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PubMed:9873047 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Cloning and characterization of RLPK, a novel RSK-related protein kinase.
T2 74-178 Sentence denotes A novel protein kinase whose activity can be stimulated by mitogen in vivo was cloned and characterized.
T3 179-348 Sentence denotes The cDNA of this gene encodes an 802-amino acid protein (termed RLPK) with the highest homology (37% identity) to the two protein kinase families, p90(RSK) and p70(RSK).
T4 349-450 Sentence denotes Like p90(RSR), but not p70(RSK), RLPK also contains two complete nonidentical protein kinase domains.
T5 451-561 Sentence denotes RLPK mRNA is widely expressed in all human tissues examined and is enriched in the brain, heart, and placenta.
T6 562-812 Sentence denotes In HeLa cells, transiently expressed epitope-tagged RLPK can be strongly induced by epidermal growth factor, serum, and phorbol 12-myristate 13-acetate, but only moderately up-regulated by tumor necrosis factor-alpha and other stress-related stimuli.
T7 813-1172 Sentence denotes The activity of RLPK stimulated by epidermal growth factor was not inhibited by several known protein kinase C inhibitors nor by rapamycin, a known specific inhibitor for p70(RSK), but could be inhibited by herbimycin A, a tyrosine kinase inhibitor, and partially inhibited by PD98059 or SB203580, inhibitors for the mitogen-activated protein kinase pathways.
T8 1173-1278 Sentence denotes Recombinant RLPK possesses high phosphorylation activity toward histone 2B and the S6 peptide, RRRLSSLRA.
T9 1279-1420 Sentence denotes Although purified recombinant RLPK can be phosphorylated by ERK2 and p38alpha in vitro, its activity is not affected by this phosphorylation.
T10 1421-1519 Sentence denotes Moreover, the treatment of RLPK with acid phosphatase did not reduce its in vitro kinase activity.
T11 1520-1681 Sentence denotes These data suggest that RLPK is structurally similar to previously isolated RSKs, but its regulatory mechanism may be distinct from either p70(RSK) or p90(RSK)s.