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PubMed:9295357 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C.
T1 0-132 Sentence denotes Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C.
T2 133-230 Sentence denotes The leukocyte integrin genes CD11c and CD11b are expressed predominately in myelomonocytic cells.
T2 133-230 Sentence denotes The leukocyte integrin genes CD11c and CD11b are expressed predominately in myelomonocytic cells.
T3 231-436 Sentence denotes In previous experiments, the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter were shown to be essential for Sp1-mediated activation of these genes.
T3 231-436 Sentence denotes In previous experiments, the -70 to -65 and -121 to -103 regions of the CD11c promoter and the -66 to -59 region of the CD11b promoter were shown to be essential for Sp1-mediated activation of these genes.
T4 437-551 Sentence denotes In vivo genomic footprinting had also revealed cell-specific binding of protein, presumably Sp1, to these regions.
T4 437-551 Sentence denotes In vivo genomic footprinting had also revealed cell-specific binding of protein, presumably Sp1, to these regions.
T5 552-689 Sentence denotes In this study, electrophoretic mobility shift analysis showed that the Sp1-related factor, Sp3, also binds at or near these same regions.
T5 552-689 Sentence denotes In this study, electrophoretic mobility shift analysis showed that the Sp1-related factor, Sp3, also binds at or near these same regions.
T6 690-857 Sentence denotes Cotransfection of Sp3 along with CD11c promoter-luciferase constructs into Sp-deficient Drosophila Schneider 2 cells showed that Sp3 could activate the CD11c promoter.
T6 690-857 Sentence denotes Cotransfection of Sp3 along with CD11c promoter-luciferase constructs into Sp-deficient Drosophila Schneider 2 cells showed that Sp3 could activate the CD11c promoter.
T7 858-979 Sentence denotes Deletion of both the -70 to -65 and -121 to -103 regions of the CD11c promoter resulted in the loss of activation by Sp3.
T7 858-979 Sentence denotes Deletion of both the -70 to -65 and -121 to -103 regions of the CD11c promoter resulted in the loss of activation by Sp3.
T8 980-1087 Sentence denotes Both sites showed activation by Sp3; however, the -70 to -65 region was more responsive to Sp3 than to Sp1.
T8 980-1087 Sentence denotes Both sites showed activation by Sp3; however, the -70 to -65 region was more responsive to Sp3 than to Sp1.
T9 1088-1197 Sentence denotes Similar transfection analysis of the -66 to -59 region of the CD11b promoter showed Sp3-dependent expression.
T9 1088-1197 Sentence denotes Similar transfection analysis of the -66 to -59 region of the CD11b promoter showed Sp3-dependent expression.
T10 1198-1346 Sentence denotes Further, cotransfection analysis in Drosophila cells showed that Sp3, as was previously shown for Sp1, also synergizes with c-Jun to activate CD11c.
T10 1198-1346 Sentence denotes Further, cotransfection analysis in Drosophila cells showed that Sp3, as was previously shown for Sp1, also synergizes with c-Jun to activate CD11c.
T11 1347-1535 Sentence denotes Antisense experiments that knocked out endogenous Sp3 expression in the myelomocytic cell line, HL60, revealed that Sp3 participates in activation of the CD11c and CD11b promoters in vivo.
T11 1347-1535 Sentence denotes Antisense experiments that knocked out endogenous Sp3 expression in the myelomocytic cell line, HL60, revealed that Sp3 participates in activation of the CD11c and CD11b promoters in vivo.