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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-147 Sentence denotes Structure-function relations of heparin-mimetic sulfated xylan oligosaccharides: inhibition of human immunodeficiency virus-1 infectivity in vitro.
T1 0-147 Sentence denotes Structure-function relations of heparin-mimetic sulfated xylan oligosaccharides: inhibition of human immunodeficiency virus-1 infectivity in vitro.
TextSentencer_T2 148-307 Sentence denotes Heparins/heparan sulfates modulate the function of proteins and cell membranes in numerous biological systems including normal and disease processes in humans.
T2 148-307 Sentence denotes Heparins/heparan sulfates modulate the function of proteins and cell membranes in numerous biological systems including normal and disease processes in humans.
TextSentencer_T3 308-531 Sentence denotes Heparin has been used for many years as an anticoagulant, and anticoagulant heparin-mimetics were developed several decades ago by chemical sulfation of non-mammalian polysaccharides, e.g., an antithrombotic sulfated xylan.
T3 308-531 Sentence denotes Heparin has been used for many years as an anticoagulant, and anticoagulant heparin-mimetics were developed several decades ago by chemical sulfation of non-mammalian polysaccharides, e.g., an antithrombotic sulfated xylan.
TextSentencer_T4 532-793 Sentence denotes This pharmaceutical, which comprises a mixture of sulfated oligoxylans, also mimics most other biological actions of natural heparins in vitro, including inhibition of the human immunodeficiency virus, but the molecular basis for these actions has been unclear.
T4 532-793 Sentence denotes This pharmaceutical, which comprises a mixture of sulfated oligoxylans, also mimics most other biological actions of natural heparins in vitro, including inhibition of the human immunodeficiency virus, but the molecular basis for these actions has been unclear.
TextSentencer_T5 794-1063 Sentence denotes Here, numerous Components of the sulfated oligoxylan mixture were isolated and when bioassayed in the case of anti-HIV-1 infectivity revealed that a structural specificity underlines the capacity of sulfated xylan to inhibit HIV-1, rather than a non-specific mechanism.
T5 794-1063 Sentence denotes Here, numerous Components of the sulfated oligoxylan mixture were isolated and when bioassayed in the case of anti-HIV-1 infectivity revealed that a structural specificity underlines the capacity of sulfated xylan to inhibit HIV-1, rather than a non-specific mechanism.
TextSentencer_T6 1064-1172 Sentence denotes Components were isolated by chromatographic fractionation through Bio-Gel P10 in 0.5 M ammonium bicarbonate.
T6 1064-1172 Sentence denotes Components were isolated by chromatographic fractionation through Bio-Gel P10 in 0.5 M ammonium bicarbonate.
TextSentencer_T7 1173-1397 Sentence denotes This fractionation revealed an elution range associated with apparent molecular weights of approximately 22000 to <1500 relative to standard heparin and heparan sulfates and newly prepared sulfated oligosaccharide standards.
T7 1173-1397 Sentence denotes This fractionation revealed an elution range associated with apparent molecular weights of approximately 22000 to <1500 relative to standard heparin and heparan sulfates and newly prepared sulfated oligosaccharide standards.
TextSentencer_T8 1398-1640 Sentence denotes Components were characterized by metachromatic absorption spectroscopy, ultracentrifugation, GlcA analysis, and potency against HIV-1 infectivity, both in the tetrazolium cytotoxicity assay and in syncytium-forming assays, in CD4-lymphocytes.
T8 1398-1640 Sentence denotes Components were characterized by metachromatic absorption spectroscopy, ultracentrifugation, GlcA analysis, and potency against HIV-1 infectivity, both in the tetrazolium cytotoxicity assay and in syncytium-forming assays, in CD4-lymphocytes.
TextSentencer_T9 1641-1736 Sentence denotes Structural specificity was indicated by the differential potencies exhibited by the Components:
T9 1641-1736 Sentence denotes Structural specificity was indicated by the differential potencies exhibited by the Components:
TextSentencer_T10 1737-2008 Sentence denotes Highest activity (cytotoxicity) was exhibited by Components in the chromatographic region > or = approximately 5500 in mass (50% effective (inhibitory) concentration = 0.5-0.7 microg ml(-1) in the first fractionation series, and 0.1-0.5 microg ml(-1) in a second series).
T10 1737-2008 Sentence denotes Highest activity (cytotoxicity) was exhibited by Components in the chromatographic region > or = approximately 5500 in mass (50% effective (inhibitory) concentration = 0.5-0.7 microg ml(-1) in the first fractionation series, and 0.1-0.5 microg ml(-1) in a second series).
TextSentencer_T11 2009-2241 Sentence denotes The potency declined sharply below approximately 5400 in mass, but with an exception; a second structure exhibiting relatively high potency eluted among low-mass oligosaccharides which had an average size of approximately a nonomer.
T11 2009-2241 Sentence denotes The potency declined sharply below approximately 5400 in mass, but with an exception; a second structure exhibiting relatively high potency eluted among low-mass oligosaccharides which had an average size of approximately a nonomer.
TextSentencer_T12 2242-2342 Sentence denotes Components displayed differential potencies also against the syncytium-forming infectivity of HIV-1.
T12 2242-2342 Sentence denotes Components displayed differential potencies also against the syncytium-forming infectivity of HIV-1.
TextSentencer_T13 2343-2519 Sentence denotes The high potency against syncytium-formation was retained by Components down to a minimum size of about 4500 in mass, smaller than the > or = approximately 5400 required above.
T13 2343-2519 Sentence denotes The high potency against syncytium-formation was retained by Components down to a minimum size of about 4500 in mass, smaller than the > or = approximately 5400 required above.
TextSentencer_T14 2520-2636 Sentence denotes One in ten of the beta1,4-linked xyloses in the native xylan are substituted with a monomeric alpha1,2 DGlcA branch.
T14 2520-2636 Sentence denotes One in ten of the beta1,4-linked xyloses in the native xylan are substituted with a monomeric alpha1,2 DGlcA branch.
TextSentencer_T15 2637-2896 Sentence denotes We have speculated that pharmaceutical actions of sulfated xylan might be related to structures involving the alpha-D linked substituents and this was examined using a space-filling model of a sulfated octaxylan and by analyses of Components for GlcA content.
T15 2637-2896 Sentence denotes We have speculated that pharmaceutical actions of sulfated xylan might be related to structures involving the alpha-D linked substituents and this was examined using a space-filling model of a sulfated octaxylan and by analyses of Components for GlcA content.
TextSentencer_T16 2897-3146 Sentence denotes Understanding structure/function relations in the heparin-like actions of these agents would be of general significance for the careful examination of their potential clinical usefulness in many human processes modulated by heparins, including AIDS.
T16 2897-3146 Sentence denotes Understanding structure/function relations in the heparin-like actions of these agents would be of general significance for the careful examination of their potential clinical usefulness in many human processes modulated by heparins, including AIDS.