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of the annexins contains a typical nuclear localization signal and their mechanism of nuclear import remains to be elucidated. For Annexin A11 it was shown that nuclear localization is mediated by its N-terminal region, which also contains a binding side for the S100 protein calcyclin [29]. More recently Tomas and Moss [32] showed, that Annexin A11 and S100A6 assemble at the nuclear envelope during nuclear breakdown. Their role in this process is not known. In general it seems that the nuclear localization of the annexins is actively regulated. For example the nucleocytoplasmic compartmentalization of Annexin A2 is controlled by sequestration of the AnxA2/p11 complex modulated by phosphorylation and by a nuclear export signal found in the AnxA2 3–12 region [33]. One function of Annexin A2 in the nucleus, that appears not to involve binding of p11, has been suggested by its purification as part of a primer recognition protein complex that enhances DNA polymeraseα-activity in vitro [34]. The annexins may participate in a nuclear response to initial cell stimulation or to a Ca2+-transient, presumably by regulating DNA replication. For Annexin A7 such a pathway is very speculative at the moment. Future studies are however directed by these findings and will concentrate on the identification of the nuclear localization signal of Annexin A7 as well as on the role of Annexin A7 in the nuclear compartment."}

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For Annexin A11 it was shown that nuclear localization is mediated by its N-terminal region, which also contains a binding side for the S100 protein calcyclin [29]. More recently Tomas and Moss [32] showed, that Annexin A11 and S100A6 assemble at the nuclear envelope during nuclear breakdown. Their role in this process is not known. In general it seems that the nuclear localization of the annexins is actively regulated. For example the nucleocytoplasmic compartmentalization of Annexin A2 is controlled by sequestration of the AnxA2/p11 complex modulated by phosphorylation and by a nuclear export signal found in the AnxA2 3–12 region [33]. One function of Annexin A2 in the nucleus, that appears not to involve binding of p11, has been suggested by its purification as part of a primer recognition protein complex that enhances DNA polymeraseα-activity in vitro [34]. The annexins may participate in a nuclear response to initial cell stimulation or to a Ca2+-transient, presumably by regulating DNA replication. For Annexin A7 such a pathway is very speculative at the moment. Future studies are however directed by these findings and will concentrate on the identification of the nuclear localization signal of Annexin A7 as well as on the role of Annexin A7 in the nuclear compartment."}

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