2849"},{"id":"R1784","pred":"amod","subj":"T2851","obj":"T2849"},{"id":"R1785","pred":"compound","subj":"T2852","obj":"T2849"},{"id":"R1786","pred":"punct","subj":"T2853","obj":"T2854"},{"id":"R1787","pred":"parataxis","subj":"T2854","obj":"T2819"},{"id":"R1788","pred":"punct","subj":"T2855","obj":"T2854"},{"id":"R1789","pred":"punct","subj":"T2856","obj":"T2819"},{"id":"R1790","pred":"advcl","subj":"T2858","obj":"T2859"},{"id":"R1791","pred":"amod","subj":"T2860","obj":"T2861"},{"id":"R1792","pred":"nmod","subj":"T2861","obj":"T2862"},{"id":"R1793","pred":"dobj","subj":"T2862","obj":"T2858"},{"id":"R1794","pred":"poss","subj":"T2863","obj":"T2862"},{"id":"R1795","pred":"case","subj":"T2864","obj":"T2863"},{"id":"R1796","pred":"prep","subj":"T2865","obj":"T2858"},{"id":"R1797","pred":"amod","subj":"T2866","obj":"T2867"},{"id":"R1798","pred":"pobj","subj":"T2867","obj":"T2865"},{"id":"R1799","pred":"punct","subj":"T2868","obj":"T2859"},{"id":"R1800","pred":"amod","subj":"T2869","obj":"T2870"},{"id":"R1801","pred":"nsubjpass","subj":"T2870","obj":"T2859"},{"id":"R1802","pred":"prep","subj":"T2871","obj":"T2870"},{"id":"R1803","pred":"amod","subj":"T2872","obj":"T2873"},{"id":"R1804","pred":"pobj","subj":"T2873","obj":"T2871"},{"id":"R1805","pred":"compound","subj":"T2874","obj":"T2873"},{"id":"R1806","pred":"auxpass","subj":"T2875","obj":"T2859"},{"id":"R1807","pred":"punct","subj":"T2876","obj":"T2859"},{"id":"R1808","pred":"det","subj":"T2878","obj":"T2879"},{"id":"R1809","pred":"nsubj","subj":"T2879","obj":"T2883"},{"id":"R1810","pred":"amod","subj":"T2880","obj":"T2881"},{"id":"R1811","pred":"nmod","subj":"T2881","obj":"T2879"},{"id":"R1812","pred":"amod","subj":"T2882","obj":"T2879"},{"id":"R1813","pred":"prep","subj":"T2884","obj":"T2879"},{"id":"R1814","pred":"preconj","subj":"T2885","obj":"T2886"},{"id":"R1815","pred":"pobj","subj":"T2886","obj":"T2884"},{"id":"R1816","pred":"det","subj":"T2887","obj":"T2886"},{"id":"R1817","pred":"cc","subj":"T2888","obj":"T2886"},{"id":"R1818","pred":"det","subj":"T2889","obj":"T2890"},{"id":"R1819","pred":"nmod","subj":"T2890","obj":"T2891"},{"id":"R1820","pred":"conj","subj":"T2891","obj":"T2886"},{"id":"R1821","pred":"amod","subj":"T2892","obj":"T2891"},{"id":"R1822","pred":"acomp","subj":"T2893","obj":"T2883"},{"id":"R1823","pred":"punct","subj":"T2894","obj":"T2883"},{"id":"R1824","pred":"det","subj":"T2896","obj":"T2897"},{"id":"R1825","pred":"nsubj","subj":"T2897","obj":"T2899"},{"id":"R1826","pred":"amod","subj":"T2898","obj":"T2897"},{"id":"R1827","pred":"advmod","subj":"T2900","obj":"T2901"},{"id":"R1828","pred":"acomp","subj":"T2901","obj":"T2899"},{"id":"R1829","pred":"prep","subj":"T2902","obj":"T2899"},{"id":"R1830","pred":"amod","subj":"T2903","obj":"T2904"},{"id":"R1831","pred":"pobj","subj":"T2904","obj":"T2902"},{"id":"R1832","pred":"prep","subj":"T2905","obj":"T2904"},{"id":"R1833","pred":"compound","subj":"T2906","obj":"T2907"},{"id":"R1834","pred":"pobj","subj":"T2907","obj":"T2905"},{"id":"R1835","pred":"punct","subj":"T2908","obj":"T2907"},{"id":"R1836","pred":"prep","subj":"T2909","obj":"T2904"},{"id":"R1837","pred":"det","subj":"T2910","obj":"T2911"},{"id":"R1838","pred":"pobj","subj":"T2911","obj":"T2909"},{"id":"R1839","pred":"punct","subj":"T2912","obj":"T2913"},{"id":"R1840","pred":"parataxis","subj":"T2913","obj":"T2899"},{"id":"R1841","pred":"nmod","subj":"T2914","obj":"T2913"},{"id":"R1842","pred":"cc","subj":"T2915","obj":"T2913"},{"id":"R1843","pred":"conj","subj":"T2916","obj":"T2913"},{"id":"R1844","pred":"punct","subj":"T2917","obj":"T2913"},{"id":"R1845","pred":"advmod","subj":"T2918","obj":"T2913"},{"id":"R1846","pred":"punct","subj":"T2919","obj":"T2913"},{"id":"R1847","pred":"punct","subj":"T2920","obj":"T2899"},{"id":"R1848","pred":"det","subj":"T2922","obj":"T2923"},{"id":"R1849","pred":"nsubj","subj":"T2923","obj":"T2924"},{"id":"R1850","pred":"prep","subj":"T2925","obj":"T2923"},{"id":"R1851","pred":"det","subj":"T2926","obj":"T2927"},{"id":"R1852","pred":"pobj","subj":"T2927","obj":"T2925"},{"id":"R1853","pred":"compound","subj":"T2928","obj":"T2927"},{"id":"R1854","pred":"advmod","subj":"T2929","obj":"T2930"},{"id":"R1855","pred":"acomp","subj":"T2930","obj":"T2924"},{"id":"R1856","pred":"cc","subj":"T2931","obj":"T2924"},{"id":"R1857","pred":"compound","subj":"T2932","obj":"T2933"},{"id":"R1858","pred":"nsubjpass","subj":"T2933","obj":"T2934"},{"id":"R1859","pred":"conj","subj":"T2934","obj":"T2924"},{"id":"R1860","pred":"auxpass","subj":"T2935","obj":"T2934"},{"id":"R1861","pred":"advmod","subj":"T2936","obj":"T2934"},{"id":"R1862","pred":"prep","subj":"T2937","obj":"T2934"},{"id":"R1863","pred":"det","subj":"T2938","obj":"T2939"},{"id":"R1864","pred":"pobj","subj":"T2939","obj":"T2937"},{"id":"R1865","pred":"amod","subj":"T2940","obj":"T2941"},{"id":"R1866","pred":"compound","subj":"T2941","obj":"T2939"},{"id":"R1867","pred":"punct","subj":"T2942","obj":"T2934"},{"id":"R1868","pred":"prep","subj":"T2944","obj":"T2945"},{"id":"R1869","pred":"pobj","subj":"T2946","obj":"T2944"},{"id":"R1870","pred":"punct","subj":"T2947","obj":"T2945"},{"id":"R1871","pred":"det","subj":"T2948","obj":"T2949"},{"id":"R1872","pred":"nsubj","subj":"T2949","obj":"T2945"},{"id":"R1873","pred":"prep","subj":"T2950","obj":"T2949"},{"id":"R1874","pred":"compound","subj":"T2951","obj":"T2952"},{"id":"R1875","pred":"pobj","subj":"T2952","obj":"T2950"},{"id":"R1876","pred":"prep","subj":"T2953","obj":"T2952"},{"id":"R1877","pred":"det","subj":"T2954","obj":"T2955"},{"id":"R1878","pred":"pobj","subj":"T2955","obj":"T2953"},{"id":"R1879","pred":"nmod","subj":"T2956","obj":"T2955"},{"id":"R1880","pred":"amod","subj":"T2957","obj":"T2955"},{"id":"R1881","pred":"advmod","subj":"T2958","obj":"T2959"},{"id":"R1882","pred":"amod","subj":"T2959","obj":"T2960"},{"id":"R1883","pred":"dobj","subj":"T2960","obj":"T2945"},{"id":"R1884","pred":"acl","subj":"T2961","obj":"T2960"},{"id":"R1885","pred":"prep","subj":"T2962","obj":"T2961"},{"id":"R1886","pred":"npadvmod","subj":"T2963","obj":"T2964"},{"id":"R1887","pred":"amod","subj":"T2964","obj":"T2966"},{"id":"R1888","pred":"punct","subj":"T2965","obj":"T2964"},{"id":"R1889","pred":"pobj","subj":"T2966","obj":"T2962"},{"id":"R1890","pred":"punct","subj":"T2967","obj":"T2968"},{"id":"R1891","pred":"parataxis","subj":"T2968","obj":"T2945"},{"id":"R1892","pred":"nummod","subj":"T2969","obj":"T2968"},{"id":"R1893","pred":"punct","subj":"T2970","obj":"T2968"},{"id":"R1894","pred":"punct","subj":"T2971","obj":"T2945"},{"id":"R1895","pred":"compound","subj":"T2973","obj":"T2974"},{"id":"R1896","pred":"nsubj","subj":"T2974","obj":"T2975"},{"id":"R1897","pred":"prep","subj":"T2976","obj":"T2974"},{"id":"R1898","pred":"det","subj":"T2977","obj":"T2978"},{"id":"R1899","pred":"pobj","subj":"T2978","obj":"T2976"},{"id":"R1900","pred":"amod","subj":"T2979","obj":"T2978"},{"id":"R1901","pred":"amod","subj":"T2980","obj":"T2981"},{"id":"R1902","pred":"dobj","subj":"T2981","obj":"T2975"},{"id":"R1903","pred":"compound","subj":"T2982","obj":"T2981"},{"id":"R1904","pred":"prep","subj":"T2983","obj":"T2981"},{"id":"R1905","pred":"compound","subj":"T2984","obj":"T2985"},{"id":"R1906","pred":"pobj","subj":"T2985","obj":"T2983"},{"id":"R1907","pred":"prep","subj":"T2986","obj":"T2985"},{"id":"R1908","pred":"det","subj":"T2987","obj":"T2988"},{"id":"R1909","pred":"pobj","subj":"T2988","obj":"T2986"},{"id":"R1910","pred":"compound","subj":"T2989","obj":"T2988"},{"id":"R1911","pred":"punct","subj":"T2990","obj":"T2991"},{"id":"R1912","pred":"parataxis","subj":"T2991","obj":"T2975"},{"id":"R1913","pred":"nummod","subj":"T2992","obj":"T2991"},{"id":"R1914","pred":"punct","subj":"T2993","obj":"T2994"},{"id":"R1915","pred":"prep","subj":"T2994","obj":"T2991"},{"id":"R1916","pred":"punct","subj":"T2995","obj":"T2991"},{"id":"R1917","pred":"punct","subj":"T2996","obj":"T2975"},{"id":"R1918","pred":"det","subj":"T2998","obj":"T2999"},{"id":"R1919","pred":"nsubj","subj":"T2999","obj":"T3000"},{"id":"R1920","pred":"prep","subj":"T3001","obj":"T2999"},{"id":"R1921","pred":"pobj","subj":"T3002","obj":"T3001"},{"id":"R1922","pred":"prep","subj":"T3003","obj":"T2999"},{"id":"R1923","pred":"compound","subj":"T3004","obj":"T3005"},{"id":"R1924","pred":"pobj","subj":"T3005","obj":"T3003"},{"id":"R1925","pred":"prep","subj":"T3006","obj":"T3005"},{"id":"R1926","pred":"det","subj":"T3007","obj":"T3008"},{"id":"R1927","pred":"pobj","subj":"T3008","obj":"T3006"},{"id":"R1928","pred":"amod","subj":"T3009","obj":"T3008"},{"id":"R1929","pred":"acomp","subj":"T3010","obj":"T3000"},{"id":"R1930","pred":"prep","subj":"T3011","obj":"T3000"},{"id":"R1931","pred":"pobj","subj":"T3012","obj":"T3011"},{"id":"R1932","pred":"prep","subj":"T3013","obj":"T3011"},{"id":"R1933","pred":"pobj","subj":"T3014","obj":"T3013"},{"id":"R1934","pred":"punct","subj":"T3015","obj":"T3000"},{"id":"R1935","pred":"prep","subj":"T3017","obj":"T3018"},{"id":"R1936","pred":"det","subj":"T3019","obj":"T3020"},{"id":"R1937","pred":"pobj","subj":"T3020","obj":"T3017"},{"id":"R1938","pred":"punct","subj":"T3021","obj":"T3022"},{"id":"R1939","pred":"parataxis","subj":"T3022","obj":"T3020"},{"id":"R1940","pred":"nummod","subj":"T3023","obj":"T3022"},{"id":"R1941","pred":"punct","subj":"T3024","obj":"T3022"},{"id":"R1942","pred":"punct","subj":"T3025","obj":"T3018"},{"id":"R1943","pred":"advmod","subj":"T3026","obj":"T3027"},{"id":"R1944","pred":"nsubj","subj":"T3027","obj":"T3018"},{"id":"R1945","pred":"amod","subj":"T3028","obj":"T3027"},{"id":"R1946","pred":"aux","subj":"T3029","obj":"T3018"},{"id":"R1947","pred":"dobj","subj":"T3030","obj":"T3018"},{"id":"R1948","pred":"cc","subj":"T3031","obj":"T3018"},{"id":"R1949","pred":"det","subj":"T3032","obj":"T3033"},{"id":"R1950","pred":"nsubj","subj":"T3033","obj":"T3035"},{"id":"R1951","pred":"compound","subj":"T3034","obj":"T3033"},{"id":"R1952","pred":"conj","subj":"T3035","obj":"T3018"},{"id":"R1953","pred":"neg","subj":"T3036","obj":"T3035"},{"id":"R1954","pred":"advmod","subj":"T3037","obj":"T3038"},{"id":"R1955","pred":"acomp","subj":"T3038","obj":"T3035"},{"id":"R1956","pred":"punct","subj":"T3039","obj":"T3018"},{"id":"R1957","pred":"prep","subj":"T3041","obj":"T3042"},{"id":"R1958","pred":"det","subj":"T3043","obj":"T3044"},{"id":"R1959","pred":"pobj","subj":"T3044","obj":"T3041"},{"id":"R1960","pred":"expl","subj":"T3045","obj":"T3042"},{"id":"R1961","pred":"amod","subj":"T3046","obj":"T3047"},{"id":"R1962","pred":"attr","subj":"T3047","obj":"T3042"},{"id":"R1963","pred":"prep","subj":"T3048","obj":"T3042"},{"id":"R1964","pred":"det","subj":"T3049","obj":"T3050"},{"id":"R1965","pred":"pobj","subj":"T3050","obj":"T3048"},{"id":"R1966","pred":"punct","subj":"T3051","obj":"T3052"},{"id":"R1967","pred":"parataxis","subj":"T3052","obj":"T3042"},{"id":"R1968","pred":"nummod","subj":"T3053","obj":"T3052"},{"id":"R1969","pred":"punct","subj":"T3054","obj":"T3052"},{"id":"R1970","pred":"punct","subj":"T3055","obj":"T3042"},{"id":"R1971","pred":"mark","subj":"T3056","obj":"T3057"},{"id":"R1972","pred":"advcl","subj":"T3057","obj":"T3042"},{"id":"R1973","pred":"nsubj","subj":"T3058","obj":"T3057"},{"id":"R1974","pred":"amod","subj":"T3059","obj":"T3060"},{"id":"R1975","pred":"dobj","subj":"T3060","obj":"T3057"},{"id":"R1976","pred":"compound","subj":"T3061","obj":"T3060"},{"id":"R1977","pred":"punct","subj":"T3062","obj":"T3063"},{"id":"R1978","pred":"parataxis","subj":"T3063","obj":"T3057"},{"id":"R1979","pred":"nummod","subj":"T3064","obj":"T3063"},{"id":"R1980","pred":"punct","subj":"T3065","obj":"T3063"},{"id":"R1981","pred":"punct","subj":"T3066","obj":"T3042"},{"id":"R1982","pred":"det","subj":"T3068","obj":"T3069"},{"id":"R1983","pred":"nsubjpass","subj":"T3069","obj":"T3070"},{"id":"R1984","pred":"prep","subj":"T3071","obj":"T3069"},{"id":"R1985","pred":"nummod","subj":"T3072","obj":"T3073"},{"id":"R1986","pred":"pobj","subj":"T3073","obj":"T3071"},{"id":"R1987","pred":"compound","subj":"T3074","obj":"T3073"},{"id":"R1988","pred":"prep","subj":"T3075","obj":"T3073"},{"id":"R1989","pred":"det","subj":"T3076","obj":"T3077"},{"id":"R1990","pred":"pobj","subj":"T3077","obj":"T3075"},{"id":"R1991","pred":"amod","subj":"T3078","obj":"T3077"},{"id":"R1992","pred":"auxpass","subj":"T3079","obj":"T3070"},{"id":"R1993","pred":"advmod","subj":"T3080","obj":"T3070"},{"id":"R1994","pred":"punct","subj":"T3081","obj":"T3070"},{"id":"R1995","pred":"cc","subj":"T3082","obj":"T3070"},{"id":"R1996","pred":"nsubj","subj":"T3083","obj":"T3084"},{"id":"R1997","pred":"conj","subj":"T3084","obj":"T3070"},{"id":"R1998","pred":"amod","subj":"T3085","obj":"T3086"},{"id":"R1999","pred":"dobj","subj":"T3086","obj":"T3084"},{"id":"R2039","pred":"pobj","subj":"T3128","obj":"T3126"},{"id":"R2040","pred":"compound","subj":"T3129","obj":"T3128"},{"id":"R2041","pred":"punct","subj":"T3130","obj":"T3103"},{"id":"R2047","pred":"dep","subj":"T3138","obj":"T3139"},{"id":"R2048","pred":"advcl","subj":"T3139","obj":"T3137"},{"id":"R2049","pred":"det","subj":"T3140","obj":"T3139"},{"id":"R2050","pred":"prep","subj":"T3141","obj":"T3139"},{"id":"R2051","pred":"det","subj":"T3142","obj":"T3143"},{"id":"R2052","pred":"pobj","subj":"T3143","obj":"T3141"},{"id":"R2053","pred":"amod","subj":"T3144","obj":"T3143"},{"id":"R2054","pred":"prep","subj":"T3145","obj":"T3143"},{"id":"R2055","pred":"det","subj":"T3146","obj":"T3147"},{"id":"R2056","pred":"pobj","subj":"T3147","obj":"T3145"},{"id":"R2057","pred":"nummod","subj":"T3148","obj":"T3147"},{"id":"R2058","pred":"compound","subj":"T3149","obj":"T3147"},{"id":"R2059","pred":"punct","subj":"T3150","obj":"T3137"},{"id":"R2060","pred":"nsubj","subj":"T3151","obj":"T3137"},{"id":"R2061","pred":"dobj","subj":"T3152","obj":"T3137"},{"id":"R2062","pred":"cc","subj":"T3153","obj":"T3152"},{"id":"R2063","pred":"conj","subj":"T3154","obj":"T3152"},{"id":"R2064","pred":"prep","subj":"T3155","obj":"T3152"},{"id":"R2065","pred":"pobj","subj":"T3156","obj":"T3155"},{"id":"R2066","pred":"prep","subj":"T3157","obj":"T3152"},{"id":"R2067","pred":"det","subj":"T3158","obj":"T3159"},{"id":"R2068","pred":"pobj","subj":"T3159","obj":"T3157"},{"id":"R2069","pred":"nmod","subj":"T3160","obj":"T3159"},{"id":"R2070","pred":"amod","subj":"T3161","obj":"T3159"},{"id":"R2071","pred":"punct","subj":"T3162","obj":"T3133"},{"id":"R2072","pred":"aux","subj":"T3164","obj":"T3165"},{"id":"R2073","pred":"advcl","subj":"T3165","obj":"T3166"},{"id":"R2074","pred":"mark","subj":"T3167","obj":"T3168"},{"id":"R2075","pred":"ccomp","subj":"T3168","obj":"T3165"},{"id":"R2076","pred":"det","subj":"T3169","obj":"T3170"},{"id":"R2077","pred":"nsubjpass","subj":"T3170","obj":"T3168"},{"id":"R2078","pred":"aux","subj":"T3171","obj":"T3168"},{"id":"R2079","pred":"auxpass","subj":"T3172","obj":"T3168"},{"id":"R2080","pred":"prep","subj":"T3173","obj":"T3168"},{"id":"R2081","pred":"prep","subj":"T3174","obj":"T3168"},{"id":"R2082","pred":"amod","subj":"T3175","obj":"T3176"},{"id":"R2083","pred":"compound","subj":"T3176","obj":"T3178"},{"id":"R2084","pred":"compound","subj":"T3177","obj":"T3176"},{"id":"R2085","pred":"pobj","subj":"T3178","obj":"T3174"},{"id":"R2086","pred":"punct","subj":"T3179","obj":"T3166"},{"id":"R2087","pred":"amod","subj":"T3180","obj":"T3181"},{"id":"R2088","pred":"nsubjpass","subj":"T3181","obj":"T3166"},{"id":"R2089","pred":"compound","subj":"T3182","obj":"T3181"},{"id":"R2090","pred":"punct","subj":"T3183","obj":"T3181"},{"id":"R2091","pred":"auxpass","subj":"T3184","obj":"T3166"},{"id":"R2092","pred":"aux","subj":"T3185","obj":"T3186"},{"id":"R2093","pred":"advcl","subj":"T3186","obj":"T3166"},{"id":"R2094","pred":"compound","subj":"T3187","obj":"T3188"},{"id":"R2095","pred":"dobj","subj":"T3188","obj":"T3186"},{"id":"R2096","pred":"prep","subj":"T3189","obj":"T3188"},{"id":"R2097","pred":"det","subj":"T3190","obj":"T3191"},{"id":"R2098","pred":"pobj","subj":"T3191","obj":"T3189"},{"id":"R2099","pred":"amod","subj":"T3192","obj":"T3193"},{"id":"R2100","pred":"compound","subj":"T3193","obj":"T3191"},{"id":"R2101","pred":"compound","subj":"T3194","obj":"T3193"},{"id":"R2102","pred":"compound","subj":"T3195","obj":"T3191"},{"id":"R2103","pred":"punct","subj":"T3196","obj":"T3191"},{"id":"R2104","pred":"appos","subj":"T3197","obj":"T3191"},{"id":"R2105","pred":"punct","subj":"T3198","obj":"T3166"},{"id":"R2106","pred":"prep","subj":"T3200","obj":"T3201"},{"id":"R2107","pred":"amod","subj":"T3202","obj":"T3203"},{"id":"R2108","pred":"compound","subj":"T3203","obj":"T3204"},{"id":"R2109","pred":"pobj","subj":"T3204","obj":"T3200"},{"id":"R2110","pred":"punct","subj":"T3205","obj":"T3201"},{"id":"R2111","pred":"compound","subj":"T3206","obj":"T3207"},{"id":"R2112","pred":"nsubj","subj":"T3207","obj":"T3201"},{"id":"R2113","pred":"quantmod","subj":"T3208","obj":"T3209"},{"id":"R2114","pred":"nummod","subj":"T3209","obj":"T3213"},{"id":"R2115","pred":"punct","subj":"T3210","obj":"T3209"},{"id":"R2116","pred":"punct","subj":"T3211","obj":"T3209"},{"id":"R2117","pred":"punct","subj":"T3212","obj":"T3209"},{"id":"R2118","pred":"dobj","subj":"T3213","obj":"T3201"},{"id":"R2119","pred":"prep","subj":"T3214","obj":"T3213"},{"id":"R2120","pred":"compound","subj":"T3215","obj":"T3216"},{"id":"R2121","pred":"pobj","subj":"T3216","obj":"T3214"},{"id":"R2122","pred":"punct","subj":"T3217","obj":"T3216"},{"id":"R2123","pred":"punct","subj":"T3218","obj":"T3219"},{"id":"R2124","pred":"parataxis","subj":"T3219","obj":"T3213"},{"id":"R2125","pred":"nsubj","subj":"T3220","obj":"T3219"},{"id":"R2126","pred":"punct","subj":"T3221","obj":"T3219"},{"id":"R2127","pred":"punct","subj":"T3222","obj":"T3219"},{"id":"R2128","pred":"punct","subj":"T3223","obj":"T3201"},{"id":"R2129","pred":"cc","subj":"T3224","obj":"T3201"},{"id":"R2130","pred":"prep","subj":"T3225","obj":"T3226"},{"id":"R2131","pred":"conj","subj":"T3226","obj":"T3201"},{"id":"R2132","pred":"det","subj":"T3227","obj":"T3228"},{"id":"R2133","pred":"pobj","subj":"T3228","obj":"T3225"},{"id":"R2134","pred":"amod","subj":"T3229","obj":"T3228"},{"id":"R2135","pred":"det","subj":"T3230","obj":"T3231"},{"id":"R2136","pred":"nsubj","subj":"T3231","obj":"T3226"},{"id":"R2137","pred":"quantmod","subj":"T3232","obj":"T3233"},{"id":"R2138","pred":"attr","subj":"T3233","obj":"T3226"},{"id":"R2139","pred":"punct","subj":"T3234","obj":"T3233"},{"id":"R2140","pred":"punct","subj":"T3235","obj":"T3233"},{"id":"R2141","pred":"punct","subj":"T3236","obj":"T3233"},{"id":"R2142","pred":"punct","subj":"T3237","obj":"T3238"},{"id":"R2143","pred":"parataxis","subj":"T3238","obj":"T3233"},{"id":"R2144","pred":"nsubj","subj":"T3239","obj":"T3238"},{"id":"R2145","pred":"punct","subj":"T3240","obj":"T3238"},{"id":"R2146","pred":"punct","subj":"T3241","obj":"T3238"},{"id":"R2147","pred":"punct","subj":"T3242","obj":"T3226"},{"id":"R2148","pred":"compound","subj":"T3244","obj":"T3245"},{"id":"R2149","pred":"nsubj","subj":"T3245","obj":"T3246"},{"id":"R2150","pred":"prep","subj":"T3247","obj":"T3245"},{"id":"R2151","pred":"det","subj":"T3248","obj":"T3249"},{"id":"R2152","pred":"pobj","subj":"T3249","obj":"T3247"},{"id":"R2153","pred":"compound","subj":"T3250","obj":"T3249"},{"id":"R2154","pred":"quantmod","subj":"T3251","obj":"T3252"},{"id":"R2155","pred":"nummod","subj":"T3252","obj":"T3256"},{"id":"R2156","pred":"punct","subj":"T3253","obj":"T3252"},{"id":"R2157","pred":"punct","subj":"T3254","obj":"T3252"},{"id":"R2158","pred":"punct","subj":"T3255","obj":"T3252"},{"id":"R2159","pred":"dobj","subj":"T3256","obj":"T3246"},{"id":"R2160","pred":"prep","subj":"T3257","obj":"T3256"},{"id":"R2161","pred":"compound","subj":"T3258","obj":"T3259"},{"id":"R2162","pred":"pobj","subj":"T3259","obj":"T3257"},{"id":"R2163","pred":"prep","subj":"T3260","obj":"T3256"},{"id":"R2164","pred":"pobj","subj":"T3261","obj":"T3260"},{"id":"R2165","pred":"punct","subj":"T3262","obj":"T3263"},{"id":"R2166","pred":"parataxis","subj":"T3263","obj":"T3256"},{"id":"R2167","pred":"nsubj","subj":"T3264","obj":"T3263"},{"id":"R2168","pred":"punct","subj":"T3265","obj":"T3263"},{"id":"R2169","pred":"punct","subj":"T3266","obj":"T3263"},{"id":"R2170","pred":"punct","subj":"T3267","obj":"T3246"},{"id":"R2171","pred":"cc","subj":"T3268","obj":"T3246"},{"id":"R2172","pred":"prep","subj":"T3269","obj":"T3270"},{"id":"R2173","pred":"conj","subj":"T3270","obj":"T3246"},{"id":"R2174","pred":"det","subj":"T3271","obj":"T3272"},{"id":"R2175","pred":"pobj","subj":"T3272","obj":"T3269"},{"id":"R2176","pred":"amod","subj":"T3273","obj":"T3272"},{"id":"R2177","pred":"det","subj":"T3274","obj":"T3275"},{"id":"R2178","pred":"nsubj","subj":"T3275","obj":"T3270"},{"id":"R2179","pred":"quantmod","subj":"T3276","obj":"T3277"},{"id":"R2180","pred":"attr","subj":"T3277","obj":"T3270"},{"id":"R2181","pred":"punct","subj":"T3278","obj":"T3277"},{"id":"R2182","pred":"punct","subj":"T3279","obj":"T3277"},{"id":"R2183","pred":"punct","subj":"T3280","obj":"T3277"},{"id":"R2184","pred":"punct","subj":"T3281","obj":"T3282"},{"id":"R2185","pred":"parataxis","subj":"T3282","obj":"T3270"},{"id":"R2186","pred":"nsubj","subj":"T3283","obj":"T3282"},{"id":"R2187","pred":"punct","subj":"T3284","obj":"T3282"},{"id":"R2188","pred":"punct","subj":"T3285","obj":"T3282"},{"id":"R2189","pred":"punct","subj":"T3286","obj":"T3270"},{"id":"R2190","pred":"prep","subj":"T3288","obj":"T3289"},{"id":"R2191","pred":"det","subj":"T3290","obj":"T3291"},{"id":"R2192","pred":"pobj","subj":"T3291","obj":"T3288"},{"id":"R2193","pred":"amod","subj":"T3292","obj":"T3291"},{"id":"R2194","pred":"compound","subj":"T3293","obj":"T3291"},{"id":"R2195","pred":"prep","subj":"T3294","obj":"T3291"},{"id":"R2196","pred":"pobj","subj":"T3295","obj":"T3294"},{"id":"R2197","pred":"punct","subj":"T3296","obj":"T3289"},{"id":"R2198","pred":"expl","subj":"T3297","obj":"T3289"},{"id":"R2199","pred":"det","subj":"T3298","obj":"T3299"},{"id":"R2200","pred":"attr","subj":"T3299","obj":"T3289"},{"id":"R2201","pred":"amod","subj":"T3300","obj":"T3299"},{"id":"R2202","pred":"prep","subj":"T3301","obj":"T3299"},{"id":"R2203","pred":"compound","subj":"T3302","obj":"T3303"},{"id":"R2204","pred":"pobj","subj":"T3303","obj":"T3301"},{"id":"R2205","pred":"prep","subj":"T3304","obj":"T3289"},{"id":"R2206","pred":"det","subj":"T3305","obj":"T3306"},{"id":"R2207","pred":"pobj","subj":"T3306","obj":"T3304"},{"id":"R2208","pred":"nmod","subj":"T3307","obj":"T3306"},{"id":"R2209","pred":"amod","subj":"T3308","obj":"T3306"},{"id":"R2210","pred":"punct","subj":"T3309","obj":"T3310"},{"id":"R2211","pred":"parataxis","subj":"T3310","obj":"T3289"},{"id":"R2212","pred":"nsubj","subj":"T3311","obj":"T3310"},{"id":"R2213","pred":"punct","subj":"T3312","obj":"T3310"},{"id":"R2214","pred":"punct","subj":"T3313","obj":"T3310"},{"id":"R2215","pred":"punct","subj":"T3314","obj":"T3289"},{"id":"R2216","pred":"mark","subj":"T3315","obj":"T3316"},{"id":"R2217","pred":"advcl","subj":"T3316","obj":"T3289"},{"id":"R2218","pred":"advmod","subj":"T3317","obj":"T3316"},{"id":"R2219","pred":"punct","subj":"T3318","obj":"T3319"},{"id":"R2220","pred":"parataxis","subj":"T3319","obj":"T3289"},{"id":"R2221","pred":"punct","subj":"T3320","obj":"T3319"},{"id":"R2222","pred":"punct","subj":"T3321","obj":"T3289"},{"id":"R2223","pred":"advmod","subj":"T3323","obj":"T3324"},{"id":"R2224","pred":"punct","subj":"T3325","obj":"T3324"},{"id":"R2225","pred":"det","subj":"T3326","obj":"T3327"},{"id":"R2226","pred":"nsubj","subj":"T3327","obj":"T3324"},{"id":"R2227","pred":"amod","subj":"T3328","obj":"T3327"},{"id":"R2228","pred":"compound","subj":"T3329","obj":"T3327"},{"id":"R2229","pred":"prep","subj":"T3330","obj":"T3327"},{"id":"R2230","pred":"det","subj":"T3331","obj":"T3332"},{"id":"R2231","pred":"pobj","subj":"T3332","obj":"T3330"},{"id":"R2232","pred":"amod","subj":"T3333","obj":"T3332"},{"id":"R2233","pred":"punct","subj":"T3334","obj":"T3327"},{"id":"R2234","pred":"dep","subj":"T3335","obj":"T3336"},{"id":"R2235","pred":"relcl","subj":"T3336","obj":"T3327"},{"id":"R2236","pred":"amod","subj":"T3337","obj":"T3338"},{"id":"R2237","pred":"dobj","subj":"T3338","obj":"T3336"},{"id":"R2238","pred":"compound","subj":"T3339","obj":"T3338"},{"id":"R2239","pred":"punct","subj":"T3340","obj":"T3324"},{"id":"R2240","pred":"aux","subj":"T3341","obj":"T3324"},{"id":"R2241","pred":"neg","subj":"T3342","obj":"T3324"},{"id":"R2242","pred":"amod","subj":"T3343","obj":"T3344"},{"id":"R2243","pred":"dobj","subj":"T3344","obj":"T3324"},{"id":"R2244","pred":"compound","subj":"T3345","obj":"T3346"},{"id":"R2245","pred":"compound","subj":"T3346","obj":"T3344"},{"id":"R2246","pred":"punct","subj":"T3347","obj":"T3324"},{"id":"R4660","pred":"amod","subj":"T6955","obj":"T6956"},{"id":"R4661","pred":"prep","subj":"T6957","obj":"T6956"},{"id":"R4662","pred":"det","subj":"T6958","obj":"T6959"},{"id":"R4663","pred":"pobj","subj":"T6959","obj":"T6957"},{"id":"R4664","pred":"amod","subj":"T6960","obj":"T6959"},{"id":"R4665","pred":"prep","subj":"T6961","obj":"T6959"},{"id":"R4666","pred":"amod","subj":"T6962","obj":"T6963"},{"id":"R4667","pred":"nmod","subj":"T6963","obj":"T6964"},{"id":"R4668","pred":"pobj","subj":"T6964","obj":"T6961"},{"id":"R4669","pred":"cc","subj":"T6965","obj":"T6963"},{"id":"R4670","pred":"conj","subj":"T6966","obj":"T6963"},{"id":"R4671","pred":"prep","subj":"T6967","obj":"T6964"},{"id":"R4672","pred":"det","subj":"T6968","obj":"T6969"},{"id":"R4673","pred":"pobj","subj":"T6969","obj":"T6967"},{"id":"R4674","pred":"amod","subj":"T6970","obj":"T6969"},{"id":"R4675","pred":"amod","subj":"T6971","obj":"T6969"},{"id":"R4676","pred":"punct","subj":"T6972","obj":"T6956"},{"id":"R4677","pred":"nsubjpass","subj":"T6974","obj":"T6975"},{"id":"R4678","pred":"auxpass","subj":"T6976","obj":"T6975"},{"id":"R4679","pred":"dep","subj":"T6977","obj":"T6975"},{"id":"R4680","pred":"cc","subj":"T6978","obj":"T6975"},{"id":"R4681","pred":"conj","subj":"T6979","obj":"T6975"},{"id":"R4682","pred":"prep","subj":"T6980","obj":"T6979"},{"id":"R4683","pred":"pobj","subj":"T6981","obj":"T6980"},{"id":"R4684","pred":"prep","subj":"T6982","obj":"T6979"},{"id":"R4685","pred":"amod","subj":"T6983","obj":"T6984"},{"id":"R4686","pred":"pobj","subj":"T6984","obj":"T6982"},{"id":"R4687","pred":"punct","subj":"T6985","obj":"T6975"},{"id":"R4688","pred":"det","subj":"T6987","obj":"T6988"},{"id":"R4689","pred":"nsubj","subj":"T6988","obj":"T6989"},{"id":"R4690","pred":"prep","subj":"T6990","obj":"T6989"},{"id":"R4691","pred":"det","subj":"T6991","obj":"T6992"},{"id":"R4692","pred":"pobj","subj":"T6992","obj":"T6990"},{"id":"R4693","pred":"amod","subj":"T6993","obj":"T6992"},{"id":"R4694","pred":"prep","subj":"T6994","obj":"T6992"},{"id":"R4695","pred":"det","subj":"T6995","obj":"T6996"},{"id":"R4696","pred":"pobj","subj":"T6996","obj":"T6994"},{"id":"R4697","pred":"amod","subj":"T6997","obj":"T6996"},{"id":"R4698","pred":"punct","subj":"T6999","obj":"T7000"},{"id":"R4699","pred":"meta","subj":"T7000","obj":"T7001"},{"id":"R4700","pred":"punct","subj":"T7002","obj":"T7000"},{"id":"R4701","pred":"amod","subj":"T7003","obj":"T7001"},{"id":"R4702","pred":"prep","subj":"T7004","obj":"T7001"},{"id":"R4703","pred":"det","subj":"T7005","obj":"T7006"},{"id":"R4704","pred":"pobj","subj":"T7006","obj":"T7004"},{"id":"R4705","pred":"compound","subj":"T7007","obj":"T7006"},{"id":"R4706","pred":"punct","subj":"T7008","obj":"T7001"},{"id":"R4707","pred":"punct","subj":"T7010","obj":"T7011"},{"id":"R4708","pred":"meta","subj":"T7011","obj":"T7012"},{"id":"R4709","pred":"punct","subj":"T7013","obj":"T7011"},{"id":"R4710","pred":"prep","subj":"T7014","obj":"T7012"},{"id":"R4711","pred":"det","subj":"T7015","obj":"T7016"},{"id":"R4712","pred":"pobj","subj":"T7016","obj":"T7014"},{"id":"R4713","pred":"compound","subj":"T7017","obj":"T7016"},{"id":"R4714","pred":"punct","subj":"T7018","obj":"T7012"},{"id":"R4715","pred":"punct","subj":"T7020","obj":"T7021"},{"id":"R4716","pred":"meta","subj":"T7021","obj":"T7022"},{"id":"R4717","pred":"punct","subj":"T7023","obj":"T7021"},{"id":"R4718","pred":"amod","subj":"T7024","obj":"T7022"},{"id":"R4719","pred":"prep","subj":"T7025","obj":"T7022"},{"id":"R4720","pred":"det","subj":"T7026","obj":"T7027"},{"id":"R4721","pred":"pobj","subj":"T7027","obj":"T7025"},{"id":"R4722","pred":"amod","subj":"T7028","obj":"T7027"},{"id":"R4723","pred":"punct","subj":"T7029","obj":"T7022"},{"id":"R4724","pred":"punct","subj":"T7031","obj":"T7032"},{"id":"R4725","pred":"meta","subj":"T7032","obj":"T7033"},{"id":"R4726","pred":"punct","subj":"T7034","obj":"T7032"},{"id":"R4727","pred":"dep","subj":"T7035","obj":"T7032"},{"id":"R4728","pred":"punct","subj":"T7036","obj":"T7032"},{"id":"R4729","pred":"prep","subj":"T7037","obj":"T7033"},{"id":"R4730","pred":"det","subj":"T7038","obj":"T7039"},{"id":"R4731","pred":"pobj","subj":"T7039","obj":"T7037"},{"id":"R4732","pred":"amod","subj":"T7040","obj":"T7039"},{"id":"R4733","pred":"punct","subj":"T7041","obj":"T7033"},{"id":"R4734","pred":"punct","subj":"T7043","obj":"T7044"},{"id":"R4735","pred":"meta","subj":"T7044","obj":"T7045"},{"id":"R4736","pred":"punct","subj":"T7046","obj":"T7044"},{"id":"R4737","pred":"dep","subj":"T7047","obj":"T7044"},{"id":"R4738","pred":"punct","subj":"T7048","obj":"T7044"},{"id":"R4739","pred":"prep","subj":"T7049","obj":"T7045"},{"id":"R4740","pred":"det","subj":"T7050","obj":"T7051"},{"id":"R4741","pred":"pobj","subj":"T7051","obj":"T7049"},{"id":"R4742","pred":"amod","subj":"T7052","obj":"T7053"},{"id":"R4743","pred":"compound","subj":"T7053","obj":"T7051"},{"id":"R4744","pred":"prep","subj":"T7054","obj":"T7051"},{"id":"R4745","pred":"det","subj":"T7055","obj":"T7056"},{"id":"R4746","pred":"pobj","subj":"T7056","obj":"T7054"},{"id":"R4747","pred":"punct","subj":"T7057","obj":"T7045"},{"id":"R4748","pred":"det","subj":"T7058","obj":"T7059"},{"id":"R4749","pred":"nsubj","subj":"T7059","obj":"T7045"},{"id":"R4750","pred":"acomp","subj":"T7060","obj":"T7045"},{"id":"R4751","pred":"cc","subj":"T7061","obj":"T7045"},{"id":"R4752","pred":"conj","subj":"T7062","obj":"T7045"},{"id":"R4753","pred":"amod","subj":"T7063","obj":"T7064"},{"id":"R4754","pred":"dobj","subj":"T7064","obj":"T7062"},{"id":"R4755","pred":"punct","subj":"T7065","obj":"T7066"},{"id":"R4756","pred":"parataxis","subj":"T7066","obj":"T7062"},{"id":"R4757","pred":"punct","subj":"T7067","obj":"T7066"},{"id":"R4758","pred":"punct","subj":"T7068","obj":"T7045"},{"id":"R4759","pred":"punct","subj":"T7070","obj":"T7071"},{"id":"R4760","pred":"meta","subj":"T7071","obj":"T7072"},{"id":"R4761","pred":"punct","subj":"T7073","obj":"T7071"},{"id":"R4762","pred":"prep","subj":"T7074","obj":"T7072"},{"id":"R4763","pred":"det","subj":"T7075","obj":"T7076"},{"id":"R4764","pred":"pobj","subj":"T7076","obj":"T7074"},{"id":"R4765","pred":"compound","subj":"T7077","obj":"T7076"},{"id":"R4766","pred":"prep","subj":"T7078","obj":"T7076"},{"id":"R4767","pred":"det","subj":"T7079","obj":"T7080"},{"id":"R4768","pred":"pobj","subj":"T7080","obj":"T7078"},{"id":"R4769","pred":"compound","subj":"T7081","obj":"T7080"},{"id":"R4770","pred":"punct","subj":"T7082","obj":"T7072"},{"id":"R4771","pred":"det","subj":"T7083","obj":"T7084"},{"id":"R4772","pred":"nsubj","subj":"T7084","obj":"T7072"},{"id":"R4773","pred":"compound","subj":"T7085","obj":"T7084"},{"id":"R4774","pred":"advmod","subj":"T7086","obj":"T7087"},{"id":"R4775","pred":"acomp","subj":"T7087","obj":"T7072"},{"id":"R4776","pred":"cc","subj":"T7088","obj":"T7087"},{"id":"R4777","pred":"conj","subj":"T7089","obj":"T7087"},{"id":"R4778","pred":"prep","subj":"T7090","obj":"T7089"},{"id":"R4779","pred":"npadvmod","subj":"T7091","obj":"T7092"},{"id":"R4780","pred":"amod","subj":"T7092","obj":"T7094"},{"id":"R4781","pred":"punct","subj":"T7093","obj":"T7092"},{"id":"R4782","pred":"pobj","subj":"T7094","obj":"T7090"},{"id":"R4783","pred":"punct","subj":"T7095","obj":"T7096"},{"id":"R4784","pred":"parataxis","subj":"T7096","obj":"T7072"},{"id":"R4785","pred":"punct","subj":"T7097","obj":"T7096"},{"id":"R4786","pred":"punct","subj":"T7098","obj":"T7072"},{"id":"R4787","pred":"prep","subj":"T7100","obj":"T7101"},{"id":"R4788","pred":"det","subj":"T7102","obj":"T7103"},{"id":"R4789","pred":"pobj","subj":"T7103","obj":"T7100"},{"id":"R4790","pred":"compound","subj":"T7104","obj":"T7103"},{"id":"R4791","pred":"prep","subj":"T7105","obj":"T7103"},{"id":"R4792","pred":"det","subj":"T7106","obj":"T7107"},{"id":"R4793","pred":"pobj","subj":"T7107","obj":"T7105"},{"id":"R4794","pred":"amod","subj":"T7108","obj":"T7107"},{"id":"R4795","pred":"punct","subj":"T7109","obj":"T7101"},{"id":"R4796","pred":"det","subj":"T7110","obj":"T7111"},{"id":"R4797","pred":"nsubj","subj":"T7111","obj":"T7101"},{"id":"R4798","pred":"neg","subj":"T7112","obj":"T7101"},{"id":"R4799","pred":"advmod","subj":"T7113","obj":"T7101"},{"id":"R4800","pred":"acomp","subj":"T7114","obj":"T7101"},{"id":"R4801","pred":"prep","subj":"T7115","obj":"T7114"},{"id":"R4802","pred":"amod","subj":"T7116","obj":"T7117"},{"id":"R4803","pred":"pobj","subj":"T7117","obj":"T7115"},{"id":"R4804","pred":"punct","subj":"T7118","obj":"T7119"},{"id":"R4805","pred":"parataxis","subj":"T7119","obj":"T7101"},{"id":"R4806","pred":"punct","subj":"T7120","obj":"T7119"},{"id":"R4807","pred":"punct","subj":"T7121","obj":"T7101"},{"id":"R4808","pred":"cc","subj":"T7122","obj":"T7101"},{"id":"R4809","pred":"det","subj":"T7123","obj":"T7124"},{"id":"R4810","pred":"nsubj","subj":"T7124","obj":"T7125"},{"id":"R4811","pred":"conj","subj":"T7125","obj":"T7101"},{"id":"R4812","pred":"amod","subj":"T7126","obj":"T7127"},{"id":"R4813","pred":"acomp","subj":"T7127","obj":"T7125"},{"id":"R4814","pred":"punct","subj":"T7128","obj":"T7129"},{"id":"R4815","pred":"parataxis","subj":"T7129","obj":"T7125"},{"id":"R4816","pred":"punct","subj":"T7130","obj":"T7129"},{"id":"R4817","pred":"punct","subj":"T7131","obj":"T7101"},{"id":"R4818","pred":"det","subj":"T7133","obj":"T7134"},{"id":"R4819","pred":"nsubj","subj":"T7134","obj":"T7136"},{"id":"R4820","pred":"compound","subj":"T7135","obj":"T7134"},{"id":"R4821","pred":"prep","subj":"T7137","obj":"T7134"},{"id":"R4822","pred":"det","subj":"T7138","obj":"T7139"},{"id":"R4823","pred":"pobj","subj":"T7139","obj":"T7137"},{"id":"R4824","pred":"amod","subj":"T7140","obj":"T7139"},{"id":"R4825","pred":"advmod","subj":"T7141","obj":"T7142"},{"id":"R4826","pred":"dobj","subj":"T7142","obj":"T7136"},{"id":"R4827","pred":"amod","subj":"T7143","obj":"T7142"},{"id":"R4828","pred":"punct","subj":"T7144","obj":"T7145"},{"id":"R4829","pred":"parataxis","subj":"T7145","obj":"T7136"},{"id":"R4830","pred":"punct","subj":"T7146","obj":"T7145"},{"id":"R4831","pred":"punct","subj":"T7147","obj":"T7136"},{"id":"R4832","pred":"mark","subj":"T7148","obj":"T7149"},{"id":"R4833","pred":"advcl","subj":"T7149","obj":"T7136"},{"id":"R4834","pred":"nsubj","subj":"T7150","obj":"T7149"},{"id":"R4835","pred":"amod","subj":"T7151","obj":"T7152"},{"id":"R4836","pred":"dobj","subj":"T7152","obj":"T7149"},{"id":"R4837","pred":"compound","subj":"T7153","obj":"T7152"},{"id":"R4838","pred":"cc","subj":"T7154","obj":"T7152"},{"id":"R4839","pred":"compound","subj":"T7155","obj":"T7156"},{"id":"R4840","pred":"conj","subj":"T7156","obj":"T7152"},{"id":"R4841","pred":"punct","subj":"T7157","obj":"T7158"},{"id":"R4842","pred":"parataxis","subj":"T7158","obj":"T7149"},{"id":"R4843","pred":"punct","subj":"T7159","obj":"T7158"},{"id":"R4844","pred":"punct","subj":"T7160","obj":"T7136"},{"id":"R4845","pred":"advmod","subj":"T7162","obj":"T7163"},{"id":"R4846","pred":"punct","subj":"T7164","obj":"T7163"},{"id":"R4847","pred":"det","subj":"T7165","obj":"T7166"},{"id":"R4848","pred":"nsubjpass","subj":"T7166","obj":"T7163"},{"id":"R4849","pred":"compound","subj":"T7167","obj":"T7166"},{"id":"R4850","pred":"prep","subj":"T7168","obj":"T7166"},{"id":"R4851","pred":"det","subj":"T7169","obj":"T7170"},{"id":"R4852","pred":"pobj","subj":"T7170","obj":"T7168"},{"id":"R4853","pred":"amod","subj":"T7171","obj":"T7170"},{"id":"R4854","pred":"auxpass","subj":"T7172","obj":"T7163"},{"id":"R4855","pred":"advmod","subj":"T7173","obj":"T7174"},{"id":"R4856","pred":"advmod","subj":"T7174","obj":"T7163"},{"id":"R4857","pred":"prep","subj":"T7175","obj":"T7163"},{"id":"R4858","pred":"prep","subj":"T7176","obj":"T7175"},{"id":"R4859","pred":"pobj","subj":"T7177","obj":"T7176"},{"id":"R4860","pred":"prep","subj":"T7178","obj":"T7177"},{"id":"R4861","pred":"det","subj":"T7179","obj":"T7180"},{"id":"R4862","pred":"pobj","subj":"T7180","obj":"T7178"},{"id":"R4863","pred":"compound","subj":"T7181","obj":"T7180"},{"id":"R4864","pred":"punct","subj":"T7182","obj":"T7163"},{"id":"R2000","pred":"punct","subj":"T3087","obj":"T3084"},{"id":"R2001","pred":"nsubj","subj":"T3088","obj":"T3089"},{"id":"R2002","pred":"conj","subj":"T3089","obj":"T3084"},{"id":"R2003","pred":"det","subj":"T3090","obj":"T3091"},{"id":"R2004","pred":"dobj","subj":"T3091","obj":"T3089"},{"id":"R2005","pred":"punct","subj":"T3092","obj":"T3089"},{"id":"R2006","pred":"cc","subj":"T3093","obj":"T3089"},{"id":"R2007","pred":"nsubj","subj":"T3094","obj":"T3095"},{"id":"R2008","pred":"conj","subj":"T3095","obj":"T3089"},{"id":"R2009","pred":"amod","subj":"T3096","obj":"T3097"},{"id":"R2010","pred":"dobj","subj":"T3097","obj":"T3095"},{"id":"R2011","pred":"prep","subj":"T3098","obj":"T3097"},{"id":"R2012","pred":"pobj","subj":"T3099","obj":"T3098"},{"id":"R2013","pred":"punct","subj":"T3100","obj":"T3084"},{"id":"R2014","pred":"prep","subj":"T3102","obj":"T3103"},{"id":"R2015","pred":"det","subj":"T3104","obj":"T3105"},{"id":"R2016","pred":"pobj","subj":"T3105","obj":"T3102"},{"id":"R2017","pred":"punct","subj":"T3106","obj":"T3103"},{"id":"R2018","pred":"predet","subj":"T3107","obj":"T3108"},{"id":"R2019","pred":"nsubj","subj":"T3108","obj":"T3103"},{"id":"R2020","pred":"det","subj":"T3109","obj":"T3108"},{"id":"R2021","pred":"compound","subj":"T3110","obj":"T3108"},{"id":"R2022","pred":"prep","subj":"T3111","obj":"T3108"},{"id":"R2023","pred":"det","subj":"T3112","obj":"T3113"},{"id":"R2024","pred":"pobj","subj":"T3113","obj":"T3111"},{"id":"R2025","pred":"amod","subj":"T3114","obj":"T3113"},{"id":"R2026","pred":"amod","subj":"T3115","obj":"T3116"},{"id":"R2027","pred":"dobj","subj":"T3116","obj":"T3103"},{"id":"R2028","pred":"compound","subj":"T3117","obj":"T3116"},{"id":"R2029","pred":"cc","subj":"T3118","obj":"T3116"},{"id":"R2030","pred":"amod","subj":"T3119","obj":"T3120"},{"id":"R2031","pred":"conj","subj":"T3120","obj":"T3116"},{"id":"R2032","pred":"compound","subj":"T3121","obj":"T3120"},{"id":"R2033","pred":"prep","subj":"T3122","obj":"T3103"},{"id":"R2034","pred":"prep","subj":"T3123","obj":"T3122"},{"id":"R2035","pred":"compound","subj":"T3124","obj":"T3125"},{"id":"R2036","pred":"pobj","subj":"T3125","obj":"T3123"},{"id":"R2037","pred":"prep","subj":"T3126","obj":"T3125"},{"id":"R2038","pred":"det","subj":"T3127","obj":"T3128"},{"id":"R2042","pred":"advmod","subj":"T3132","obj":"T3133"},{"id":"R2043","pred":"punct","subj":"T3134","obj":"T3133"},{"id":"R2044","pred":"nsubj","subj":"T3135","obj":"T3133"},{"id":"R2045","pred":"mark","subj":"T3136","obj":"T3137"},{"id":"R2046","pred":"ccomp","subj":"T3137","obj":"T3133"}],"text":"CF mice on the mixed background have less intestinal mucus accumulation\nThe most striking histological difference in the CF mouse small intestine is the accumulation of mucus in intestinal crypts which is associated with the lethal obstruction that results in death of these mice on a standard solid chow diet [32]. Using periodic acid Schiff's staining for neutral mucins, histological analysis of small intestine tissues was performed. The wild type small intestine on both the B6 and the mixed genetic backgrounds were similar. The intestinal crypts were very small with only traces of PAS-reactivity in the lumen (Fig. 3A and 3C, respectively). The surfaces of the villus epithelium were moderately stained and goblet cells were strongly stained in the wild type tissues. In contrast, the intestine of CF mice on the B6 genetic background exhibited greatly dilated crypts filled with PAS-reactive mucus (Fig. 3B). CF mice on the mixed background had less mucus accumulation than CF mice on the B6 background (Fig. 3D-F). The amount of mucus in CF mice on the mixed background was variable from mouse to mouse. In some mice (Fig. 3D), only occasional crypts had accumulated mucus and the crypt lumina were not very dilated. In some mice there was more mucus in the crypts (Fig. 3E), while others had moderate mucus accumulation (Fig. 3F). A total of six CF mice on the mixed background were examined histologically, and three had little mucus, one had some mucus, and two had moderate amounts of mucus. Despite the variability, all the CF mice on the mixed background had less crypt dilation and less mucus accumulation compared to CF mice on the B6 background.\nFigure 3 Histological appearance of the small intestine of wild type and CF mice on the different genetic backgrounds. Tissue was paraffin embedded and stained with PAS for neutral mucins. The sections are from the middle portion of the small intestine (A) Wild type on the B6 background. (B) CF on the B6 background. (C) Wild type on the mixed background. (D-F) CF on the mixed background. (A, C) In the wild type tissue from both backgrounds, the crypts are small and have narrow lumina (arrows). (B) In the CF tissue on the B6 background, the crypt lumina are greatly dilated and filled with PAS-reactive mucus (arrows). In some CF mice on the mixed background, the crypts are not apparently different than wild type (D), and the crypts are normal appearing (arrows). Some CF mice on the mixed background had mildly affected crypts (E), while others had greater crypt dilation and mucus accumulation (F). Overall, the CF mice on the mixed background were less severely affected compared to those on the B6 background. Thus, it appears that whatever the nature of the genetic differences between the two background strains, they affect secretion and accumulation of mucus in the CF small intestine. To determine if the difference could be accounted for by altered mucin gene expression, quantitative RT-PCR was used to measure mRNA expression of the intestinal goblet cell mucin gene, Muc2. In wild type intestine, B6 mice had 0.079 +/- 0.024 copies of Muc2/GAPDH (n = 8), and on the mixed background the level was 0.077 +/- 0.012 (n = 11). CF mice on the B6 background had 0.059 +/- 0.024 copies of Muc2 mRNA per GAPDH (n = 11), and on the mixed background the level was 0.056 +/- 0.010 (n = 11). Despite the increased mucus accumulation in CF, there is a slight decrease in Muc2 mRNA in the CF small intestine (P \u003c 0.0001), as previously reported [33]. However, the milder CF phenotype on the mixed background, which includes less mucus accumulation, does not involve decreased mucin gene expression."}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T2718","span":{"begin":53,"end":58},"obj":"UBERON:0000912"},{"id":"T2719","span":{"begin":124,"end":129},"obj":"NCBITaxon:10088"},{"id":"T2720","span":{"begin":130,"end":145},"obj":"UBERON:0002108"},{"id":"T2721","span":{"begin":169,"end":174},"obj":"UBERON:0000912"},{"id":"T2722","span":{"begin":178,"end":195},"obj":"UBERON:0001983"},{"id":"T2723","span":{"begin":225,"end":231},"obj":"GO_EXT:fatality_or_lethality"},{"id":"T2724","span":{"begin":260,"end":265},"obj":"GO:0016265"},{"id":"T2725","span":{"begin":275,"end":279},"obj":"NCBITaxon:10088"},{"id":"T2726","span":{"begin":300,"end":304},"obj":"CHEBI_EXT:33290"},{"id":"T2727","span":{"begin":322,"end":335},"obj":"CHEBI:29149"},{"id":"T2728","span":{"begin":399,"end":414},"obj":"UBERON:0002108"},{"id":"T2729","span":{"begin":415,"end":422},"obj":"UBERON:0000479"},{"id":"T2730","span":{"begin":442,"end":451},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T2731","span":{"begin":452,"end":467},"obj":"UBERON:0002108"},{"id":"T2732","span":{"begin":497,"end":504},"obj":"SO_EXT:0000704"},{"id":"T2733","span":{"begin":535,"end":552},"obj":"UBERON:0001983"},{"id":"T2734","span":{"begin":611,"end":616},"obj":"GO_UBERON_EXT:lumen"},{"id":"T2735","span":{"begin":669,"end":675},"obj":"GO_UBERON_EXT:villus"},{"id":"T2736","span":{"begin":669,"end":686},"obj":"UBERON:0013636"},{"id":"T2737","span":{"begin":715,"end":727},"obj":"CL:0000160"},{"id":"T2738","span":{"begin":722,"end":727},"obj":"CL_GO_EXT:cell"},{"id":"T2739","span":{"begin":757,"end":766},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T2740","span":{"begin":767,"end":774},"obj":"UBERON:0000479"},{"id":"T2741","span":{"begin":793,"end":802},"obj":"UBERON:0000160"},{"id":"T2742","span":{"begin":809,"end":813},"obj":"NCBITaxon:10088"},{"id":"T2743","span":{"begin":824,"end":831},"obj":"SO_EXT:0000704"},{"id":"T2744","span":{"begin":869,"end":875},"obj":"UBERON:0001983"},{"id":"T2745","span":{"begin":901,"end":906},"obj":"UBERON:0000912"},{"id":"T2746","span":{"begin":921,"end":925},"obj":"NCBITaxon:10088"},{"id":"T2747","span":{"begin":959,"end":964},"obj":"UBERON:0000912"},{"id":"T2748","span":{"begin":986,"end":990},"obj":"NCBITaxon:10088"},{"id":"T2749","span":{"begin":1039,"end":1044},"obj":"UBERON:0000912"},{"id":"T2750","span":{"begin":1051,"end":1055},"obj":"NCBITaxon:10088"},{"id":"T2751","span":{"begin":1098,"end":1103},"obj":"NCBITaxon:10088"},{"id":"T2752","span":{"begin":1107,"end":1112},"obj":"NCBITaxon:10088"},{"id":"T2753","span":{"begin":1122,"end":1126},"obj":"NCBITaxon:10088"},{"id":"T2754","span":{"begin":1154,"end":1160},"obj":"UBERON:0001983"},{"id":"T2755","span":{"begin":1177,"end":1182},"obj":"UBERON:0000912"},{"id":"T2756","span":{"begin":1191,"end":1196},"obj":"UBERON:0001983"},{"id":"T2757","span":{"begin":1197,"end":1203},"obj":"GO_UBERON_EXT:lumen"},{"id":"T2758","span":{"begin":1235,"end":1239},"obj":"NCBITaxon:10088"},{"id":"T2759","span":{"begin":1255,"end":1260},"obj":"UBERON:0000912"},{"id":"T2760","span":{"begin":1268,"end":1274},"obj":"UBERON:0001983"},{"id":"T2761","span":{"begin":1312,"end":1317},"obj":"UBERON:0000912"},{"id":"T2762","span":{"begin":1360,"end":1364},"obj":"NCBITaxon:10088"},{"id":"T2763","span":{"begin":1440,"end":1445},"obj":"UBERON:0000912"},{"id":"T2764","span":{"begin":1460,"end":1465},"obj":"UBERON:0000912"},{"id":"T2765","span":{"begin":1499,"end":1504},"obj":"UBERON:0000912"},{"id":"T2766","span":{"begin":1542,"end":1546},"obj":"NCBITaxon:10088"},{"id":"T2767","span":{"begin":1580,"end":1585},"obj":"UBERON:0001983"},{"id":"T2768","span":{"begin":1604,"end":1609},"obj":"UBERON:0000912"},{"id":"T2769","span":{"begin":1638,"end":1642},"obj":"NCBITaxon:10088"},{"id":"T2770","span":{"begin":2736,"end":2743},"obj":"SO_EXT:0000704"},{"id":"T2771","span":{"begin":2804,"end":2813},"obj":"GO_EXT:secretion_entity_or_process"},{"id":"T2772","span":{"begin":2834,"end":2839},"obj":"UBERON:0000912"},{"id":"T2773","span":{"begin":2850,"end":2865},"obj":"UBERON:0002108"},{"id":"T2774","span":{"begin":2938,"end":2942},"obj":"SO_EXT:0000704"},{"id":"T2775","span":{"begin":2938,"end":2953},"obj":"GO:0010467"},{"id":"T2776","span":{"begin":2968,"end":2970},"obj":"GO_EXT:reverse_transcription_or_reverse_transcriptase"},{"id":"T2777","span":{"begin":2995,"end":2999},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T2778","span":{"begin":3000,"end":3010},"obj":"GO:0010467"},{"id":"T2779","span":{"begin":3018,"end":3028},"obj":"UBERON:0000160"},{"id":"T2780","span":{"begin":3029,"end":3040},"obj":"CL:0000160"},{"id":"T2781","span":{"begin":3036,"end":3040},"obj":"CL_GO_EXT:cell"},{"id":"T2782","span":{"begin":3047,"end":3051},"obj":"SO_EXT:0000704"},{"id":"T2783","span":{"begin":3053,"end":3057},"obj":"PR_EXT:000010764"},{"id":"T2784","span":{"begin":3062,"end":3071},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T2785","span":{"begin":3072,"end":3081},"obj":"UBERON:0000160"},{"id":"T2786","span":{"begin":3086,"end":3090},"obj":"NCBITaxon:10088"},{"id":"T2787","span":{"begin":3111,"end":3117},"obj":"SO_EXT:sequence_copy_entity"},{"id":"T2788","span":{"begin":3121,"end":3125},"obj":"PR_EXT:000010764"},{"id":"T2789","span":{"begin":3126,"end":3131},"obj":"GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase"},{"id":"T2790","span":{"begin":3212,"end":3216},"obj":"NCBITaxon:10088"},{"id":"T2791","span":{"begin":3258,"end":3264},"obj":"SO_EXT:sequence_copy_entity"},{"id":"T2792","span":{"begin":3268,"end":3272},"obj":"PR_EXT:000010764"},{"id":"T2793","span":{"begin":3273,"end":3277},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T2794","span":{"begin":3282,"end":3287},"obj":"GO_PR_EXT:glyceraldehyde_3_phosphate_dehydrogenase"},{"id":"T2795","span":{"begin":3388,"end":3393},"obj":"UBERON:0000912"},{"id":"T2796","span":{"begin":3444,"end":3448},"obj":"PR_EXT:000010764"},{"id":"T2797","span":{"begin":3449,"end":3453},"obj":"CHEBI_SO_EXT:mRNA"},{"id":"T2798","span":{"begin":3464,"end":3479},"obj":"UBERON:0002108"},{"id":"T2799","span":{"begin":3601,"end":3606},"obj":"UBERON:0000912"},{"id":"T2800","span":{"begin":3654,"end":3658},"obj":"SO_EXT:0000704"},{"id":"T2801","span":{"begin":3654,"end":3669},"obj":"GO:0010467"},{"id":"T6930","span":{"begin":1706,"end":1721},"obj":"UBERON:0002108"},{"id":"T6931","span":{"begin":1725,"end":1734},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6932","span":{"begin":1742,"end":1746},"obj":"NCBITaxon:10088"},{"id":"T6933","span":{"begin":1764,"end":1771},"obj":"SO_EXT:0000704"},{"id":"T6934","span":{"begin":1785,"end":1791},"obj":"UBERON:0000479"},{"id":"T6935","span":{"begin":1903,"end":1918},"obj":"UBERON:0002108"},{"id":"T6936","span":{"begin":1923,"end":1932},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6937","span":{"begin":1988,"end":1997},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6938","span":{"begin":2071,"end":2080},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6939","span":{"begin":2081,"end":2087},"obj":"UBERON:0000479"},{"id":"T6940","span":{"begin":2115,"end":2121},"obj":"UBERON:0001983"},{"id":"T6941","span":{"begin":2148,"end":2154},"obj":"GO_UBERON_EXT:lumen"},{"id":"T6942","span":{"begin":2179,"end":2185},"obj":"UBERON:0000479"},{"id":"T6943","span":{"begin":2212,"end":2217},"obj":"UBERON:0001983"},{"id":"T6944","span":{"begin":2218,"end":2224},"obj":"GO_UBERON_EXT:lumen"},{"id":"T6945","span":{"begin":2274,"end":2279},"obj":"UBERON:0000912"},{"id":"T6946","span":{"begin":2301,"end":2305},"obj":"NCBITaxon:10088"},{"id":"T6947","span":{"begin":2335,"end":2341},"obj":"UBERON:0001983"},{"id":"T6948","span":{"begin":2376,"end":2385},"obj":"SO_EXT:wild_type_entity_or_quality"},{"id":"T6949","span":{"begin":2399,"end":2405},"obj":"UBERON:0001983"},{"id":"T6950","span":{"begin":2445,"end":2449},"obj":"NCBITaxon:10088"},{"id":"T6951","span":{"begin":2494,"end":2500},"obj":"UBERON:0001983"},{"id":"T6952","span":{"begin":2531,"end":2536},"obj":"UBERON:0001983"},{"id":"T6953","span":{"begin":2550,"end":2555},"obj":"UBERON:0000912"},{"id":"T6954","span":{"begin":2590,"end":2594},"obj":"NCBITaxon:10088"},{"id":"T2716","span":{"begin":3,"end":7},"obj":"NCBITaxon:10088"},{"id":"T2717","span":{"begin":42,"end":52},"obj":"UBERON:0000160"}],"text":"CF mice on the mixed background have less intestinal mucus accumulation\nThe most striking histological difference in the CF mouse small intestine is the accumulation of mucus in intestinal crypts which is associated with the lethal obstruction that results in death of these mice on a standard solid chow diet [32]. Using periodic acid Schiff's staining for neutral mucins, histological analysis of small intestine tissues was performed. The wild type small intestine on both the B6 and the mixed genetic backgrounds were similar. The intestinal crypts were very small with only traces of PAS-reactivity in the lumen (Fig. 3A and 3C, respectively). The surfaces of the villus epithelium were moderately stained and goblet cells were strongly stained in the wild type tissues. In contrast, the intestine of CF mice on the B6 genetic background exhibited greatly dilated crypts filled with PAS-reactive mucus (Fig. 3B). CF mice on the mixed background had less mucus accumulation than CF mice on the B6 background (Fig. 3D-F). The amount of mucus in CF mice on the mixed background was variable from mouse to mouse. In some mice (Fig. 3D), only occasional crypts had accumulated mucus and the crypt lumina were not very dilated. In some mice there was more mucus in the crypts (Fig. 3E), while others had moderate mucus accumulation (Fig. 3F). A total of six CF mice on the mixed background were examined histologically, and three had little mucus, one had some mucus, and two had moderate amounts of mucus. Despite the variability, all the CF mice on the mixed background had less crypt dilation and less mucus accumulation compared to CF mice on the B6 background.\nFigure 3 Histological appearance of the small intestine of wild type and CF mice on the different genetic backgrounds. Tissue was paraffin embedded and stained with PAS for neutral mucins. The sections are from the middle portion of the small intestine (A) Wild type on the B6 background. (B) CF on the B6 background. (C) Wild type on the mixed background. (D-F) CF on the mixed background. (A, C) In the wild type tissue from both backgrounds, the crypts are small and have narrow lumina (arrows). (B) In the CF tissue on the B6 background, the crypt lumina are greatly dilated and filled with PAS-reactive mucus (arrows). In some CF mice on the mixed background, the crypts are not apparently different than wild type (D), and the crypts are normal appearing (arrows). Some CF mice on the mixed background had mildly affected crypts (E), while others had greater crypt dilation and mucus accumulation (F). Overall, the CF mice on the mixed background were less severely affected compared to those on the B6 background. Thus, it appears that whatever the nature of the genetic differences between the two background strains, they affect secretion and accumulation of mucus in the CF small intestine. To determine if the difference could be accounted for by altered mucin gene expression, quantitative RT-PCR was used to measure mRNA expression of the intestinal goblet cell mucin gene, Muc2. In wild type intestine, B6 mice had 0.079 +/- 0.024 copies of Muc2/GAPDH (n = 8), and on the mixed background the level was 0.077 +/- 0.012 (n = 11). CF mice on the B6 background had 0.059 +/- 0.024 copies of Muc2 mRNA per GAPDH (n = 11), and on the mixed background the level was 0.056 +/- 0.010 (n = 11). Despite the increased mucus accumulation in CF, there is a slight decrease in Muc2 mRNA in the CF small intestine (P \u003c 0.0001), as previously reported [33]. However, the milder CF phenotype on the mixed background, which includes less mucus accumulation, does not involve decreased mucin gene expression."}

{"project":"craft-ca-core-dev","denotations":[{"id":"T2657","span":{"begin":300,"end":304},"obj":"CHEBI:33290"},{"id":"T2658","span":{"begin":322,"end":335},"obj":"CHEBI:29149"},{"id":"T2659","span":{"begin":399,"end":414},"obj":"UBERON:0002108"},{"id":"T2660","span":{"begin":415,"end":422},"obj":"UBERON:0000479"},{"id":"T2661","span":{"begin":452,"end":467},"obj":"UBERON:0002108"},{"id":"T2662","span":{"begin":497,"end":504},"obj":"SO:0000704"},{"id":"T2663","span":{"begin":535,"end":552},"obj":"UBERON:0001983"},{"id":"T2664","span":{"begin":669,"end":686},"obj":"UBERON:0013636"},{"id":"T2665","span":{"begin":715,"end":727},"obj":"CL:0000160"},{"id":"T2666","span":{"begin":767,"end":774},"obj":"UBERON:0000479"},{"id":"T2667","span":{"begin":793,"end":802},"obj":"UBERON:0000160"},{"id":"T2668","span":{"begin":809,"end":813},"obj":"NCBITaxon:10088"},{"id":"T2669","span":{"begin":824,"end":831},"obj":"SO:0000704"},{"id":"T2670","span":{"begin":869,"end":875},"obj":"UBERON:0001983"},{"id":"T2671","span":{"begin":901,"end":906},"obj":"UBERON:0000912"},{"id":"T2672","span":{"begin":921,"end":925},"obj":"NCBITaxon:10088"},{"id":"T2673","span":{"begin":959,"end":964},"obj":"UBERON:0000912"},{"id":"T2674","span":{"begin":986,"end":990},"obj":"NCBITaxon:10088"},{"id":"T2675","span":{"begin":1039,"end":1044},"obj":"UBERON:0000912"},{"id":"T2676","span":{"begin":1051,"end":1055},"obj":"NCBITaxon:10088"},{"id":"T2677","span":{"begin":1098,"end":1103},"obj":"NCBITaxon:10088"},{"id":"T2678","span":{"begin":1107,"end":1112},"obj":"NCBITaxon:10088"},{"id":"T2679","span":{"begin":1122,"end":1126},"obj":"NCBITaxon:10088"},{"id":"T2680","span":{"begin":1154,"end":1160},"obj":"UBERON:0001983"},{"id":"T2681","span":{"begin":1177,"end":1182},"obj":"UBERON:0000912"},{"id":"T2682","span":{"begin":1191,"end":1196},"obj":"UBERON:0001983"},{"id":"T2683","span":{"begin":1235,"end":1239},"obj":"NCBITaxon:10088"},{"id":"T2684","span":{"begin":1255,"end":1260},"obj":"UBERON:0000912"},{"id":"T2685","span":{"begin":1268,"end":1274},"obj":"UBERON:0001983"},{"id":"T2686","span":{"begin":1312,"end":1317},"obj":"UBERON:0000912"},{"id":"T2687","span":{"begin":1360,"end":1364},"obj":"NCBITaxon:10088"},{"id":"T2688","span":{"begin":1440,"end":1445},"obj":"UBERON:0000912"},{"id":"T2689","span":{"begin":1460,"end":1465},"obj":"UBERON:0000912"},{"id":"T2690","span":{"begin":1499,"end":1504},"obj":"UBERON:0000912"},{"id":"T2691","span":{"begin":1542,"end":1546},"obj":"NCBITaxon:10088"},{"id":"T2692","span":{"begin":1580,"end":1585},"obj":"UBERON:0001983"},{"id":"T2693","span":{"begin":1604,"end":1609},"obj":"UBERON:0000912"},{"id":"T2694","span":{"begin":1638,"end":1642},"obj":"NCBITaxon:10088"},{"id":"T2695","span":{"begin":2736,"end":2743},"obj":"SO:0000704"},{"id":"T2696","span":{"begin":2834,"end":2839},"obj":"UBERON:0000912"},{"id":"T2697","span":{"begin":2850,"end":2865},"obj":"UBERON:0002108"},{"id":"T2698","span":{"begin":2938,"end":2942},"obj":"SO:0000704"},{"id":"T2699","span":{"begin":2938,"end":2953},"obj":"GO:0010467"},{"id":"T2700","span":{"begin":3000,"end":3010},"obj":"GO:0010467"},{"id":"T2701","span":{"begin":3018,"end":3028},"obj":"UBERON:0000160"},{"id":"T2702","span":{"begin":3029,"end":3040},"obj":"CL:0000160"},{"id":"T2703","span":{"begin":3047,"end":3051},"obj":"SO:0000704"},{"id":"T2704","span":{"begin":3053,"end":3057},"obj":"PR:000010764"},{"id":"T2705","span":{"begin":3072,"end":3081},"obj":"UBERON:0000160"},{"id":"T2706","span":{"begin":3086,"end":3090},"obj":"NCBITaxon:10088"},{"id":"T2707","span":{"begin":3121,"end":3125},"obj":"PR:000010764"},{"id":"T2708","span":{"begin":3212,"end":3216},"obj":"NCBITaxon:10088"},{"id":"T2709","span":{"begin":3268,"end":3272},"obj":"PR:000010764"},{"id":"T2710","span":{"begin":3388,"end":3393},"obj":"UBERON:0000912"},{"id":"T2711","span":{"begin":3444,"end":3448},"obj":"PR:000010764"},{"id":"T2712","span":{"begin":3464,"end":3479},"obj":"UBERON:0002108"},{"id":"T2713","span":{"begin":3601,"end":3606},"obj":"UBERON:0000912"},{"id":"T2714","span":{"begin":3654,"end":3658},"obj":"SO:0000704"},{"id":"T2715","span":{"begin":3654,"end":3669},"obj":"GO:0010467"},{"id":"T6912","span":{"begin":1706,"end":1721},"obj":"UBERON:0002108"},{"id":"T6913","span":{"begin":1742,"end":1746},"obj":"NCBITaxon:10088"},{"id":"T6914","span":{"begin":1764,"end":1771},"obj":"SO:0000704"},{"id":"T6915","span":{"begin":1785,"end":1791},"obj":"UBERON:0000479"},{"id":"T6916","span":{"begin":1903,"end":1918},"obj":"UBERON:0002108"},{"id":"T6917","span":{"begin":2081,"end":2087},"obj":"UBERON:0000479"},{"id":"T6918","span":{"begin":2115,"end":2121},"obj":"UBERON:0001983"},{"id":"T6919","span":{"begin":2179,"end":2185},"obj":"UBERON:0000479"},{"id":"T6920","span":{"begin":2212,"end":2217},"obj":"UBERON:0001983"},{"id":"T6921","span":{"begin":2274,"end":2279},"obj":"UBERON:0000912"},{"id":"T6922","span":{"begin":2301,"end":2305},"obj":"NCBITaxon:10088"},{"id":"T6923","span":{"begin":2335,"end":2341},"obj":"UBERON:0001983"},{"id":"T6924","span":{"begin":2399,"end":2405},"obj":"UBERON:0001983"},{"id":"T6925","span":{"begin":2445,"end":2449},"obj":"NCBITaxon:10088"},{"id":"T6926","span":{"begin":2494,"end":2500},"obj":"UBERON:0001983"},{"id":"T6927","span":{"begin":2531,"end":2536},"obj":"UBERON:0001983"},{"id":"T6928","span":{"begin":2550,"end":2555},"obj":"UBERON:0000912"},{"id":"T6929","span":{"begin":2590,"end":2594},"obj":"NCBITaxon:10088"},{"id":"T2648","span":{"begin":3,"end":7},"obj":"NCBITaxon:10088"},{"id":"T2649","span":{"begin":42,"end":52},"obj":"UBERON:0000160"},{"id":"T2650","span":{"begin":53,"end":58},"obj":"UBERON:0000912"},{"id":"T2651","span":{"begin":124,"end":129},"obj":"NCBITaxon:10088"},{"id":"T2652","span":{"begin":130,"end":145},"obj":"UBERON:0002108"},{"id":"T2653","span":{"begin":169,"end":174},"obj":"UBERON:0000912"},{"id":"T2654","span":{"begin":178,"end":195},"obj":"UBERON:0001983"},{"id":"T2655","span":{"begin":260,"end":265},"obj":"GO:0016265"},{"id":"T2656","span":{"begin":275,"end":279},"obj":"NCBITaxon:10088"}],"text":"CF mice on the mixed background have less intestinal mucus accumulation\nThe most striking histological difference in the CF mouse small intestine is the accumulation of mucus in intestinal crypts which is associated with the lethal obstruction that results in death of these mice on a standard solid chow diet [32]. Using periodic acid Schiff's staining for neutral mucins, histological analysis of small intestine tissues was performed. The wild type small intestine on both the B6 and the mixed genetic backgrounds were similar. The intestinal crypts were very small with only traces of PAS-reactivity in the lumen (Fig. 3A and 3C, respectively). The surfaces of the villus epithelium were moderately stained and goblet cells were strongly stained in the wild type tissues. In contrast, the intestine of CF mice on the B6 genetic background exhibited greatly dilated crypts filled with PAS-reactive mucus (Fig. 3B). CF mice on the mixed background had less mucus accumulation than CF mice on the B6 background (Fig. 3D-F). The amount of mucus in CF mice on the mixed background was variable from mouse to mouse. In some mice (Fig. 3D), only occasional crypts had accumulated mucus and the crypt lumina were not very dilated. In some mice there was more mucus in the crypts (Fig. 3E), while others had moderate mucus accumulation (Fig. 3F). A total of six CF mice on the mixed background were examined histologically, and three had little mucus, one had some mucus, and two had moderate amounts of mucus. Despite the variability, all the CF mice on the mixed background had less crypt dilation and less mucus accumulation compared to CF mice on the B6 background.\nFigure 3 Histological appearance of the small intestine of wild type and CF mice on the different genetic backgrounds. Tissue was paraffin embedded and stained with PAS for neutral mucins. The sections are from the middle portion of the small intestine (A) Wild type on the B6 background. (B) CF on the B6 background. (C) Wild type on the mixed background. (D-F) CF on the mixed background. (A, C) In the wild type tissue from both backgrounds, the crypts are small and have narrow lumina (arrows). (B) In the CF tissue on the B6 background, the crypt lumina are greatly dilated and filled with PAS-reactive mucus (arrows). In some CF mice on the mixed background, the crypts are not apparently different than wild type (D), and the crypts are normal appearing (arrows). Some CF mice on the mixed background had mildly affected crypts (E), while others had greater crypt dilation and mucus accumulation (F). Overall, the CF mice on the mixed background were less severely affected compared to those on the B6 background. Thus, it appears that whatever the nature of the genetic differences between the two background strains, they affect secretion and accumulation of mucus in the CF small intestine. To determine if the difference could be accounted for by altered mucin gene expression, quantitative RT-PCR was used to measure mRNA expression of the intestinal goblet cell mucin gene, Muc2. In wild type intestine, B6 mice had 0.079 +/- 0.024 copies of Muc2/GAPDH (n = 8), and on the mixed background the level was 0.077 +/- 0.012 (n = 11). CF mice on the B6 background had 0.059 +/- 0.024 copies of Muc2 mRNA per GAPDH (n = 11), and on the mixed background the level was 0.056 +/- 0.010 (n = 11). Despite the increased mucus accumulation in CF, there is a slight decrease in Muc2 mRNA in the CF small intestine (P \u003c 0.0001), as previously reported [33]. However, the milder CF phenotype on the mixed background, which includes less mucus accumulation, does not involve decreased mucin gene expression."}