PMC:1064873 / 25679-26395 JSONTXT

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{"project":"GO-BP","denotations":[{"id":"T22898","span":{"begin":242,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0001775"},{"id":"T22897","span":{"begin":240,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_1903905"},{"id":"T22896","span":{"begin":240,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0050863"},{"id":"T22895","span":{"begin":240,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0050798"},{"id":"T22894","span":{"begin":240,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0042110"},{"id":"T22893","span":{"begin":240,"end":257},"obj":"http://purl.obolibrary.org/obo/GO_0051132"},{"id":"T22891","span":{"begin":41,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0001816"},{"id":"T22890","span":{"begin":36,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0035745"},{"id":"T22889","span":{"begin":36,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0035744"},{"id":"T22888","span":{"begin":36,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0002368"},{"id":"T22887","span":{"begin":36,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0032762"},{"id":"T22886","span":{"begin":36,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0002371"},{"id":"T22885","span":{"begin":36,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0002370"},{"id":"T22884","span":{"begin":34,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0002724"},{"id":"T22883","span":{"begin":34,"end":60},"obj":"http://purl.obolibrary.org/obo/GO_0002369"},{"id":"T22880","span":{"begin":511,"end":526},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1]. However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20]. More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33]. This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2."}

{"project":"GO-CC","denotations":[{"id":"T23663","span":{"begin":619,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1]. However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20]. More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33]. This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2."}

{"project":"GO-MF","denotations":[{"id":"T23620","span":{"begin":711,"end":715},"obj":"http://purl.obolibrary.org/obo/GO_0005134"},{"id":"T23564","span":{"begin":644,"end":649},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T23563","span":{"begin":407,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0005141"},{"id":"T23562","span":{"begin":0,"end":5},"obj":"http://purl.obolibrary.org/obo/GO_0005141"}],"text":"IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1]. However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20]. More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33]. This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2."}

{"project":"sentences","denotations":[{"id":"T22812","span":{"begin":533,"end":716},"obj":"Sentence"},{"id":"T22811","span":{"begin":392,"end":532},"obj":"Sentence"},{"id":"T22810","span":{"begin":156,"end":391},"obj":"Sentence"},{"id":"T22809","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T152","span":{"begin":0,"end":155},"obj":"Sentence"},{"id":"T153","span":{"begin":156,"end":391},"obj":"Sentence"},{"id":"T154","span":{"begin":392,"end":532},"obj":"Sentence"},{"id":"T155","span":{"begin":533,"end":716},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1]. However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20]. More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33]. This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2."}

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{"project":"BioNLP16_DUT","denotations":[{"id":"T30167","span":{"begin":711,"end":715},"obj":"Protein"},{"id":"T30166","span":{"begin":701,"end":706},"obj":"Protein"},{"id":"T30165","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T30164","span":{"begin":644,"end":649},"obj":"Protein"},{"id":"T30163","span":{"begin":612,"end":615},"obj":"Protein"},{"id":"T30162","span":{"begin":497,"end":501},"obj":"Protein"},{"id":"T30161","span":{"begin":407,"end":412},"obj":"Protein"},{"id":"T30160","span":{"begin":338,"end":342},"obj":"Protein"},{"id":"T30159","span":{"begin":329,"end":333},"obj":"Protein"},{"id":"T30158","span":{"begin":29,"end":32},"obj":"Protein"},{"id":"T30157","span":{"begin":0,"end":5},"obj":"Protein"},{"id":"T30350","span":{"begin":634,"end":643},"obj":"Negative_regulation"},{"id":"T30349","span":{"begin":650,"end":660},"obj":"Negative_regulation"},{"id":"T30348","span":{"begin":682,"end":692},"obj":"Gene_expression"},{"id":"T30347","span":{"begin":669,"end":681},"obj":"Positive_regulation"},{"id":"T30346","span":{"begin":511,"end":526},"obj":"Phosphorylation"},{"id":"T30345","span":{"begin":486,"end":496},"obj":"Negative_regulation"},{"id":"T30344","span":{"begin":295,"end":302},"obj":"Gene_expression"}],"relations":[{"id":"R16106","pred":"themeOf","subj":"T30159","obj":"T30344"},{"id":"R16108","pred":"themeOf","subj":"T30162","obj":"T30346"},{"id":"R16110","pred":"themeOf","subj":"T30164","obj":"T30350"},{"id":"R16111","pred":"themeOf","subj":"T30164","obj":"T30349"},{"id":"R16112","pred":"themeOf","subj":"T30165","obj":"T30347"},{"id":"R16113","pred":"themeOf","subj":"T30166","obj":"T30348"},{"id":"R16114","pred":"themeOf","subj":"T30167","obj":"T30348"},{"id":"R16169","pred":"themeOf","subj":"T30346","obj":"T30345"},{"id":"R16171","pred":"themeOf","subj":"T30348","obj":"T30349"},{"id":"R16172","pred":"themeOf","subj":"T30348","obj":"T30349"},{"id":"R16173","pred":"themeOf","subj":"T30348","obj":"T30347"},{"id":"R16174","pred":"themeOf","subj":"T30348","obj":"T30347"}],"text":"IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1]. However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20]. More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33]. This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T26710","span":{"begin":682,"end":692},"obj":"Gene_expression"},{"id":"T26709","span":{"begin":634,"end":643},"obj":"Negative_regulation"},{"id":"T26708","span":{"begin":669,"end":681},"obj":"Positive_regulation"},{"id":"T26707","span":{"begin":650,"end":660},"obj":"Negative_regulation"},{"id":"T26706","span":{"begin":511,"end":526},"obj":"Phosphorylation"},{"id":"T26705","span":{"begin":486,"end":496},"obj":"Negative_regulation"},{"id":"T26523","span":{"begin":711,"end":715},"obj":"Protein"},{"id":"T26522","span":{"begin":701,"end":706},"obj":"Protein"},{"id":"T26521","span":{"begin":664,"end":668},"obj":"Protein"},{"id":"T26520","span":{"begin":644,"end":649},"obj":"Protein"},{"id":"T26519","span":{"begin":612,"end":615},"obj":"Protein"},{"id":"T26518","span":{"begin":497,"end":501},"obj":"Protein"},{"id":"T26517","span":{"begin":407,"end":412},"obj":"Protein"},{"id":"T26516","span":{"begin":338,"end":342},"obj":"Protein"},{"id":"T26515","span":{"begin":329,"end":333},"obj":"Protein"},{"id":"T26514","span":{"begin":29,"end":32},"obj":"Protein"},{"id":"T26513","span":{"begin":0,"end":5},"obj":"Protein"}],"relations":[{"id":"R13482","pred":"causeOf","subj":"T26517","obj":"T26705"},{"id":"R13484","pred":"themeOf","subj":"T26518","obj":"T26706"},{"id":"R13486","pred":"themeOf","subj":"T26520","obj":"T26709"},{"id":"R13488","pred":"themeOf","subj":"T26521","obj":"T26708"},{"id":"R13489","pred":"themeOf","subj":"T26522","obj":"T26710"},{"id":"R13491","pred":"themeOf","subj":"T26523","obj":"T26710"},{"id":"R13573","pred":"themeOf","subj":"T26706","obj":"T26705"},{"id":"R13576","pred":"themeOf","subj":"T26710","obj":"T26707"},{"id":"R13578","pred":"themeOf","subj":"T26710","obj":"T26707"},{"id":"R13579","pred":"themeOf","subj":"T26710","obj":"T26708"},{"id":"R13580","pred":"themeOf","subj":"T26710","obj":"T26708"}],"text":"IL-10-mediated inhibition of CD4+ T-cell cytokine production is principally dependent on its inhibition of macrophage antigen-presenting cell function [1]. However, this indirect inhibitory effect is thought to be restricted at the site of T-cell activation in RA, because macrophages in the ST express high levels of cytokines, CD80 and CD86 molecules, and MHC class II antigens [10,18-20]. More recently, IL-10 has been shown to induce the antigen-specific T-cell unresponsiveness by inhibiting CD28 tyrosine phosphorylation [33]. This direct effect also may be limited in active RA patients, because their PB CD4+ T cells showed a defective IL-10 inhibition of CD28-costimulated production of both IFN-γ and IL-2."}

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