| Id |
Subject |
Object |
Predicate |
Lexical cue |
Negation |
Speculation |
| T5 |
678-686 |
Positive_regulation |
denotes |
required |
|
|
| T6 |
690-698 |
Regulation |
denotes |
regulate |
|
|
| T7 |
699-704 |
Protein |
denotes |
HSP27 |
|
|
| T8 |
705-720 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T463 |
1131-1135 |
Protein |
denotes |
PKD1 |
|
|
| T464 |
1137-1141 |
Protein |
denotes |
PKD2 |
|
|
| T465 |
1146-1150 |
Protein |
denotes |
PKD3 |
|
|
| T466 |
1755-1762 |
Binding |
denotes |
binding |
|
|
| T467 |
1775-1786 |
Positive_regulation |
denotes |
contributes |
|
|
| T468 |
1790-1794 |
Protein |
denotes |
PKD1 |
|
|
| T469 |
1795-1805 |
Positive_regulation |
denotes |
activation |
|
|
| T470 |
2413-2417 |
Protein |
denotes |
PKD1 |
|
|
| T471 |
2431-2436 |
Protein |
denotes |
HSP27 |
|
|
| T472 |
2640-2644 |
Protein |
denotes |
MEF2 |
|
|
| T473 |
3193-3206 |
Positive_regulation |
denotes |
indispensable |
|
|
| T474 |
3211-3216 |
Protein |
denotes |
HSP27 |
|
|
| T475 |
3217-3232 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T1658 |
3832-3836 |
Protein |
denotes |
PKD1 |
|
|
| T1659 |
3841-3845 |
Protein |
denotes |
PKD3 |
|
|
| T1660 |
3853-3857 |
Protein |
denotes |
PKD1 |
|
|
| T1661 |
3858-3859 |
Protein |
denotes |
3 |
|
|
| T2103 |
4555-4560 |
Protein |
denotes |
HSP27 |
|
true |
| T2104 |
4561-4576 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2105 |
4647-4654 |
Gene_expression |
denotes |
express |
|
|
| T2106 |
4673-4677 |
Protein |
denotes |
PKD1 |
|
|
| T2107 |
4682-4686 |
Protein |
denotes |
PKD3 |
|
|
| T2108 |
4766-4770 |
Negative_regulation |
denotes |
lack |
|
|
| T2109 |
4771-4781 |
Gene_expression |
denotes |
expression |
|
|
| T2110 |
4792-4796 |
Protein |
denotes |
PKD1 |
|
|
| T2111 |
4800-4804 |
Protein |
denotes |
PKD3 |
|
|
| T2112 |
4887-4891 |
Protein |
denotes |
PKD1 |
|
|
| T2113 |
4902-4906 |
Protein |
denotes |
PKD3 |
|
|
| T2114 |
4925-4934 |
Gene_expression |
denotes |
expressed |
|
|
| T2115 |
4942-4946 |
Protein |
denotes |
PKD3 |
|
|
| T2116 |
5056-5060 |
Protein |
denotes |
PKD3 |
|
|
| T2117 |
5061-5071 |
Gene_expression |
denotes |
expression |
|
true |
| T2118 |
5075-5079 |
Protein |
denotes |
PKD1 |
|
|
| T2119 |
5080-5081 |
Protein |
denotes |
3 |
|
|
| T2120 |
5089-5097 |
Negative_regulation |
denotes |
knockout |
|
|
| T2121 |
5132-5136 |
Protein |
denotes |
PKD3 |
|
|
| T2122 |
5439-5443 |
Protein |
denotes |
PKD1 |
|
|
| T2123 |
5444-5445 |
Protein |
denotes |
3 |
|
|
| T2124 |
5551-5556 |
Protein |
denotes |
HSP27 |
|
|
| T2125 |
5589-5593 |
Protein |
denotes |
PKD1 |
|
|
| T2126 |
5670-5679 |
Negative_regulation |
denotes |
defective |
|
|
| T2127 |
5680-5695 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2128 |
5699-5704 |
Protein |
denotes |
HSP27 |
|
|
| T2129 |
5708-5714 |
Entity |
denotes |
serine |
|
|
| T2130 |
5732-5736 |
Protein |
denotes |
PKD1 |
|
|
| T2131 |
5787-5797 |
Regulation |
denotes |
regulation |
|
|
| T2132 |
5801-5806 |
Protein |
denotes |
HSP27 |
|
|
| T2133 |
5807-5822 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2134 |
5833-5841 |
Negative_regulation |
denotes |
knockout |
|
|
| T2135 |
5855-5862 |
Negative_regulation |
denotes |
lacking |
|
|
| T2136 |
5870-5874 |
Protein |
denotes |
PKD1 |
|
|
| T2137 |
5878-5882 |
Protein |
denotes |
PKD3 |
|
|
| T2138 |
5966-5975 |
Positive_regulation |
denotes |
increased |
|
|
| T2139 |
5990-5995 |
Protein |
denotes |
HSP27 |
|
|
| T2140 |
5996-6011 |
Phosphorylation |
denotes |
phosphorylation |
true |
|
| T2141 |
6015-6018 |
Entity |
denotes |
S82 |
|
|
| T2142 |
6094-6102 |
Positive_regulation |
denotes |
increase |
|
|
| T2143 |
6103-6108 |
Protein |
denotes |
HSP27 |
|
|
| T2144 |
6109-6124 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2145 |
6128-6132 |
Protein |
denotes |
PKD1 |
|
|
| T2146 |
6136-6140 |
Protein |
denotes |
PKD3 |
|
|
| T2147 |
6148-6156 |
Negative_regulation |
denotes |
knockout |
|
|
| T2148 |
6213-6220 |
Positive_regulation |
denotes |
induced |
|
|
| T2149 |
6221-6236 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2150 |
6240-6245 |
Protein |
denotes |
HSP27 |
|
|
| T2151 |
6249-6252 |
Entity |
denotes |
S82 |
|
|
| T2152 |
6257-6266 |
Negative_regulation |
denotes |
abolished |
|
|
| T2153 |
6283-6289 |
Negative_regulation |
denotes |
lacked |
|
|
| T2154 |
6295-6299 |
Protein |
denotes |
PKD1 |
|
|
| T2155 |
6304-6308 |
Protein |
denotes |
PKD3 |
|
|
| T2156 |
6347-6354 |
Positive_regulation |
denotes |
induced |
|
|
| T2157 |
6355-6365 |
Gene_expression |
denotes |
expression |
|
|
| T2158 |
6378-6382 |
Protein |
denotes |
PKD3 |
|
|
| T2159 |
6455-6465 |
Regulation |
denotes |
regulation |
|
|
| T2160 |
6469-6474 |
Protein |
denotes |
HSP27 |
|
|
| T2161 |
6475-6490 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2162 |
6515-6525 |
Gene_expression |
denotes |
expression |
|
|
| T2163 |
6531-6537 |
Negative_regulation |
denotes |
kinase |
|
|
| T2164 |
6538-6547 |
Negative_regulation |
denotes |
deficient |
|
|
| T2165 |
6548-6552 |
Protein |
denotes |
PKD3 |
|
|
| T2166 |
6613-6620 |
Positive_regulation |
denotes |
restore |
|
|
| T2167 |
6643-6650 |
Positive_regulation |
denotes |
induced |
|
|
| T2168 |
6651-6656 |
Protein |
denotes |
HSP27 |
|
|
| T2169 |
6657-6672 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2170 |
6691-6695 |
Protein |
denotes |
PKD3 |
|
|
| T2171 |
6707-6711 |
Protein |
denotes |
PKD1 |
|
|
| T2172 |
6716-6724 |
Regulation |
denotes |
regulate |
|
|
| T2173 |
6725-6730 |
Protein |
denotes |
HSP27 |
|
|
| T2174 |
6731-6746 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T2175 |
6789-6798 |
Negative_regulation |
denotes |
redundant |
|
|
| T2176 |
6802-6807 |
Protein |
denotes |
HSP27 |
|
|
| T3755 |
7182-7186 |
Protein |
denotes |
PKD1 |
|
|
| T3756 |
7187-7188 |
Protein |
denotes |
3 |
|
|
| T3757 |
7198-7202 |
Protein |
denotes |
PKD3 |
|
|
| T3758 |
7219-7223 |
Protein |
denotes |
PKD1 |
|
|
| T3759 |
7224-7225 |
Protein |
denotes |
3 |
|
|
| T3760 |
7300-7304 |
Protein |
denotes |
PKD1 |
|
|
| T3761 |
7305-7306 |
Protein |
denotes |
3 |
|
|
| T3762 |
7347-7349 |
Positive_regulation |
denotes |
re |
|
|
| T3763 |
7349-7350 |
Gene_expression |
denotes |
- |
|
|
| T3764 |
7350-7360 |
Gene_expression |
denotes |
expression |
|
|
| T3765 |
7369-7373 |
Protein |
denotes |
PKD3 |
|
|
| T3766 |
7463-7467 |
Protein |
denotes |
PKD1 |
|
|
| T3767 |
7468-7469 |
Protein |
denotes |
3 |
|
|
| T3768 |
7637-7641 |
Protein |
denotes |
PKD1 |
|
|
| T3769 |
7642-7643 |
Protein |
denotes |
3 |
|
|
| T3770 |
7761-7765 |
Protein |
denotes |
PKD3 |
|
|
| T3771 |
7766-7769 |
Gene_expression |
denotes |
re- |
|
|
| T3772 |
7769-7779 |
Gene_expression |
denotes |
expression |
|
|
| T3773 |
7816-7820 |
Protein |
denotes |
PKD1 |
|
|
| T3774 |
7821-7822 |
Protein |
denotes |
3 |
|
|
| T3775 |
8109-8113 |
Protein |
denotes |
PKD1 |
|
|
| T3776 |
8118-8122 |
Protein |
denotes |
PKD2 |
|
|
| T3777 |
8438-8442 |
Negative_regulation |
denotes |
loss |
|
|
| T3778 |
8446-8450 |
Protein |
denotes |
PKD1 |
|
|
| T3779 |
8451-8452 |
Protein |
denotes |
3 |
|
|
| T3780 |
8453-8463 |
Gene_expression |
denotes |
expression |
|
|
| T3781 |
8775-8784 |
Negative_regulation |
denotes |
inhibitor |
|
|
| T4882 |
9235-9245 |
Gene_expression |
denotes |
expression |
|
|
| T4883 |
9261-9268 |
Negative_regulation |
denotes |
reduced |
|
|
| T4884 |
9272-9276 |
Protein |
denotes |
PKD1 |
|
|
| T4885 |
9277-9278 |
Protein |
denotes |
3 |
|
|
| T4886 |
9290-9294 |
Protein |
denotes |
PKD1 |
|
|
| T4887 |
9295-9296 |
Protein |
denotes |
3 |
|
|
| T4888 |
9305-9309 |
Protein |
denotes |
PKD3 |
|
|
| T4889 |
9419-9423 |
Protein |
denotes |
PKD1 |
true |
|
| T4890 |
9424-9425 |
Protein |
denotes |
3 |
|
|
| T4891 |
9577-9584 |
Positive_regulation |
denotes |
induced |
true |
|
| T4892 |
9585-9595 |
Positive_regulation |
denotes |
activation |
|
|
| T4893 |
9603-9606 |
Protein |
denotes |
Akt |
true |
|
| T4894 |
9608-9612 |
Protein |
denotes |
mTOR |
true |
|
| T4895 |
9640-9660 |
Protein |
denotes |
S6 ribosomal protein |
true |
|
| T4896 |
9661-9676 |
Phosphorylation |
denotes |
phosphorylation |
true |
|
| T4897 |
9733-9737 |
Protein |
denotes |
PKD1 |
|
|
| T4898 |
9738-9739 |
Protein |
denotes |
3 |
|
|
| T4899 |
9740-9744 |
Negative_regulation |
denotes |
null |
|
|
| T4900 |
9943-9947 |
Protein |
denotes |
PKD1 |
|
|
| T4901 |
9948-9949 |
Protein |
denotes |
3 |
|
|
| T4902 |
9950-9954 |
Negative_regulation |
denotes |
null |
|
|
| T4903 |
10053-10063 |
Regulation |
denotes |
regulation |
|
|
| T4904 |
10071-10075 |
Protein |
denotes |
Erk1 |
|
|
| T4905 |
10076-10080 |
Protein |
denotes |
RSK1 |
|
|
| T4906 |
10104-10111 |
Negative_regulation |
denotes |
reduced |
|
|
| T4907 |
10115-10119 |
Protein |
denotes |
PKD1 |
|
|
| T4908 |
10120-10121 |
Protein |
denotes |
3 |
|
|
| T4909 |
10412-10419 |
Positive_regulation |
denotes |
induced |
|
|
| T4910 |
10424-10439 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4911 |
10449-10456 |
Negative_regulation |
denotes |
reduced |
|
|
| T4912 |
10460-10464 |
Protein |
denotes |
PKD1 |
|
|
| T4913 |
10465-10466 |
Protein |
denotes |
3 |
|
|
| T4914 |
10475-10479 |
Protein |
denotes |
PKD3 |
|
|
| T4915 |
10559-10563 |
Protein |
denotes |
PKD1 |
|
|
| T4916 |
10564-10565 |
Protein |
denotes |
3 |
|
|
| T4917 |
10574-10578 |
Protein |
denotes |
PKD1 |
|
|
| T4918 |
10579-10580 |
Protein |
denotes |
3 |
|
|
| T4919 |
10589-10593 |
Protein |
denotes |
PKD3 |
|
|
| T4920 |
10783-10787 |
Protein |
denotes |
PKD1 |
|
|
| T4921 |
10788-10789 |
Protein |
denotes |
3 |
|
|
| T4922 |
11096-11100 |
Protein |
denotes |
PKD1 |
|
|
| T4923 |
11101-11102 |
Protein |
denotes |
3 |
|
|
| T4924 |
11201-11205 |
Protein |
denotes |
PKD1 |
|
|
| T4925 |
11206-11207 |
Protein |
denotes |
3 |
|
|
| T4926 |
11377-11381 |
Negative_regulation |
denotes |
loss |
|
|
| T4927 |
11385-11389 |
Protein |
denotes |
PKD1 |
|
|
| T4928 |
11390-11391 |
Protein |
denotes |
3 |
|
|
| T4929 |
11626-11634 |
Protein |
denotes |
MAPKAPK2 |
|
|
| T4930 |
12250-12266 |
Protein |
denotes |
Bcr-Abl oncogene |
|
|
| T4931 |
12315-12324 |
Positive_regulation |
denotes |
activated |
|
|
| T4932 |
12325-12329 |
Protein |
denotes |
PKD1 |
|
|
| T4933 |
12346-12350 |
Protein |
denotes |
HPK1 |
|
|
| T4934 |
12414-12423 |
Regulation |
denotes |
regulated |
|
|
| T4935 |
12436-12440 |
Protein |
denotes |
PKCβ |
|
|
| T4936 |
12634-12638 |
Protein |
denotes |
PKD1 |
|
|
| T4937 |
12639-12640 |
Protein |
denotes |
3 |
|
|
| T4938 |
12803-12808 |
Protein |
denotes |
PKCβ− |
|
|
| T4939 |
12893-12912 |
Phosphorylation |
denotes |
autophosphorylation |
|
|
| T4940 |
12916-12920 |
Protein |
denotes |
PKD1 |
|
|
| T4941 |
12950-12955 |
Protein |
denotes |
PKCβ− |
|
|
| T6982 |
13270-13285 |
Phosphorylation |
denotes |
phosphorylation |
|
true |
| T6983 |
13290-13297 |
Entity |
denotes |
nuclear |
|
|
| T6984 |
13298-13310 |
Localization |
denotes |
localisation |
|
|
| T6985 |
13337-13352 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T6986 |
13356-13361 |
Protein |
denotes |
HSP27 |
|
|
| T6987 |
14136-14140 |
Regulation |
denotes |
role |
|
|
| T6988 |
14153-14163 |
Regulation |
denotes |
regulating |
|
|
| T6989 |
14168-14183 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T6990 |
14187-14192 |
Protein |
denotes |
HSP27 |
|
|
| T6991 |
14196-14205 |
Entity |
denotes |
serine 82 |
|
|
| T6992 |
14260-14268 |
Protein |
denotes |
MAPKAPK2 |
|
|
| T6993 |
14650-14654 |
Protein |
denotes |
PKD1 |
|
|
| T6994 |
14655-14656 |
Protein |
denotes |
2 |
|
|
| R1790 |
T2103 |
T2104 |
themeOf |
HSP27,phosphorylation |
| R1791 |
T2106 |
T2105 |
themeOf |
PKD1,express |
| R1792 |
T2107 |
T2105 |
themeOf |
PKD3,express |
| R1793 |
T2109 |
T2108 |
themeOf |
expression,lack |
| R1794 |
T2110 |
T2109 |
themeOf |
PKD1,expression |
| R1795 |
T2111 |
T2109 |
themeOf |
PKD3,expression |
| R1796 |
T2115 |
T2114 |
themeOf |
PKD3,expressed |
| R1797 |
T2116 |
T2117 |
themeOf |
PKD3,expression |
| R1798 |
T2118 |
T2120 |
themeOf |
PKD1,knockout |
| R1799 |
T2127 |
T2126 |
themeOf |
phosphorylation,defective |
| R1800 |
T2132 |
T2133 |
themeOf |
HSP27,phosphorylation |
| R1801 |
T2133 |
T2131 |
themeOf |
phosphorylation,regulation |
| R1802 |
T2134 |
T2131 |
causeOf |
knockout,regulation |
| R1803 |
T2135 |
T2131 |
causeOf |
lacking,regulation |
| R1804 |
T2136 |
T2135 |
themeOf |
PKD1,lacking |
| R1805 |
T2137 |
T2135 |
themeOf |
PKD3,lacking |
| R1806 |
T2139 |
T2140 |
themeOf |
HSP27,phosphorylation |
| R1807 |
T2140 |
T2138 |
themeOf |
phosphorylation,increased |
| R1808 |
T2141 |
T2140 |
themeOf |
S82,phosphorylation |
| R1809 |
T2141 |
T2139 |
partOf |
S82,HSP27 |
| R1810 |
T2143 |
T2144 |
themeOf |
HSP27,phosphorylation |
| R1811 |
T2144 |
T2142 |
themeOf |
phosphorylation,increase |
| R1812 |
T2145 |
T2147 |
themeOf |
PKD1,knockout |
| R1813 |
T2146 |
T2147 |
themeOf |
PKD3,knockout |
| R1814 |
T2148 |
T2152 |
themeOf |
induced,abolished |
| R1815 |
T2149 |
T2148 |
themeOf |
phosphorylation,induced |
| R1816 |
T2149 |
T2152 |
themeOf |
phosphorylation,abolished |
| R1817 |
T2151 |
T2149 |
themeOf |
S82,phosphorylation |
| R1818 |
T2151 |
T2150 |
partOf |
S82,HSP27 |
| R1819 |
T2153 |
T2152 |
causeOf |
lacked,abolished |
| R1820 |
T2154 |
T2153 |
themeOf |
PKD1,lacked |
| R1821 |
T2155 |
T2153 |
themeOf |
PKD3,lacked |
| R1822 |
T2157 |
T2156 |
themeOf |
expression,induced |
| R1823 |
T2158 |
T2157 |
themeOf |
PKD3,expression |
| R1824 |
T2160 |
T2161 |
themeOf |
HSP27,phosphorylation |
| R1825 |
T2161 |
T2159 |
themeOf |
phosphorylation,regulation |
| R1826 |
T2165 |
T2164 |
themeOf |
PKD3,deficient |
| R1827 |
T2165 |
T2162 |
themeOf |
PKD3,expression |
| R1828 |
T2167 |
T2166 |
themeOf |
induced,restore |
| R1829 |
T2168 |
T2169 |
themeOf |
HSP27,phosphorylation |
| R1830 |
T2169 |
T2167 |
themeOf |
phosphorylation,induced |
| R1831 |
T2170 |
T2172 |
causeOf |
PKD3,regulate |
| R1832 |
T2171 |
T2172 |
causeOf |
PKD1,regulate |
| R1833 |
T2173 |
T2174 |
themeOf |
HSP27,phosphorylation |
| R1834 |
T2174 |
T2172 |
themeOf |
phosphorylation,regulate |
| R3047 |
T3778 |
T3780 |
themeOf |
PKD1,expression |
| R3048 |
T3779 |
T3780 |
themeOf |
3,expression |
| R3049 |
T3780 |
T3777 |
themeOf |
expression,loss |
| R3888 |
T4882 |
T4883 |
themeOf |
expression,reduced |
| R3889 |
T4892 |
T4891 |
themeOf |
activation,induced |
| R3890 |
T4893 |
T4892 |
themeOf |
Akt,activation |
| R3891 |
T4894 |
T4892 |
themeOf |
mTOR,activation |
| R3892 |
T4895 |
T4896 |
themeOf |
S6 ribosomal protein,phosphorylation |
| R3893 |
T4896 |
T4892 |
themeOf |
phosphorylation,activation |
| R3894 |
T4897 |
T4899 |
themeOf |
PKD1,null |
| R3895 |
T4898 |
T4899 |
themeOf |
3,null |
| R3896 |
T4900 |
T4902 |
themeOf |
PKD1,null |
| R3897 |
T4901 |
T4902 |
themeOf |
3,null |
| R3898 |
T4909 |
T4911 |
themeOf |
induced,reduced |
| R3899 |
T4910 |
T4909 |
themeOf |
phosphorylation,induced |
| R3900 |
T4910 |
T4911 |
themeOf |
phosphorylation,reduced |
| R3901 |
T4927 |
T4926 |
themeOf |
PKD1,loss |
| R3902 |
T4935 |
T4934 |
causeOf |
PKCβ,regulated |
| R3903 |
T4940 |
T4939 |
themeOf |
PKD1,autophosphorylation |
| R4 |
T6 |
T5 |
themeOf |
regulate,required |
| R419 |
T466 |
T467 |
causeOf |
binding,contributes |
| R420 |
T468 |
T469 |
themeOf |
PKD1,activation |
| R421 |
T469 |
T467 |
themeOf |
activation,contributes |
| R422 |
T474 |
T475 |
themeOf |
HSP27,phosphorylation |
| R423 |
T475 |
T473 |
themeOf |
phosphorylation,indispensable |
| R5 |
T7 |
T8 |
themeOf |
HSP27,phosphorylation |
| R5519 |
T6983 |
T6984 |
locationOf |
nuclear,localisation |
| R5520 |
T6986 |
T6985 |
themeOf |
HSP27,phosphorylation |
| R5521 |
T6989 |
T6988 |
themeOf |
phosphorylation,regulating |
| R5522 |
T6991 |
T6990 |
partOf |
serine 82,HSP27 |
| R5523 |
T6991 |
T6989 |
themeOf |
serine 82,phosphorylation |
| R6 |
T8 |
T6 |
themeOf |
phosphorylation,regulate |
