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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-61 Sentence denotes Degradation of macrophage ApoE in a nonlysosomal compartment.
T1 0-61 Sentence denotes Degradation of macrophage ApoE in a nonlysosomal compartment.
TextSentencer_T2 62-84 Sentence denotes Regulation by sterols.
T2 62-84 Sentence denotes Regulation by sterols.
TextSentencer_T3 85-210 Sentence denotes Macrophage-derived apoE has been shown to play an important role in the susceptibility of the vessel wall to atherosclerosis.
T3 85-210 Sentence denotes Macrophage-derived apoE has been shown to play an important role in the susceptibility of the vessel wall to atherosclerosis.
TextSentencer_T4 211-376 Sentence denotes Previous studies have shown that macrophage sterol content modulates apoE synthesis and secretion, associated with a large transcriptional response of the apoE gene.
T4 211-376 Sentence denotes Previous studies have shown that macrophage sterol content modulates apoE synthesis and secretion, associated with a large transcriptional response of the apoE gene.
TextSentencer_T5 377-548 Sentence denotes The current studies were undertaken to evaluate the existence of additional post-transcriptional regulatory loci for the effect of sterols on apoE synthesis and secretion.
T5 377-548 Sentence denotes The current studies were undertaken to evaluate the existence of additional post-transcriptional regulatory loci for the effect of sterols on apoE synthesis and secretion.
TextSentencer_T6 549-834 Sentence denotes Using a macrophage cell line transfected to constitutively express an apoE cDNA to facilitate detection of a post-transcriptional regulatory locus, we demonstrated that preincubations in 25-hydroxycholesterol and cholesterol lead to increased apoE secretion in pulse/chase experiments.
T6 549-834 Sentence denotes Using a macrophage cell line transfected to constitutively express an apoE cDNA to facilitate detection of a post-transcriptional regulatory locus, we demonstrated that preincubations in 25-hydroxycholesterol and cholesterol lead to increased apoE secretion in pulse/chase experiments.
TextSentencer_T7 835-1081 Sentence denotes Examination of cell lysates in these experiments showed that apoE not secreted by control cells was degraded and not detectable, suggesting that the preincubation in sterols increased secretion by decreasing degradation of newly synthesized apoE.
T7 835-1081 Sentence denotes Examination of cell lysates in these experiments showed that apoE not secreted by control cells was degraded and not detectable, suggesting that the preincubation in sterols increased secretion by decreasing degradation of newly synthesized apoE.
TextSentencer_T8 1082-1292 Sentence denotes The measurement of total protein and apoE degradation in cell fractions revealed an intermediate density fraction that degraded significant amounts of newly synthesized total protein and newly synthesized apoE.
T8 1082-1292 Sentence denotes The measurement of total protein and apoE degradation in cell fractions revealed an intermediate density fraction that degraded significant amounts of newly synthesized total protein and newly synthesized apoE.
TextSentencer_T9 1293-1536 Sentence denotes In this fraction, degradation of total protein and apoE was unaffected by chloroquine but was substantially reduced by N-acetyl-Leu-Leu-norleucinal plus N-acetyl-Leu-Leu-methioninal or by lactacystin, suggesting the involvement of proteasomes.
T9 1293-1536 Sentence denotes In this fraction, degradation of total protein and apoE was unaffected by chloroquine but was substantially reduced by N-acetyl-Leu-Leu-norleucinal plus N-acetyl-Leu-Leu-methioninal or by lactacystin, suggesting the involvement of proteasomes.
TextSentencer_T10 1537-1698 Sentence denotes Preincubation in sterol/oxysterol or acetylated low density lipoprotein did not modify total protein degradation by this fraction but inhibited apoE degradation.
T10 1537-1698 Sentence denotes Preincubation in sterol/oxysterol or acetylated low density lipoprotein did not modify total protein degradation by this fraction but inhibited apoE degradation.
TextSentencer_T11 1699-1815 Sentence denotes Similar results were obtained using intermediate density fractions isolated from human monocyte-derived macrophages.
T11 1699-1815 Sentence denotes Similar results were obtained using intermediate density fractions isolated from human monocyte-derived macrophages.
TextSentencer_T12 1816-2021 Sentence denotes The results of our studies indicate that newly synthesized apoE in the macrophage can be degraded in an intermediate density nonlysosomal cellular compartment, which is sensitive to proteasomal inhibitors.
T12 1816-2021 Sentence denotes The results of our studies indicate that newly synthesized apoE in the macrophage can be degraded in an intermediate density nonlysosomal cellular compartment, which is sensitive to proteasomal inhibitors.
TextSentencer_T13 2022-2205 Sentence denotes Alteration of cellular lipid homeostasis by preincubation in sterol/oxysterol or acetylated low density lipoprotein inhibits apoE, but not total protein, degradation in this fraction.
T13 2022-2205 Sentence denotes Alteration of cellular lipid homeostasis by preincubation in sterol/oxysterol or acetylated low density lipoprotein inhibits apoE, but not total protein, degradation in this fraction.
TextSentencer_T14 2206-2346 Sentence denotes Inhibition of the degradation of apoE in this fraction likely contributes to the increased apoE secretion observed in sterol-enriched cells.
T14 2206-2346 Sentence denotes Inhibition of the degradation of apoE in this fraction likely contributes to the increased apoE secretion observed in sterol-enriched cells.