> top > projects > sentences > docs > PubMed:9888462 > annotations
sentences Home  

PubMed:9888462 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-95 Sentence denotes Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells.
T1 0-95 Sentence denotes Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells.
TextSentencer_T2 96-226 Sentence denotes Intact mycobacteria and mycobacterial cell wall extracts have been shown to inhibit the growth of human and murine bladder cancer.
T2 96-226 Sentence denotes Intact mycobacteria and mycobacterial cell wall extracts have been shown to inhibit the growth of human and murine bladder cancer.
TextSentencer_T3 227-284 Sentence denotes Their mechanism of action is, however, poorly understood.
T3 227-284 Sentence denotes Their mechanism of action is, however, poorly understood.
TextSentencer_T4 285-465 Sentence denotes Mycobacterium phlei mycobacterial cell complex (MCC) is a cell wall preparation that has mycobacterial DNA in the form of short oligonucleotides complexed on the cell wall surface.
T4 285-465 Sentence denotes Mycobacterium phlei mycobacterial cell complex (MCC) is a cell wall preparation that has mycobacterial DNA in the form of short oligonucleotides complexed on the cell wall surface.
TextSentencer_T5 466-783 Sentence denotes In this study, we have investigated the possibility that MCC has anti-cancer activity that is mediated by two different mechanisms--a direct effect on cancer cell proliferation and viability and an indirect effect mediated by the production of interleukin 12 (IL-12), a cytokine known to possess anti-cancer activity.
T5 466-783 Sentence denotes In this study, we have investigated the possibility that MCC has anti-cancer activity that is mediated by two different mechanisms--a direct effect on cancer cell proliferation and viability and an indirect effect mediated by the production of interleukin 12 (IL-12), a cytokine known to possess anti-cancer activity.
TextSentencer_T6 784-1114 Sentence denotes We have found that, although MCC is a potent inducer of IL-12 and IL-6 synthesis in monocytes and macrophages either in vitro or in vivo, it is unable to induce the synthesis of either IL-12, IL-6 or granulocyte-macrophage colony-stimulating factor (GM-CSF) by the human transitional bladder cancer cell lines HT-1197 and HT-1376.
T6 784-1114 Sentence denotes We have found that, although MCC is a potent inducer of IL-12 and IL-6 synthesis in monocytes and macrophages either in vitro or in vivo, it is unable to induce the synthesis of either IL-12, IL-6 or granulocyte-macrophage colony-stimulating factor (GM-CSF) by the human transitional bladder cancer cell lines HT-1197 and HT-1376.
TextSentencer_T7 1115-1294 Sentence denotes MCC is not directly cytotoxic towards these cancer cells, but induces apoptosis as determined by nuclear DNA fragmentation and by the release of nuclear mitotic apparatus protein.
T7 1115-1294 Sentence denotes MCC is not directly cytotoxic towards these cancer cells, but induces apoptosis as determined by nuclear DNA fragmentation and by the release of nuclear mitotic apparatus protein.
TextSentencer_T8 1295-1385 Sentence denotes Mycobacterium phlei DNA associated with MCC is responsible for the induction of apoptosis.
T8 1295-1385 Sentence denotes Mycobacterium phlei DNA associated with MCC is responsible for the induction of apoptosis.
TextSentencer_T9 1386-1663 Sentence denotes Our results indicate that MCC directly effects bladder cancer cells by inhibiting cellular proliferation through the induction of apoptosis, and has the potential for an indirect anti-cancer activity by stimulating cancer-infiltrating monocytes/macrophages to synthesize IL-12.
T9 1386-1663 Sentence denotes Our results indicate that MCC directly effects bladder cancer cells by inhibiting cellular proliferation through the induction of apoptosis, and has the potential for an indirect anti-cancer activity by stimulating cancer-infiltrating monocytes/macrophages to synthesize IL-12.