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PubMed:9211933 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
T1 0-98 Sentence denotes Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
T2 99-163 Sentence denotes Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
T2 99-163 Sentence denotes Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
T3 164-271 Sentence denotes Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
T3 164-271 Sentence denotes Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
T4 272-447 Sentence denotes This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
T4 272-447 Sentence denotes This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
T5 448-724 Sentence denotes Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
T5 448-724 Sentence denotes Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
T6 725-905 Sentence denotes Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
T6 725-905 Sentence denotes Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
T7 906-1025 Sentence denotes In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
T7 906-1025 Sentence denotes In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
T8 1026-1094 Sentence denotes LPS stimulation increased the binding of c-Jun-containing complexes.
T8 1026-1094 Sentence denotes LPS stimulation increased the binding of c-Jun-containing complexes.
T9 1095-1260 Sentence denotes In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
T9 1095-1260 Sentence denotes In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
T10 1261-1444 Sentence denotes The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
T10 1261-1444 Sentence denotes The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
T11 1445-1628 Sentence denotes Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
T11 1445-1628 Sentence denotes Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
T12 1629-1800 Sentence denotes These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.
T12 1629-1800 Sentence denotes These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.