PMC:1087847 / 27964-29513 JSONTXT

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Although the members of the annexin family are generally found at the plasma membrane, in the cytoplasm or in association with the cytoskeleton, Annexins A1, A2, A4, A5 and A11 have been described to be localized at least partially in the nucleus [26,29,30]. Studies with human foreskin fibroblasts demonstrated that Annexin A1, A4 and A5 are all present in the nucleus at higher concentration than in the cytosol [31]. Raising intracellular Ca2+ led to relocation of these annexins to the nuclear membrane. An important role for annexins in mediating the Ca2+-signal within the nuclei of the fibroblasts was proposed. 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