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PubMed:9028321 JSONTXT 33 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-128 Sentence denotes Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.
T1 0-128 Sentence denotes Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis.
TextSentencer_T2 129-278 Sentence denotes Programmed cell death (or apoptosis) is a physiological process essential to the normal development and homeostatic maintenance of the immune system.
T2 129-278 Sentence denotes Programmed cell death (or apoptosis) is a physiological process essential to the normal development and homeostatic maintenance of the immune system.
TextSentencer_T3 279-553 Sentence denotes The Fas/Apo-1 receptor plays a crucial role in the regulation of apoptosis, as demonstrated by lymphoproliferation in MRL-lpr/lpr mice and by the recently described autoimmune lymphoproliferative syndrome (ALPS) in humans, both of which are due to mutations in the Fas gene.
T3 279-553 Sentence denotes The Fas/Apo-1 receptor plays a crucial role in the regulation of apoptosis, as demonstrated by lymphoproliferation in MRL-lpr/lpr mice and by the recently described autoimmune lymphoproliferative syndrome (ALPS) in humans, both of which are due to mutations in the Fas gene.
TextSentencer_T4 554-730 Sentence denotes We describe a novel family with ALPS in which three affected siblings carry two distinct missense mutations on both the Fas gene alleles and show lack of Fas-induced apoptosis.
T4 554-730 Sentence denotes We describe a novel family with ALPS in which three affected siblings carry two distinct missense mutations on both the Fas gene alleles and show lack of Fas-induced apoptosis.
TextSentencer_T5 731-875 Sentence denotes The children share common clinical features including splenomegaly and lymphadenopathy, but only one developed severe autoimmune manifestations.
T5 731-875 Sentence denotes The children share common clinical features including splenomegaly and lymphadenopathy, but only one developed severe autoimmune manifestations.
TextSentencer_T6 876-1267 Sentence denotes In all three siblings, we demonstrated the presence of anergic CD3+CD4-CD8- (double negative, [DN]) T cells; moreover, a chronic lymphocyte activation was found, as demonstrated by the presence of high levels of HLA-DR expression on peripheral CD3+ cells and by the presence of high levels of serum activation markers such as soluble interleukin-2 receptor (slL-2R) and soluble CD30 (sCD30).
T6 876-1267 Sentence denotes In all three siblings, we demonstrated the presence of anergic CD3+CD4-CD8- (double negative, [DN]) T cells; moreover, a chronic lymphocyte activation was found, as demonstrated by the presence of high levels of HLA-DR expression on peripheral CD3+ cells and by the presence of high levels of serum activation markers such as soluble interleukin-2 receptor (slL-2R) and soluble CD30 (sCD30).