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PubMed:9717831 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-203 Sentence denotes Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
T1 0-203 Sentence denotes Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
TextSentencer_T2 204-379 Sentence denotes The expression of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been associated with tumor sensitivity to antitumor polyamine analogues.
T2 204-379 Sentence denotes The expression of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been associated with tumor sensitivity to antitumor polyamine analogues.
TextSentencer_T3 380-461 Sentence denotes In the sensitive cell types the level of SSAT is greatly induced by these agents.
T3 380-461 Sentence denotes In the sensitive cell types the level of SSAT is greatly induced by these agents.
TextSentencer_T4 462-598 Sentence denotes Although SSAT expression is regulated at many levels, the initial regulation of this X-linked gene occurs at the level of transcription.
T4 462-598 Sentence denotes Although SSAT expression is regulated at many levels, the initial regulation of this X-linked gene occurs at the level of transcription.
TextSentencer_T5 599-890 Sentence denotes Because most previous work in human cell lines has been performed in cells of male origin and because the SSAT gene is located near the pseudoautosomal region of the X chromosome, we investigated the possibility that both copies of SSAT could be expressed in normal and tumor cells in women.
T5 599-890 Sentence denotes Because most previous work in human cell lines has been performed in cells of male origin and because the SSAT gene is located near the pseudoautosomal region of the X chromosome, we investigated the possibility that both copies of SSAT could be expressed in normal and tumor cells in women.
TextSentencer_T6 891-1069 Sentence denotes DNA methyl-sensitive restriction enzyme analysis of DNA from normal peripheral lymphocytes suggested that like most X-linked genes, only one copy of SSAT is actively transcribed.
T6 891-1069 Sentence denotes DNA methyl-sensitive restriction enzyme analysis of DNA from normal peripheral lymphocytes suggested that like most X-linked genes, only one copy of SSAT is actively transcribed.
TextSentencer_T7 1070-1335 Sentence denotes However, in an examination of four representative human lung tumor cell lines derived from women, two were found to have a methylation pattern identical to male-derived cells, suggesting a reactivation of the normally inactive allele or loss of the inactive allele.
T7 1070-1335 Sentence denotes However, in an examination of four representative human lung tumor cell lines derived from women, two were found to have a methylation pattern identical to male-derived cells, suggesting a reactivation of the normally inactive allele or loss of the inactive allele.
TextSentencer_T8 1336-1625 Sentence denotes Microsatellite repeat polymorphism analysis indicated that one of the lines, a female carcinoid line, NCI H727, had reactivated the previously inactive copy, thus providing H727 with two active alleles, whereas a small cell lung cancer line, H889, appears to have lost the inactive allele.
T8 1336-1625 Sentence denotes Microsatellite repeat polymorphism analysis indicated that one of the lines, a female carcinoid line, NCI H727, had reactivated the previously inactive copy, thus providing H727 with two active alleles, whereas a small cell lung cancer line, H889, appears to have lost the inactive allele.
TextSentencer_T9 1626-1859 Sentence denotes Most importantly, the H727 line expressed high amounts of SSAT mRNA and protein in response to treatment with the polyamine analogue, N1,N12-bis(ethyl)spermine, a compound known to increase SSAT transcription in sensitive cell types.
T9 1626-1859 Sentence denotes Most importantly, the H727 line expressed high amounts of SSAT mRNA and protein in response to treatment with the polyamine analogue, N1,N12-bis(ethyl)spermine, a compound known to increase SSAT transcription in sensitive cell types.
TextSentencer_T10 1860-1945 Sentence denotes H727 was also the only female line that responded to treatment in a cytotoxic manner.
T10 1860-1945 Sentence denotes H727 was also the only female line that responded to treatment in a cytotoxic manner.
TextSentencer_T11 1946-2160 Sentence denotes These data suggest that both copies of the SSAT allele may be expressed and that the inappropriate expression of the second copy can lead to an increase in tumor sensitivity to polyamine analogues that induce SSAT.
T11 1946-2160 Sentence denotes These data suggest that both copies of the SSAT allele may be expressed and that the inappropriate expression of the second copy can lead to an increase in tumor sensitivity to polyamine analogues that induce SSAT.