| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T0 |
0-20 |
GENE |
denotes |
Topoisomerase IIbeta |
| T1 |
21-29 |
REG |
denotes |
mediated |
| T2 |
30-54 |
MPA |
denotes |
DNA double-strand breaks |
| T3 |
56-68 |
REG |
denotes |
implications |
| T4 |
72-98 |
DISEASE |
denotes |
doxorubicin cardiotoxicity |
| T5 |
84-98 |
DISEASE |
denotes |
cardiotoxicity |
| T6 |
103-113 |
NEGREG |
denotes |
prevention |
| T7 |
130-141 |
MPA |
denotes |
Doxorubicin |
| T8 |
227-241 |
DISEASE |
denotes |
cardiotoxicity |
| T9 |
289-306 |
MPA |
denotes |
doxorubicin-based |
| T10 |
421-447 |
DISEASE |
denotes |
doxorubicin cardiotoxicity |
| T11 |
433-447 |
DISEASE |
denotes |
cardiotoxicity |
| T12 |
473-499 |
MPA |
denotes |
doxorubicin cardiotoxicity |
| T13 |
485-499 |
DISEASE |
denotes |
cardiotoxicity |
| T14 |
508-531 |
MPA |
denotes |
cardioprotective effect |
| T15 |
644-653 |
NEGREG |
denotes |
abolished |
| T16 |
676-686 |
GENE |
denotes |
gamma-H2AX |
| T17 |
676-686 |
GENE |
denotes |
gamma-H2AX |
| T18 |
687-694 |
REG |
denotes |
induced |
| T19 |
698-709 |
MPA |
denotes |
doxorubicin |
| T20 |
719-731 |
MPA |
denotes |
camptothecin |
| T21 |
778-808 |
MPA |
denotes |
Doxorubicin-induced DNA damage |
| T22 |
831-840 |
NEGREG |
denotes |
abolished |
| T23 |
859-869 |
NEGREG |
denotes |
inhibitors |
| T24 |
900-907 |
NEGREG |
denotes |
reduced |
| T25 |
911-923 |
GENE |
denotes |
top2beta(-/- |
| T26 |
954-957 |
DISEASE |
denotes |
MEF |
| T27 |
973-985 |
GENE |
denotes |
TOP2beta(+/+ |
| T28 |
993-1003 |
REG |
denotes |
suggesting |
| T29 |
1008-1019 |
REG |
denotes |
involvement |
| T30 |
1023-1033 |
GENE |
denotes |
proteasome |
| T31 |
1038-1062 |
GENE |
denotes |
DNA topoisomerase IIbeta |
| T32 |
1064-1072 |
GENE |
denotes |
Top2beta |
| T33 |
1064-1072 |
GENE |
denotes |
Top2beta |
| T34 |
1103-1115 |
NEGREG |
denotes |
antagonizing |
| T35 |
1116-1120 |
GENE |
denotes |
Top2 |
| T36 |
1121-1147 |
MPA |
denotes |
cleavage complex formation |
| T37 |
1174-1179 |
POSREG |
denotes |
rapid |
| T38 |
1180-1191 |
MPA |
denotes |
degradation |
| T39 |
1195-1203 |
GENE |
denotes |
Top2beta |
| T40 |
1195-1203 |
GENE |
denotes |
Top2beta |
| T41 |
1211-1221 |
REG |
denotes |
paralleled |
| T42 |
1226-1235 |
NEGREG |
denotes |
reduction |
| T43 |
1239-1269 |
MPA |
denotes |
doxorubicin-induced DNA damage |
| T44 |
1318-1329 |
NEGREG |
denotes |
antagonizes |
| T45 |
1330-1360 |
MPA |
denotes |
doxorubicin-induced DNA damage |
| T46 |
1373-1385 |
REG |
denotes |
interference |
| T47 |
1391-1399 |
GENE |
denotes |
Top2beta |
| T48 |
1391-1399 |
GENE |
denotes |
Top2beta |
| T49 |
1413-1422 |
REG |
denotes |
implicate |
| T50 |
1423-1431 |
GENE |
denotes |
Top2beta |
| T51 |
1423-1431 |
GENE |
denotes |
Top2beta |
| T52 |
1435-1461 |
DISEASE |
denotes |
doxorubicin cardiotoxicity |
| T53 |
1447-1461 |
DISEASE |
denotes |
cardiotoxicity |
| T54 |
1476-1487 |
REG |
denotes |
involvement |
| T55 |
1491-1501 |
GENE |
denotes |
proteasome |
| T56 |
1506-1514 |
GENE |
denotes |
Top2beta |
| T57 |
1506-1514 |
GENE |
denotes |
Top2beta |
| T58 |
1518-1548 |
MPA |
denotes |
doxorubicin-induced DNA damage |
| T59 |
1552-1562 |
REG |
denotes |
consistent |
| T60 |
1585-1607 |
MPA |
denotes |
proteasomal processing |
| T61 |
1611-1662 |
MPA |
denotes |
doxorubicin-induced Top2beta-DNA covalent complexes |
| T62 |
1631-1643 |
GENE |
denotes |
Top2beta-DNA |
| T63 |
1663-1670 |
NEGREG |
denotes |
exposes |
| T65 |
1675-1693 |
GENE |
denotes |
Top2beta-concealed |
| T64 |
1675-1718 |
MPA |
denotes |
Top2beta-concealed DNA double-strand breaks |
| R0 |
T0 |
T1 |
ThemeOf |
Topoisomerase IIbeta,mediated |
| R1 |
T2 |
T1 |
ThemeOf |
DNA double-strand breaks,mediated |
| R10 |
T21 |
T22 |
ThemeOf |
Doxorubicin-induced DNA damage,abolished |
| R11 |
T23 |
T22 |
CauseOf |
inhibitors,abolished |
| R12 |
T23 |
T24 |
CauseOf |
inhibitors,reduced |
| R13 |
T28 |
T29 |
ThemeOf |
suggesting,involvement |
| R14 |
T30 |
T28 |
ThemeOf |
proteasome,suggesting |
| R15 |
T30 |
T29 |
ThemeOf |
proteasome,involvement |
| R16 |
T31 |
T28 |
ThemeOf |
DNA topoisomerase IIbeta,suggesting |
| R17 |
T31 |
T29 |
ThemeOf |
DNA topoisomerase IIbeta,involvement |
| R18 |
T32 |
T29 |
ThemeOf |
Top2beta,involvement |
| R19 |
T32 |
T30 |
ThemeOf |
Top2beta,proteasome |
| R2 |
T2 |
T3 |
ThemeOf |
DNA double-strand breaks,implications |
| R20 |
T36 |
T34 |
ThemeOf |
cleavage complex formation,antagonizing |
| R21 |
T34 |
T42 |
CauseOf |
antagonizing,reduction |
| R22 |
T35 |
T34 |
ThemeOf |
Top2,antagonizing |
| R23 |
T35 |
T36 |
ThemeOf |
Top2,cleavage complex formation |
| R24 |
T38 |
T37 |
ThemeOf |
degradation,rapid |
| R25 |
T39 |
T38 |
ThemeOf |
Top2beta,degradation |
| R26 |
T38 |
T41 |
ThemeOf |
degradation,paralleled |
| R27 |
T39 |
T37 |
ThemeOf |
Top2beta,rapid |
| R28 |
T42 |
T41 |
ThemeOf |
reduction,paralleled |
| R29 |
T43 |
T42 |
ThemeOf |
doxorubicin-induced DNA damage,reduction |
| R3 |
T4 |
T1 |
ThemeOf |
doxorubicin cardiotoxicity,mediated |
| R30 |
T46 |
T44 |
CauseOf |
interference,antagonizes |
| R31 |
T45 |
T44 |
ThemeOf |
doxorubicin-induced DNA damage,antagonizes |
| R32 |
T45 |
T46 |
ThemeOf |
doxorubicin-induced DNA damage,interference |
| R33 |
T46 |
T49 |
CauseOf |
interference,implicate |
| R34 |
T47 |
T46 |
ThemeOf |
Top2beta,interference |
| R35 |
T50 |
T49 |
ThemeOf |
Top2beta,implicate |
| R36 |
T52 |
T46 |
ThemeOf |
doxorubicin cardiotoxicity,interference |
| R37 |
T52 |
T49 |
ThemeOf |
doxorubicin cardiotoxicity,implicate |
| R38 |
T55 |
T54 |
ThemeOf |
proteasome,involvement |
| R39 |
T55 |
T58 |
ThemeOf |
proteasome,doxorubicin-induced DNA damage |
| R4 |
T4 |
T3 |
ThemeOf |
doxorubicin cardiotoxicity,implications |
| R40 |
T55 |
T59 |
ThemeOf |
proteasome,consistent |
| R41 |
T56 |
T54 |
ThemeOf |
Top2beta,involvement |
| R42 |
T56 |
T58 |
ThemeOf |
Top2beta,doxorubicin-induced DNA damage |
| R43 |
T56 |
T59 |
ThemeOf |
Top2beta,consistent |
| R44 |
T58 |
T54 |
ThemeOf |
doxorubicin-induced DNA damage,involvement |
| R45 |
T58 |
T59 |
ThemeOf |
doxorubicin-induced DNA damage,consistent |
| R46 |
T60 |
T54 |
ThemeOf |
proteasomal processing,involvement |
| R47 |
T60 |
T59 |
ThemeOf |
proteasomal processing,consistent |
| R48 |
T61 |
T60 |
ThemeOf |
doxorubicin-induced Top2beta-DNA covalent complexes,proteasomal processing |
| R49 |
T61 |
T59 |
ThemeOf |
doxorubicin-induced Top2beta-DNA covalent complexes,consistent |
| R5 |
T12 |
T14 |
ThemeOf |
doxorubicin cardiotoxicity,cardioprotective effect |
| R50 |
T64 |
T63 |
ThemeOf |
Top2beta-concealed DNA double-strand breaks,exposes |
| R6 |
T16 |
T15 |
ThemeOf |
gamma-H2AX,abolished |
| R7 |
T16 |
T18 |
ThemeOf |
gamma-H2AX,induced |
| R8 |
T19 |
T18 |
ThemeOf |
doxorubicin,induced |
| R9 |
T20 |
T18 |
ThemeOf |
camptothecin,induced |
