| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-128 |
Sentence |
denotes |
Activation of E2F-mediated transcription by human T-cell leukemia virus type I Tax protein in a p16(INK4A)-negative T-cell line. |
| T2 |
129-223 |
Sentence |
denotes |
The human T-cell leukemia virus type I (HTLV-I) is a causative agent of adult T-cell leukemia. |
| T3 |
224-381 |
Sentence |
denotes |
Although the exact mechanism by which HTLV-I contributes to leukemogenesis is still unclear, the Tax protein is thought to play a major role in this process. |
| T4 |
382-463 |
Sentence |
denotes |
This 40-kDa polypeptide is able to interact with the tumor suppressor p16(INK4A). |
| T5 |
464-628 |
Sentence |
denotes |
Consequently, Tax can activate the signaling pathway that lead to the release of E2F that in turn induces expression of factors required for cell cycle progression. |
| T6 |
629-741 |
Sentence |
denotes |
In this paper, we demonstrate that Tax can also activate E2F-mediated transcription independently of p16(INK4A). |
| T7 |
742-990 |
Sentence |
denotes |
Indeed, when Tax is coexpressed with the E2F-1 transcription factor in CEM T-cells, which lack expression of p16(INK4A), it strongly potentiates the E2F-dependent activation of a reporter construct driven by a promoter containing E2F binding sites. |
| T8 |
991-1066 |
Sentence |
denotes |
This stimulation is abrogated by mutations affecting the E2F-binding sites. |
| T9 |
1067-1143 |
Sentence |
denotes |
In addition, Tax also stimulates the transcription of the E2F-1 gene itself. |
| T10 |
1144-1439 |
Sentence |
denotes |
Using Tax mutants that fail to activate either ATF- or NF-kappaB-dependent promoters and different 5' truncation mutants of the E2F-1 promoter, we show that the Tax-dependent transcriptional control of the E2F1 gene involves, at least in part, the ATF binding site located in the E2F-1 promoter. |
