| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-60 |
Sentence |
denotes |
Genes implicated in the pathogenesis of Alzheimer's disease. |
| T1 |
0-60 |
Sentence |
denotes |
Genes implicated in the pathogenesis of Alzheimer's disease. |
| TextSentencer_T2 |
61-158 |
Sentence |
denotes |
Both the early and late-onset Alzheimer's disease affect millions of people throughout the world. |
| T2 |
61-158 |
Sentence |
denotes |
Both the early and late-onset Alzheimer's disease affect millions of people throughout the world. |
| TextSentencer_T3 |
159-245 |
Sentence |
denotes |
A number of molecules have been implicated in the pathogenesis of Alzheimer's disease. |
| T3 |
159-245 |
Sentence |
denotes |
A number of molecules have been implicated in the pathogenesis of Alzheimer's disease. |
| TextSentencer_T4 |
246-334 |
Sentence |
denotes |
These include presenilin 1 and 2 (PS1 and PS2), a beta-amyloid peptide, and tau protein. |
| T4 |
246-334 |
Sentence |
denotes |
These include presenilin 1 and 2 (PS1 and PS2), a beta-amyloid peptide, and tau protein. |
| TextSentencer_T5 |
335-436 |
Sentence |
denotes |
Presenilin 1 and 2 genes implicated in the early-onset familial Alzheimer's disease have been cloned. |
| T5 |
335-436 |
Sentence |
denotes |
Presenilin 1 and 2 genes implicated in the early-onset familial Alzheimer's disease have been cloned. |
| TextSentencer_T6 |
437-535 |
Sentence |
denotes |
Both PS1 and PS2 are integral membrane proteins and may function as receptors or channel proteins. |
| T6 |
437-535 |
Sentence |
denotes |
Both PS1 and PS2 are integral membrane proteins and may function as receptors or channel proteins. |
| TextSentencer_T7 |
536-658 |
Sentence |
denotes |
Missense mutations in PS1 and PS2 genes have been found in families that cosegregate with early-onset Alzheimer's disease. |
| T7 |
536-658 |
Sentence |
denotes |
Missense mutations in PS1 and PS2 genes have been found in families that cosegregate with early-onset Alzheimer's disease. |
| TextSentencer_T8 |
659-755 |
Sentence |
denotes |
Overexpression of the mutated PS1 gene produced amyloid plaques in the brain of transgenic mice. |
| T8 |
659-755 |
Sentence |
denotes |
Overexpression of the mutated PS1 gene produced amyloid plaques in the brain of transgenic mice. |
| TextSentencer_T9 |
756-932 |
Sentence |
denotes |
Secreted beta-amyloid protein similar to that in the senile plaques of Alzheimer's disease was found to be elevated in fibroblast media from subjects with PS1 or PS2 mutations. |
| T9 |
756-932 |
Sentence |
denotes |
Secreted beta-amyloid protein similar to that in the senile plaques of Alzheimer's disease was found to be elevated in fibroblast media from subjects with PS1 or PS2 mutations. |
| TextSentencer_T10 |
933-1147 |
Sentence |
denotes |
Transgenic mice which carried the mutant form of the beta-amyloid precursor protein gene expressed high concentrations of mutant copy of the gene and exhibited abundant amyloid plaques in the brain and memory loss. |
| T10 |
933-1147 |
Sentence |
denotes |
Transgenic mice which carried the mutant form of the beta-amyloid precursor protein gene expressed high concentrations of mutant copy of the gene and exhibited abundant amyloid plaques in the brain and memory loss. |
| TextSentencer_T11 |
1148-1197 |
Sentence |
denotes |
The mutated PS2 gene enhanced apoptotic activity. |
| T11 |
1148-1197 |
Sentence |
denotes |
The mutated PS2 gene enhanced apoptotic activity. |
| TextSentencer_T12 |
1198-1333 |
Sentence |
denotes |
This enhanced apoptotic activity may accelerate the process of neurodegeneration leading to an earlier age in the onset of the disease. |
| T12 |
1198-1333 |
Sentence |
denotes |
This enhanced apoptotic activity may accelerate the process of neurodegeneration leading to an earlier age in the onset of the disease. |
| TextSentencer_T13 |
1334-1488 |
Sentence |
denotes |
Identification of lesions in the molecules that are important in the Alzheimer's disease should allow developing therapeutic approaches for its treatment. |
| T13 |
1334-1488 |
Sentence |
denotes |
Identification of lesions in the molecules that are important in the Alzheimer's disease should allow developing therapeutic approaches for its treatment. |