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PubMed:9765464 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-105 Sentence denotes Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection.
T1 0-105 Sentence denotes Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection.
TextSentencer_T2 106-236 Sentence denotes Expression of many early viral genes during human cytomegalovirus (HCMV) infection is dependent on cellular transcription factors.
T2 106-236 Sentence denotes Expression of many early viral genes during human cytomegalovirus (HCMV) infection is dependent on cellular transcription factors.
TextSentencer_T3 237-541 Sentence denotes Several immediate-early and early viral promoters contain DNA binding sites for cellular factors such as CREB, AP-1, serum response factor, and Elk-1, and these transcription factors can be activated by phosphorylation via the cellular mitogen-activated protein kinase (MAPK) signal transduction cascade.
T3 237-541 Sentence denotes Several immediate-early and early viral promoters contain DNA binding sites for cellular factors such as CREB, AP-1, serum response factor, and Elk-1, and these transcription factors can be activated by phosphorylation via the cellular mitogen-activated protein kinase (MAPK) signal transduction cascade.
TextSentencer_T4 542-730 Sentence denotes To determine if the extracellular signal-regulated MAPKs, ERK1 and ERK2, play a role in transcription factor activation during infection, we tested for ERK activity during viral infection.
T4 542-730 Sentence denotes To determine if the extracellular signal-regulated MAPKs, ERK1 and ERK2, play a role in transcription factor activation during infection, we tested for ERK activity during viral infection.
TextSentencer_T5 731-916 Sentence denotes We found that HCMV infection resulted in the maintenance of previously activated ERK1 and ERK2 by a mechanism which appears to involve the inhibition of a cellular phosphatase activity.
T5 731-916 Sentence denotes We found that HCMV infection resulted in the maintenance of previously activated ERK1 and ERK2 by a mechanism which appears to involve the inhibition of a cellular phosphatase activity.
TextSentencer_T6 917-1083 Sentence denotes ERK phosphorylation and activity were sustained for at least 8 h after infection, whereas in mock-infected cells, ERK activity steadily declined by 1 h postinfection.
T6 917-1083 Sentence denotes ERK phosphorylation and activity were sustained for at least 8 h after infection, whereas in mock-infected cells, ERK activity steadily declined by 1 h postinfection.
TextSentencer_T7 1084-1209 Sentence denotes The activity of at least one cellular substrate of the ERKs, the protein kinase RSK1, was also maintained during this period.
T7 1084-1209 Sentence denotes The activity of at least one cellular substrate of the ERKs, the protein kinase RSK1, was also maintained during this period.
TextSentencer_T8 1210-1315 Sentence denotes UV inactivation experiments suggested that viral gene expression was required for sustained ERK activity.
T8 1210-1315 Sentence denotes UV inactivation experiments suggested that viral gene expression was required for sustained ERK activity.
TextSentencer_T9 1316-1563 Sentence denotes In turn, activation of the ERKs appeared to be important for viral gene expression, as evidenced by the observed decrease in the transcriptional activity of the HCMV UL112-113 promoter during infection in the presence of the MEK inhibitor PD98059.
T9 1316-1563 Sentence denotes In turn, activation of the ERKs appeared to be important for viral gene expression, as evidenced by the observed decrease in the transcriptional activity of the HCMV UL112-113 promoter during infection in the presence of the MEK inhibitor PD98059.
TextSentencer_T10 1564-1767 Sentence denotes These data suggest that HCMV utilizes cellular signal transduction pathways to activate viral or cellular transcription factors involved in the control of early viral gene expression and DNA replication.
T10 1564-1767 Sentence denotes These data suggest that HCMV utilizes cellular signal transduction pathways to activate viral or cellular transcription factors involved in the control of early viral gene expression and DNA replication.