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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-60 Sentence denotes Components of a calmodulin-dependent protein kinase cascade.
T2 61-190 Sentence denotes Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.
T3 191-389 Sentence denotes Ca2+/calmodulin-dependent protein kinases I and IV (CaMKI and CaMKIV, respectively) require phosphorylation on an equivalent single Thr in the activation loop of subdomain VIII for maximal activity.
T4 390-512 Sentence denotes Two distinct CaMKI/IV kinases, CaMKKalpha and CaMKKbeta, were purified from rat brain and partially sequenced (Edelman, A.
T5 513-545 Sentence denotes M., Mitchelhill, K., Selbert, M.
T6 546-562 Sentence denotes A., Anderson, K.
T7 563-575 Sentence denotes A., Hook, S.
T8 576-608 Sentence denotes S., Stapleton, D., Goldstein, E.
T9 609-622 Sentence denotes G., Means, A.
T10 623-639 Sentence denotes R., and Kemp, B.
T11 640-652 Sentence denotes E. (1996) J.
T12 653-658 Sentence denotes Biol.
T13 659-664 Sentence denotes Chem.
T14 665-683 Sentence denotes 271, 10806-10810).
T15 684-922 Sentence denotes We report here the cloning and sequencing of cDNAs for human and rat CaMKKbeta, tissue and regional brain localization of CaMKKbeta protein, and mRNA and functional characterization of recombinant CaMKKbeta in vitro and in Jurkat T cells.
T16 923-1077 Sentence denotes The sequences of human and rat CaMKKbeta demonstrate 65% identity and 80% similarity with CaMKKalpha and 30-40% identity with CaMKI and CaMKIV themselves.
T17 1078-1220 Sentence denotes CaMKKbeta is broadly distributed among rat tissues with highest levels in CaMKIV-expressing tissues such as brain, thymus, spleen, and testis.
T18 1221-1294 Sentence denotes In brain, CaMKKbeta tracks more closely with CaMKIV than does CaMKKalpha.
T19 1295-1470 Sentence denotes Bacterially expressed CaMKKbeta undergoes intramolecular autophosphorylation, is regulated by Ca2+/CaM, and phosphorylates CaMKI and CaMKIV on Thr177 and Thr200, respectively.
T20 1471-1649 Sentence denotes CaMKKbeta activates both CaMKI and CaMKIV when coexpressed in Jurkat T cells as judged by phosphorylated cAMP response element-binding protein-dependent reporter gene expression.
T21 1650-1793 Sentence denotes CaMKKbeta activity is enhanced by elevation of intracellular Ca2+, although substantial activity is observed at the resting Ca2+ concentration.
T22 1794-1965 Sentence denotes The strict Ca2+ requirement of CaMKIV-dependent phosphorylation of cAMP response element-binding protein, is therefore controlled at the level of CaMKIV rather than CaMKK.