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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-142 Sentence denotes Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
T1 0-142 Sentence denotes Models of lineage switching in hematopoietic development: a new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential.
TextSentencer_T2 143-345 Sentence denotes A new human leukemia cell line with an eosinophilic phenotype, designated YJ, was established from the peripheral blood cells of a patient with chronic myelomonocytic leukemia (CMMoL) with eosinophilia.
T2 143-345 Sentence denotes A new human leukemia cell line with an eosinophilic phenotype, designated YJ, was established from the peripheral blood cells of a patient with chronic myelomonocytic leukemia (CMMoL) with eosinophilia.
TextSentencer_T3 346-510 Sentence denotes When cultured in RPMI 1640 medium containing 10% fetal bovine serum, most YJ cells were myeloblastoid with a small number of the cells having eosinophilic granules.
T3 346-510 Sentence denotes When cultured in RPMI 1640 medium containing 10% fetal bovine serum, most YJ cells were myeloblastoid with a small number of the cells having eosinophilic granules.
TextSentencer_T4 511-613 Sentence denotes Cell surface markers in the YJ cells were positive for CD33 and were negative for CD34, CD16 and CD23.
T4 511-613 Sentence denotes Cell surface markers in the YJ cells were positive for CD33 and were negative for CD34, CD16 and CD23.
TextSentencer_T5 614-984 Sentence denotes The eosinophilic characteristics of YJ cells were confirmed by histochemical staining with Fast-Green/Neutral-Red and by the expression of mRNAs for eosinophil-associated granule proteins, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), and for the Charcot-Leyden crystal (CLC) protein.
T5 614-984 Sentence denotes The eosinophilic characteristics of YJ cells were confirmed by histochemical staining with Fast-Green/Neutral-Red and by the expression of mRNAs for eosinophil-associated granule proteins, eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), and for the Charcot-Leyden crystal (CLC) protein.
TextSentencer_T6 985-1107 Sentence denotes The YJ cells could be induced towards monocytic differentiation by stimulation with phorbol 12-myristate 13-acetate (PMA).
T6 985-1107 Sentence denotes The YJ cells could be induced towards monocytic differentiation by stimulation with phorbol 12-myristate 13-acetate (PMA).
TextSentencer_T7 1108-1318 Sentence denotes The monocytic characteristics of YJ cells treated with PMA were confirmed by morphological analysis with alpha-naphthyl butyrate esterase staining, by CD14 expression, and by increased expression of Egr-1 mRNA.
T7 1108-1318 Sentence denotes The monocytic characteristics of YJ cells treated with PMA were confirmed by morphological analysis with alpha-naphthyl butyrate esterase staining, by CD14 expression, and by increased expression of Egr-1 mRNA.
TextSentencer_T8 1319-1445 Sentence denotes Furthermore, YJ cells could be differentiated towards the neutrophil lineage by stimulation with all-trans retinoic acid (RA).
T8 1319-1445 Sentence denotes Furthermore, YJ cells could be differentiated towards the neutrophil lineage by stimulation with all-trans retinoic acid (RA).
TextSentencer_T9 1446-1656 Sentence denotes YJ cells treated in vitro with 2 microM RA differentiated into metamyelocytes and band neutrophils, and increased the number of nitroblue tetrazolium (NBT)-positive cells and increased gp91phox mRNA expression.
T9 1446-1656 Sentence denotes YJ cells treated in vitro with 2 microM RA differentiated into metamyelocytes and band neutrophils, and increased the number of nitroblue tetrazolium (NBT)-positive cells and increased gp91phox mRNA expression.
TextSentencer_T10 1657-1831 Sentence denotes Thus, the YJ cell line exhibited eosinophilic characteristics, but was able to differentiate to the monocytic or neutrophilic lineages in response to PMA or RA, respectively.
T10 1657-1831 Sentence denotes Thus, the YJ cell line exhibited eosinophilic characteristics, but was able to differentiate to the monocytic or neutrophilic lineages in response to PMA or RA, respectively.
TextSentencer_T11 1832-1958 Sentence denotes The expression of genes for transcription factors involved in myeloid differentiation was evaluated by Northern blot analysis.
T11 1832-1958 Sentence denotes The expression of genes for transcription factors involved in myeloid differentiation was evaluated by Northern blot analysis.
TextSentencer_T12 1959-2034 Sentence denotes Increased expression of Egr-1 was observed with macrophage differentiation.
T12 1959-2034 Sentence denotes Increased expression of Egr-1 was observed with macrophage differentiation.
TextSentencer_T13 2035-2141 Sentence denotes In contrast, increased expressions of C/EBPbeta and MZF-1 mRNA occurred with neutrophilic differentiation.
T13 2035-2141 Sentence denotes In contrast, increased expressions of C/EBPbeta and MZF-1 mRNA occurred with neutrophilic differentiation.
TextSentencer_T14 2142-2301 Sentence denotes The YJ cell line should be useful for elucidating the molecular mechanisms governing lineage switching from the eosinophil to monocytic or neutrophil lineages.
T14 2142-2301 Sentence denotes The YJ cell line should be useful for elucidating the molecular mechanisms governing lineage switching from the eosinophil to monocytic or neutrophil lineages.