| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-123 |
Sentence |
denotes |
The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB. |
| T2 |
124-284 |
Sentence |
denotes |
Forkhead-related activator 2 (FREAC-2) is a human transcription factor expressed in lung and placenta that binds to cis-elements in several lung-specific genes. |
| T3 |
285-472 |
Sentence |
denotes |
We have identified the parts of FREAC-2 responsible for trans-activation and found two functionally redundant activation domains on the C-terminal side of the DNA binding forkhead domain. |
| T4 |
473-652 |
Sentence |
denotes |
Activation domain 1 consists of the most C-terminal 23 amino acids of FREAC-2 and contains a sequence motif conserved in an activation domain of another forkhead protein, FREAC-1. |
| T5 |
653-760 |
Sentence |
denotes |
Activation domain 2 is built up by three synergistic subdomains in the central part of the FREAC-2 protein. |
| T6 |
761-819 |
Sentence |
denotes |
FREAC-2 was shown to interact in vitro with TBP and TFIIB. |
| T7 |
820-920 |
Sentence |
denotes |
The target site for FREAC-2 on TBP was localized to the N-terminal repeat in the core domain of TBP. |
| T8 |
921-993 |
Sentence |
denotes |
TFIIB binds FREAC-2 close to the cleft between its two globular domains. |
| T9 |
994-1103 |
Sentence |
denotes |
The part of FREAC-2 that binds TBP was mapped to 21 amino acids in the C-terminal end of the forkhead domain. |
| T10 |
1104-1283 |
Sentence |
denotes |
This sequence is well conserved among forkhead proteins, raising the possibility that interaction with TBP may be a general characteristic of this family of transcription factors. |
| T11 |
1284-1398 |
Sentence |
denotes |
Overexpression of TFIIB potentiates activation by FREAC-2 in a manner dependent on the FREAC-2 activation domains. |
| T12 |
1399-1502 |
Sentence |
denotes |
Nuclear localization of FREAC-2 was found to depend on sequences from both ends of the forkhead domain. |
