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PubMed:9988682 JSONTXT 40 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-37 Sentence denotes Control of O-glycan branch formation.
T2 38-153 Sentence denotes Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.
T3 154-316 Sentence denotes A novel human UDP-GlcNAc:Gal/GlcNAcbeta1-3GalNAcalpha beta1, 6GlcNAc-transferase, designated C2/4GnT, was identified by BLAST analysis of expressed sequence tags.
T4 317-451 Sentence denotes The sequence of C2/4GnT encoded a putative type II transmembrane protein with significant sequence similarity to human C2GnT and IGnT.
T5 452-664 Sentence denotes Expression of the secreted form of C2/4GnT in insect cells showed that the gene product had UDP-N-acetyl-alpha-D-glucosamine:acceptor beta1, 6-N-acetylglucosaminyltransferase (beta1,6GlcNAc-transferase) activity.
T6 665-790 Sentence denotes Analysis of substrate specificity revealed that the enzyme catalyzed O-glycan branch formation of the core 2 and core 4 type.
T7 791-901 Sentence denotes NMR analyses of the product formed with core 3-para-nitrophenyl confirmed the product core 4-para-nitrophenyl.
T8 902-996 Sentence denotes The coding region of C2/4GnT was contained in a single exon and located to chromosome 15q21.3.
T9 997-1122 Sentence denotes Northern analysis revealed a restricted expression pattern of C2/4GnT mainly in colon, kidney, pancreas, and small intestine.
T10 1123-1250 Sentence denotes No expression of C2/4GnT was detected in brain, heart, liver, ovary, placenta, spleen, thymus, and peripheral blood leukocytes.
T11 1251-1353 Sentence denotes The expression of core 2 O-glycans has been correlated with cell differentiation processes and cancer.
T12 1354-1496 Sentence denotes The results confirm the predicted existence of a beta1,6GlcNAc-transferase that functions in both core 2 and core 4 O-glycan branch formation.
T13 1497-1725 Sentence denotes The redundancy in beta1,6GlcNAc-transferases capable of forming core 2 O-glycans is important for understanding the mechanisms leading to specific changes in core 2 branching during cell development and malignant transformation.