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PubMed:9774399 JSONTXT 28 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.
T1 0-122 Sentence denotes Mutation at histidine 338 of gp91(phox) depletes FAD and affects expression of cytochrome b558 of the human NADPH oxidase.
TextSentencer_T2 123-239 Sentence denotes Defective NADPH oxidase components prevent superoxide (O-2) generation, causing chronic granulomatous disease (CGD).
T2 123-239 Sentence denotes Defective NADPH oxidase components prevent superoxide (O-2) generation, causing chronic granulomatous disease (CGD).
TextSentencer_T3 240-506 Sentence denotes X-linked CGD patients have mutations in the gene encoding the gp91(phox) subunit of cytochrome b558 and usually lack gp91(phox) protein completely (X91(0)). gp91(phox) is considered to be a flavocytochrome that contains binding sites for NADPH, FAD, as well as heme.
T3 240-506 Sentence denotes X-linked CGD patients have mutations in the gene encoding the gp91(phox) subunit of cytochrome b558 and usually lack gp91(phox) protein completely (X91(0)). gp91(phox) is considered to be a flavocytochrome that contains binding sites for NADPH, FAD, as well as heme.
TextSentencer_T4 507-741 Sentence denotes We here report a rare X-linked CGD patient whose neutrophils entirely failed to produce O-2, but presented a diminished expression of gp91(phox) containing about one-third of the heme present in normal individuals by Soret absorption.
T4 507-741 Sentence denotes We here report a rare X-linked CGD patient whose neutrophils entirely failed to produce O-2, but presented a diminished expression of gp91(phox) containing about one-third of the heme present in normal individuals by Soret absorption.
TextSentencer_T5 742-812 Sentence denotes Translocation of cytosolic factors p67(phox) and p47(phox) was normal.
T5 742-812 Sentence denotes Translocation of cytosolic factors p67(phox) and p47(phox) was normal.
TextSentencer_T6 813-960 Sentence denotes However, the FAD content in his neutrophil membranes was as low as that of X91(0) patients, suggesting complete depletion of FAD in his gp91(phox).
T6 813-960 Sentence denotes However, the FAD content in his neutrophil membranes was as low as that of X91(0) patients, suggesting complete depletion of FAD in his gp91(phox).
TextSentencer_T7 961-1145 Sentence denotes This was in agreement with the finding that a single base substitution (C1024 to T) changed His-338 to Tyr in gp91(phox) in a predicted FAD-binding domain of the flavocytochrome model.
T7 961-1145 Sentence denotes This was in agreement with the finding that a single base substitution (C1024 to T) changed His-338 to Tyr in gp91(phox) in a predicted FAD-binding domain of the flavocytochrome model.
TextSentencer_T8 1146-1367 Sentence denotes The loss of FAD could not be corrected even after addition of reagent FAD or a FAD-rich dehydrogenase fraction isolated from normal neutrophils to the patient's membranes, in a reconstitution in vitro with normal cytosol.
T8 1146-1367 Sentence denotes The loss of FAD could not be corrected even after addition of reagent FAD or a FAD-rich dehydrogenase fraction isolated from normal neutrophils to the patient's membranes, in a reconstitution in vitro with normal cytosol.
TextSentencer_T9 1368-1483 Sentence denotes These results indicate that His-338 is a very critical residue for FAD incorporation into the NADPH oxidase system.
T9 1368-1483 Sentence denotes These results indicate that His-338 is a very critical residue for FAD incorporation into the NADPH oxidase system.
TextSentencer_T10 1484-1529 Sentence denotes This is the first such mutation found in CGD.
T10 1484-1529 Sentence denotes This is the first such mutation found in CGD.