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altered subcellular location during embryogenesis was also reported for Annexin A11. The developing gray matter of the rat embryonic spinal cord exhibited primarily nuclear localization of Annexin A11, while immunoreactivity was lost from the nuclei in the adult spinal cord [26]. In contrast, our studies show a relocation of Annexin A7 from the cytosol to the nucleus in cells of the embryonic neuronal tissue. The Annexin A7 distribution is determined by a variety of factors. An important one appears to be Ca2+, which promotes binding of Annexin A7 to membranes and also allows aggregation of annexins [27]. Binding partners of Annexin A7 such as sorcin might represent additional factors [28]. Although the members of the annexin family are generally found at the plasma membrane, in the cytoplasm or in association with the cytoskeleton, Annexins A1, A2, A4, A5 and A11 have been described to be localized at least partially in the nucleus [26,29,30]. Studies with human foreskin fibroblasts demonstrated that Annexin A1, A4 and A5 are all present in the nucleus at higher concentration than in the cytosol [31]. Raising intracellular Ca2+ led to relocation of these annexins to the nuclear membrane. An important role for annexins in mediating the Ca2+-signal within the nuclei of the fibroblasts was proposed. These results mirror studies with stably transfected C6 cells, in which high intracellular Ca2+-concentrations induced a marked redistribution of Annexin A7 from its localization in the nucleoplasm to the nuclear membrane [19]."}

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