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PubMed:9115242 JSONTXT 29 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site.
T1 0-141 Sentence denotes Transcriptional induction of collagenase-1 in differentiated monocyte-like (U937) cells is regulated by AP-1 and an upstream C/EBP-beta site.
T2 142-307 Sentence denotes In this report, we demonstrate that the AP-1 site and a distal promoter element regulate transcriptional induction of collagenase-1 during monocytic differentiation.
T2 142-307 Sentence denotes In this report, we demonstrate that the AP-1 site and a distal promoter element regulate transcriptional induction of collagenase-1 during monocytic differentiation.
T3 308-609 Sentence denotes Chloramphenicol acetyltransferase expression constructs containing regions of the human collagenase-1 promoter were stably or transiently transfected into U937 cells, and reporter activity was assessed at various times after the onset of phorbol 12-myristate 13-acetate (PMA)-mediated differentiation.
T3 308-609 Sentence denotes Chloramphenicol acetyltransferase expression constructs containing regions of the human collagenase-1 promoter were stably or transiently transfected into U937 cells, and reporter activity was assessed at various times after the onset of phorbol 12-myristate 13-acetate (PMA)-mediated differentiation.
T4 610-829 Sentence denotes Rapid and strong induction of promoter activity was lost in constructs with a mutant AP-1 element; however, at 16-96 h post-PMA, the mutant collagenase-1 promoter displayed AP-1 independent PMA-mediated transactivation.
T4 610-829 Sentence denotes Rapid and strong induction of promoter activity was lost in constructs with a mutant AP-1 element; however, at 16-96 h post-PMA, the mutant collagenase-1 promoter displayed AP-1 independent PMA-mediated transactivation.
T5 830-931 Sentence denotes The AP-1 mutant constructs also showed delayed transcriptional activation in PMA-treated fibroblasts.
T5 830-931 Sentence denotes The AP-1 mutant constructs also showed delayed transcriptional activation in PMA-treated fibroblasts.
T6 932-1077 Sentence denotes Western and supershift analyses indicated that functional Jun and Fos proteins were present in nuclear extracts of PMA-differentiated U937 cells.
T6 932-1077 Sentence denotes Western and supershift analyses indicated that functional Jun and Fos proteins were present in nuclear extracts of PMA-differentiated U937 cells.
T7 1078-1210 Sentence denotes Promoter deletion constructs demonstrated the potential role of distal promoter sequences in regulating collagenase-1 transcription.
T7 1078-1210 Sentence denotes Promoter deletion constructs demonstrated the potential role of distal promoter sequences in regulating collagenase-1 transcription.
T8 1211-1449 Sentence denotes In particular, Western, supershift, and promoter deletion analyses suggested a role for CCAAT/enhancer-binding protein-beta (C/EBP-beta) binding site between -2010 and -1954 in regulating transcription of collagenase-1 in monocytic cells.
T8 1211-1449 Sentence denotes In particular, Western, supershift, and promoter deletion analyses suggested a role for CCAAT/enhancer-binding protein-beta (C/EBP-beta) binding site between -2010 and -1954 in regulating transcription of collagenase-1 in monocytic cells.
T9 1450-1587 Sentence denotes Our findings suggest that distinct regulatory elements, acting somewhat independently of each other, control expression of collagenase-1.
T9 1450-1587 Sentence denotes Our findings suggest that distinct regulatory elements, acting somewhat independently of each other, control expression of collagenase-1.
T10 1588-1816 Sentence denotes In addition, our data suggests that the rapid PMA-mediated induction of collagenase-1 transcription is controlled by a mechanism distinct from that regulating the sustained expression of this proteinase in activated macrophages.
T10 1588-1816 Sentence denotes In addition, our data suggests that the rapid PMA-mediated induction of collagenase-1 transcription is controlled by a mechanism distinct from that regulating the sustained expression of this proteinase in activated macrophages.