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PubMed:9235954 JSONTXT 22 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes p38-2, a novel mitogen-activated protein kinase with distinct properties.
T1 0-73 Sentence denotes p38-2, a novel mitogen-activated protein kinase with distinct properties.
T2 74-154 Sentence denotes Mitogen-activated protein (MAP) kinases are involved in many cellular processes.
T2 74-154 Sentence denotes Mitogen-activated protein (MAP) kinases are involved in many cellular processes.
T3 155-332 Sentence denotes Here we describe the cloning and characterization of a new MAP kinase, p38-2. p38-2 belongs to the p38 subfamily of MAP kinases and shares with it the TGY phosphorylation motif.
T3 155-332 Sentence denotes Here we describe the cloning and characterization of a new MAP kinase, p38-2. p38-2 belongs to the p38 subfamily of MAP kinases and shares with it the TGY phosphorylation motif.
T4 333-399 Sentence denotes The complete p38-2 cDNA was isolated by polymerase chain reaction.
T4 333-399 Sentence denotes The complete p38-2 cDNA was isolated by polymerase chain reaction.
T5 400-461 Sentence denotes It encodes a 364-amino acid protein with 73% identity to p38.
T5 400-461 Sentence denotes It encodes a 364-amino acid protein with 73% identity to p38.
T6 462-533 Sentence denotes Two shorter isoforms missing the phosphorylation motif were identified.
T6 462-533 Sentence denotes Two shorter isoforms missing the phosphorylation motif were identified.
T7 534-620 Sentence denotes Analysis of various tissues demonstrated that p38-2 is differently expressed from p38.
T7 534-620 Sentence denotes Analysis of various tissues demonstrated that p38-2 is differently expressed from p38.
T8 621-687 Sentence denotes Highest expression levels were found in heart and skeletal muscle.
T8 621-687 Sentence denotes Highest expression levels were found in heart and skeletal muscle.
T9 688-774 Sentence denotes Like p38, p38-2 is activated by stress-inducing signals and proinflammatory cytokines.
T9 688-774 Sentence denotes Like p38, p38-2 is activated by stress-inducing signals and proinflammatory cytokines.
T10 775-813 Sentence denotes The preferred upstream kinase is MEK6.
T10 775-813 Sentence denotes The preferred upstream kinase is MEK6.
T11 814-985 Sentence denotes Although p38-2 and p38 phosphorylate the same substrates, the site specificity of phosphorylation can differ as shown by two-dimensional phosphopeptide analysis of Sap-1a.
T11 814-985 Sentence denotes Although p38-2 and p38 phosphorylate the same substrates, the site specificity of phosphorylation can differ as shown by two-dimensional phosphopeptide analysis of Sap-1a.
T12 986-1120 Sentence denotes Additionally, kinetic studies showed that p38-2 appears to be about 180 times more active than p38 on certain substrates such as ATF2.
T12 986-1120 Sentence denotes Additionally, kinetic studies showed that p38-2 appears to be about 180 times more active than p38 on certain substrates such as ATF2.
T13 1121-1301 Sentence denotes Both kinases are inhibited by a class of pyridinyl imidazoles. p38-2 phosphorylation of ATF2 and Sap-1a but not Elk1 results in increased transcriptional activity of these factors.
T13 1121-1301 Sentence denotes Both kinases are inhibited by a class of pyridinyl imidazoles. p38-2 phosphorylation of ATF2 and Sap-1a but not Elk1 results in increased transcriptional activity of these factors.
T14 1302-1388 Sentence denotes A sequential kinetic mechanism of p38-2 is suggested by steady state kinetic analysis.
T14 1302-1388 Sentence denotes A sequential kinetic mechanism of p38-2 is suggested by steady state kinetic analysis.
T15 1389-1502 Sentence denotes In conclusion, p38-2 may be an important component of the stress response required for the homeostasis of a cell.
T15 1389-1502 Sentence denotes In conclusion, p38-2 may be an important component of the stress response required for the homeostasis of a cell.