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PubMed:9794719 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Stretch-activated cation channel in human umbilical vein endothelium in normal pregnancy and in preeclampsia.
T1 0-109 Sentence denotes Stretch-activated cation channel in human umbilical vein endothelium in normal pregnancy and in preeclampsia.
TextSentencer_T2 110-120 Sentence denotes OBJECTIVE:
T2 110-120 Sentence denotes OBJECTIVE:
TextSentencer_T3 121-537 Sentence denotes To determine whether stretch-activated cation channels (SAC) are present in intact human umbilical vein endothelium (HUVE) and in an endothelial cell line (EA.hy) and whether they act as endothelial mechanosensors, and to determine whether endothelial SAC in HUVE from women with pregnancies complicated by preeclampsia undergo functional changes compared with those in HUVE from women with normotensive pregnancies.
T3 121-537 Sentence denotes To determine whether stretch-activated cation channels (SAC) are present in intact human umbilical vein endothelium (HUVE) and in an endothelial cell line (EA.hy) and whether they act as endothelial mechanosensors, and to determine whether endothelial SAC in HUVE from women with pregnancies complicated by preeclampsia undergo functional changes compared with those in HUVE from women with normotensive pregnancies.
TextSentencer_T4 538-558 Sentence denotes METHODS AND RESULTS:
T4 538-558 Sentence denotes METHODS AND RESULTS:
TextSentencer_T5 559-662 Sentence denotes By use of the patch-clamp technique we identified a SAC in intact HUVE and in an endothelial cell line.
T5 559-662 Sentence denotes By use of the patch-clamp technique we identified a SAC in intact HUVE and in an endothelial cell line.
TextSentencer_T6 663-753 Sentence denotes The SAC had mean conductances of 29+/-5 pS (n = 38) for K+ and 12+/-2 pS (n = 4) for Ca2+.
T6 663-753 Sentence denotes The SAC had mean conductances of 29+/-5 pS (n = 38) for K+ and 12+/-2 pS (n = 4) for Ca2+.
TextSentencer_T7 754-886 Sentence denotes Administration of 50 micromol/I gadolinium, a blocker of mechanosensitive ion channels, completely blocked activity of this channel.
T7 754-886 Sentence denotes Administration of 50 micromol/I gadolinium, a blocker of mechanosensitive ion channels, completely blocked activity of this channel.
TextSentencer_T8 887-1129 Sentence denotes We found from single-channel recordings that influx of Ca2+ through SAC directly activated high-conductance Ca2+-dependent potassium channels, proving that a significant influx of Ca2+ through SAC occurs at physiologic concentrations of Ca2+.
T8 887-1129 Sentence denotes We found from single-channel recordings that influx of Ca2+ through SAC directly activated high-conductance Ca2+-dependent potassium channels, proving that a significant influx of Ca2+ through SAC occurs at physiologic concentrations of Ca2+.
TextSentencer_T9 1130-1403 Sentence denotes In a comparative study, apparent channel density of SAC (percentage of patches with SAC activity) in HUVE from women with pregnancies complicated by preeclampsia (36.2 +/- 4.3%) was twofold higher than that in HUVE from women with normal pregnancies (17.9+/-2.9%, P< 0.01).
T9 1130-1403 Sentence denotes In a comparative study, apparent channel density of SAC (percentage of patches with SAC activity) in HUVE from women with pregnancies complicated by preeclampsia (36.2 +/- 4.3%) was twofold higher than that in HUVE from women with normal pregnancies (17.9+/-2.9%, P< 0.01).
TextSentencer_T10 1404-1494 Sentence denotes Channel conductance and sensitivity to stretching of SAC were not altered by preeclampsia.
T10 1404-1494 Sentence denotes Channel conductance and sensitivity to stretching of SAC were not altered by preeclampsia.
TextSentencer_T11 1495-1507 Sentence denotes CONCLUSIONS:
T11 1495-1507 Sentence denotes CONCLUSIONS:
TextSentencer_T12 1508-1690 Sentence denotes Since SAC are capable of acting as endothelial mechanosensors, the greater than normal density of SAC associated with preeclampsia might reflect an alteration of mechanotransduction.
T12 1508-1690 Sentence denotes Since SAC are capable of acting as endothelial mechanosensors, the greater than normal density of SAC associated with preeclampsia might reflect an alteration of mechanotransduction.